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3.5
Benzo[a]pyrene
- Monohydroxybenzo[a]pyrene (OH-BaP) was found in male urine
samples.1)
3.6 PCBs
- PCBs were found in maternal body, maternal peripheral blood
and cord blood as 35 homologues and isomers in a range of 60-99 ng/g fat.1)
- Exposure as studied by autopsy is summarized as follows. The
average concentrations of mono-o-PCBs (8 compounds) in the liver
(57 samples), mesenteric fat (54 samples) and abdominal wall fat
(54 samples) were 8.95, 19.16 and 20.59 pg TEQ/g fat. Those of
di-o-PCBs were 11.36, 24.79 and 20.59 pg TEQ/g fat. It is noted
that the levels in the liver were about a half of those in the
other samples for both substances. The relative abundance ratio
of the 12 compounds studied was almost the same for the liver,
mesenteric fat and abdominal wall fat. Blood (38) and bile (42)
samples were also studied. Among mono-o-PCBs, the concentration
of 2,3',4,4',5-PenCB (#118) of 159 ± 156 ppt on an average was
the highest, as in the liver and fat tissue. The next highest
value was 74 ± 52 ppt on an average for 2,3,3',4,4',5-HexCB
(#156). A similar pattern was observed for the bile: 347 ± 194 ppt of #118 and 171
± 99 ppt of #156 were the two highest
average values. The total concentration of mono-o-PCBs in the
bile was about two times as high as in the blood.5)
3.7 Dioxins
- Exposure as studied by autopsy is summarized as follows. The
dioxin concentrations in the blood and bile (57 samples) were
42.6 ± 24.3 and 43.4 ± 30.8 pg TEQ/g fat, respectively, and
127.2 ± 53.4 pg TEQ/g fat in the liver. The concentration the
blood was highly correlated with that in the bile. The
concentration per unit weight of fat was higher in the liver
than in blood or bile. Elimination from bile depended on the
dioxin isomers. OCDD showed the highest concentration, followed
by PeCB and HxCB. The concentrations of 1,2,3,6,7,8-HxCDD, TeCB,
2,3,4,7,8-PeCDD and 1,2,3,4,6,7,8-HpCDD were moderately high.
The distribution of isomers showed a pattern similar to that in
the blood, but the concentration was about 1/2 times that in the
blood for HxCDF and HpCDF, about 2/3 times for HxCDD, about 1/2
times for HpCDD and OCDD, and about 1/2 times for TeCB. The
concentration of other isomers in the bile and blood were
comparable. The liver showed generally high concentrations of
PCDDs and coplanar PCBs: OCDD, PeCB, HxCB, 1,2,3,4,6,7,8-HpCCD.
1,2,3,6,7,8-HxCDD, TeCB, 2,3,4,7,8-PeCDD in the descending order
of concentration. The concentration of 1,2,3,4,6,7,8-HpDF in the
liver was 20 times as high as in bile and 10 times as in blood;
1,2,3,4,7,8,9-HpCDF 10 times as in bile and 8 times as in blood;
OCDD 5 times as in blood and 9 times as in bile.
The kidney, spleen and lung showed accumulation of dioxins of
138, 113, 163 and 178 pg TEQ/g fat, respectively, on an average,
with ratios of homologues similar to those in other organs. The
average concentration of dioxins in the pancreas was 20-30 times
as high as in the other organs with respect to the whole organ,
but was approximately at the same level with respect to fat. The
dioxin accumulation level in the central nerve system in 7 cases
was close to that in the liver, and that in the mammary gland in
7 cases was close to that in the fatty tissue.
Analysis of correlation with age and sex revealed that the
accumulation of dioxins and PCBs increases with aging. As for
bromine-based dioxins, the blood, bile, liver and fat tissues
contained 4,087 ± 4,428, 2､953 ± 2,916, 4,001 ± 3,191 and 5399 ±
4826 pg/g fat, respectively, of 25 isomers of polybrominated
diphenyl ethers (PBDEs) (BDE-#17, 25, 28, 30, 32, 33, 35, 37,
47,49, 66, 71, 75, 77, 85, 99, 100, 116, 119, 126, 138, 153,
154, 155, 166). 2,2',4,4'-TetraBDE (#47) and
2,2',4,4',5,5'-hexaBDE (#153) showed the highest concentrations
among the 27 isomers measured, and accounted for 70% of the
total PBDEs. The correlation coefficients between the levels in
heart blood and bile on the one hand, and heart blood and liver
tissue on the other, were 0.64 and 0.60, respectively. PBDEs
were found to be eliminated via bile as dioxins.5)
- High-sensitivity CALUX, detection limit 4.0 pg/ml TEQ/g blood:
Measurement of dioxin concentration (PCDDs/Fs fraction) in the
blood of 47 young male subjects (20.0 years of age on an
average) revealed an average exposure of 10.18 (4-19) pg/TEQ.
The values obtained in this analysis were lower than those of
CALUX results by Kayama in another project in which many samples
gave 20 pg TEQ/g fat or higher. The results in the present work
were comparable to those obtained by HRGC/HRMS, although the
CALUX method is reported to give generally 2-3 times higher
values than HRGC/HRMS.6)
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