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- FcγRIIIaの遺伝子多型(158V/F)がバイオアッセイの性能に及ぼす影響
概要
Aoyama M, Tada M, Ishii-Watabe A
FcγRIIIa-158V/F polymorphism affects the performance of FcγRIIIa-related bioassay.
Biochemical and Biophysical Research Communications. 2022; 608: 149-155.
PMID: 35398612 DOI: 10.1016/j.bbrc.2022.04.001
- Fcγ受容体を介した細胞内取込による抗体薬物複合体凝集体のオフターゲット毒性
概要
Aoyama M, Tada M, Yokoo H, Demizu Y, Ishii-Watabe A
Fcγ receptor-dependent internalization and off-target cytotoxicity of antibody-drug conjugate aggregates.
Pharmaceutical Research 2022; 39(1): 89-103.
PMID: 34961908 DOI: 10.1007/s11095-021-03158-x
- 抗体改変によるFcの機能及び立体構造に対する影響:FcRn親和性改変抗体及びFc融合タンパク質医薬品の解析
概要
Suzuki T, Hashii N, Tada M, Ishii-Watabe A
The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein.
mAbs 2021; 13(1) 1923366.
PMID: 34030575 DOI: 10.1080/19420862.2021.1923366
- Peptide Adsorption-Controlled (PAC)-LC/MSを用いた抗体医薬品の血中濃度測定法
概要
Bioanalysis of therapeutic monoclonal antibody by peptide adsorption-controlled LC-MS.
Hashii N, Tousaka Y, Arai K*1, Enoki Y*2, Fukuda S*2, Goda R*3, Inoue N*4, Kawabata M*2, Murata K*5, Nakatsuji M*4, Okuzono T*6, Shigeyama T*5, Tachiki H*4, Yamaguchi T*5, Yamane S*6, Yamaoka M*4, Saito Y, Ishii-Watabe A
Bioanalysis. 2021;13:265-276.
PMID: 33543661 DOI: 10.4155/bio-2020-0262
*1 LSI Medience Corp., *2 Shin Nippon Biomedical Laboratories, Ltd., *3 Daiichi Sankyo Co., Ltd., *4 Towa Pharmaceutical Co., Ltd., *5 Sumika Chemical Analysis Service, Ltd., *6 Sekisui Medical Co., Ltd.
- 形態,三次元立体画像,Fcγ受容体活性化の観点に基づいた,シリコンオイル-凝集抗体複合体の特性解析
概要
Characterization of Aggregated Antibody-Silicone Oil Complexes; From Perspectives of Morphology, 3D Image, and Fcγ Receptor Activation.
Kiyoshi M, Tada M, Shibata H, Aoyama M, Ishii-Watabe A.
J Pharm. Sci. 2020; S0022-3549 (20): 30614-6.
PMID: 33069712 DOI: 10.1016/j.xphs.2020.10.022
- 抗体医薬品の特性解析及び品質管理のための高精度なMAM手法の構築 概要
Establishment of a Highly Precise Multi-attribute Method for the Characterization and Quality Control of Therapeutic Monoclonal Antibodies.
Tajiri-Tsukada M*, Hashii N, Ishii-Watabe A.
Bioengineered. 2020; 11: 984-1000.
PMID: 32942957 DOI: 10.1080/21655979.2020.1814683
* 現所属:横浜市立大学
- トランスジェニックカイコによって産生されたTNFR-Fc融合タンパク質(エタネルセプト)の構造特性と安定性 概要
Structural insight and stability of TNFR-Fc fusion protein (Etanercept) produced by Using transgenic silkworms.
Kiyoshi M, Tatematsu KI*, Tada M, Sezutsu H*, Shibata H, Ishii-Watabe A.
J Biochem. 2020; mvaa092.
PMID: 32766842 DOI: 10.1093/jb/mvaa092
* 農業・食品産業技術総合研究所