2008年以降（2008-2019）の発表論文（原著，和文，単行本，総説を含む）

2023年 | 2022年 | 2021年 | 2020年 | 2019年 | 2018年 | 2017年 | 2016年 | 2015年 | 2014年 | 2013年 | 2012年 | 2011年 | 2010年 | 2009年 | 2008年

Special 病理部50周年 記念業績集

Special 学会賞受賞リスト

2023年

• Toyoda T, Kobayashi T, Miyoshi N, Matsushita K, Akane H, Morikawa T, Ogawa K.
  Mucosal damage and γ-H2AX formation in the rat urinary bladder induced by aromatic amines with structures similar to o-toluidine and o-anisidine.
  Arch Toxicol, 2023, in press.
• Akagi J, Cho YM, Toyoda T, Mizuta Y, Ogawa K.
  EpCAM and APN expression in combination with γ-H2AX as biomarkers for detecting hepatocarcinogens in rats.
  Cancer Sci, 2023, in press.
• Ishii Y, Shi L, Takasu S, Ogawa K, Umemura T.
  A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin.
  Food Chem Toxicol, 2023; 179: 113965.
• Matsushita K, Toyoda T, Akane H, Morikawa T, Ogawa K.
  A 13-week subchronic toxicity study of heme iron in SD rats.
  Food Chem Toxicol, 2023; 175: 113702.
• Strupp C, Corvaro M, Cohen SM, Corton JC, Ogawa K, Richert L, Jacobs MN.
  Increased cell proliferation as a key event in chemical carcinogenesis: application in an integrated approach for the testing and assessment of non-genotoxic carcinogenesis.
  Int J Mol Sci, 2023; 24: 13246.
• Ishii Y, Namiki M, Takasu S, Nakamura K, Takimoto N, Mitsumoto T, Ogawa K.
  Lack of genotoxic mechanisms in isoeugenol-induced hepatocellular tumorigenesis in male B6C3F1 mice.
  Jpn J Food Chem Safety, 2023; 30: 9-22.
• Akagi J, Mizuta Y, Akane H, Toyoda T, Ogawa K.
  Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats.
  Part Fibre Toxicol, 2023; 20: 23.
• Toyoda T, Sone M, Matsushita K, Akane H, Akagi J, Morikawa T, Mizuta Y, Cho YM, Ogawa K.
  Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX.
  J Toxicol Sci, 2023; 48: 323-32.
• IARC Monographs Vol 134 Group, Ogawa K.
  Carcinogenicity of aspartame, methyleugenol, and isoeugenol.
  Lancet Oncol, 2023; 24: 848-50.
• IARC Monographs Vol 133 Group, Toyoda T.
  Carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite.
  Lancet Oncol, 2023; 24: 431-2.
• 小川久美子．
  食品中残留動物用医薬品の急性参照用量と水産動物用医薬品の規制の現状．
  食品衛生研究，2023; 73: 7-25.
• 小川久美子，西村次平，西川秋佳．
  安全性に関するトピックスの動向ICH-S1B（R1）：医薬品のがん原性試験ガイドライン改定．
  医薬品医療機器レギュラトリーサイエンス，2023; 54: 87-91.

2022年

• Kobayashi T, Kishimoto S, Watanabe S, Yoshioka Y, Toyoda T, Ogawa K, Watanabe K, Totsuka Y, Wakabayashi K, Miyoshi N.
  Cytotoxic homo- and hetero-dimers of o-toluidine, o-anisidine, and aniline formed by in vitro metabolism.
  Chem Res Toxicol, 2022; 35: 1625-30.
• Takasu S, Ishii Y, Namiki M, Nakamura K, Mitsumoto T, Takimoto N, Nohmi T, Ogawa K.
  Comprehensive analysis of the general toxicity, genotoxicity, and carcinogenicity of 3-acetyl-2,5-dimethylfuran in male gpt delta rats.
  Food Chem Toxicol, 2022; 172: 113544.
• Kuroda K, Ishii Y, Takasu S, Matsushita K, Kijima K, Nohmi T, Umemura T.
  Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.
  Food Chem Toxicol, 2022; 168: 113365.
• Ishii Y, Nakamura K, Mitsumoto T, Takimoto N, Namiki M, Takasu S, Ogawa K.
  Visualization of the distribution of anthraquinone components from madder roots in rat kidneys by desorption electrospray ionization-time-of-flight mass spectrometry imaging.
  Food Chem Toxicol, 2022; 161: 112851.
• Akane H, Toyoda T, Mizuta Y, Cho YM, Ide T, Kosaka T, Tajima H, Aoyama H, Ogawa K.
  Histopathological and immunohistochemical evaluation for detecting changes in blood hormone levels caused by endocrine disruptors in a 28-day repeated-dose study in rats.
  J Appl Toxicol, 2022; 42: 1603-17.
• Saito K, Ishikawa R, Kitamura I, Ogawa K, Arakawa N, Sun Y, Imai K, Maeda T, Saito Y, Hasegawa C.
  Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.
  J Pharmacol Sci, 2022; 150: 49-55.
• Arakawa N, Matsuyama S, Matsuoka M, Kitamura I, Miyashita K, Kitagawa Y, Imai K, Ogawa K, Maeda T, Saito Y, Hasegawa C.
  Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression.
  J Pharmacol Sci, 2022; 150: 21-30.
• Toyoda T, Ogawa K.
  Early detection of urinary bladder carcinogens in rats by immunohistochemistry for γ-H2AX: a review from analyses of 100 chemicals.
  J Toxicol Pathol, 2022; 35: 283-98.
• Toyoda T, Kobayashi T, Miyoshi N, Matsushita K, Akane H, Morikawa T, Ogawa K.
  Toxicological effects of two metabolites derived from o-toluidine and o-anisidine after 28-day oral administration to rats.
  J Toxicol Sci, 2022; 47: 457-66.
• Arakawa N, Ushiki A, Abe M, Matsuyama S, Saito Y, Kashiwada T, Horimasu Y, Gemma A, Tatsumi K, Hattori N, Tsushima K, Miyashita K, Saito K, Nakamura R, Toyoda T, Ogawa K, Sato M, Takamatsu K, Mori K, Nishiya T, Izumi T, Ohno Y, Saito Y, Hanaoka M.
  Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
  Nat Commun, 2022; 13: 5854.
• Yamada T, Toyoda T, Matsushita K, Akane H, Morikawa T, Cho YM, Ogawa K.
  Persistent γ-H2AX formation and expression of stem cell markers in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats.
  Toxicol Sci, 2022; 189: 51-61.
• 小川久美子，西村次平，野中瑞穂，西川秋佳．
  ICH-S1B（R1）：医薬品のがん原性試験ガイドライン改定について．
  医薬品医療機器レギュラトリーサイエンス，2022; 53: 25-8.
• 小川久美子，石井雄二，豊田武士．
  医薬品と化学物質の毒性評価における病理組織標本の役割と応用．
  日本薬理学雑誌，2022; 157: 139-45.
• 村垣善浩，岡本芳晴，小川久美子，野村祐介，蓜島由二．
  疾患動物の診断・治療データを用いた医療機器の安全性・有効性評価の基本的考え方．
  レギュラトリーサイエンス学会誌，2022; 12: 179-93.

2021年

• Matsushita K, Takasu T, Ishii Y, Toyoda T, Yamada T, Morikawa T, Ogawa K.
  In vivo mutagenicity and tumor-promoting activity of 1,3-dichloro-2-propanol in the liver and kidneys of gpt delta rats.
  Arch Toxicol, 2021; 95: 3117-31.
• Nakamura K, Ishii Y, Takasu S, Nohmi T, Shibutani M, Ogawa K.
  Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
  Arch Toxicol, 2021; 95: 2851-65.
• Yamada T, Toyoda T, Matsushita K, Cho YM, Akagi J, Morikawa T, Mizuta Y, Ogawa K.
  Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for γ-H2AX.
  Arch Toxicol, 2021; 95: 715-26.
• Kobayashi T, Toyoda T, Tajima Y, Kishimoto S, Tsunematsu Y, Sato M, Matsushita K, Yamada T, Shimamura Y, Masuda S, Ochiai M, Ogawa K, Watanabe K, Takamura-Enya T, Totsuka Y, Wakabayashi K, Miyoshi N.
  o-Anisidine dimer, 2-methoxy-N⁴-(2-methoxyphenyl) benzene-1,4-diamine, in rat urine associated with urinary bladder carcinogenesis.
  Chem Res Toxicol, 2021; 34: 912-9.
• Nakamura K, Ishii Y, Takasu S, Ogawa K.
  A 90-day subchronic toxicity study of 5-methyl-2-phenyl-2-hexenal in F344 rats.
  Food Chem Toxicol, 2021; 150: 112041.
• Matsushita K, Toyoda T, Yamada T, Morikawa T, Ogawa K.
  Specific expression of survivin, SOX9, and CD44 in renal tubules in adaptive and maladaptive repair processes after acute kidney injury in rats.
  J Appl Toxicol, 2021; 41: 607-17.
• Toyoda T, Matsushita K, Akane H, Morikawa T, Ogawa K.
  A 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in F344 rats.
  J Toxicol Pathol, 2021; 34: 309-17.
• Ide T, Cho YM, Oishi Y, Ogawa K.
  Spontaneous adenolipoma of the mammary gland in the male F344 rat.
  J Toxicol Pathol, 2021; 34: 231-4.
• Yamada T, Toyoda T, Ide T, Matsushita K, Morikawa T, Ogawa K.
  Neuromuscular and vascular hamartoma of the small intestine in an F344 rat.
  J Toxicol Pathol, 2021; 34: 113-7.
• Matsushita K, Ishii Y, Kijima A, Takasu S, Kuroda K, Takagi H, Nohmi T, Ogawa K, Umemura T.
  Background data of 2-year-old male and female F344 gpt delta rats.
  J Toxicol Pathol, 2021; 34: 23-31.
• IARC Monographs Vol 128 Group, Ogawa K.
  Carcinogenicity of acrolein, crotonaldehyde, and arecoline.
  Lancet Oncol, 2021; 22: 19-20.
• Ishii Y, Takasu S, Gruz P, Masumura K, Ogawa K, Nohmi T, Umemura T.
  The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.
  Mutagenesis, 2021; 36: 155-64.
• Nishikawa A.
  Perspectives on the elimination of animal assays in the assessment of carcinogenicity.
  Regul Toxicol Pharmacol, 2021; 126: 105031.
• Nishikawa A, Nagano K, Kojima H, Ogawa K.
  A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity.
  Regul Toxicol Pharmacol, 2021; 123: 104937.
• 小川久美子．
  安全性に関するトピックの動向　ICH S1（R1）：医薬品のがん原性試験（改定）．
  医薬品医療機器レギュラトリーサイエンス，2021; 52: 455-60.

