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論文（2017～）

2021

  1. Kanda Y, Satsuka A, Hayashi S, Hagiwara-Nagasawa M, Sugiyama A. Assessment of contractility in human iPS cell-derived cardiomyocytes using motion vector analysis. Methods in Molecular Biology (in press).
  2. Yamada S, Kanda Y. Evaluation of barrier functions in human iPSC-derived intestine. Methods in Molecular Biology (in press).
  3. Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H, Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A. Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. J Med Chem. 2021 Jan 14;64(1):516-526.
  4. Figarol A, Naka Y, Shigemoto-Mogami Y, Furihata T, Sato K, Matsusaki M. In Vitro Self-Organized Three-Dimensional Model of the Blood-Brain Barrier Microvasculature. Biomedical Materials. (in press)

2020

  1. Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, Osada T, Smith G, Czysz K, Kettenhofen R, Lu HR, Cai B, Shi H, Herron TJ, Dang Q, Burton F, Pang L, Traebert M, Abassi Y, Pierson JB, Blinova K. Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations. Regul Toxicol Pharmacol. 2020 Nov;117:104756.
  2. Fukushima H, Yoshioka M, Kawatou M, López-Dávila V, Takeda M, Kanda Y, Sekino Y, Yoshida Y, Yamashita JK. Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells. PLoS One. 2020 Nov 2;15(11):e0241287
  3. Izumi-Nakaseko H, Chiba K, Hagiwara-Nagasawa M, Satsuka A, Goto A, Nunoi Y, Kambayashi R, Matsumoto A, Takei Y, Kanda Y, Naito AT, Sugiyama A. Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion. Front Cell Dev Biol. 2020 Sep 10;8:542562.
  4. Izumi-Nakaseko H, Fujiyoshi M, Hagiwara-Nagasawa M, Goto A, Chiba K, Kambayashi R, Naito AT, Ando K, Kanda Y, Ishii I, Sugiyama A. Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors. Cardiovasc Toxicol. 2020 Feb;20(1):58-70.
  5. Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines. Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I. Toxicol In Vitro. 2020 Dec;69:104999.
  6. Fueta Y, Ueno S, Ishidao T, Yoshida Y, Kanda Y, Hori H. Exposure to 1-bromopropane vapors during pregnancy enhances the development of hippocampal neuronal excitability in rat pups during lactation. J Occup Health. 2020 Jan;62(1):e12135.
  7. Pettit SD, Jerome KR, Rouquié D, Mari B, Barbry P, Kanda Y, Matsumoto M, Hester S, Wehmas L, Botten JW, Bruce EA. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Mol Med. 2020 Jun 8;12(6):e12634.
  8. Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama EN, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T. Synthetic biology based construction of biological activity-related library of fungal decalin-containing diteoid pyrones. Nat Commun. 2020 Apr 14;11(1):1830.
  9. Satsuka A, Kanda Y. Cardiotoxicity Assessment of Drugs Using Human iPS Cell-Derived Cardiomyocytes: Toward Proarrhythmic Risk and Cardio-Oncology. Curr Pharm Biotechnol. 2020;21(9):765-772.
  10. Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J. TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle. Circulation Research. 2020 Feb 14;126(4):417-435.
  11. Parish ST, Aschner M, Casey W, Corvaro M, Embry MR, Fitzpatrick S, Kidd D, Kleinstreuer NC, Lima BS, Settivari RS, Wolf DC, Yamazaki D, Boobis A. An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory Toxicology and Pharmacology. 2020 Apr;112:104592.
  12. Ozawa S, Tamura H, Omura R, Sato H, Suzuki R, Ono R, Yoshida K, Kikuchi T, Namba T, Ishida S, Terashima J, Habano W: A Hepatocelluar Co-Culture System for the Investigation of Cellular-Based Mechanisms of Troglitazone-Induced Liver Injury. Japanese Journal of Gastroenterology and Hepatology. 2020, V4(4): 1-5
  13. Chihiro Yamasaki, Yuji Ishida, Ami Yanagi, Yasumi Yoshizane, Yuha Kojima,Yuko Ogawa, Yutaka Kageyama, Yumiko Iwasaki, Seiichi Ishida, Kazuaki Chayama, and Chise Tateno. Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional twodimensional in vitro tool for developing new drugs. PLoS One. 2020 Sep 23;15(9):e0239540.
  14. Mizoi K, Fukai Y, Matsumoto E, Koyama S, Ishida S, Kojima H, Ogihara T: Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction. Fundamental Toxicological Sciences. 2020; 7: 9-14
  15. Miyajima A, Kuroda Y, Sakemi-Hoshikawa K, Usami M, Mitsunaga K, Irie T, et al. Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes. Toxicology reports. 2020;7:979-85. Epub 2020/09/03.
  16. Irie T, Yamazaki D, Kikura-Hanajiri R. F-phenibut (beta-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K(+) current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells. Eur J Pharmacol. 2020;884:173437.

