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2.3 Ovarian cancer [Summary]
Literature survey concerning epidemiology of endocrine
disruptors (except dioxins) and ovarian cancer was performed.
Searching the PubMed database retrieved 2 cohort studies, 2
case-control studies and 2 ecological studies up to Dec. 31,
2000. Since Jan. 1, 2001, a cohort study, 2 ecological studies
and a case report were published. No Japanese subject was
studied in these papers. Examination of these reports shows that
diethylstilbestrol is not likely to be an ovarian cancer risk.
Substances other than diethylstilbestrol have been scarcely
addressed and need more extensive study.
[Purpose]
Some organochlorine compounds have estrogen-like activities. The
relationship of exposure to these compounds with
endocrine-related cancer has been attracted attention (2000).
Literature was surveyed in order to summarize the present status
of epidemiologic research on the relationship of chemical
substances and ovarian cancer, which is an endocrine-related
tumor.
[Method]
The PubMed database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi)
provided by National Library of Medicine was searched with a
strategy "(Ovarian Neoplasms) AND (Insecticides OR Pesticides OR
Chlorinated Hydrocarbons OR PCBs OR Bisphenol OR Phenol OR
Phthalate OR Styrene OR Furan OR Organotin OR Diethylstilbestrol
OR Ethinyl Estradiol) AND (human)". From among 104 citations
retrieved original papers reporting epidemiologic studies on
human populations were selected, and, as necessary, other
articles cited in these papers or reviews were added.
[Results]
1. Organochlorine compounds
Very few epidemiological studies were found on organochlorine
compounds (PCBs, pesticides, etc.) as related to ovarian cancer.
1) Prospective cohort studies
No paper in this category was found.
2) Case-control studies
Donna et al. (1989) observed in a case-control study a
significantly higher risk (OR = 3.0) for a group of farm workers
certainly exposed to triazine. Donna et al. (1984) studied the
relationship of pesticide exposure with ovarian mesothelioma,
and found a significant risk increase (OR = 4.38) for a group
certainly or possibly exposed to pesticides, of which, however,
specific product names were not mentioned.
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