2020年

• Jacobs MN, Colacci A, Corvi R, Vaccari M, Aguila MC, Corvaro M, Delrue N, Desaulniers D, Ertych N, Jacobs A, Luijten M, Madia F, Nishikawa A, Ogawa K, Ohmori K, Paparella M, Sharma AK, Vasseur A.
  Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens.
  Arch Toxicol, 2020; 94: 2899-923.
• Tajima Y, Toyoda T, Hirayama Y, Matsushita K, Yamada T, Ogawa K, Watanabe K, Takamura-Enya T, Totsuka Y, Wakabayashi K, Miyoshi N.
  A novel o-toluidine metabolite in rat urine associated with urinary bladder carcinogenesis.
  Chem Res Toxicol. 2020; 33: 1907-14.
• Akagi J, Hashimoto K, Suzuki K, Yokoi M, de Wind N, Iwai S, Ohmori H, Moriya M, Hanaoka F.
  Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.
  DNA Repair, 2020; 87: 102771.
• Matsushita K, Toyoda T, Yamada T, Morikawa T, Ogawa K.
  Comprehensive expression analysis of mRNA and microRNA for investigation of compensatory mechanisms in the rat kidney after unilateral nephrectomy.
  J Appl Toxicol, 2020; 40: 1373-83.
• Yamada T, Toyoda T, Matsushita K, Morikawa T, Ogawa K.
  Dose dependency of γ-H2AX formation in the rat urinary bladder treated with genotoxic and nongenotoxic bladder carcinogens.
  J Appl Toxicol, 2020; 40: 1219-27.
• Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H.
  Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats.
  J Toxicol Pathol, 2020; 33: 279-85.
• IARC Monographs Vol 127 Group, Toyoda T.
  Carcinogenicity of some aromatic amines and related compounds.
  Lancet Oncol, 2020; 21: 1017-8.
• Ide T, Mizuta Y, Akagi J, Masumoto N, Sugimoto N, Sato K, Ogawa K, Cho YM.
  A 90-day repeated oral dose toxicity study of four stereoisomers of 2,4-dimethyl-4-phenyltetrahydrofuran, a synthetic flavoring substance, in F344 rats.
  Regul Toxicol Pharmacol, 2020; 114: 104664.
• Sakai W, Yuasa-Sunagawa M, Kusakabe M, Kishimoto A, Matsui T, Kaneko Y, Akagi J, Huyghe N, Ikura M, Ikura T, Hanaoka F, Yokoi M, Sugasawa K.
  Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair.
  Sci Rep, 2020; 10: 19704.
• Takasu S, Ishii Y, Kijima A, Ogawa K, Nakane S, Umemura T.
  Furan induced characteristic glutathione S-transferase placental form-positive foci in terms of cell kinetics and gene expression.
  Toxicol Pathol, 2020; 48: 756-65.
• Nakamura K, Ishii Y, Takasu S, Nohmi T, Shibutani M, Ogawa K.
  Lack of in vivo mutagenicity of acetamide in a 13-week comprehensive toxicity study using F344 gpt delta rats.
  Toxicol Sci, 2020; 177: 431-40.

2019年

• Toyoda T, Matsushita K, Morikawa T, Yamada T, Miyoshi N, Ogawa K.
  Distinct differences in the mechanisms of mucosal damage and γ-H2AX formation in the rat urinary bladder treated with o-toluidine and o-anisidine.
  Arch Toxicol, 2019; 93: 753-62.
• Matsushita K, Toyoda T, Morikawa T, Ogawa K.
  A 13-week subchronic toxicity study of vanillin propylene glycol acetal in F344 rats.
  Food Chem Toxicol, 2019; 132: 110643.
• Ishii Y, Yokoo Y, Kijima A, Takasu S, Ogawa K, Umemura T.
  DNA modifications that do not cause gene mutations confer the potential for mutagenicity by combined treatment with food chemicals.
  Food Chem Toxicol, 2019; 129: 144-52.
• Yang Q, Yasuda T, Choi E, Toyoda T, Roland JT, Uchida E, Yoshida H, Seto Y, Goldenring JR, Nomura S.
  MEK inhibitor reverses metaplasia and allows re-emergence of normal lineages in Helicobacter pylori-infected gerbils.
  Gastroenterology, 2019; 156: 577-81.
• Sone M, Toyoda T, Cho YM, Akagi J, Matsushita K, Mizuta Y, Morikawa T, Nishikawa A, Ogawa K.
  Immunohistochemistry of γ-H2AX as a method of early detection of urinary bladder carcinogenicity in mice.
  J Appl Toxicol, 2019; 39: 868-76.
• Ishii Y, Kijima A, Takasu S, Ogawa K, Umemura T.
  Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin-3-O-primeveroside.
  J Appl Toxicol, 2019; 39: 650-7.
• Toyoda T, Cho YM, Matsushita K, Tachibana S, Senuma M, Akagi J, Ogawa K.
  A 13-week subchronic toxicity study of hexyl acetate in SD rats.
  J Toxicol Pathol, 2019; 32: 205-12.
• Suzuki S, Toyoda T, Kato H, Naiki-Ito A, Yamashita Y, Akagi J, Cho YM, Ogawa K, Takahashi S.
  Dimethylarsinic acid may promote prostate carcinogenesis in rats.
  J Toxicol Pathol, 2019; 32: 73-7.
• Funahashi S, Okazaki Y, Nagai H, Chew SH, Ogawa K, Toyoda T, Cho YM, Toyokuni S.
  Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.
  J Toxicol Pathol, 2019; 32: 19-26.
• Hirata T, Cho YM, Suzuki I, Toyoda T, Akagi J, Nakamura Y, Numasawa S, Ogawa K.
  4-Methylthio-3-butenyl isothiocyanate (MTBITC) induced apoptotic cell death and G2/M cell cycle arrest via ROS production in human esophageal epithelial cancer cells.
  J Toxicol Sci, 2019; 44: 73-81.
• Akagi J, Cho YM, Mizuta Y, Tatebe C, Sato K, Ogawa K.
  Subchronic toxicity evaluation of isoeugenyl methyl ether in F344/DuCrj rats by 13-week oral administration.
  Regul Toxicol Pharmacol, 2019; 102: 34-39.
• Takasu S, Yokoo Y, Ishii Y, Kijima A, Ogawa K, Umemura T.
  Molecular pathological differences in global gene expression between two sustained proliferative lesions, nodular regenerative hepatocellular hyperplasia and hepatocellular adenoma, in mice.
  Toxicol Pathol, 2019; 47: 44-52.

2018年

• Akagi J, Yokoi M, Cho YM, Toyoda T, Ohmori H, Hanaoka F, Ogawa K.
  Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening.
  DNA Repair. 2018; 61: 76-85.
• Akagi J, Cho YM, Mizuta Y, Toyoda T, Ogawa K.
  Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats.
  Food Chem Toxicol, 2018; 122: 80-6.
• Toyoda T, Totsuka Y, Matsushita K, Morikawa T, Miyoshi N, Wakabayashi K, Ogawa K.
  γ-H2AX formation in the urinary bladder of rats treated with two norharman derivatives obtained from o-toluidine and aniline.
  J Appl Toxicol, 2018; 38: 537-43.
• Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.
  Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure.
  J Invest Dermatol, 2018; 138: 2550-7.
• Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T.
  Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin.
  J Toxicol Pathol, 2018; 31: 179-88.
• Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T.
  Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice.
  J Toxicol Pathol, 2018; 31: 169-78.
• Cho YM, Mizuta Y, Akagi J, Toyoda T, Sone M, Ogawa K.
  Size-dependent acute toxicity of silver nanoparticles in mice.
  J Toxicol Pathol, 2018; 31: 73-80.
• Toyoda T, Cho YM, Akagi J, Mizuta Y, Matsushita K, Nishikawa A, Imaida K, Ogawa K.
  A 13-week subchronic toxicity study of acetaminophen using an obese rat model.
  J Toxicol Sci, 2018; 43: 423-33.
• IARC Monographs Vol 123 Group, Ogawa K.
  Carcinogenicity of some nitrobenzenes and other industrial chemicals.
  Lancet Oncol, 2018; 19: e681-2.
• Matsushita K, Toyoda T, Morikawa T, Takahashi M, Inoue K, Ogawa K.
  A 13-week subchronic toxicity study of 2-ethylbutanal in F344 rats.
  Regul Toxicol Pharmacol, 2018; 100: 118-26.
• Matsushita K, Takasu S, Kuroda K, Ishii Y, Kijima A, Ogawa K, Umemura T.
  Mechanisms underlying exacerbation of osmotic nephrosis caused by pre-existing kidney injury.
  Toxicol Sci, 2018; 165: 420-30.
• Ambe K, Ishihara K, Ochibe T, Ohya K, Tamura S, Inoue K, Yoshida M, Tohkin M.
  In silico prediction of chemical-induced hepatocellular hypertrophy using molecular descriptors.
  Toxicol Sci, 2018; 162: 667-75.

