| |
[Discussion]
Literature search for epidemiologic studies on endocrine
disruptors and endometrial cancer found only a few reports
published since 1998. Both the two case-control studies did not
establish any risk increase due to high serum levels of DDT or
PCB. Nested cohort studies, which principally provide higher
reliability, were not found on this topic.
The scant epidemiologic findings on the relationship of
endocrine disruptors and endometrial cancer do not permit
adequate evaluation of their causality. Nested case-control
studies on endometrial cancer should be conducted in future.
[Conclusions]
Literature search for epidemiologic studies on endocrine
disruptors and endometrial cancer found only a few reports,
which do not permit adequate evaluation of their causality.
Large-scale studies on this topic in more reliable designs
should be conducted in future.
[Literature]
Adami HO, Lipworth L, Titus-Ernstoff L, et al. Organochlorine
compounds and estrogen-related cancers in women. Cancer Causes
Control 1995;6:551-6.
Stugeon SR, Brock JW, Potishman N, Needham LL, Rothman N,
Brinton LA, Hoover RN. Serum concentrations of organochlorine
compounds and endometrial cancer risk (United States). Cancer
Causes Control 1998; 9:417-24.
Weiderpass E, Adami HO, Baron JA, Wicklund-Glynn A, Aune M,
Atuma S, Persson I. Organochlorines and endometrial cancer risk.
Cancer Epidemiol Biomarker Prev 2000;9:487-93.
Bertazzi PA, Consonni D, Bachetti S, et al. Health effects of
dioxin exposure: a 20-year mortality study.Am J Epidemiol.
2001;153:1031-44.
Table 2.2: Case-control studies on endocrine disruptors and endometrial cancer incidence |
