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2.5 Testicular cancer [Summary]
Literature survey concerning epidemiology of endocrine
disruptors (except dioxins) and testicular cancer was performed.
Searching the PubMed database retrieved 16 reports published up
to Dec. 31, 2000, consisting of 7 cohort studies, 7 case-control
studies and 2 ecological studies. Since Jan. 1, 2001, 2
case-control studies (from a single project) and 1 ecological
study were published. No Japanese subject was studied in these
papers. Few of them address organochlorine compounds. While
relevance of mother's exposure has been revealed, exposure
during the fetal period still needs study. Recent prospective
studies found no significant correlation of testicular cancer
risk with prenatal exposure to diethylstilbestrol. Other
endocrine disruptors were not studied. Thus findings on the
relationship of endocrine disruptors and testicular cancer are
thus scanty.
[Purpose]
Some organochlorine compounds have estrogen- or androgen-like
activities. The relationship of exposure to these compounds with
endocrine-related cancer has been attracted attention.
Literature was surveyed in order to summarize the present status
of epidemiologic research on the relationship of chemical
substances and testicular cancer.
[Method]
The PubMed database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi)
provided by National Library of Medicine was searched with a
strategy "(Testicular Neoplasms) AND(Insecticides OR Pesticides
OR Chlorinated Hydrocarbons OR PCBs OR Bisphenol OR Phenol OR
Phthalate OR Styrene OR Furan OR Organotin OR Diethylstilbestrol
OR Ethinyl Estradiol) AND (human)". From among 71 citations
retrieved, original papers reporting epidemiologic studies on
human populations were selected, and, as necessary, other
articles cited in these papers or reviews were added.
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