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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.4 |
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- Epidemiologic studies on occupational populations
Epidemiologic studies of observational type on occupational
populations under relatively severe exposure have played a major
role in hazard and risk evaluation of chemical substances. The
relatively stable occupational populations and fairly good
availability of information based on workplace monitoring and
health check in Japan offer favorable conditions for
epidemiologic studies of occupational cohorts. The retrospective
cohort study on subjects exposed to chemicals is the most
efficient design, but prospective research is needed for
exposure to new chemicals. In either case, a large cohort
comprising more than one workplace is needed to achieve a high
precision of the results. It will be useful to establish a
registration system of information on chemical exposure
throughout all workplaces, because new health problems may
appear by discovery of endocrine disrupting activities of
substances considered to be harmless in the past. In addition,
development and validation of biomarkers for evaluation of
non-disease end points.
A study group supported by Health and Labor Sciences Research
Grants (Studies on Chemical Risks) has started an epidemiologic
study on occupational populations. This program should further
be enhanced.
(3) Continuing disclosure of literature review on health
effects of endocrine disruptors
Epidemiologic studies on health effects of organochlorines and
other compounds are rapidly developing in response to heightened
interest all over the world. The number of research publications
is increasing. In order to follow this trend, literature review
as included in the present report should be continued, and the
results should be made available to public, e.g. via the
Internet, and regularly updated. This should provide a basis for
the public and the administration to share information of
endocrine disruptor problems supported by scientific evidence.
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