業務 (2017年以降) |
■原著論文 (査読付、* 責任著者)
- Ozawa S, Tamura H, Omura R, Sato H, Suzuki R, Ono R, Yoshida K, Kikuchi T, Namba T, Ishida S, Terashima J, Habano W: A Hepatocelluar Co-Culture System for the Investigation of Cellular-Based Mechanisms of Troglitazone-Induced Liver Injury. Japanese Journal of Gastroenterology and Hepatology. in press
- Chihiro Yamasaki, Yuji Ishida, Ami Yanagi, Yasumi Yoshizane, Yuha Kojima,Yuko Ogawa, Yutaka Kageyama, Yumiko Iwasaki, Seiichi Ishida, Kazuaki Chayama, and Chise Tateno. Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional twodimensional in vitro tool for developing new drugs. PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.
- Mizoi K, Fukai Y, Matsumoto E, Koyama S, Ishida S, Kojima H, Ogihara T: Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction. Fundamental Toxicological Sciences.. 2020; 7: 9-14
- Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, Nakatsu N, Harada K, Ito S, Yamada H, Yamaura Y, Hirata K, Ishida S, Mizuguchi H: Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction. Cell Mol Gastroenterol Hepatol. 2019 Jun 19. doi: 10.1016/j.jcmgh.2019.06.004.
- Nakai S, Shibata I, Shitamichi T, Yamaguchi H, Takagi N, Inoue T, Nakagawa T, Kiyokawa J, Wakabayashi S, Miyoshi T, Higashi E, Ishida S, Shiraki N, Kume S: Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells. Biol Open. 2019 Jun 10. doi: 10.1242/bio.042192
- Inamura K, Komizu Y, Yamakuchi M, Ishida S, Matsumoto Y, Matsushita T: Inhibitory effect of hybrid liposomes on the growth of liver cancer stem cells. Biochem Biophys Res Commun. 2019; 509: 268-274
- Horiuchi S, Kuroda Y, Fujii R, Kim SR, Ishida S*: Deactivation of Hepatic Stellate Cells by Culturing on VECELL Inserts. AATEX. 2018; 23: 53-62
- Watari R, Kakiki M, Yamasaki C, Ishida Y, Tateno C, Kuroda Y, Ishida S, Kusano K: Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and fresh hepatocytes isolated from liver humanized mice. Biol. Pharm. Bull. 2019; 42: 348-353
- Watari R, Kakiki M, Oshikata A, Takezawa T, Yamasaki C, Ishida Y, Tateno C, Kuroda Y, Ishida S, Kusano K: A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers. J Toxicol Sci. 2018; 43: 521-529.
【2019年度日本毒性学会技術賞対象論文】
- Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T: A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. Lab Chip. 2017; 18; 115-125.
- Mizutami T, Ishii T, Komizu Y, Iwasa T, Kawabe M, Togawa N, Ishida S, Matsushita T: Maintenance of viability and functional expression of cryopreserved human hepatocytes using silicate fiber-based three-dimensional scaffold. AATEX. 2017; 22, 101-6.
■総説
- 石田誠一: MPSの医薬品安全性・毒性評価への応用と課題. レギュラトリーサイエンス学会誌、2020 in press
- 石田誠一: 薬物性肝障害評価へのin vitro細胞アッセイ活用に向けた取り組み. 毒性質問箱、2020 in press
- 石田誠一: 臓器チップの備えるべき要件. 細胞、2020;52:187-190
- 石田誠一、金森敏幸: Microphysiological System(MPS)の期待と現状. 薬理学雑誌、2019;154:345-351.
- 石田誠一: Organs-on-a-chipの医薬品安全性評価への応用. ファルマシア、2019;55:432-434.
- 石田誠一: 医薬品のヒト体内動態評価のためのin vitro培養細胞の現状. 医学のあゆみ、2018;264:603-608.
- Ishida S: Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies. Drug Metab Pharmacokinet. 2018;33(1):49-54.
- 石田誠一: 創薬プロセスに応用されるインビトロ細胞アッセイ法. 生物工学会誌, 第95 巻 第8 号 450–475.2017;95:451-454.
■単行本
- Ishida S: Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease., in “Organ-on-a-chip” (Ed. Hoeng J, Bovard D, Peitsch MC) Academic Press, 2020, 181-213.
- 石田誠一. 探索段階における細胞を利用した安全評価におけるポイント, 「医薬品の創薬におけるスクリーニング手法と関連技術」情報機構, 2019
- 石田誠一. Microphyisiological Systems用細胞とその標準化, 「臓器チップの技術と開発動向」(酒井康行、金森敏幸監修)シーエムシー・リサーチ, 2018,
- 石田誠一. ヒトiPS細胞由来肝細胞を用いた薬剤毒性評価技術の構築, 「創薬のための細胞利用技術の最新動向と市場」(古江(楠田)美保、関野祐子編)シーエムシー・リサーチ, 2018,
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