業績

原著論文、総論、単行本

令和6年度(2024)

  • Hidenobu Miyaso, Satoshi Yokota, Kousuke Suga, Yui Hashimoto, Céline Kouno, Kenta Nagahori, Masahiro Itoh, Satoshi Kitajima: Histological differences between the central and peripheral areas of the testes of busulfan-administered mice. J Toxicol Sci. 2024; 49(4): 139-149.
    [doi.org/10.2131/jts.49.139]
  • 齊藤洋克、北嶋聡:化学物質を発生-発達期に曝露した際の情動認知行動影響検出, 化学物質と環境 : 化学物質と環境との調和をめざす情報誌, 2024; 184: 3-6

令和5年度(2023)

  • Ryuichi Ono, Makiko Kuwagata, Mie Naruse, Akihito Watanabe, Masao Takano, Takuro Hasegawa, Hiromasa Takashima, Yusuke Yoshioka, Takahiro Ochiya, Yoko Hirabayashi, Satoshi Kitajima: Extracellular vesicle small RNAs secreted from mouse amniotic fluid induced by repeated oral administration of VPA to pregnant mice. Fundam. Toxicol. Sci. 2024; 11(1): 37-56.
    [doi.org/10.2131/fts.11.37]
  • Takeshi Hase, Samik Ghosh, Ken-ichi Aisaki, Satoshi Kitajima, Jun Kanno, Hiroaki Kitano, Ayako Yachie: DTox: A deep neural network-based in visio lens for large scale toxicogenomics data. J Toxicol Sci. 2024; 49(3): 105-115.
    [doi.org/10.2131/jts.49.105]
  • 菅野純、相﨑健一、北嶋聡: 遺伝子発現を指標とした毒性評価・予測, 単行本「化学物質の複合影響と健康リスク評価」, 2024; 第2章 複合曝露による毒性の評価手法 第1節, 医歯薬出版(東京)
    [ISBN: 978-4-263-73220-5]
  • Yu Takahashi, Ryota Wakabayashi, Satoshi Kitajima, Hideho Uchiyama: Epichordal vertebral column formation in Xenopus laevis. J Morphol, 2023; jmor.21664
    [doi.org/10.1002/jmor.21664]
  • 五十嵐智女、西村拓也、北嶋聡: 細胞培養食品に係る開発や諸外国の衛生規制に関する最近の動向, 月刊「食品衛生研究」, 2023; 通巻885号(73巻12号), 公益社団法人日本食品衛生協会(東京)
    [ISSN: 0559-8974]
  • Satoshi Yokota, Tomohiko Wakayama, Hidenobu Miyaso, Kousuke Suga, Masakatsu Fujinoki, Satoru Kaneko, Satoshi Kitajima: Reactive Blue 2 Labels Protamine in Late-Haploid Spermatids and Spermatozoa and Can Be Used for Toxicity Evaluation. Andrologia, 2023; 2023:7364862
    [doi.org/10.1155/2023/7364862]
  • Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina: Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem Cells, 2023; sxad071
    [doi.org/10.1093/stmcls/sxad071]
  • Hirokatsu Saito, Yusuke Furukawa, Takahiro Sasaki, Satoshi Kitajima, Jun Kanno, Kentaro Tanemura: Behavioral effects of adult male mice induced by low-level acetamiprid, imidacloprid, and nicotine exposure in early-life. Front. Neurosci. 2023; 17:1239808.
    [doi.org/10.3389/fnins.2023.1239808]
  • Hirokatsu Saito, Satoshi Yokota, Satoshi Kitajima: Immunohistochemical analysis of the vimentin filaments in Sertoli cells is a powerful tool for the prediction of spermatogenic dysfunction. Acta Histochem. 2023; 125(5): 152046.
    [doi.org/10.1016/j.acthis.2023.152046]

令和4年度(2022)