2017年

• Takeshima H, Niwa T, Toyoda T, Wakabayashi M, Yamashita S, Ushijima T.
  The degree of methylation burden is determined by the exposure period to carcinogenic factors.
  Cancer Sci, 2017; 108: 316-21.
• Zhang H, Taya K, Nagaoka K, Yoshida M, Watanabe G.
  4-Nitrophenol (PNP) inhibits the expression of estrogen receptor β and disrupts steroidogenesis during the ovarian development in female rats.
  Environ Pollut, 2017; 229: 1-9.
• Komine C, Nakajima S, Kondo Y, Horii Y, Yoshida M, Kawaguchi M.
  Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat.
  J Appl Toxicol, 2017; 37: 996-1003.
• Cho YM, Hasumura M, Imai T, Takami S, Nishikawa A, Ogawa K.
  Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water.
  J Appl Toxicol, 2017; 37: 853-62.
• Hirata T, Cho YM, Toyoda T, Akagi J, Suzuki I, Nishikawa A, Ogawa K.
  Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination.
  J Appl Toxicol, 2017; 37: 683-91.
• Suzuki I, Cho YM, Hirata T, Toyoda T, Akagi J, Nakamura Y, Sasaki A, Nakamura T, Okamoto S, Shirota K, Suetome N, Nishikawa A, Ogawa K.
  Toxic effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity.
  J Appl Toxicol, 2017; 37: 485-94.
• Hibi D, Yokoo Y, Suzuki Y, Ishii Y, Jin M, Kijima A, Nohmi T, Nishikawa A, Umemura T.
  Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis in gpt delta rats.
  J Appl Toxicol, 2017; 37: 142-9.
• Matsushita K, Toyoda T, Inoue K, Morikawa T, Sone M, Ogawa K.
  Spontaneous infarcted adenoma of the mammary gland in a Wistar Hannover GALAS rat.
  J Toxicol Pathol, 2017; 30: 57-62.
• Toyoda T, Cho YM, Akagi J, Mizuta Y, Matsushita K, Nishikawa A, Imaida K, Ogawa K.
  Altered susceptibility of an obese rat model to 13-week subchronic toxicity induced by 3-monochloropropane-1,2-diol.
  J Toxicol Sci, 2017; 42: 1-11.
• Takasu S, Ishii Y, Yokoo Y, Tsuchiya T, Kijima A, Kodama Y, Ogawa K, Umemura T.
  In vivo reporter gene mutation and micronucleus assays in gpt delta mice treated with a flame retardant decabromodiphenyl ether.
  Mutat Res, 2017; 816-817: 7-11.
• Nonaka M, Amakasu K, Saegusa Y, Naota M, Nishimura T, Ogawa K, Nishikawa A.
  Non-neoplastic lesions found only in the two-year bioassays but not in shorter toxicity studies of rats.
  Regul Toxicol Pharmacol, 2017; 86: 199-204.
• Takahashi M, Ichimura R, Inoue K, Morikawa T, Kuwata K, Watanabe G, Yoshida M.
  The role of estrogen receptor subtypes for induction of delayed effects on the estrous cycle and female reproductive organs in rats.
  Reprod Biol, 2017; 17: 111-9.
• Miyake Y, Tokumura M, Nakayama H, Wang Q, Amagai T, Ogo S, Kume K, Kobayashi T, Takasu S, Ogawa K, Kannan K.
  Simultaneous determination of brominated and phosphate flame retardants in flame-retarded polyester curtains by a novel extraction method.
  Sci Total Environ, 2017; 601-602: 1333-9.
• Ishii Y, Kuroda K, Matsushita K, Yokoo Y, Takasu S, Kijima A, Nohmi T, Ogawa K, Umemura T.
  Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis.
  Toxicol Appl Pharmacol, 2017; 336: 75-83.
• Zhang H, Taya K, Nagaoka K, Yoshida M, Watanabe G.
  Neonatal exposure to 17α-ethynyl estradiol (EE) disrupts follicle development and reproductive hormone profiles in female rats.
  Toxicol Lett, 2017; 276: 92-9.
• Kuwata K, Inoue K, Ichimura R, Takahashi M, Kodama Y, Shibutani M, Yoshida M.
  β-Catenin mutations are not involved in early-stage hepatocarcinogenesis induced by protoporphyrinogen oxidase inhibitors in mice.
  Toxicol Pathol, 2017; 45: 493-505.

2016年

• Zhang H, Nagaoka K, Usuda K, Nozawa K, Taya K, Yoshida M, Watanabe G.
  Estrogenic compounds impair primordial follicle formation by inhibiting the expression of proapoptotic Hrk in neonatal rat ovary.
  Biol Reprod, 2016; 95: 78.
• Yokoo Y, Kijima A, Ishii Y, Takasu S, Tsuchiya T, Umemura T.
  Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice.
  Cancer Med, 2016; 5: 1228-38.
• Sekimoto M, Sumi H, Hosaka T, Umemura T, Nishikawa A, Degawa M.
  Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines.
  Food Chem Toxicol, 2016; 97: 256-64.
• Kuwata K, Inoue K, Ichimura R, Takahashi M, Kodama Y, Yoshida M.
  Constitutive active/androstane receptor, peroxisome proliferator-activated receptor α, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.
  Food Chem Toxicol, 2016; 88: 75-86.
• Toyoda T, Shi L, Takasu S, Cho YM, Kiriyama Y, Nishikawa A, Ogawa K, Tatematsu M, Tsukamoto T.
  Anti-inflammatory effects of capsaicin and piperine on Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.
  Helicobacter, 2016; 21: 131-42.
• Goto K, Ogawa K.
  Lanthanum deposition is frequently observed in the gastric mucosa of dialysis patients with lanthanum carbonate therapy: a clinicopathologic study of 13 cases, including 1 case of lanthanum granuloma in the colon and 2 nongranulomatous gastric cases.
  Int J Surg Pathol, 2016; 24: 89-92.
• Taketa Y, Inoue K, Takahashi M, Sakamoto Y, Watanabe G, Taya K, Yoshida M.
  Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats.
  J Appl Toxicol, 2016; 36: 769-76.
• Suzuki I, Cho YM, Hirata T, Toyoda T, Akagi J, Nakamura Y, Park EY, Sasaki A, Nakamura T, Okamoto S, Shirota K, Suetome N, Nishikawa A, Ogawa K.
  4-Methylthio-3-butenyl isothiocyanate (Raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats.
  J Toxicol Pathol, 2016; 29: 237-46.
• Tamura K, Inoue K, Takahashi M, Matsuo S, Kodama Y, Yoshida M.
  A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.
  J Toxicol Sci, 2016; 41: 801-11.
• Ichimura R, Takahashi M, Morikawa T, Inoue K, Kuwata K, Usuda K, Yokosuka M, Watanabe G, Yoshida M.
  Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats.
  Neurotoxicology, 2016; 56: 64-75.
• Shiga T, Nakamura TJ, Komine C, Goto Y, Mizoguchi Y, Yoshida M, Kondo Y, Kawaguchi M.
  A single neonatal injection of ethinyl estradiol impairs passive avoidance learning and reduces expression of estrogen receptor α in the hippocampus and cortex of adult female rats.
  PLoS One, 2016; 11: e0146136.
• Takahashi M, Ichimura R, Inoue K, Morikawa T, Watanabe G, Yoshida M.
  The impact of neonatal exposure to 17alpha-ethynylestradiol on the development of kisspeptin neurons in female rats.
  Reprod Toxicol, 2016; 60: 33-8.
• Kuwata K, Inoue K, Ichimura R, Takahashi M, Kodama Y, Shibutani M, Yoshida M.
  Involvement of mouse constitutive androstane receptor in acifluorfen-induced liver injury and subsequent tumor development.
  Toxicol Sci, 2016; 151: 271-85.
• Kakehashi A, Yoshida M, Tago Y, Ishii N, Okuno T, Gi M, Wanibuchi H.
  Pueraria mirifica exerts estrogenic effects in the mammary gland and uterus and promotes mammary carcinogenesis in Donryu rats.
  Toxins, 2016; 8: E275.

