業績
論文・総説 （2010～2015）
2015
●Sato K. Microglia effects on neuronal development, GLIA (in press)
●Fujieda T., Koganezawa N., Ide Y., Shirao T., Sekino Y. An inhibitory pathway controlling the gating mechanism of the mouse lateral amygdala revealed by voltage-sensitive dye imaging. Neurosci Lett., 590C, 126-131, 2015.
●Fujimori K, Takaki J, Shigemoto-Mogami Y, Sekino Y, Suzuki T, Sato K. Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. J Pharmacol Sci., 127, 145-149, 2015.
2014
●Shigemoto-Mogami Y, Fujimori K, Ikarashi Y, Hirose A, Sekino Y, Sato K, Residual metals in carbon nanotubes suppress the proliferation of neural stem cells. Fundam Toxcol Sci, 1, 87-94, 2014.
●Nagakubo T., Demizu Y., Kanda Y., Misawa T., Shoda T., Okuhira K., Sekino Y., Naito M., Kurihara M. Development of Cell-Penetrating R7 Fragment-Conjugated Helical Peptides as Inhibitors of Estrogen Receptor-Mediated Transcription. Bioconjug Chem., 25, 1921-1924, 2014.
●Hirata N., Yamada S., Shoda T., Kurihara M., Sekino Y., Kanda Y. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun., 5: 4806, 2014.
●Kim SR., Kubo T., Hojyo M., Matsuo T., Miyajima A., Usami M., Sekino Y., Matsushita T., Ishida S. Comparative metabolome analysis of cultured fetal and adult hepatocytes in human. J Toxicol Sci., 39, 717-723, 2014.
●Yamada S., Kotake Y., Demizu Y., Kurihara Y., Sekino Y., Kanda Y. NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells. Sci. Rep., 4: 5952, 2014.
●Nakamura Y, Matsuo J, Miyamoto N, Ojima A, Ando K, Kanda Y, Sawada K, Sugiyama A, Sekino Y. Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study. J Pharmacol Sci., 124, 494-501, 2014.
●Ishikawa M, Shiota J, Ishibashi Y, Hakamata T, Shoji S, Fukuchi M, Tsuda M, Shirao T, Sekino Y., Baraban JM, Tabuchi A. Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons. Neuroreport., 25, 585-592, 2014.
●Shigemoto-Mogami Y., Hoshikawa K., Goldman J.E., Sekino Y., Sato K. Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. J Neurosci. 34, 2231-2243, 2014.
●Yamazaki H., Kojima N., Kato K., Hirose H., Iwasaki T., Mizui T., Takahashi H., Hanamura K., Roppongi R.T., Koibuchi N., Sekino Y., Mori N., Shirao T. Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. J Neurochem., 128, 507-522, 2014.
●Mizui T., Sekino Y., Yamazaki Y., Ishizuka H., Takahashi H., Kojima N., Kojima M., Shirao T. Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines. PLoS ONE., 9(1) e85367, 2014.
●Irie T., Matsuzaki Y., Sekino Y., Hirai H. Kv3.3 channels harboring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells. J Physiol., 592, 229-247, 2014.
●Dubois-Pot-Schneider H., Fekir K., Coulouarn C., Glaise D., Aninat C., Jarnouen K., Le Guével R., Kubo T., Ishida S., Morel F., Corlu A.. Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. Hepatology., 60, 2077-2090, 2014.
●Zeiger E., Gollapudi B., Aardema MJ., Auerbach S., Boverhof D., Custer L., Dedon P., Honma M., Ishida S., Kasinski AL., Kim JH., Manjanatha MG., Marlowe J., Pfuhler S., Pogribny I., Slikker W., Stankowski LF Jr., Tanir JY., Tice R., van Benthem J., White P., Witt KL., Thybaud V. Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report. Environ Mol Mutagen. doi: 10.1002/em.21923, 2014.
●Usami M, Mitsunaga K, Irie T, Miyajima A, Doi O. Proteomic analysis of ethanol-induced embryotoxicity in cultured post-implantation rat embryos. J Toxicol Sci., 39, 285-292, 2014.
●Usami M, Mitsunaga K, Irie T, Miyajima A, Doi O. Simple in vitro migration assay for neural crest cells and the opposite effects of all-trans-retinoic acid on cephalic- and trunk-derived cells. Congenit Anom (Kyoto)., 54, 184-188, 2014.
●Irie T,* Matsuzaki Y, Sekino Y, Hirai H.* Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells. J Physiol. 2014 Jan 1;592 (Pt 1):229-47 *C.A
2013
●Takahashi,K., Ishii-Nozawa,R., Takeuchi,K., Nakazawa,K., Sekino,Y., Sato,K,* ”Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner ”Biol Pharm Bull 36(12), 1996-2004 (2013) *C.A
●Oguchi-Katayama, A., Monma, A., Sekino, Y., Moriguchi, T, Sato, K., (2013) Comparative gene expression analysis of the amygdalae of juvenile rats exposed to valproic acid at prenatal and postnatal stages. J ToxicolSci 38(3), 381-402
●Kinoshita, M., Nasu-Tada, K., Fujishita, K., Sato, K., Koizumi, S. Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of Tonic P2Y14-receptor-mediated signal(s). (2013) Cell MolNeurobiol 33 (1), 47-58
●Takata, F., Dohgu, S., Yamauchi, A., Matsumoto, J., Machida, T., Fujishita, K., Shibata, K., Shinozaki, Y., Sato, K., Kataoka, Y., Koizumi, S. (2013) In vitro blood-brain barrier models using brain capillary endothelial cells isolated from infant and adult rats retain age-related barrier properties. PLoS ONE 8 (1), e55166.