2019

  1. Ribeiro AJS, Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, Koerner J, Parish ST, Pierson JB, Brock M, Chaudhary KW, Kanda Y, Berridge B. Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes. Front Pharmacol. 2019 Aug 29;10:934.
  2. Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, Koerner J, Parish ST, Pierson JB, Ribeiro AJS, Zabka T, Chaudhary KW, Kanda Y, Berridge B. Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms. Front Pharmacol. 2019 Aug 9;10:884.
  3. Yamada S, Kanda Y. Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers. J Pharmacol Sci. 2019 Aug;140(4):337-344.
  4. Goto A, Hagiwara-Nagasawa M, Chiba K, Kambayashi R, Nunoi Y, Izumi-Nakaseko H, Matsumoto A, Kanda Y, Sugiyama A. Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs. J Pharmacol Sci. 2019 Sep;141(1):86-89.
  5. Sugiyama A, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Naito AT, Kanda Y, Matsumoto A, Izumi-Nakaseko H. Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings. J Pharmacol Sci. 2019 Aug;140(4):317-320.
  6. Kodama M, Furutani K, Kimura R, Ando T, Sakamoto K, Nagamori S, Ashihara T, Kurachi Y, Sekino Y, Furukawa T, Kanda Y, Kurokawa J. Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes. J Pharmacol Sci. 2019 Aug;140(4):325-330.
  7. Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M. Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload. Sci Signal. 2019 Jun 25;12(587):eaaw1920.
  8. Akiyama Y, Shinose M, Watanabe H, Yamada S, Kanda Y. Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7738-7743
  9. Goto A, Hagiwara-Nagasawa M, Kambayashi R, Chiba K, Izumi-Nakaseko H, Naito AT, Kanda Y, Sugiyama A. Measurement of J-Tpeakc along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals. Cardiovasc Toxicol. 2019 Aug;19(4):357-364.
  10. 10. Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K: Hyaluronan synthesis supports glutamate transporter activity. J Neurochem. 2019; 150(3):249-263.
  11. Sasaki T, Suzuki I, Yokoi R, Sato K, Ikegaya Y: Synchronous spike patterns in differently mixed cultures of human iPSC-derived glutamatergic and GABAergic neurons. Biochem Biophys Res Commun. 2019 May 28;513(2):300-305.
  12. Sato C, Yamazaki D, Sato M, Takeshima H, Memtily N, Hatano Y, Tsukuba T, Sakai E. Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM. Scientific Reports. 9, 7352, 2019.
  13. Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H: Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction. Cell Mol Gastroenterol Hepatol. 2019 Jun 19.
  14. Nakai S, Shibata I, Shitamichi T, Yamaguchi H, Takagi N, Inoue T, Nakagawa T, Kiyokawa J, Wakabayashi S, Miyoshi T, Higashi E, Ishida S, Shiraki N, Kume S: Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells. Biol Open. 2019 Jun 10.
  15. Inamura K, Komizu Y, Yamakuchi M, Ishida S, Matsumoto Y, Matsushita T: Inhibitory effect of hybrid liposomes on the growth of liver cancer stem cells. Biochem Biophys Res Commun. 2019; 509: 268-274

