Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.1.3

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3.8 Chlordane

• Trans-nonachlor was found in 63% of the samples (0.06-0.17%), and cis-nonachlor in 17% (0.03-0.05 ppb). No sample showed heptachlorepoxide, oxychlordane, trans-chlordane or cis-chlordane.1)

• It has been reported in 1999 that tributiltin was found in 33-77% of hair samples (5-44 ppb, varying with analytical procedures), and in an example high concentrations (41-45 ppb) were observed for samples from one family.1)
• Autopsy revealed in 27 liver samples monobutyltin, dibutyltin and tirbutyltin of 6.0-28, 6.5-71, and less than the detection limit-3.4 ng cation/g, respectively, and in 17 bile samples 6.0-21, 1.0-13, and less than the detection limit-3.0 ng cation/g.5)

• Procedure according to Analysis Guideline, determination limit 5 ppb:
  Freshly collected cord blood, maternal blood, breast milk and peritoneal fluid samples from 221 cases were analyzed. The compound was detected in the blood from 17 cases with a maximum level of 25.0 ppb, but not from maternal blood or cord blood. The peritoneal fluid from 9 cases showed a maximum of 19.0 ppb of 4-nonylphenol.2)

• Headspace gas chromatography (HS-GC), determination limit 0.5-500 μg/ml, detection limit 0.5 μg/ml:
  Exposure level was estimated for male workers in a pesticide plant and a non-exposed control group by analysis of metabolites in urine and blood. Workers handling active ingredients (n = 13) showed 15.9 ± 7.7 μg/mg CRE of urinary bromide ion (range 7.1-30.3 μg/mg CRE), packaging operators (n = 22) 15.6 ± 6.2 μg/mg CRE (range 7.1-30.3 μg/mg CRE), compared with 8.9 ± 3.5 μg/mg CRE for the control. Similarly, the bromide ion concentrations in the average serum were 12.9 ± 4.7 μg/ml (range 6.3-21.2 μg/ml) for workers handling ingredients, and 12.2 ± 5.0 μg/ml (range 5.0-25.3 μg/ml ) for packaging operators, which are significantly higher than 5.2 ± 1.6 μg/ml for the control. The exposure level observed in this study was close to data obtained for the past 14 years. The pesticide plant workers were exposed to higher level of chemicals, but no effect on reproduction was established at a significant level as a population.7)

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