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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_7

 

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[Effects on thyroid functions]
2.7 Effects on thyroid functions

[Summary]
Literature survey concerning epidemiology of endocrine disruptors (except dioxins) and thyroid functions was performed. The PubMed database was searched with a strategy "(Thyroid) AND (Insecticides OR Pesticides OR Chlorinated Hydrocarbons OR PCBs OR Bisphenol OR Phenol OR Phthalate OR Styrene OR Furan OR Organotin OR Diethylstilbestrol OR Ethinyl Estradiol) AND (human)". The 607 citations retrieved included 15 epidemiologic studies (2 cohort studies, 1 case-control study, 10 synchronic studies, 1 intervention study, and 1 ecological study) published between 2000 and Oct.31, 2004. Japanese subjects were studied in two reports concerning PCBs. The survey showed that the effects of PCBs are recognized in studies on highly exposed populations. Study on general populations is needed. Other endocrine disruptors are scarcely studied in relation to thyroid functions although effects are well established in animal experiments. Epidemiologic studies must thus be continued, particularly in Japan where few studies have been conducted.

[Purpose]
Since thyroid dysfunction was reported in 1994 for a subject exposed to dioxins, the relationship of thyroid functions with substances other than dioxins (e.g. PCBs) has attracted attention. Literature was surveyed in order to summarize the present status of epidemiologic research on the relationship of chemical substances and thyroid functions.

[Method]
The PubMed database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) provided by National Library of Medicine was searched with a strategy "(Thyroid) AND (Insecticides OR Pesticides OR Chlorinated Hydrocarbons OR PCBs OR Bisphenol OR Phenol OR Phthalate OR Styrene OR Furan OR Organotin OR Diethylstilbestrol OR Ethinyl Estradiol) AND (human)". From among 607 citations retrieved, original papers reporting epidemiologic studies on human populations were selected, and, as necessary, other articles cited in these papers or reviews were added.
 

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