●Ishida K., Kotake Y., Miyara M., Aoki K., Sanoh S., Kanda Y., Ohta S. Involvement of GluR2 decrease in lead-induced neuronal cell death. J. Toxicol. Sci. 38:513-21 (2013).
●Yamada S., Kotake Y., Sekino Y. and Kanda Y.*, AMP-activated protein kinase-mediated glucose transport as a novel target of tributyltin in human embryonic carcinoma cells. Metallomics 5:484-91 (2013). *C.A.
●Morizawa, Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S., Koizumi, S. (2012) Cell-autonomous enhancement of glutamate-uptake by female astrocytes. Cell MolNeurobiol32 (6), 953-6.
2012
●Kato, K., Shirao, T., Yamazaki, H., Imamura ,K., Sekino, Y.“ Regulation of AMPA receptor recruitment by the action binding protein drebrin in cultured hippocampal neurons ”J.Neurosci. Neuroengineer.1：153-60（2012）
●Takaki, J., Fujimori, K., Miura M., Suzuki T., Sekino, Y., Sato, K., L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation. (2012) J. Neuroinflammation 9, 275- (C.A.)
●Morizawa, Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S., Koizumi, S. (2012) Cell-autonomous enhancement of glutamate-uptake by female astrocytes. Cell Mol Neurobiol 32 (6), 953-6.
●Ihara Y., Kanda Y., Seo M., Watanabe Y., Akamizu T. and Tanaka Y. cAMP blocking but growth stimulating antibody; as another predisposing factor of Graves’ disease (GD) -analysis using monoclonal TSH receptor antibodies derived from patients with GD. Endocrine J. (2012).
●Kuroda T., Yasuda S., Kusakawa S., Hirata N., Kanda Y., Suzuki K., Takahashi M., Nishikawa S., Kawamata S and Sato Y. Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human induced pluripotent stem cells. PLoS One 7, e37342 (2012).
●Role of α7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells.
Lin W, Hirata N. Sekino Y, Kanda Y.
Curr Drug Targets. 2012 Feb 2.
●Sato, K., Kuriwaki J., Takahashi, K., Saito Y., Oka J., Otani Y., Sha Y., Nakazawa K., Sekino Y., Ohwada T. (2012) Discovery of a tamoxifen-related compound that suppresses glial L-glutamate transport activity without Interaction with estrogen receptors. ACS Chem Neurosci 3 (2), 105-113 (C.A.)
日経産業新聞に紹介されました 「中枢神経疾病薬の候補 乳がん薬から物質開発」（2011, 12/14）
http://news.mynavi.jp/news/2011/12/08/060/index.html
2011
●Kobayashi-Yamazaki, C., Shirao, T., Sasagawa,Y., Maruyama, Y., Akita ,H., Saji,M.,Sekino,Y., "Lesions of the supramammillary nucleus decrease self-grooming behavior of rats placed in an open field" The Kitakanto Medical Jorunal 61：287-292（2011）
●Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H. Mutant PKCγ in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo. J Neurosci. 2011 Oct 5;31(40):14324-34.
●Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells.
Kanda Y. Hinata T, Kang SW, Watanabe Y.
Life Sci. 2011 Aug 15;89(7-8):250-8.
●Makoto Usami, Katsuyoshi Mitsunaga (2011) Proteomic analysis and in vitro developmental toxicity tests for mechanism-based safety evaluation of chemicals. Expert Rev Proteomics 8: 2. 153-155 Apr
●Masashi Tanaka, Taku Nagai, Makoto Usami, Kazuhisa Hasui, Sonshin Takao, Takami Matsuyama (2011) Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine. Innate Immun Jul
2010
●Takahashi, K., Ishii-Nozawa, R., Takeuchi, K., Nakazawa, K., ○Sato, K. (2010). Two NSAIDs, niflumic acid and diclofenac, inhibit the human glutamate transporter EAAT1 through different mechanisms. J Pharmacol Sci 112, 113-117. (C.A.)
●Nicotine increases cancer stem cell population in MCF-7 cells.
Hirata N. Sekino Y. Kanda Y.
Biochem Biophys Res Commun. 2010 Dec 3;403(1):138-43.
●Makoto Usami, Katsuyoshi Mitsunaga,Atsuko Miyajima, Momoko Sunouchi, Osamu Doi (2010) Complement component C3 functions as an embryotrophic factor in early postimplantation rat embryos. Int J Dev Biol 54: 8/9. 1229-1239 Jul