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Exposure in living
organisms
1 Introduction
In addition to measuring the exposure in living organisms to
endocrine disruptors, the Working Group has studied relevant
receptors, development of the effects, metabolism and
detoxification.
2 Establishment of measurement methods
Measurement methods with high sensitivity and selectivity are a
prerequisite for the study of health effects of endocrine
disruptors. Handling of samples needs particular attention:
procedures of collection, separation and storage of the sample
should not permit interference of extrinsic factors or
contamination in order to obtain reliable measurement results.
Studies for this purpose was started with Health and Labor
Research 1999-2001 "Analytical and kinetic study of endocrine
disruptors in daily utensils made of polymers" (presided by
Hiroyuki Nakazawa, Hoshi University) and continued in Health and
Labor Research 2002-04 "Studies on the reliability of analysis
and monitoring of exposure of living organisms". The guideline
for analysis developed by the Sampling and Analysis Working
Group in the present work (see relevant sections) for bisphenol
A (BPA), di-2-ethylhexyl phthalate (DEHP) and other phthalates,
and 4-nonylphenol now assures accumulation of reliable
analytical data. |
