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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.3.3 |
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The low-dose issue is far from complete. One of the fundamental
problems yet to be solved is the inability for usual animal
experiments to detect the adverse effects of agents at low doses
which may be sufficient to inhibit fertilization in humans.
Discussions on this issue must restart from the point where the
uterotrophic test was introduced.
Future studies on endocrine disruptors will need application of
genome expression analysis by the microarray technique. Unlike
many microarray applications intended for analysis of reaction
mechanisms, genome expression analysis is phenomenological in
that gene expression patterns are treated as phenotypes. It is a
promising method for the analysis of biomarkers linked to
synergistic effects or dose-specific gene expression64.
Prioritization may take into account of reports on many, less
deleterious general chemicals.
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64 See note 61. |
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