  • Hirokatsu Saito*, Kentaro Tanemura*, Yusuke Furukawa, Takahiro Sasaki, Jun Kanno, Satoshi Kitajima (*co-first author): Behavioral effects induced by the oral administration of acetamiprid in male mice during the postnatal lactation period or adulthood. J Toxicol Sci. 2023; 48(4): 203-210.
    [doi.org/10.2131/jts.48.203]
  • Makiko Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Yuhji Taquahashi, Satoshi Kitajima: A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats Fundam. Toxicol. Sci. 2023; 10: 69-82.
    [doi.org/10.2131/fts.10.69]
  • Makiko Kuwagata, Masaru Tsuboi, Toshime Igarashi, Mariko Tsurumoto, Takuya Nishimura, Yuhji Taquahashi, Satoshi Kitajima: A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats Fundam. Toxicol. Sci. 2023; 10: 59-68.
    [doi.org/10.2131/fts.10.59]
  • Takahiro Sasaki*, Hirokatsu Saito*, Yusuke Furukawa, Takashi Tominaga, Satoshi Kitajima, Jun Kanno, Kentaro Tanemura (*co-first author): Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice. J Toxicol Sci. 2023; 48(4): 211-219.
    [doi.org/10.2131/jts.48.211]
  • Satoshi Yokota, Hidenobu Miyaso, Toshinori Hirai, Kousuke Suga, Tomohiko Wakayama, Yuhji Taquahashi, Satoshi Kitajima: Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system. J Toxicol Sci. 2023; 48(2): 57-64.
    [doi.org/10.2131/jts.48.57]
  • Makiko Kuwagata, Akira Sato, Yuko Izumi, Kazuhiro Chihara, Hanako Yamasaki, Yoshihiro Katsumata, Yojiro Ooshima, Jochen Buschmann, Michio Fujiwara: Current activities between the DevTox Berlin workshops and the Japanese Teratology Society Terminology Committee in harmonizing the terminology for classifying anomalies in laboratory animals in developmental toxicity studies: Report from the Satellite Workshop of the 60th Annual Meeting of the Japanese Teratology Society. Congenit. Anom. 2022; 62: 198-202.
    [doi.org/10.1111/cga.12480]
  • 相﨑 健一、小野 竜一、菅野 純、北嶋 聡: Percellomeプロジェクト~トランスクリプトミクスとエピジェネティクスによる毒性分子機序の探求~, 日本薬理学雑誌, 2022; 157: 200-206.
    [doi.org/10.1254/fpj.21122]

令和3年度(2021)

  • Seiya Kanno, Yusuke Okubo,Tatsuto Kageyama,Lei Yan, Satoshi Kitajima, Junji Fukuda: Establishment of a developmental toxicity assay based on human iPSC reporter to detect FGF signal disruption. iScience 2022; 25: 103770.
    [doi.org/10.1016/j.isci.2022.103770]
  • Yuhji Taquahashi, Shuji Tsuruoka, Koichi Morita, Masaki Tsuji, Kousuke Suga, Ken-ich Aisaki, Satoshi Kitajima: A novel high-purity carbon-nanotube yarn electrode used to obtain biopotential measurements in small animals: flexible, wearable, less invasive, and gel-free operation. Fundam. Toxicol. Sci. 2022; 9: 17-21.
    [doi.org/10.2131/fts.9.17]
  • Kuwagata, M., Hasegawa, T., Takashima, H., Shimizu, M., Kitajima, S. and Yamazaki, H.: Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5´-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species. J Toxicol Sci. 2021; 46: 553-560.
    [doi.org/10.2131/jts.46.553]
  • Yuhji Taquahashi, Hirokatsu Saito, Makiko Kuwagata, Satoshi Kitajima: Development of an inhalation exposure system of a pressurized metered-dose inhaler (pMDI) formulation for small experimental animals. Fundam. Toxicol. Sci. 2021; 8: 169-175.
    [doi.org/10.2131/fts.8.169]
  • Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Miki Uchiyama, Atsuya Takagi, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima: Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system. Fundam. Toxicol. Sci. 2021; 8: 161-167.
    [doi.org/10.2131/fts.8.161]
  • Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno: Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways. Development 2021; 148: dev193664.
    [doi.org/10.1242/dev.193664]
  • Satoshi Yokota, Nao Sekine, Tomohiko Wakayama, Shigeru Oshio: Impact of chronic vitamin A excess on sperm morphogenesis in mice. Andrology 2021; Online ahead of print.
    [doi.org/10.1111/andr.13013]
  • Satoshi Yokota, Ken Takeda, Shigeru Oshio: Spatiotemporal Small Non-coding RNAs Expressed in the Germline as an Early Biomarker of Testicular Toxicity and Transgenerational Effects Caused by Prenatal Exposure to Nanosized Particles. Front. Toxicol. 2021; 3: 32.
    [doi.org/10.3389/ftox.2021.691070]
  • 登田 美桜、北嶋 聡: シリーズ:日本毒性学会との連携 マリンバイオトキシン;フグ毒のリスク評価について, 中毒研究(Jpn J Clin Toxicol), 2021; 34: 58-62.
    [ISSN: 0914-3777]