2015年

• Ichimura R, Takahashi M, Morikawa T, Inoue K, Kuwata K, Usuda K, Yokosuka M, Watanabe G, Yoshida M.
  The critical hormone-sensitive window for the development of delayed effects extends to 10 days after birth in female rats postnatally exposed to 17alpha-ethynylestradiol.
  Biol Reprod, 2015; 93: 32.
• Akagi J, Toyoda T, Cho YM, Mizuta Y, Nohmi T, Nishikawa A, Ogawa K.
  Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.
  Cancer Sci, 2015; 106: 529-41.
• Matsushita K, Ishii Y, Takasu S, Kuroda K, Kijima A, Tsuchiya T, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.
  A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.
  Exp Toxicol Pathol, 2015; 67: 31-9.
• Maeda J, Inoue K, Ichimura R, Takahashi M, Kodama Y, Saito N, Yoshida M.
  Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis.
  Food Chem Toxicol, 2015; 83: 201-9.
• Tamura K, Inoue K, Takahashi M, Matsuo S, Irie K, Kodama Y, Gamo T, Ozawa S, Yoshida M.
  Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides.
  Food Chem Toxicol, 2015; 78: 86-95.
• Tsaalbi-Shtylik A, Ferras C, Pauw B, Hendriks G, Temviriyanukul P, Carlee L, Calleja F, van Hees S, Akagi J, Iwai S, Hanaoka F, Jansen JG, de Wind N.
  Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.
  J Cell Biol, 2015; 209: 33-46.
• Yoshida M, Inoue K, Takahashi M.
  Predictive modes of action of pesticides in uterine adenocarcinoma development in rats.
  J Toxicol Pathol, 2015; 28: 207-16.
• Inoue K, Morikawa T, Takahashi M, Yoshida M, Ogawa K.
  Obstructive nephropathy induced with DL-potassium hydrogen tartrate in F344 rats.
  J Toxicol Pathol, 2015; 28: 89-97.
• Sakamoto Y, Yoshida M, Tamura K, Takahashi M, Kodama Y, Inoue K.
  Dose-dependent difference of nuclear receptors involved in murine liver hypertrophy by piperonyl butoxide.
  J Toxicol Sci, 2015; 40: 787-96.
• Shirota M, Kawashima J, Nakamura T, Kamiie J, Shirota K, Yoshida M.
  Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17α-ethynylestradiol on reproductive functions in female Sprague-Dawley rats.
  J Toxicol Sci, 2015; 40: 727-38.
• Abbasi A, Khalaj M, Akiyama K, Mukai Y, Matsumoto H, Acosta TA, Said N, Yoshida M, Kunieda T.
  Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary.
  Mol Cell Endocrinol, 2015; 412: 19-25.
• Ishii Y, Matsushita K, Kuroda K, Yokoo Y, Kijima A, Takasu S, Kodama Y, Nishikawa A, Umemura T.
  Acrylamide induces specific DNA adduct formation and gene mutations in a carcinogenic target site, the mouse lung.
  Mutagenesis, 2015; 30: 227-35.
• Tokudome S, Kuriki K, Yokoyama Y, Sasaki M, Joh T, Kamiya T, Cheng J, Ogawa K, Shirai T, Imaeda N, Goto C, Tokudome Y, Ichikawa H, Okuyama H.
  Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: A randomized controlled trial in polypectomized participants.
  Prostaglandins Leukot Essent Fatty Acids, 2015; 94: 1-11.
• Naiki-Ito A, Chewonarin T, Tang M, Pitchakarn P, Kuno T, Ogawa K, Asamoto M, Shirai T, Takahashi S.
  Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis.
  Prostate, 2015; 75: 151-60.
• Onami S, Cho YM, Toyoda T, Akagi J, Fujiwara S, Ochiai R, Tsujino K, Nishikawa A, Ogawa K.
  Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat.
  Regul Toxicol Pharmacol, 2015; 73: 726-31.
• Yoshida M, Suzuki S, Takahashi M, Ichimura R, Inoue K, Taya K, Watanabe G.
  Predominant role of the hypothalamic-pituitary axis, not the ovary, in different types of abnormal cycle induction by postnatal exposure to high dose p-tert-octylphenol in rats.
  Reprod Toxicol, 2015; 57: 21-8.
• Ichimura R, Takahashi M, Morikawa T, Inoue K, Maeda J, Usuda K, Yokosuka M, Watanabe G, Yoshida M.
  Prior attenuation of KiSS1/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats.
  Reprod Toxicol, 2015; 51: 145-56.
• Toyoda T, Cho YM, Akagi J, Mizuta Y, Hirata T, Nishikawa A, Ogawa K.
  Early detection of genotoxic urinary bladder carcinogens by immunohistochemistry for γ-H2AX.
  Toxicol Sci, 2015; 148: 400-8.
• Kuroda K, Hibi D, Ishii Y, Yokoo Y, Takasu S, Kijima A, Matsushita K, Masumura K, Kodama Y, Yanai T, Sakai H, Nohmi T, Ogawa K, Umemura T.
  Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.
  Toxicol Sci, 2015; 144: 65-76.
• Kijima A, Ishii Y, Takasu S, Matsushita K, Kuroda K, Hibi D, Suzuki Y, Nohmi T, Umemura T.
  Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.
  Toxicology, 2015; 331: 125-35.
• 小川久美子．
  食品添加物のリスク評価とリスク管理．
  Foods & Food Ingredients Journal of Japan, 2015; 220: 204-11.
• 吉田緑，梅村隆志，小島弘幸，井上薫，高橋美和，浦丸直人，北村繁幸，安部賀央里，頭金正博，小澤正吾，吉成浩一．
  化学物質のリスク評価における肝肥大の取扱いの基本的考え方．
  食品衛生学雑誌，2015; 56: 42-8.
• 井上薫，高橋美和，梅村隆志，吉田緑．
  食品安全委員会により公開されている農薬評価書において用いられた肝臓の病理組織学的所見名の分類とシソーラス構築：毒性病理用語・診断基準国際統一化．
  食品衛生学雑誌，2015; 56: 96-107.
• 豊田武士，塚本徹哉，小川久美子，立松正衞．
  食塩と胃癌－H. pylori感染との関連も含めて．
  臨牀消化器内科，2015; 30: 1395-400.

2014年

• Ihara K, Asanuma K, Fukuda T, Ohwada S, Yoshida M, Nishimori K.
  MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney.
  Am J Pathol, 2014; 184: 2699-708.
• Ishii Y, Takasu S, Kuroda K, Matsushita K, Kijima A, Nohmi T, Ogawa K, Umemura T.
  Combined application of comprehensive analysis for DNA modification and reporter gene mutation assay to evaluate kidneys of gpt delta rats given madder color or its constituents.
  Anal Bioanal Chem, 2014; 406: 2467-75.
• Onami S, Cho YM, Toyoda T, Mizuta Y, Yoshida M, Nishikawa A, Ogawa K.
  A 13-week repeated dose study of three 3-monochloropropane-1,2-diol fatty acid esters in F344 rats.
  Arch Toxicol, 2014; 88: 871-80.
• Saelee P, Chaiwerawattana A, Ogawa K, Cho YM, Tiwawech D, Suktangman V.
  Clinicopathological significance of BRCA1 promoter hypermethylation in Thai breast cancer patients.
  Asian Pac J Cancer Prev, 2014; 15: 10585-9.
• Takasu S, Ishii Y, Matsushita K, Kuroda K, Kijima A, Kodama Y, Ogawa K, Umemura T.
  No effect of high fat diet-induced obesity on spontaneous reporter gene mutations in gpt delta mice.
  Asian Pac J Cancer Prev, 2014; 15: 7149-52.
• Toyoda T, Yamamoto M, Takasu S, Ogawa K, Tatematsu M, Tsukamoto T.
  Molecular mechanism of gastric carcinogenesis in Helicobacter pylori-infected rodent models.
  Diseases, 2014; 2: 168-86.
• Matsushita K, Kuroda K, Ishii Y, Takasu S, Kijima A, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.
  Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.
  Exp Toxicol Pathol, 2014; 66: 313-21.
• Tasaki M, Kuroiwa Y, Inoue T, Hibi D, Matsushita K, Kijima A, Maruyama S, Nishikawa A, Umemura T.
  Lack of nrf2 results in progression of proliferative lesions to neoplasms induced by long-term exposure to non-genotoxic hepatocarcinogens involving oxidative stress.
  Exp Toxicol Pathol, 2014; 66: 19-26.
• Toyoda T, Cho YM, Mizuta Y, Akagi J, Ogawa K.
  A 13-week subchronic toxicity study of ferric citrate in F344 rats.
  Food Chem Toxicol, 2014; 74: 68-75.
• Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A, Ogawa K.
  Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats.
  Food Chem Toxicol, 2014; 73: 84-94.
• Yamada T, Wei M, Toyoda T, Yamano S, Wanibuchi H.
  Inhibitory effect of Raphanobrassica on Helicobacter pylori-induced gastritis in Mongolian gerbils.
  Food Chem Toxicol, 2014; 70: 107-13.
• Dixon D, Alison R, Bach U, Colman K, Foley GL, Harleman JH, Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, Van Esch E, Westwood FR, Vidal J, Yoshida M.
  Nonproliferative and proliferative lesions of the rat and mouse female reproductive system.
  J Toxicol Pathol, 2014; 27 (Suppl): 1-107.
• Inoue K, Takahashi M, Kodama Y, Nishikawa A, Sugita-Konishi Y, Yoshida M.
  The kidneys of infant mice are not sensitive to the food mycotoxin contaminant nivalenol.
  J Toxicol Pathol, 2014; 27: 57-66.
• Takahashi M, Inoue K, Morikawa T, Matsuo S, Hayashi S, Tamura K, Watanabe G, Taya K, Yoshida M.
  Early indicators of delayed adverse effects in female reproductive organs in rats receiving neonatal exposure to 17alpha-ethynylestradiol.
  J Toxicol Sci, 2014; 39: 775-84.
• Toyoda T, Cho YM, Mizuta Y, Akagi J, Nishikawa A, Ogawa K.
  A 13-week subchronic toxicity study of sodium iron chlorophyllin in F344 rats.
  J Toxicol Sci, 2014; 39: 109-19.
• Usuda K, Nagaoka K, Nozawa K, Zhang H, Taya K, Yoshida M, Watanabe G.
  Neonatal exposure to 17α-ethynyl estradiol affects kisspeptin expression and LH-surge level in female rats.
  J Vet Med Sci, 2014; 76: 1105-10.
• Onami S, Cho YM, Toyoda T, Horibata K, Ishii Y, Umemura T, Honma M, Nohmi T, Nishikawa A, Ogawa K.
  Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4 week comprehensive toxicity study using F344 gpt delta rats.
  Mutagenesis, 2014; 29: 295-302.
• Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, Masumura KI, Watanabe M, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T.
  Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats.
  Mutagenesis, 2014; 29: 27-36.
• Nozawa K, Nagaoka K, Zhang H, Usuda K, Okazaki S, Taya K, Yoshida M, Watanabe G.
  Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats.
  Reprod Toxicol, 2014; 46: 77-84.
• Maeda J, Kijima A, Inoue K, Ishii Y, Ichimura R, Takasu S, Kuroda K, Matsushita K, Kodama Y, Saito N, Umemura T, Yoshida M.
  In vivo genotoxicity of Ginkgo biloba extract in gpt delta mice and constitutive androstane receptor knockout mice.
  Toxicol Sci, 2014; 140: 298-306.
• Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.
  Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice.
  Toxicol Pathol, 2014; 42: 1174-87.
• Inoue K, Morikawa T, Matsuo S, Tamura K, Takahashi M, Yoshida M.
  Adaptive parotid gland hypertrophy induced by dietary treatment of GSE in rats.
  Toxicol Pathol, 2014; 42: 1016-23.
• Kawano M, Qin XY, Yoshida M, Fukuda T, Nansai H, Hayashi Y, Nakajima T, Sone H.
  Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.
  Toxicol Lett, 2014; 228: 235-40.
• 豊田武士，小川久美子，塚本徹哉，立松正衞．
  除菌後胃癌の発生機序．
  G.I. Research，2014; 22: 487-93.

