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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.1.3 |
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3 Exposure in living organisms
Another important issue is the analysis of exposure in living
organisms, or the quantity of those substances in the living
body (body burden).
Substances studied, chosen in view of the past and present
industrial production in Japan as candidates to be specified in
the final guideline, included bisphenol A (BPA)1,
chlorobenzenes2,
4-hydroxybenzoates, phthalic acid esters3,
benzopyrene4, PCBs5,
chlordane6, and tributyltin
compounds7. Some researchers in
the Working Group have also conducted their own studies. Major
findings obtained in these studies are described below.
The study plans were examined and approved by the ethical
committees of the participating organizations. The subjects were
informed of the protection of human rights and personal
information, as well as of advantages and disadvantages in
participating in the study before consent. For autopsy, the same
information was presented to the bereaved. The body was used
only if a written consent of the bereaved was obtained. (See
Literature 5)
The human genome and gene analysis was conducted according to
the Ethical Guideline for Human Genome and Gene Analysis
(Ministries of Education, Sports , Science and Technology, of
Health, Labor and Welfare, and of Economy and Industry, Mar. 29,
2001). |
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1 Used as a starting
material for resins, 151,000/tons/year produced and imported
(1998).
2 Formerly used as antiseptic and
antifungal agent, produced as an intermediate product in pigment
synthesis. The persistent, accumulating and toxic
hexachlorobenzene was classified as a Class 1 specified
substance* according to the Chemical Substance Control Law in
1979.
* The Class 1 substances of the law are prohibited to
manufacture, import, or use. Products specified by governmental
orders are also prohibited to import.
3 Used as plasticizers for plastics.
4 Released into air by incomplete
combustion of fossil fuels.
5 Formerly used as insulating oil,
classified as a Class 1 specified substance according to the
Chemical Substance Control Law in 1974.
6 Formerly used as termiticide,
classified as a Class 1 specified substance according to the
Chemical Substance Control Law in 1986.
7 Formerly used as ship bottom paint
and antifouling agent for fishing net, use stopped in domestic
shipyards since 1992, manufacture stopped in Japan since 1997. |
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