令和2年度(2020)

  • Eiichi Yamamoto, Yuhji Taquahashi, Makiko Kuwagata, Hirokatsu Saito, Kohei Matsushita, Takeshi Toyoda, Futoshi Sato, Satoshi Kitajima, Kumiko Ogawa, Ken-ichi Izutsu, Yoshiro Saito, Yoko Hirabayashi, Yasuo Iimura, Masamitsu Honma, Haruhiro Okuda, Yukihiro Goda: Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging. Int J Pharmaceutics 2021; 595: 120241.
    [doi.org/10.1016/j.ijpharm.2021.120241]
  • Hirokatsu Saito, Kenshiro Hara, Satoshi Kitajima, Kentaro Tanemura: Effect of Vitamin E deficiency on spermatogenesis in mice and its similarity to aging. Reproductive Toxicology 2020; 98: 225-232.
    [doi.org/10.1016/j.reprotox.2020.10.003]
  • Ryuichi Ono, Yusuke Yoshioka, Yusuke Furukawa, Mie Naruse, Makiko Kuwagata, Takahiro Ochiya, Satoshi Kitajima, Yoko Hirabayashi: Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4. Toxicol Rep. 2020; 7: 685-692.
    [doi 10.1016/j.toxrep.2020.05.002]
  • Richard Nock, Natalia Polouliakh, Frank Nielsen, Keigo Oka, Carlin R Connell, Cedric Heimhofer, Kazuhiro Shibanai, Samik Ghosh, Ken-Ichi Aisaki, Satoshi Kitajima, Jun Kanno, Taketo Akama, Hiroaki Kitano: A Geometric Clustering Tool (AGCT) to robustly unravel the inner cluster structures of time-series gene expressions. PLoS One 2020; 15(7): e0233755.
    [doi 10.1371/journal.pone.0233755]

平成31/令和元年度(2019)

  • Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y: CYP3A4 induction in the liver and intestine of pregnane X receptor/CYP3A-humanized mice: approaches by mass spectrometry imaging and portal blood analysis. Mol Pharmacol. 2019; 96(5): 600-608.
    [doi 10.1124/mol.119.117333]
  • Yokota S, Shirahata T, Yusa J, Sakurai Y, Ito H, Oshio S: Long-term dietary intake of excessive vitamin A impairs spermatogenesis in mice. J Toxicol Sci. 2019; 44(4): 257-71.
    [doi 10.2131/jts.44.257]
  • Nomura Y, Ikuta S, Yokota S, Mita J, Oikawa M, Matsushima H, Amano A, Shimonomura K, Seya Y, Koike C: Evaluation of critical flicker-fusion frequency measurement methods using a touchscreen-based visual temporal discrimination task in the behaving mouse. Neurosci Res. 2019 Nov; 148: 28-33.
    [doi 10.1016/j.neures.2018.12.001]
  • Goto M, Saito H, Hiradate Y, Hara K, Tanemura K: Differences in resistance against osmotic challenge among C57BL/6, DBA/2 and their hybrid mice MII stage oocytes. Zygote. 2019 Aug; 27(4): 250-254.
    [doi 10.1017/S0967199418000370]
  • Saito H, Hara K, Tominaga T, Nakashima K, Tanemura K: Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice. Journal of Applied Toxicology. 2019 Dec; 39(12): 1651-1662.
    [doi 10.1002/jat.3882]
  • Igarashi T, Suzuki H, Ushida K, Matsumoto M, Inoue K, Kanno T, Miwa Y, Ishii T, Nagase T, Katsumata Y, Hirose A: Initial hazard assessment of 1,4-dichlorobutane: Genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2020; 112: 104610.
    [doi 10.1016/j.yrtph.2020.104610]
  • Abdelgied M, El-Gazzar AM, Alexander WT, Numano T , Iigou M, Naiki-Ito A, Takase H , Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Abdou KA, Takahashi S, Alexande DB, Tsuda H: Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration. Part Fibre Toxicol 2019 Sep 2; 16(1): 34.
    [doi 10.1186/s12989-019-0316-2]
  • Abdelgied M , El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA , Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S: Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats. Arch Toxicol 2019 Apr; 93(4): 909-920.
    [doi 10.1007/s00204-019-02410-z]
  • Kuwagata M, Muneoka K, Honda K, Miyazaki A: Hypothalamic monoaminergic pathology in a neurodevelopmental rat model showing prenatal 5-bromo-2’-deoxyuridine treatment-induced hyperactivity and hyporeproductivity. Neuropsycology 2019 Nov 3; 79: 161-169.
    [doi 10.1159/000504552]
  • Solecki R, Rauch M, Gall A, Buschmann J, Kellnerd R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I: Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on developmental toxicity. Reprod Toxicol 2019; 89: 124-129.
    [doi 10.1016/j.reprotox.2019.07.003]
  • Kumamoto T, Senuma M, Todoroki M, Kumagai F, Imai H, Suzuki R, Ogawa T, Kuwagata M: 5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes. Fundam Toxicol Sci 2020; 7(2): 97-103.
    [doi 10.2131/fts.7.97]
  • Takeshi Morita, Yoshiyuki Shigeta, Toshime Igarashi: “Information Resources in Toxicology, 5th Edition.” Volume 2: The Global Arena. Chapter 20: Japan. Editor-in-Chiefs: Philip Wexler. Academic Press, Elsevier, (2020)
    [ISBN: 9780128216118]
  • 北嶋聡: 獣医毒性学<第二版>,第21章化学物質と有害作用 9.自然毒,日本比較薬理学・毒性学会編, 近代出版, pp. 210-14 (2019)
    [ISBN: 978-4-87402-260-3]
  • 北嶋聡ら: 監修:川西 徹,河村葉子,穐山 浩, 佐藤恭子:第9版 食品添加物公定書解説書、廣川書店,(2019)
    [ISBN: 978-4-567-01854-8]
  • 北嶋聡: エディトリアル:ドーピングの中毒学・毒性学, 中毒研究(Jpn J Clin Toxicol), 2019; 32: 373-374.
    [ISSN: 0914-3777]
  • 髙橋祐次: 獣医毒性学<第二版>,第17章 皮膚・粘膜毒性,第21章化学物質と有害作用 8.工業化学物質,日本比較薬理学・毒性学会編, 近代出版, pp. 162-8,pp. 207-10 (2019)
    [ISBN: 978-4-87402-260-3]

平成30年度(2018)

  • Yokota S, Oshio S: A simple and robust quantitative analysis of retinol and retinyl palmitate using a liquid chromatographic isocratic method. J Food Drug Anal. 2018. 26(2):504-11.
    [doi 10.1016/j.jfda.2017.07.002]
  • Ono R, Yasuhiko Y, Aisaki KI, Kitajima S, Kanno J, Hirabayashi Y: Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing. Communications Biology. 2019 Feb 8;2:57.
    [doi 10.1038/s42003-019-0300-2]
  • Tanabe S, Ono R: The gene and microRNA networks of stem cells and reprogramming, AIMS Cell and Tissue Engineering. 2018, 2(4): 238-245
    [doi 10.3934/celltissue.2018.4.238]
  • Mishima M, Hoffmann D, Ichihara G, Kitajima S, Shibutani M, Furukawa S, Hirose A: Derivation of acceptable daily exposure value for alanine, N,N-bis(carboxymethyl)-, trisodium salt. Fund Toxicol Sci. 2018, 5: 167-170.
    [doi 10.2131/fts.5.167]
  • Tsuboi I, Harada T, Hirabayashi Y and Aizawa S: Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis. Haematologica. 2019, 104:1995-2005
    [doi 10.3324/haematol.2018.209551]
  • Otsuka K, Yamada K, Taquahashi Y, Arakaki R, Ushio A, Saito M, Yamada A, Tsunematsu T, Kudo Y, Kanno J, Ishimaru N: Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes. PLoS One. 2018 Oct 29;13(10):e0205702.
    [doi 10.1371/journal.pone.0205702]
  • Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Tsuda H, Takahashi S: Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats. Cancer Sci. 2018 Jul;109(7):2164-2177.
    [doi 10.1111/cas.13643]
  • 矢野恒夫,長谷川功紀,佐藤達彦,蜂須賀暁子,深瀬浩一,平林容子,アルファ線核医学治療のための薬剤開発の考察(その2)マイクロドジメトリーについて,医薬品医療機器レギュラトリーサイエンス,2019, 50(3), 118-130
    [ISBN: 9784840751339]
  • 横田理: 妊娠期の免疫活性化により生じる神経発達障害のメカニズムに迫る ファルマシア, 2018; 54(9): 903
    [doi 10.14894/faruawpsj.54.9_903]
  • 大久保佑亮: タンパク質のクラスター化によるシグナル増強!? 生物工学会誌 第97巻・第2号90 (2019)
  • 笛木修,松本峰男,角田 聡,星野 裕紀子,大滝 清,鈴木 睦,佐藤 玄,木ノ本寿子,中村和市,中江 大,髙橋祐次,平林容子,西川秋佳:医薬品の安全性評価の効率化に向けたStandards for Exchange of Nonclinical Data (SEND)に基づく非臨床電子データの活用に関する基本的検討,医薬品医療機器レギュラトリーサイエンス 2019, 50(1),48-54.
    [ISBN: 9784840751315]
  • 髙橋祐次,中村るりこ,須方督夫,小島 肇夫,ヒト表皮モデルを用いた皮膚腐食性試験代替法の評価報告書,AATEX-JaCVAM 2018;7(1):1-20
  • 髙橋祐次,中村るりこ,須方督夫,小島 肇夫,経皮電気抵抗試験を用いた皮膚腐食性試験代替法の評価報告書,AATEX-JaCVAM 2018; 7(1) :21-30
  • 髙橋祐次,中村るりこ,須方督夫,小島 肇夫,In vitro膜バリア試験を用いた皮膚腐食性試験代替法の評価報告書,AATEX-JaCVAM 2018; 7(1):31-38
  • 監修:大野泰雄,編集:益山 光一,編集協力:栗原 正明,橘高敦史,髙橋祐次,黒木 由美子:新 毒物劇物取扱の手引き、時事通信社,(2018)
    [ISBN: 978-4788715509]

