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6 Proposed topics for further studies
Immediate tasks should be extending the accumulation of data on
other suspected endocrine disruptors by analyzing samples
collected from different regions of the same body. Simultaneous
sampling from a mother and her fetus is necessary for studying
exposure of the fetus via the maternal body.
Onset of effects on the living body of the substances within the
range of actual body burden should also be clarified along with
metabolism and detoxification processes.
7 Literature
1) Health and Labor Research 1999-2001 "Development of
analytical procedures for biological samples (cord blood etc.)
related to endocrine disruptors and study of their health
effects based on the analytical results" (group led by Tsunehisa
Makino, Tokai University): cord blood, maternal blood, breast
milk and peritoneal fluid taken from the same subject
simultaneously were analyzed, and the concentration distribution
with respect to different organs in the same body was studied.
2) Data for 415 samples, including those from different regions
of the same subject, according to the Analysis Guideline for
BPA, DEHP and NP developed by the Sampling and Analysis Working
Group (led by Makino). 3) Health and Labor Research 2003
"Epidemiologic study of health effects of endocrine disruptors"
(presided by Shoichiro Tsugane, National Cancer Center)
Health and Labor Research 2002 "Epidemiologic study of health
effects of endocrine disruptors" (presided by Shoichiro Tsugane,
National Cancer Center)
Tsugane, S., et al.: Validity and reproducibility of the
self-administered food frequency questionnaire in the JPHC study
Cohort 1: Study design, conduct and participant profiles.
Journal of Epidemiology 13 S2 - S12 (2003)
Ishihara, J., et al.: Validity and reproducibility of the
self-administered food frequency questionnaire in the JPHC study
Cohort 2: Study design, comparison with Cohort 1. Journal of
Epidemiology 13 S134 - S147 (2003)
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