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Advisory Committee on Health Effects of
Endocrine Disruptors
The Supplement II to the Intermediary Report
Detailed contents
March 31, 2005
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Introduction |
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Members of the Advisory Committee |
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Associated members |
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Date of meetings held |
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Results of major actions and future tasks |
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Section1: |
Test scheme |
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1 |
Introduction |
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2 |
Outline of the extended test scheme |
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Progress of study and results obtained |
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(1)Screening |
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(a) In silico screening |
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(b) In vitro screening (ii) |
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(c) In vivo screening (iii) |
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(2)Priority list |
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(3)Definitive studies |
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Future tasks |
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(1)Screening |
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(2)Definitive studies |
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Section2: |
Sampling and analysis |
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1 |
Introduction |
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2 |
Guideline for determination of endocrine disruptors in foods |
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Guideline for determination of endocrine disruptors in biological samples |
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Part 1: General testing |
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Part 2: |
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Analysis of bisphenol A in biological samples |
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Analysis of phthalic acid esters in biological samples |
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Analysis of 4-nonylphenol in biological samples |
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Guideline for determination of endocrine disruptors in feeds for experimental animals |
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Part 1: General testing |
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Part 2: |
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Analysis of bisphenol A in biological samples |
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Analysis of phthalic acid esters in animal feeds |
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Analysis of 4-nonylphenol in animal feeds |
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Analysis of phytoestrogens in feeds for experimental animals (tentative) |
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Analysis of 17β-estradiol in feeds for experimental animals (tentative) |
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Ensuring reliability of analytical results |
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Exposure of experimental animals in farm and laboratory environment |
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(1)Chemical substances in farm and laboratory environment |
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(a) Bisphenol A in feeds and litter |
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(b) Phthalic acid esters in feeds and litter |
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(c) 4-Nonylphenol in feeds and litter |
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(d) Phytoestrogens in feeds |
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(e) 17β-Estradiol in feeds |
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(2)Approach to chemical exposure via farm and laboratory environment |
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Tasks for future studies |
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Section3: |
The low-dose issue |
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1 |
Background |
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New findings concerning the low-dose issue |
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(1)Overview of the low-dose issue |
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(2)New findings on the mechanisms of action |
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(3)Findings related to the homeostatic regulatory systems |
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(4)Overview of information gathered |
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Proposed subjects for future investigations |
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(1)Highly sensitive stages of the development: fetal, neonatal and adolescent |
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(2)Highly sensitive periods and the low dose issue |
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(3)Homeostatic regulatory system: the focus of the effects on organisms |
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(4)Endocrine disruptor study using genomic techniques |
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Section4: |
Epidemiology of exposure |
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Section4-1: |
Exposure in living organisms |
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1 |
Introduction |
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Establishment of measurement methods |
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Exposure in living organisms |
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3-1 Bisphenol A |
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3-2 Chlorobenzenes |
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3-3 4-Hydroxybenzoates |
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3-4 Phthalic acid esters |
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3-5 Benzo[a]pyrene |
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3-6 PCBs |
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3-7 Dioxins |
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3-8 Chlordane |
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3-9 Organotin compounds |
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3-10 4-Nonylphenol |
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3-11 Halogenated hydrocarbon-based pesticides |
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3-12 Organophosphorus pesticides |
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3-13 Organochlorine compounds (DDTs, PCBs and dioxins) |
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3-14Organofluorine compounds (PFOS, PFOA, PFOSA) |
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3-15 Phytoestrogens |
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3-16 Heavy metals |
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3-17 Volatile organic compounds (toluene, benzene, xylene, styrene, p-dichlorobenzene, etc.) |
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Approach to exposure in living organisms |
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Onset of adverse effects in the living body |
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Proposed topics for further studies |
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7 |
Literature |
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Section4-2: |
Epidemiologic studies |
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1 |
Introduction |
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Overview of the present status of epidemiologic studies on the health effects of endocrine disruptors |
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[Carcinogenesis] |
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2-1 Breast cancer |
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2-2 Endometrial cancer |
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2-3 Ovarian cancer |
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2-4 Prostatic cancer |
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2-5 Testicular cancer |
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2-6 Thyroid cancer |
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[Effects on thyroid functions] |
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2-7 Effects on thyroid functions |
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[Effects on organ formation] |
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2-8 Hypospadias |
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2-9 Cryptorchidism |
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[Effects on infantile nerve development] |
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2-10 Effects on infantile nerve development |
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[Effects on fertility] |
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2-11 Sperm count |
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2-12 Endometriosis |
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[Effects on immune functions] |
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2-13
Effects on immune functions (allergy) |
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Summary |
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Recommendations on future studies |
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(1)Investigation of the current situation and monitoring of exposure level and relevant diseases |
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(2)Promotion of epidemiological studies (case-control studies and cohort studies) |
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(3)Continuing disclosure of literature review on health effects of endocrine disruptors |
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Section5: |
Risk communication |
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1 |
Introduction |
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Endocrine disruptor issue and risk communication |
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2-1
Necessity and purpose of risk communication |
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2-2 Persons concerned in risk communication |
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3 |
Guideline for risk communication concerning endocrine disruptors |
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(1)Contents |
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(2)Preparation of contents |
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(3)Choice of adequate communication routes |
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(4)Updating |
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(5)Literature |
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Recommendations on future studies |
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5 |
Summary of the Supplement II to the Interim Report |
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Introducing the Supplement II to the Interim Report |
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(1)Test scheme (Test and evaluation system on health effects) |
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(2)Sampling and analysis |
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(3)Low-dose issue |
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(4)Epidemiologic study of exposure |
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(4-1)Degree of exposure of living bodies |
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(4-2)Epidemiologic studies |
| Chap2: |
Summary and action plan |
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Action Plan |
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Working group members and references |
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APPENDIX |
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Summary of the Interim Report by the Advisory Committee on
Health Effects of Endocrine Disruptor (December 1998) |
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