2013年

• Kuroda K, Kijima A, Ishii Y, Takasu S, Jin M, Matsushita K, Kodama Y, Umemura T.
  Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.
  Arch Toxicol, 2013; 87: 1609-19.
• Nojiri A, Toyoda T, Tanaka T, Yoshida T, Tatematsu M, Tsukamoto T.
  Inflammation enhanced X-irradiation-induced colonic tumorigenesis in the Min mouse.
  Asian Pac J Cancer Prev, 2013; 14: 4135-9.
• Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.
  Ellagic Acid inhibits migration and invasion by prostate cancer cell lines.
  Asian Pac J Cancer Prev, 2013; 14: 2859-63.
• Toyoda T, Tsukamoto T, Yamamoto M, Ban H, Saito N, Takasu S, Shi L, Saito A, Ito S, Yamamura Y, Nishikawa A, Ogawa K, Tanaka T, Tatematsu M.
  Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer.
  BMC Gastroenterol, 2013; 13: 122.
• Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T.
  Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis.
  Cancer Lett, 2013; 340: 141-7.
• Niwa T, Toyoda T, Tsukamoto T, Mori A, Tatematsu M, Ushijima T.
  Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.
  Cancer Prev Res, 2013; 6: 263-70.
• Fujii Y, Segawa R, Kimura M, Wang L, Ishii Y, Yamamoto R, Morita R, Mitsumori K, Shibutani M.
  Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats.
  Chem Biol Interact, 2013; 205: 108-18.
• Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.
  Thickened area of external granular layer and Ki-67 positive focus are early events of medulloblastoma in Ptch1(+/-) mice.
  Exp Toxicol Pathol, 2013; 65: 863-73.
• Yamamoto R, Shimamoto K, Ishii Y, Kimura M, Fujii Y, Morita R, Suzuki K, Shibutani M, Mitsumori K.
  Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.
  Exp Toxicol Pathol, 2013; 65: 845-52.
• Kuroda K, Kijima A, Jin M, Ishii Y, Takasu S, Matsushita K, Nishikawa A, Umemura T.
  The effects of long-term exposure to ozokerite mainly consisting of an aliphatic series of hydrocarbons using F344 rats.
  Food Chem Toxicol, 2013; 55: 476-83.
• Okamura T, Umemura T, Inoue T, Tasaki M, Ishii Y, Nakamura Y, Park EY, Sato K, Matsuo T, Okamoto S, Nishikawa A, Ogawa K.
  Chemopreventive effects of 4-methylthio-3-butenyl isothiocyanate (raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters.
  J Agric Food Chem, 2013; 61: 2103-8.
• Tasaki M, Kuroiwa Y, Inoue T, Hibi D, Matsushita K, Ishii Y, Maruyama S, Nohmi T, Nishikawa A, Umemura T.
  Oxidative DNA damage and in vivo mutagenicity caused by reactive oxygen species generated in the livers of p53-proficient or -deficient gpt delta mice treated with non-genotoxic hepatocarcinogens.
  J Appl Toxicol, 2013; 33: 1433-41.
• Ogawa K, Murasaki T, Sugiura S, Nakanishi M, Shirai T.
  Organ differences in the impact of p27kip1 deficiency on carcinogenesis induced by N-methyl-N-nitrosourea.
  J Appl Toxicol, 2013; 33: 471-9.
• Ohmachi Y, Yoshida M, Ogiu T.
  Two cases of metastatic parathyroid carcinoma in male C3H mice following irradiation.
  J Toxicol Pathol, 2013; 26: 413-7.
• Toyoda T, Akagi J, Cho YM, Mizuta Y, Onami S, Suzuki I, Ogawa K.
  Detection of γ-H2AX, a biomarker for DNA double-strand breaks, in urinary bladders of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-treated rats.
  J Toxicol Pathol, 2013; 26: 215-21.
• Fujimoto H, Woo GH, Morita R, Itahashi M, Akane H, Nishikawa A, Shibutani M.
  Increased cellular distribution of vimentin and Ret in the cingulum of rat offspring after developmental exposure to decabromodiphenyl ether or 1,2,5,6,9,10-hexabromocyclododecane.
  J Toxicol Pathol, 2013; 26: 119-29.
• Matsushita K, Kijima A, Ishii Y, Takasu S, Jin M, Kuroda K, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Umemura T.
  Development of a medium-term animal model using gpt delta rats to evaluate chemical carcinogenicity and genotoxicity.
  J Toxicol Pathol, 2013; 26: 19-27.
• Hayashi S, Taketa Y, Inoue K, Takahashi M, Matsuo S, Irie K, Watanabe G, Yoshida M.
  Effects of pyperonyl butoxide on the female reproductive tract in rats.
  J Toxicol Sci, 2013; 38: 891-902.
• Nemoto K, Ikeda A, Tanaka T, Inoue K, Yoshida M, Nishikawa A, Gamou T, Habano W, Ozawa S, Degawa M.
  Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.
  J Toxicol Sci, 2013; 38: 611-7.
• Inoue K, Morikawa T, Takahashi M, Yoshida M, Ogawa K.
  A 13-week subchronic toxicity study of grape skin extract in F344 rats.
  J Toxicol Sci, 2013; 38: 559-70.
• Morita R, Yafune A, Shiraki A, Itahashi M, Ishii Y, Akane H, Nakane F, Suzuki K, Shibutani M, Mitsumori K.
  Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress.
  J Toxicol Sci, 2013; 38: 403-13.
• Yoshida M, Suzuki D, Matsumoto K, Shirota M, Inoue K, Takahashi M, Morita T, Ono A.
  Simulation of acute reference dose (ARfD) settings for pesticides in Japan.
  J Toxicol Sci, 2013; 38: 205-14.
• Hibi D, Kijima A, Kuroda K, Suzuki Y, Ishii Y, Jin M, Nakajima M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T.
  Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.
  J Toxicol Sci, 2013; 38: 57-69.
• Toyoda T, Takami S, Imai T, Cho YM, Hasumura M, Mizuta Y, Onami S, Suzuki I, Hirose M, Nishikawa A, Ogawa K.
  A 13-week subchronic toxicity study of garden balsam extract in F344 rats.
  Jpn J Food Chem Safety, 2013; 20: 52-60.
• Imai T, Cho YM, Takahashi M, Kitahashi T, Takami S, Nishikawa A, Ogawa K.
  High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis.
  Oncol Rep, 2013; 29: 1914-22.
• Takahashi M, Inoue K, Morikawa T, Matsuo S, Hayashi S,Tamura K, Watanabe G, Taya K, Yoshida M.
  Delayed effects of neonatal exposure to 17alpha-ethynylestradiol on the estrous cycle and uterine carcinogenesis in Wistar Hannover GALAS rats.
  Reprod Toxicol, 2013; 40: 16-23.
• Tsukamoto T, Toyoda T, Mizoshita T, Tatematsu M.
  Helicobacter pylori infection and gastric carcinogenesis in rodent models.
  Semin Immunopathol, 2013; 35: 177-90.
• Yoshida M, Suzuki D, Matsumoto K, Shirota M, Inoue K, Takahashi M, Morita T, Ono A.
  Basic principles for setting acute reference dose, ARfD in Japan.
  Shokuhin Eiseigaku Zasshi, 2013; 54: 331-4.
• Kuroda K, Ishii Y, Takasu S, Kijima A, Matsushita K, Watanabe M, Takahashi H, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T.
  Cell cycle progression, but not genotoxic activity, mainly contributes to citrinin-induced renal carcinogenesis.
  Toxicology, 2013; 311: 216-24.
• Suzuki S, Pitchakarn P, Ogawa K, Naiki-Ito A, Chewonarin T, Punfa W, Asamoto M, Shirai T, Takahashi S.
  Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis.
  Toxicology, 2013; 311: 115-23.
• Fujii Y, Kimura M, Ishii Y, Yamamoto R, Morita R, Hayashi SM, Suzuki K, Shibutani M.
  Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.
  Toxicology, 2013; 305: 30-40.
• Hibi D, Kijima A, Suzuki Y, Ishii Y, Jin M, Sugita-Konishi Y, Yanai T, Nishikawa A, Umemura T.
  Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.
  Toxicology, 2013; 304: 92-9.
• Jin M, Kijima A, Hibi D, Ishii Y, Takasu S, Matsushita K, Kuroda K, Nohmi T, Nishikawa A, Umemura T.
  In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure.
  Toxicol Sci, 2013; 131: 387-94.
• Tamura K, Inoue K, Takahashi M, Matsuo S, Irie K, Kodama Y, Ozawa S, Nishikawa A, Yoshida M.
  Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.
  Toxicol Lett, 2013; 221: 47-56.
• Sakamoto Y, Inoue K, Takahashi M, Taketa Y, Kodama Y, Nemoto K, Degawa M, Gamou T, Ozawa S, Nishikawa A, Yoshida M.
  Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.
  Toxicol Pathol, 2013; 41: 1078-92.
• Taketa Y, Inoue K, Takahashi M, Yamate J, Yoshida M.
  Differential morphological effects in rat corpora lutea among ethylene glycol monomethyl ether, atrazine, and bromocriptine.
  Toxicol Pathol, 2013; 41: 736-43.
• 梅村隆志，日比大介．
  オクラトキシンAの腎発がん機序の解明（カビ毒・きのこ毒の発生要因を考慮に入れたリスク評価方法の開発）．
  食品衛生研究，2013; 63: 19-26.

