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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
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2 New findings concerning the low-dose issue
The Supplement to the Interim Report by the Ministry of Health,
Labor and Welfare (2001) concludes: "Scientific knowledge
available at present does not affirm endocrine disruption by
chemicals at low doses". To the editor's knowledge, none of
reports subsequently published establishes suspected effects of
endocrine disruptors as such by means of existing or modified,
more stringent testing methods9.
This is partly because the uterotrophic assay, a traditional
method for testing hormonal actions, was addressed by OECD at
that time. It is also the reason why the development of test
methods has since been emphasized. No indicator inherent to
low-dose effects, or common characteristic as endocrine
disruptors is known for substances for which hormonal activities
have been found e.g. by gene reporter assay. It is rather likely
that the substances affect the endocrine system via a variety of
mechanisms. In fact, a number of novel mechanisms have recently
been identified10,11.
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9 Aoyama H, Suzuki K.
Enhanced one-generation reproductive toxicity study in rats for
detecting endocrine-disrupting effects of chemicals. Pure Appl
Chem 75 (11-12): 2497-2501, 2003.
10 Inoue T. Hormonally active agents and plausible
relationships to adverse effects on human health. Pure Appl.
Chem., 75: 2555-2561, 2003.
11 Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H,
Iguchi T. Low dose effect of in utero exposre to bisphenol A and
diethylstilbestrol on female mouse reproduction. Reprod Toxicol.
16: 117-122, 2002. / |
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