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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.1.1-2 |
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| Chapter 1: |
Results of major
actions and future tasks |
| Section 1: |
Test scheme |
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1. Introduction
The Ministry of Labor and Welfare have been promoting the
development of techniques for screening, in terms of hormonal
activity, of several hundreds of thousands of suspected
endocrine disruptors, which should lead to establishment of a
priority list for definitive study. The Ministry has also been
developing the methodology of the definitive study in parallel
(see Figure).
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2. Outline of the
extended test scheme |
A screening battery of the
techniques (i), (ii) and (iii) shown in the Figure has proved to
be effective in examining consecutively the hormonal activity of
hundreds of thousands of substances and, therefore, in
developing a priority list for definitive study.
The list is evolutionary in that it is regularly re-sorted e.g.
according to new data on hormonal activity of each entry. It can
also be extended by adding additional information, such as
findings on extents of exposure, thus providing more
comprehensive prioritization criteria. |
Click here to enlarge the image. |
| Definitive studies,
evaluation of hazards and exposures, and risk evaluation based
on them will be conducted for each compound according to the
listed priority. The compounds will be divided into compounds
needing risk management and those do not until new findings
require it in future. Exceptionally, for pesticides and other
substances for which large-scale tests (including
multi-generation tests) have been finished, evaluation of
hazards, exposure and risk may be started immediately if the
test data are enough to evaluate endocrine disruptive
activities. |
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