2012年

• Suzuki Y, Umemura T, Hibi D, Inoue T, Jin M, Ishii Y, Sakai H, Nohmi T, Yanai T, Nishikawa A, Ogawa K.
  Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats.
  Arch Toxicol, 2012; 86: 1593-601.
• Saegusa Y, Fujimoto H, Woo GH, Ohishi T, Wang L, Mitsumori K, Nishikawa A, Shibutani M.
  Transient aberration of neuronal development in the hippocampal dentate gyrus after developmental exposure to brominated flame retardants in rats.
  Arch Toxicol, 2012; 86: 1431-42.
• Ochi A, Ochiai K, Kobara A, Nakamura S, Hatai H, Handharyani E, Tiemann I, Tanaka III IB, Toyoda T, Abe A, Seok SH, Sunden Y, Torralba NC, Park JH, Hafez HM, Umemura T.
  Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany.
  Avian Pathol, 2012; 41: 299-309.
• Takahashi M, Matsuo S, Inoue K, Tamura K, Irie K, Kodama Y, Yoshida M.
  Development of an early induction model of medulloblastoma in Ptch1 heterozygous mice initiated with N-ethyl-N-nitrosourea.
  Cancer Sci, 2012; 103: 2051-5.
• Ogawa K, Pitchakarn P, Suzuki S, Chewonarin T, Tang M, Takahashi S, Naiki-Ito A, Sato S, Takahashi S, Asamoto M, Shirai T.
  Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells.
  Cancer Sci, 2012; 103: 860-7.
• Fujii M, Nakanishi H, Toyoda T, Tanaka I, Kondo Y, Osada H, Sekido Y.
  Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGF-β signaling and defects in the Hippo signaling cascade.
  Cell Cycle, 2012; 11: 3373-9.
• Ishii Y, Inoue K, Takasu S, Jin M, Matsushita K, Kuroda K, Fukuhara K, Nishikawa A, Umemura T.
  Determination of lucidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given lucidin-3-O-primeveroside.
  Chem Res Toxicol, 2012; 25: 1112-8.
• Taketa Y, Yoshida M, Inoue K, Takahashi M, Sakamoto Y, Watanabe G, Taya K, Yamate J, Nishikawa A.
  The newly formed corpora lutea of normal cycling rats exhibit drastic changes in steroidogenic and luteolytic gene expressions.
  Exp Toxicol Pathol, 2012; 64: 775-82.
• Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T.
  Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3.
  Food Chem Toxicol, 2012; 50: 840-7.
• Takami S, Imai T, Cho YM, Ogawa K, Hirose M, Nishikawa A.
  Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks.
  J Appl Toxicol, 2012; 32: 959-67.
• Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.
  TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth.
  J Exp Med, 2012; 209: 479-94.
• Yoshida M, Katsuda S, Maekawa A.
  Involvements of estrogen receptor, proliferating cell nuclear antigen and p53 in endometrial adenocarcinoma development in Donryu rats.
  J Toxicol Pathol, 2012; 25: 241-7.
• Matsushita K, Ishii Y, Kijima A, Jin M, Takasu S, Kuroda K, Kodama Y, Ogawa K, Umemura T.
  Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods.
  J Toxicol Sci, 2012; 37: 1077-82.
• Cho YM, Imai T, Takami S, Ogawa K, Nishikawa A.
  Female heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model.
  J Toxicol Sci, 2012; 37: 1025-34.
• Jin M, Kijima A, Suzuki Y, Hibi D, Ishii Y, Nohmi T, Nishikawa A, Ogawa K, Umemura T.
  In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice.
  J Toxicol Sci, 2012; 37: 711-21.
• Hayashi H, Shimamoto K, Taniai E, Ishii Y, Morita R, Suzuki K, Shibutani M, Mitsumori K.
  Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
  J Toxicol Sci, 2012; 37: 491-501.
• Hojo Y, Shiraki A, Tsuchiya T, Shimamoto K, Ishii Y, Suzuki K, Shibutani M, Mitsumori K.
  Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.
  J Toxicol Sci, 2012; 37: 297-306.
• Fujimoto N, Inoue K, Yoshida M, Nishikawa A, Ozawa S, Gamou T, Nemoto K, Degawa M.
  Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats.
  J Toxicol Sci, 2012; 37: 281-6.
• Suzuki Y, Umemura T, Ishii Y, Hibi D, Inoue T, Jin M, Sakai H, Kodama Y, Nohmi T, Yanai T, Nishikawa A, Ogawa K.
  Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice.
  Mutat Res, 2012; 749: 23-8.
• Fujimoto H, Woo GH, Inoue K, Igarashi K, Kanno J, Hirose M, Nishikawa A, Shibutani M.
  Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents.
  Reprod Toxicol, 2012; 34: 93-100.
• Ota Y, Imai T, Hasumura M, Cho YM, Takami S, Oyamada T, Hirose M, Nishikawa A, Ogawa K.
  Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
  Toxicol Sci, 2012; 127: 339-47.
• 中村考志，糸井昭太郎，藤井雅弓，中村貴子，城田浩治，末留昇，曺永晩，小川久美子，西村秋佳，松尾友明，岡本繁久，朴恩榮，佐藤健司．
  京野菜の食品機能性における普及種に対する優位性とそれを活かした需要の創出．
  調理食品と技術，2012; 18: 43-51.
• 高橋美和．
  医食住のマイコトキシン6　マイコトキシンの健康被害　4-3）その他の毒性．
  防菌防黴，2012; 40: 529-34.

2011年

• Iwasaki Y, Nomoto M, Oda M, Mochizuki K, Nakano Y, Ishii Y, Ito R, Saito K, Umemura T, Nishikawa A, Nakazawa H.
  Characterization of nitrated phenolic compounds for their anti-oxidant, pro-oxidant, and nitration activities.
  Arch Biochem Biophys, 2011; 513: 10-8.
• Morita R, Shimamoto K, Ishii Y, Kuwata K, Ogawa B, Imaoka M, Hayashi S, Suzuki K, Shibutani M, Mitsumori K.
  Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
  Arch Toxicol, 2011; 85: 1475-84.
• Takahashi M, Inoue K, Koyama N, Yoshida M, Irie K, Morikawa T, Shibutani M, Honma M, Nishikawa A.
  Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicity.
  Arch Toxicol, 2011; 85: 1109-20.
• Ogawa B, Ohishi T, Wang L, Takahashi M, Taniai E, Hayashi H, Mitsumori K, Shibutani M.
  Disruptive neuronal development by acrylamide in the hippocampal dentate hilus after developmental exposure in rats.
  Arch Toxicol, 2011; 85: 987-94.
• Dewa Y, Nishimura J, Jin M, Kawai M, Saegusa Y, Kenmochi S, Shimamoto K, Harada T, Shibutani M, Mitsumori K.
  Immunohistochemical analyses at the late stage of tumor promotion by oxfendazole in a rat hepatocarcinogenesis model.
  Arch Toxicol, 2011; 85: 155-62.
• Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T.
  Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf.
  Cancer Lett, 2011; 306: 142-50.
• Hur K, Niwa T, Toyoda T, Tsukamoto T, Tatematsu M, Yang HK, Ushijima T.
  Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation.
  Carcinogenesis, 2011; 32: 35-41.
• Ishii Y, Suzuki Y, Hibi D, Jin M, Fukuhara K, Umemura T, Nishikawa A.
  Detection and quantification of specific DNA adducts by liquid chromatography-tandem mass spectrometry in the livers of rats given estragole at the carcinogenic dose.
  Chem Res Toxicol, 2011; 24: 532-41.
• Cho YM, Hasumura M, Takami S, Imai T, Hirose M, Ogawa K, Nishikawa A.
  A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats.
  Food Chem Toxicol, 2011; 49: 1782-6.
• Kemmochi S, Fujimoto H, Woo GH, Inoue K, Takahashi M, Mitsumori K, Hirose M, Nishikawa A, Shibutani M.
  Involvement of PTEN/Akt signaling in capsular invasive carcinomas developed in a rat two-stage thyroid carcinogenesis model after promotion with sulfadimethoxine.
  J Cancer Res Clin Oncol, 2011; 137: 723-32.
• Toyoda T, Tsukamoto T, Cho YM, Onami S, Takasu S, Shi L, Saito A, Matsuo S, Tatematsu M, Nishikawa A, Ogawa K.
  Undifferentiated sarcoma of the salivary gland in a Mongolian gerbil (Meriones unguiculatus).
  J Toxicol Pathol, 2011; 24: 173-7.
• Takami S, Ogawa K, Umemura T, Hibi D, Ishii Y, Okamura T, Tasaki M, Inoue T, Suzuki Y, Jin M, Cho YM, Nishikawa A.
  Uterine carcinosarcoma in a 2-year-old female Wistar Hannover GALAS rat.
  J Toxicol Pathol, 2011; 24: 63-7.
• Shimamoto K, Hayashi H, Taniai E, Morita R, Imaoka M, Ishii Y, Suzuki K, Shibutani M, Mitsumori, K.
  Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.
  J Toxicol Sci, 2011; 36: 775-86.
• Hasumura M, Imai T, Cho YM, Ueda M, Hirose M, Nishikawa A, Ogawa K.
  Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats.
  J Toxicol Sci, 2011; 36: 763-74.
• Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.
  Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
  J Toxicol Sci, 2011; 36: 613-23.
• Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.
  Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.
  J Toxicol Sci, 2011; 36: 507-14.
• Yoshida M, Takahashi M, Inoue K, Nakae D, Nishikawa A.
  Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats.
  J Toxicol Sci, 2011; 36: 297-311.
• Kawamoto K, Sato I, Tsuda S, Yoshida M, Yaegashi K, Saito N, Liu W, Jin Y.
  Ultrasonic-induced tonic convulsion in rats after subchronic exposure to perfluorooctane sulfonate (PFOS).
  J Toxicol Sci, 2011; 36: 55-62.
• Kemmochi S, Fujimoto H, Woo GH, Hirose M, Nishikawa A, Mitsumori K, Shibutani M.
  Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model.
  J Vet Med Sci, 2011; 73: 655-64.
• Tatematsu K, Koide A, Hirose M, Nishikawa A, Mori Y.
  Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver.
  Mutagenesis, 2011; 26: 323-30.
• Fujimoto H, Woo GH, Inoue K, Takahashi M, Hirose M, Nishikawa A, Shibutani M.
  Impaired oligodendroglial development by decabromodiphenyl ether in rat offspring after maternal exposure from mid-gestation through lactation.
  Reprod Toxicol, 2011; 31: 86-94.
• Yoshida M, Takahashi M, Inoue K, Hayashi S, Maekawa A, Nishikawa A.
  Delayed adverse effects of neonatal exposure to diethylstilbestrol and their dose dependency in female rats.
  Toxicol Pathol, 2011; 39: 823-34.
• Taketa Y, Inomata A, Hosokawa S, Sonoda J, Hayakawa K, Nakano K, Momozawa Y, Yamate J, Yoshida M, Aoki T, Tsukidate K.
  Histopathological characteristics of lutela hypertrohy induced by ethylene glycol monomethyl ether with a comparison to normal luteal morphology in rats.
  Toxicol Pathol, 2011; 39: 372-80.
• Hibi D, Suzuki Y, Ishii Y, Jin M, Watanabe M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T
  Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A.
  Toxicol Sci, 2011; 122: 406-14.
• Taketa Y, Yoshida M, Inoue K, Takahashi M, Sakamoto Y, Watanabe G, Taya K, Yamate J, Nishikawa A.
  Differential stimulation pathways of progesterone secretion from newly formed corpora lutea in rats treated with ethylene glycol monomethyl ether, sulpiride, or atrazine.
  Toxicol Sci, 2011; 121: 267-78.
• Jin M, Kijima A, Suzuki Y, Hibi D, Inoue T, Ishii Y, Nohmi T, Nishikawa A, Ogawa K, Umemura T.
  Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.
  Toxicology, 2011; 290: 313-22.
• Shimamoto K, Dewa Y, Ishii Y, Kemmochi S, Taniai E, Hayashi H, Imaoka M, Morita R, Kuwata K, Suzuki K, Shibutani M, Mitsumori K.
  Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
  Toxicology, 2011; 283: 109-17.
• Iwasaki Y, Hirasawa T, Maruyama Y, Ishii Y, Ito R, Saito K, Umemura T, Nishikawa A, Nakazawa H.
  Effect of interaction between phenolic compounds and copper ion on antioxidant and pro-oxidant activities.
  Toxicol In Vitro, 2011; 25: 1320-7.

