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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_7 |
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From among residents in a HCB-polluted rural area of Flix,
Spain, where a manufacturing plant of electronic chemicals is
located, 98 infants born in 1997-99 and their mothers were
selected, and organochlorine compounds (HCB, p,p'-DDE, β-HCH and
PCB) in the cord blood of 70 neonates were determined by a gas
chromatograph with an electron capture detector. The plasma
thyroid stimulating hormone (TSH) was determined for all the
neonates 3 days after birth; the levels were all in the normal
range (< 25 mU/l; < 10 mU/l for 60 cases and ≧ 10 mU/l for 10
cases). Association with the high TSH was found for p,p'-DDE, β-HCH,
PCB-138 and PCB-118, among which only β-HCH was significantly
correlated with TSH according to multivariate analysis after
correction for age of conception: the odds ratio of β-HCH to TSH
≧ 10 mU/l was 1.81 (95% CI = 1.06-3.11, p = 0.03). No
correlation was found between the HCB and TSH levels.
4) Intervention study
It is known that organochlorine compounds are released from the
body fat into blood during body weight reduction, and may impair
thyroid status involved in the control of resting metabolism
rate (RMR). This prompted Pelletier et al. (2002) to study
whether the increase in plasma organochlorine level due to loss
of weight is related to the decrease in serum T3 level and RMR.
Plasma organochlorine concentrations, serum T3 concentration,
and RMR were measured before and after weight loss in 16 obese
men who followed a nonmacronutrient-specific energy-restricted
diet for 15 weeks. A significant decrease in serum T3
concentration and RMR was observed after the program. Of the 17
organochloriens found in plasma (β-HCH, p,p'-DDT, p,p'-DDE, HCB,
mirex, oxychlordane, trans-nonachlor, arochlor-1260, PCB-28,
PCB-99, PCB-118, PCB-138, PCB-153, PCB-156, PCB-170, PCB-180,
PCB-187), 13 showed significant level increase during weight
loss. Changes in organochlorine concentrations were inversely
associated with changes in serum T3 concentration (significantly
for p,p`-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and
PCB 170) and with changes in RMR adjusted for weight loss
(significantly for HCB and PCB 156).
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