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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_7 |
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These results suggest slight metabolic influences of HCB in the
body on thyroid functions and enzyme induction. Health effects
of these substances should further be studied in more sensitive
periods such as infants.
Hagmar et al. (2001) studied effects of dietary exposure of male
adults to high concentrations of organohalogen compounds on
hormone levels. Data was collected from 43 fishermen, 23-69
years of age, living in five villages around Riga Bay
(Southeastern Sweden) (Swedish group) in 1991 and from 67 male
residents, 24-79 years of age, in Riga and four small inland
villages (Latvian group).
Monthly fish intakes were 4 meals n the Swedish group and 6
meals in the Latvian group, with rather wide ranges (0-20 and
0-32, respectively). Analysis was made on 18 PCB congeners
including CB-153, 5 hydroxy-PCBs including 4-OH-CB107, p,p'-DDT,
p,p'-DDE, hexachlorobenzene, pentachlorophenol (PCP), and BDE-47
(2,2',4,4'-tetrabromodiphenylether) in plasma. Follicle
stimulating hormone, lutenizing hormone (LH), prolactin, thyroid
stimulating hormone, total free T3, total free T4 and free
testosterone in plasma were also analyzed.
Only inverse correlations of BDE-47 with plasma thyroid
stimulating hormone (p <0.001) and with follicle stimulating
hormone (p = 0.04) were observed after correction for age. The
small inverse correlations of free testosterone with p,p'-DDE,
total PCB, total hydroxy-PCB and HCB were not significant after
correction for age. OHS showed no significant correlation with
plasma LH, prolactin, TT3, FT3, TT4 or FT4.
Hagmar et al. (2001) also studied the relationship of PCB with
thyroid stimulating hormone (TSH) and thyroid hormones in plasma
of female adults. Analysis was made on 182 fishermen's wives in
the east coast of Sweden who delivered between 1973 and 1991.
The subjects, whose median age was 42 years (range 23-62), took
polluted fatty fish from Baltic Sea at least two times a month.
Plasma TSH, free and total triiodothyronine (FT3, TT3), and free
and total thyroxine (FT4, TT4) were determined by
immunofluorescence photometry, and
2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) by gas chromatography
with an electron capture detector. In addition, other 20 PCB
congeners and 2 hydroxy-PCBs were analyzed for 16 cases each
from the groups with the highest and lowest CB-153 levels
(275-776 and 16-103 ng/g fat, respectively). The plasma CB-153
level (16-776 ng/g fat) was inversely correlated with TTE level
(1.0-3.0 mmol/l) (rs = -0.29, P < 0.001). Multivariate analysis
showed a small inverse correlation between CB-153 and TT3 levels
(p = 0.03) after age correction. Correlation between CB-153 and
TT4 was not significant (rs = -0.13, p = 007). CB-153 was not
correlated with any other hormone parameter.
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