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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_4

 

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2.4 Prostatic cancer

[Summary]
Literature survey concerning epidemiology of endocrine disruptors (except dioxins) and prostatic cancer was performed. Searching the PubMed database retrieved 13 reports published up to Dec. 31, 2000, consisting of 7 cohort studies, 3 case-control studies and 3 ecological studies. Since Jan. 1, 2001, 3 cohort studies, 3 nested case-control studies and 2 ecological studies were published. No Japanese subject was studied in these papers. The results of the two cohort studies on atrazine did not agree and thus did not permit conclusion on the relevance. Epidemiologic studies on the relationship of organochlorine compounds and prostatic cancer were so few that it was impossible to evaluate the causality. Increase in prostatic cancer risk by exposure to pesticides was suggested but evaluation for specific products was not possible. Endocrine disruptors other than organochlorine compounds were scarcely studied in relation to prostatic cancer, and need more epidemiologic study.

[Purpose]
Some organochlorine compounds have affinity to estrogen or androgen receptors. The relationship of exposure to these compounds with endocrine-related cancer has been attracted attention. Exposure of rats to testostreone caused prostatic cancer in an animal experiment. Literature was surveyed in order to summarize the present status of epidemiologic research on the relationship of chemical substances and prostatic cancer.

[Method]
The PubMed database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) provided by National Library of Medicine was searched with a strategy "(Prostatic Neoplasms) AND (Insecticides OR Pesticides OR Chlorinated Hydrocarbons OR PCBs OR Bisphenol OR Phenol OR Phthalate OR Styrene OR Furan OR Organotin OR Diethylstilbestrol OR Ethinyl Estradiol) AND (human)". From among 1347 citations retrieved, original papers reporting epidemiologic studies on human populations were selected, and, as necessary, other articles cited in these papers or reviews were added.
 

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