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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_7 |
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[Results]
1. PCBs
1) Cohort studies
Persky et al. (2001) studied the relationships of PCB and DDE
with thyroid and steroid hormones for subjects selected from the
cohort in a large-scale study on effects of intake of Great
Lakes fish on PCB exposure and the reproductive functions of
humans.
The subjects selected from the original cohort studied in fall
1993 consisted of 179 men (117 mariners and 34 fishers) and 51
women (38 mariners and 4 fishers). As the control group 28 men
and 8 women were added.
The serum PCB level and intake of Great Lakes fish were
significantly correlated with the lower thyroxine (T4) and free
thyroxine index (FTI) in women and the lower T4 in men. Fish
intake was significantly inverse-correlated with
triiodothyronine (T3) level in men. Results obtained for thyroid
stimulating hormone (TSH) were inconsistent. Men showed
significant reverse correlations of the level of testosterone
bound to sex hormone binding globulin (SHBG) with both PCB level
and fish intake, but no correlation with SHBG or free
testosterone level. Estrone sulfate, follicle stimulating
hormone, lutenizing hormone and dehydroepiandrosterone were
generally not significantly correlated with PCB, DDE or fish
intake.
Matsuura et al. (2004) studied effects on infants of dioxins
structurally similar to thyroid hormones (PCDD/Fs) in Tokyo,
Saitama, Ishikawa and Osaka prefectures, Japan, for three years
from 1997. They also studied thyroid and immune functions in
those areas plus an additional 20 prefectures in 1999-2000.
Breast milk was collected from mothers 30 days after delivery.
Blood samples were collected from 337 breast-fed infants and, as
the control, 53 artificially fed infants one year of age for
determination of T4, T3, FT4 and TSH in the serum.
The T4, T3, FT4 and TSH levels in the plasma were normal in both
the breast-fed and artificially fed groups; no significant
difference was observed. The dioxin and PCB levels in breast
milk 30 days after delivery showed significant differences by
area. The dioxin plus co-PCB level ranged from 13.1 to 29.5 pg
TEQ/g fat. The TSH level in one year-old infants was not
dependent on area and not significantly correlated with TEQ in
breast milk. The serum TSH level and the TSH level in filter
paper dry blood spots showed a significant correlation.
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