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3. Pesticides
A cross-sectional study on American qualified pesticide spraying
operators by Garry et al. (2002) showed a higher prevalence rate
in the wives of the subjects living in countryside than those of
city dwellers, but contribution of pesticide exposure is not
clear.
[Discussion]
The literature survey found a relatively small number of
epidemiologic studies on endocrine disruptors and endometriosis.
Two cross-sectional studies found higher endometriosis
prevalence for exposed groups, but the difference was
significant in one of them only.
As for substances other than DES, high PCB levels were reported
in some papers but not in others before 2000. A paper appeared
thereafter which reported that no difference was found in serum
PCB levels of the cases and control.
Studies on endocrine disruptors and endometriosis are thus too
few to evaluate the causal relationship. Experimental designs
with high reliability are needed for future studies on this
problem.
[Conclusions]
Survey of literature on epidemiologic studies on endocrine
disruptors and endometriosis resulted in too few citations to
evaluate the causal relationship. No Japanese cases were
addressed in those studies. Experimental designs with high
reliability are needed for future studies on this problem.
[Literature]
Table 2.12.1:
Case-control studies on the relationship of endocrine disruptors
with endometriosis
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