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Reports
Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report

Detailed contents

March 31, 2005

Introduction

  Members of the Advisory Committee
  Associated members
  Date of meetings held
Chap1: Results of major actions and future tasks
  Section1: Test scheme
  1 Introduction
  2 Outline of the extended test scheme
  3 Progress of study and results obtained
    (1)Screening
    (a) In silico screening
    (b) In vitro screening (ii)
    (c) In vivo screening (iii)
    (2)Priority list
    (3)Definitive studies
  4 Future tasks
    (1)Screening
    (2)Definitive studies
  Section2: Sampling and analysis
  1 Introduction
  2 Guideline for determination of endocrine disruptors in foods
  3 Guideline for determination of endocrine disruptors in biological samples
    Part 1: General testing
    Part 2:
    Analysis of bisphenol A in biological samples
    Analysis of phthalic acid esters in biological samples
    Analysis of 4-nonylphenol in biological samples
 

4

Guideline for determination of endocrine disruptors in feeds for experimental animals
    Part 1: General testing
    Part 2:
    Analysis of bisphenol A in biological samples
    Analysis of phthalic acid esters in animal feeds
    Analysis of 4-nonylphenol in animal feeds
    Analysis of phytoestrogens in feeds for experimental animals (tentative)
    Analysis of 17β-estradiol in feeds for experimental animals (tentative)
 

5

Ensuring reliability of analytical results
 

6

Exposure of experimental animals in farm and laboratory environment
    (1)Chemical substances in farm and laboratory environment
    (a) Bisphenol A in feeds and litter
    (b) Phthalic acid esters in feeds and litter
    (c) 4-Nonylphenol in feeds and litter
    (d) Phytoestrogens in feeds
    (e) 17β-Estradiol in feeds
    (2)Approach to chemical exposure via farm and laboratory environment
 

7

Tasks for future studies
  Section3: The low-dose issue
 

1

Background
 

2

New findings concerning the low-dose issue
    (1)Overview of the low-dose issue
    (2)New findings on the mechanisms of action
    (3)Findings related to the homeostatic regulatory systems
    (4)Overview of information gathered
 

3

Proposed subjects for future investigations
    (1)Highly sensitive stages of the development: fetal, neonatal and adolescent
    (2)Highly sensitive periods and the low dose issue
    (3)Homeostatic regulatory system: the focus of the effects on organisms
    (4)Endocrine disruptor study using genomic techniques
  Section4: Epidemiology of exposure
  Section4-1: Exposure in living organisms
 

1

Introduction
 

2

Establishment of measurement methods
 

3

Exposure in living organisms
    3-1 Bisphenol A
    3-2 Chlorobenzenes
    3-3 4-Hydroxybenzoates
    3-4 Phthalic acid esters
    3-5 Benzo[a]pyrene
    3-6 PCBs
    3-7 Dioxins
    3-8 Chlordane
    3-9 Organotin compounds
    3-10 4-Nonylphenol
    3-11 Halogenated hydrocarbon-based pesticides
    3-12 Organophosphorus pesticides
    3-13 Organochlorine compounds (DDTs, PCBs and dioxins)
    3-14Organofluorine compounds (PFOS, PFOA, PFOSA)
    3-15 Phytoestrogens
    3-16 Heavy metals
    3-17 Volatile organic compounds (toluene, benzene, xylene, styrene, p-dichlorobenzene, etc.)
 

4

Approach to exposure in living organisms
 

5

Onset of adverse effects in the living body
 

6

Proposed topics for further studies
 

7

Literature
  Section4-2: Epidemiologic studies
  1 Introduction
  2 Overview of the present status of epidemiologic studies on the health effects of endocrine disruptors
    [Carcinogenesis]
    2-1 Breast cancer
    2-2 Endometrial cancer
    2-3 Ovarian cancer
    2-4 Prostatic cancer
    2-5 Testicular cancer
    2-6 Thyroid cancer
    [Effects on thyroid functions]
    2-7 Effects on thyroid functions
    [Effects on organ formation]
    2-8 Hypospadias
    2-9 Cryptorchidism
    [Effects on infantile nerve development]
    2-10 Effects on infantile nerve development
    [Effects on fertility]
    2-11 Sperm count
    2-12 Endometriosis
    [Effects on immune functions]
    2-13 Effects on immune functions (allergy)
 

3

Summary
 

4

Recommendations on future studies
    (1)Investigation of the current situation and monitoring of exposure level and relevant diseases
    (2)Promotion of epidemiological studies (case-control studies and cohort studies)
    (3)Continuing disclosure of literature review on health effects of endocrine disruptors
  Section5: Risk communication
  1 Introduction
  2 Endocrine disruptor issue and risk communication
    2-1 Necessity and purpose of risk communication
    2-2 Persons concerned in risk communication
 

3

Guideline for risk communication concerning endocrine disruptors
    (1)Contents
    (2)Preparation of contents
    (3)Choice of adequate communication routes
    (4)Updating
    (5)Literature
 

4

Recommendations on future studies
 

5

Summary of the Supplement II to the Interim Report
    Introducing the Supplement II to the Interim Report
    (1)Test scheme (Test and evaluation system on health effects)
    (2)Sampling and analysis
    (3)Low-dose issue
    (4)Epidemiologic study of exposure
    (4-1)Degree of exposure of living bodies
    (4-2)Epidemiologic studies
Chap2: Summary and action plan
  Action Plan
  Working group members and references
  APPENDIX
    Summary of the Interim Report by the Advisory Committee on Health Effects of Endocrine Disruptor (December 1998)
     
     
     
     
 

 

   

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