2018

  1. Yamada S, Yamazaki D, Kanda Y. 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. J Toxicol Sci. 2018;43(12):727-734
  2. Kanda Y, Yamazaki D, Osada T, Yoshinaga T, Sawada K. Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update. J Pharmacol Sci. 2018 Dec;138(4):233-239.
  3. Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G. International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment. Cell Rep. 2018 Sep 25;24(13):3582-3592.
  4. Izumi-Nakaseko H, Hagiwara-Nagasawa M, Naito AT, Goto A, Chiba K, Sekino Y, Kanda Y, Sugiyama A. Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers. J Pharmacol Sci. 2018 Aug;137(4):372-378.
  5. Yamada S, Kubo Y, Yamazaki D, Sekino Y, Nomura Y, Yoshida S, Kanda Y. Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells. Sci Rep. 2018 Aug 14;8(1):12155.
  6. Wallis R, Benson C, Darpo B, Gintant G, Kanda Y, Prasad K, Strauss DG, Valentin JP. CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion. J Pharmacol Toxicol Methods. 2018 Sep-Oct;93:15-25.
  7. Yamada S, Yamazaki D, Kanda Y. Silver nanoparticles inhibit neural induction in human induced pluripotent stem cells. Nanotoxicology. 2018 Oct;12(8):836-846.
  8. Kobayashi H, Misawa T, Oba M, Hirata N, Kanda Y, Tanaka M, Matsuno K, Demizu Y. Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives. Chem Pharm Bull (Tokyo). 2018;66(5):575-580.
  9. Yamazaki D, Kitaguchi T, Ishimura M, Taniguchi T, Yamanishi A, Saji D, Takahashi E, Oguchi M, Moriyama Y, Maeda S, Miyamoto K, Morimura K, Ohnaka H, Tashibu H, Sekino Y, Miyamoto N, Kanda Y. Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes. J Pharmacol Sci. 2018 Apr;136(4):249-256.
  10. Fueta Y, Sekino Y, Yoshida S, Kanda Y, Ueno S. Prenatal exposure to valproic acid alters the development of excitability in the postnatal rat hippocampus. Neurotoxicology. 2018 Mar;65:1-8.
  11. Shigemoto-Mogami Y, Hoshikawa K, Sato K: Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model. Front Cell Neurosci 2018; 12:494.
  12. Horiuchi S, Kuroda Y, Fujii R, Kim SR, Ishida S: Deactivation of Hepatic Stellate Cells by Culturing on VECELL Inserts. AATEX. 2018; 23: 53-62
  13. Watari R, Kakiki M, Yamasaki C, Ishida Y, Tateno C, Kuroda Y, Ishida S, Kusano K: Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and fresh hepatocytes isolated from liver humanized mice. Biol. Pharm. Bull. 2019; 42: 348-353
  14. Ishida S: Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies. Drug Metab Pharmacokinet. 2018;33(1):49-54.
  15. Irie T. Loose coupling between SK and P/Q-type Ca(2+) channels in cartwheel cells of the dorsal cochlear nucleus. J Neurophysiol. 2019;122(4):1721-7. Epub 2019/08/29.
  16. Miyajima A, Kuroda Y, Sakemi-Hoshikawa K, Usami M, Mitsunaga K, Irie T, et al. In vitro metabolism of 4-methyl- and 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, in rat liver microsomes. Fundamental Toxicological Sciences. 2018;5(3):133-16.

2017

  1. Izumi-Nakaseko H, Kanda Y, Nakamura Y, Hagiwara-Nagasawa M, Wada T, Ando K, Naito AT, Sekino Y, Sugiyama A. Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets. J Pharmacol Sci. 2017 Sep;135(1):44-50.
  2. Ishida K, Aoki K, Takishita T, Miyara M, Sakamoto S, Sanoh S, Kimura T, Kanda Y, Ohta S, Kotake Y. Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition. Int J Mol Sci. 2017 Aug 11;18(8):1754.
  3. Li M, Kanda Y, Ashihara T, Sasano T, Nakai Y, Kodama M, Hayashi E, Sekino Y, Furukawa T, Kurokawa J. Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs. J Pharmacol Sci. 2017 Jun;134(2):75-85.
  4. Hirata N, Yamada S, Sekino Y, Kanda Y. Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells. J Toxicol Sci. 2017;42(2):193-204.
  5. Izumi-Nakaseko H, Nakamura Y, Wada T, Ando K, Kanda Y, Sekino Y, Sugiyama A. Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance. J Toxicol Sci. 2017;42(2):183-192.
  6. Yamada S, Kubo Y, Yamazaki D, Sekino Y, Kanda Y. Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells. Sci Rep. 2017 Jan 23;7:40925.
  7. Ando H, Yoshinaga T, Yamamoto W, Asakura K, Uda T, Taniguchi T, Ojima A, Shinkyo R, Kikuchi K, Osada T, Hayashi S, Kasai C, Miyamoto N, Tashibu H, Yamazaki D, Sugiyama A, Kanda Y, Sawada K, Sekino Y. A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods. 2017 Mar-Apr;84:111-127.
  8. Gao M, Igata H, Takeuchi A, Sato K, Ikegaya Y: Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds. J Pharmacol Sci. 2017: 133: 70-78.
  9. Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T: A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. Lab Chip. 2017; 18; 115-125.
  10. Mizutami T, Ishii T, Komizu Y, Iwasa T, Kawabe M, Togawa N, Ishida S, Matsushita T: Maintenance of viability and functional expression of cryopreserved human hepatocytes using silicate fiber-based three-dimensional scaffold. AATEX. 2017; 22, 101-6.
  11. Usami M, Takamatsu M, Kazama S, Mitsunaga K, Miyajima A, Irie T, et al. Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos. Fundamental Toxicological Sciences. 2017;4(1):31-5.
  12. Miyajima A, Sakemi-Hoshikawa K, Usami M, Mitsunaga K, Irie T, Ohno Y, et al. Thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole and its methyl derivatives, cause both inhibition and induction of drug-metabolizing activity in rat liver microsomes after repeated oral administration. Biochem Biophys Res Commun. 2017;492(1):116-20.
  13. Irie T, Trussell LO. Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing. Neuron. 2017;96(4):856-70.
  14. Irie T, Kawakami T, Sato K, Usami M. Sub-toxic concentrations of nano-ZnO and nano-TiO2 suppress neurite outgrowth in differentiated PC12 cells. The Journal of toxicological sciences. 2017;42(6):723-9.