2010年

• Ichimura R, Mizukami S, Takahashi M, Taniai E, Kemmochi S, Mitsumori K, Shibutani M.
  Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.
  Toxicol Appl Pharmacol, 2010; 246: 128-40.
• Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A.
  Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats.
  Toxicol Pathol, 2010; 38: 598-605.
• Tasaki M, Umemura T, Suzuki Y, Hibi D, Inoue T, Okamura T, Ishii Y, Maruyama S, Nohmi T, Nishikawa A.
  Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency.
  Cancer Sci, 2010; 101: 2525-30.
• Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.
  Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo.
  Cancer Sci, 2010; 101: 2234-40.
• Hibi D, Imazawa T, Kijima A, Suzuki Y, Ishii Y, Jin M, Umemura T, Nishikawa A.
  Investigation of carcinogenicity for levamisole administered in the diet to F344 rats.
  Food Chem Toxicol, 2010; 48: 3321-6.
• Kawamoto K, Sato I, Yoshida M, Tsuda S.
  Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung.
  J Toxicol Sci, 2010; 35: 929-33.
• Okamura T, Ishii Y, Suzuki Y, Inoue T, Tasaki M, Kodama Y, Nohmi T, Mitsumori K, Umemura T, Nishikawa A.
  Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice.
  J Toxicol Sci, 2010; 35: 731-41.
• Okamura T, Ishii Y, Suzuki Y, Inoue T, Tasaki M, Kodama Y, Nohmi T, Mitsumori K, Umemura T, Nishikawa A.
  Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
  J Toxicol Sci, 2010; 35: 709-20.
• Yahia D, El-Nasser MA, Abedel-Latif M, Tsukuba C, Yoshida M, Sato I, Tsuda S.
  Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction.
  J Toxicol Sci, 2010; 35: 527-33.
• Jin M, Dewa Y, Kawai M, Nishimura J, Saegusa Y, Kemmochi S, Harada T, Shibutani M, Mitsumori K.
  The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.
  J Toxicol Sci, 2010; 35: 69-78.
• Takami S, Imai T, Cho YM, Hirose M, Nishikawa A.
  Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats.
  J Toxicol Sci, 2010; 35(1): 57-68.
• Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M.
  Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
  Arch Toxicol, 2010; 84: 319-31.
• Suzuki T, Jin M, Dewa Y, Ichimura R, Shimada Y, Mizukami S, Shibutani M, Mitsumori K.
  Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration.
  Arch Toxicol, 2010; 84: 493-500.
• Kawai M, Saegusa Y, Dewa Y, Nishimura J, Kemmochi S, Harada T, Ishii Y, Umemura T, Shibutani M, Mitsumori K.
  Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice.
  Arch Toxicol, 2010; 84(2): 155-64.
• 塚本徹哉，豊田武士，溝下勤，立松正衞．
  動物感染モデルを用いたピロリ菌発癌機構解析．
  細胞工学，2010; 29: 549-53.
• 塚本徹哉，豊田武士，溝下勤，立松正衞．
  Helicobacter pylori研究におけるスナネズミモデルの有用性―とくに胃癌を念頭に置いて―．
  Helicobacter Res, 2010; 14: 447-53.
• 西川秋佳．
  代替法より得られる結果の評価．
  Food & Food Ingredient J Jpn, 2010; 215: 398-401.
• 西川秋佳，井上達，梅村隆志，井上薫，吉田緑，関田清司，石井雄二，小川久美子，広瀬明彦，高木篤也，堤智昭，大野泰雄，渋谷淳，高橋美和，小西良子，穐山浩，菅野純．
  食品安全性生物試験関連のトピックス．
  食品衛生学雑誌，2010; 51: 415-43.
• Saegusa Y, Woo GH, Fujimoto H, Kemmochi S, Shimamoto K, Hirose M, Mitsumori K, Nishikawa A, Shibutani M.
  Sustained production of Reelin-expressing interneurons in the hippocampal dentate hilus after developmental exposure to anti-thyroid agents in rats.
  Reprod Toxicol, 2010; 29: 407-14.
• Toyoda-Hokaiwado N, Inoue T, Masumura K, Hayashi H, Kawamura Y, Kurata Y, Takamune M, Yamada M, Sanada H, Umemura T, Nishikawa A, Nohmi T.
  Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.
  Toxicol Sci, 2010; 114(1): 71-8.
• Saegusa Y, Woo GH, Fujimoto H, Inoue K, Takahashi M, Hirose M, Igarashi K, Kanno J, Mitsumori K, Nishikawa A, Shibutani M.
  Gene expression profiling and cellular distribution of molecules with altered expression in the hippocampal CA1 region after developmental exposure to anti-thyroid agents in rats.
  J Vet Med Sci, 2010; 72(2): 187-95.
• Ishii Y, Okamura T, Inoue T, Fukuhara K, Umemura T, Nishikawa A.
  Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside.
  Chem Res Toxicol, 2010; 23(1): 134-41.

2009年

• Inoue K, Yoshida M, Takahashi M, Fujimoto H, Shibutani M, Hirose M, Nishikawa A.
  Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay.
  Cancer Sci, 2009; 100(12): 2261-7.
• Imai T, Hasumura M, Cho YM, Ota Y, Takami S, Hirose M, Nishikawa A.
  Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
  Cancer Sci, 2009; 100(10): 1794-800.
• Woo GH, Takahashi M, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A, Shibutani M.
  Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model.
  Cancer Sci, 2009; 100(4): 617-25.
• Saegusa Y, Fujimoto H, Woo GH, Inoue K, Takahashi M, Mitsumori K, Hirose M, Nishikawa A, Shibutani M.
  Developmental toxicity of brominated flame retardants, tetrabromobisphenol A and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from mid-gestation through lactation.
  Reprod Toxicol, 2009; 28(4): 456-67.
• Shibutani M, Woo GH, Fujimoto H, Saegusa Y, Takahashi M, Inoue K, Hirose M, Nishikawa A.
  Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.
  Reprod Toxicol, 2009; 28(3): 297-307.
• Tasaki M, Umemura T, Kijima A, Inoue T, Okamura T, Kuroiwa Y, Ishii Y, Nishikawa A.
  Simultaneous induction of non-neoplastic and neoplastic lesions with highly proliferative hepatocytes following dietary exposure of rats to tocotrienol for 2 years.
  Arch Toxicol, 2009; 83(11): 1021-30.
• Takahashi M, Shibutani M, Nakahigashi J, Sakaguchi N, Inoue K, Morikawa T, Yoshida M, Nishikawa A.
  Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periods.
  Arch Toxicol, 2009; 83(8): 785-93.
• Dewa Y, Nishimura J, Muguruma M, Jin M, Kawai M, Saegusa Y, Okamura T, Umemura T, Mitsumori K.
  Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats.
  Arch Toxicol, 2009; 83(5): 503-11.
• Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K.
  Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems.
  Part Fibre Toxicol, 2009; 6: 23.
• Inoue K, Yoshida M, Takahashi M, Cho YM, Takami S, Nishikawa A.
  Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat.
  J Toxicol Pathol, 2009; 22(3): 195-8.
• Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A.
  A ninety-day toxicity study of semicarbazide hydrochloride in Wistar Hannover GALAS rats.
  Food Chem Toxicol, 2009; 47(10): 2490-8.
• Cho YM, Imai T, Ito Y, Takami S, Hasumura M, Yamazaki T, Hirose M, Nishikawa A.
  A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats.
  Food Chem Toxicol, 2009; 47(8): 2150-6.
• Inoue K, Yoshida M, Takahashi M, Fujimoto H, Ohnishi K, Nakashima K, Shibutani M, Hirose M, Nishikawa A.
  Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats.
  Food Chem Toxicol, 2009; 47(4): 752-9.
• Takahashi M, Inoue K, Yoshida M, Morikawa T, Shibutani M, Nishikawa A.
  Lack of chronic toxicity or carcinogenicity of dietary N-acetylglucosamine in F344 rats.
  Food Chem Toxicol, 2009; 47(2): 462-71.
• Inoue K, Yoshida M, Takahashi M, Shibutani M, Takagi H, Hirose M, Nishikawa A.
  Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study.
  Food Chem Toxicol, 2009; 47(1): 184-91.
• Kawasaki Y, Hirabayashi Y, Kaneko T, Kanno J, Kodama Y, Matsushima Y, Ogawa Y, Saitoh M, Sekita K, Uchida O, Umemura T, Yoon BI, Inoue T.
  Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice.
  Toxicol Sci, 2009; 110(2): 293-306.
• Jin M, Dewa Y, Kawai M, Nishimura J, Saegusa Y, Kemmochi S, Harada T, Shibutani M, Mitsumori K.
  Induction of liver preneoplastic foci in F344 rats subjected to 28-day oral administration of diheptyl phthalate and its in vivo genotoxic potential.
  Toxicology, 2009; 1-2(1): 16-25.
• Ishii Y, Okamura T, Inoue T, Tasaki M, Umemura T, Nishikawa A.
  Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
  Toxicology, 2009; 263(2-3): 93-9.
• Umemura T, Tasaki M, Kijima A, Okamura T, Inoue T, Ishii Y, Suzuki Y, Masui N, Nohmi T, Nishikawa A.
  Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate.
  Toxicology, 2009; 257(1-2): 46-52.
• 西川秋佳．
  わが国における食品によるがん化学予防研究の現況と将来への展望－行政よりみた現況と将来．
  Administrative View of the Present and Future.
  Food & Food Ingredient J Jpn, 2009; 214(3): 235-7.
• 西川秋佳．
  既存添加物の安全性評価－JECFAにおける評価を含めて－．
  ＪＡＦＡＮ 日本食品添加物ニュース，2009; 29（2）: 103-7.
• Cho YM, Imai T, Hasumura M, Watanabe N, Ushijima T, Hirose M, Nishikawa A.
  Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
  J Toxicol Sci, 2009; 34(4): 407-12.
• Ota Y, Imai T, Onose J, Takami S, Cho YM, Hirose M, Nishikawa A.
  A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.
  J Toxicol Sci, 2009; 34(3): 305-13.
• Yoshida M, Sanbuissyo A, Hisada S, Takahash M, Ohno Y, Nishikawa A.
  Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection.
  J Toxicol Sci, 2009; 34: S189-97.
• Yoshida M, Watanabe G, Suzuki T, Inoue K, Takahashi M, Maekawa A, Taya K, Nishikawa A.
  Long-term treatment with bromocriptine inhibits endometrial adenocarcinoma development in rats.
  J Reprod Dev, 2009; 55(2): 105-9.
• Imai T, Takami S, Cho YM, Hirose M, Nishikawa A.
  Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
  Toxicol Lett, 2009; 185(3): 160-7.

2008年

• Nishimura J, Dewa Y, Okamura T, Jin M, Saegusa Y, Kawai M, Umemura T, Shibutani M, Mitsumori K.
  Role of Nrf2 and oxidative stress on fenofibrate-induced hepatocarcinogenesis in rats.
  Toxicol Sci. 2008 Dec; 106(2): 339-49.
• Kuroiwa Y, Yamada M, Matsui K, Okamura T, Ishii Y, Masumura K, Tasaki M, Umemura T, Mitsumori K, Nohmi T, Hirose M, Nishikawa A.
  Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium.
  Toxicol Sci, 2008; 104(2): 274-82.
• Takahashi M, Shibutani M, Woo GH, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A.
  Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
  Carcinogenesis. 2008; 29(11): 2218-26.
• Nishikawa A, Umemura T, Ishii Y, Tasaki M, Okamura T, Inoue T, Masumura K, Nohmi T.
  In vivo approaches to study mechanism of action of genotoxic carcinogens.
  Gene Environ, 2008; 30(4): 120-4.
• Nakamura Y, Matsuo T, Okamoto S, Nishikawa A, Imai T, Park EY, Sato K.
  Antimutagenic and anticarcinogenic properties of Kyo-yasai, heirloom vegetables in Kyoto.
  Gene Environ, 2008; 30(2): 41-7.
• Inoue K, Shibutani M, Masutomi N, Toyoda K, Takagi H, Takahashi M, Fujimoto H, Hirose M, Nishikawa A.
  One-year chronic toxicity of madder color in F344 rats - Induction of preneoplastic/neoplastic lesions in the kidney and liver.
  Food Chem Toxicol, 2008; 46(10): 3303-10.
• Umemura T, Maeda M, Kijima A, Ishii Y, Tasaki M, Okamura T, Inoue T, Hirose M, Nishikawa A.
  Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
  Food Chem Toxicol, 2008; 46(9): 3206-12.
• Inoue T, Umemura T, Maeda M, Ishii Y, Okamura T, Tasaki M, Nishikawa A.
  Safety assessment of dietary administered paprika color in combined chronic toxicity and carcinogenicity studies using F344 rats.
  Food Chem Toxicol, 2008; 46(8): 2689-93.
• Takami S, Imai T, Hasumura M, Cho YM, Onose J, Hirose M.
  Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats.
  Food Chem Toxicol, 2008; 46: 2224-9.
• Onose J, Imai T, Hasumura M, Ueda M, Ozeki Y, Hirose M.
  Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment.
  Food Chem Toxicol, 2008; 46(6): 2184-9.
• Tasaki M, Umemura T, Maeda M, Ishii Y, Okamura T, Inoue T, Kuroiwa Y, Hirose M, Nishikawa A.
  Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats.
  Food Chem Toxicol, 2008; 46(3): 1119-24.
• Inoue K, Shibutani M, Masutomi N, Toyoda K, Takagi H, Uneyama C, Nishikawa A, Hirose M.
  A 13-week subchronic toxicity study of madder color in F344 rats.
  Food Chem Toxicol, 2008; 46(1): 241-52.
• Takahashi M, Shibutani M, Sugita-Konishi Y, Aihara M, Inoue K, Woo GH, Fujimoto H, Hirose M.
  A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats.
  Food Chem Toxicol, 2008; 46(1): 125-35.
• Tasaki M, Umemura T, Inoue T, Okamura T, Kuroiwa Y, Ishii Y, Maeda M, Hirose M, Nishikawa A.
  Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year.
  Toxicology, 2008; 250(2-3): 143-50.
• Dewa Y, Nishimura J, Muguruma M, Jin M, Saegusa Y, Okamura T, Tasaki M, Umemura T, Mitsumori K.
  beta-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats.
  Toxicology, 2008; 244(2-3): 179-89.
• Cho YM, Imai T, Ota Y, Hasumura M, Takami S, Hirose M, Nishikawa A.
  A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
  Toxicol Pathol, 2008; 36(3): 459-64.
• Kanki K, Umemura T, Kitamura Y, Ishii Y, Kuroiwa Y, Kodama Y, Itoh K, Yamamoto M, Nishikawa A, Hirose M.
  A possible role of Nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate.
  Toxicol Pathol, 2008; 36(2): 353-61.
• 今井俊夫．
  化学物質誘発性の炎症関連ラット大腸発がんモデルの病理学的解析．
  日本がん予防学会News Letter, 2008; 50: 4-5.
• 西川秋佳．
  ダイコンの辛味成分による膵発がんの抑制効果．
  日本がん予防学会News Letter, 2008; 56: 2-3.
• 西川秋佳．
  安全性試験におけるGLPの現状．
  Histo-Logic Japan, 2008; 36(2): 18-21.
• Nishimura J, Dewa Y, Okamura T, Muguruma M, Jin M, Saegusa Y, Umemura T, Mitsumori K.
  Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.
  Arch Toxicol, 2008: 82(9): 641-54.
• Nakamura Y, Nakamura K, Asai Y, Wada T, Tanaka K, Matsuo T, Okamoto S, Meijer J, Kitamura Y, Nishikawa A, Park EY, Sato K, Ohtsuki K.
  Comparison of the glucosinolate-myrosinase systems among daikon (Raphanus sativus, Japanese white radish) varieties.
  J Agric Food Chem, 2008; 56(8): 2702-7.
• Takahashi M, Shibutani M, Inoue K, Fujimoto H, Hirose M, Nishikawa A.
  Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study.
  J Toxicol Sci, 2008; 33(1): 11-24.
• Kuroiwa Y, Okamura T, Ishii Y, Umemura T, Tasaki M, Kanki K, Mitsumori K, Hirose M, Nishikawa A.
  Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation.
  Cancer Sci, 2008; 99(1): 7-13.