平成29年度(2017)

  • Yasuhiko Y, Hirabayashi Y, Ono R: LTRs of Endogenous Retroviruses as a Source of Tbx6 Binding Sites. Frontiers in Chemistry. 2017 Jun 15;5:34.
    [doi 10.3389/fchem.2017.00034]
  • Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J: Thioredoxin-1 maintains mTOR function during oxidative stress in cardiomyocytes. J Biol Chem, 2017; 292:18988-19000.
    [doi 10.1074/jbc.M117.807735]
  • Ideta-Otsuka M, Igarashi K, Narita, M, Hirabayashi Y: Epigenetic Toxicity of Environmental Chemicals Upon Exposure During Development - Bisphenol a and Valproic Acid May Have Epigenetic Effects. Food Chem Toxicol 109, no. Pt 1 (Nov 2017): 812-16.
    [doi 10.1016/j.fct.2017.09.014]
  • Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Vilahur N, Mattock H, Straif K: International Agency for Research on Cancer Monograph Working G. Carcinogenicity of benzene. Lancet Oncol, 2017; 18: 1574-1575.
    [doi 10.1016/S1470-2045(17)30832-X]
  • 髙橋祐次:LD50は時代遅れの指標? Intensivist、2017;9(3):530-34
    [doi 10.11477/mf.3102200410]
  • 髙橋祐次,小児用医薬品開発のための非臨床安全性試験-幼若動物を用いた非臨床安全性試験の必要性とICH S11 ガイドラインの現状-,PHARMSTAGE,2017;17(3): 1-3
  • 髙橋祐次,安全性に関するトピックの動向 S11: 小児用医薬品開発のための非臨床安全性試験,医薬品医療機器レギュラトリーサイエンス,2017;48(8):549-551
    [ISBN: 978-4-8407-4918-3]
  • 平林容子:“機能性食品開発のための初期評価試験プロトコール集”, 安全性評価の考え方,山本(前田)万里編, 株式会社シー・エム・シー出版,東京,pp.357-60(2017)
    [ISBN: 978-4781312484]
  • 平林容子:“機能性食品開発のための初期評価試験プロトコール集”,機能性関与成分の安全性の評価について,山本(前田)万里編, 株式会社シー・エム・シー出版,東京,pp. 361-66(2017)
    [ISBN: 978-4781312484]
  • 平林容子:“トキシコロジ-(第3版)”,血液毒性,(一社)日本毒性学会教育委員会編, 株式会社朝倉書店,東京,pp.171-80(2018)
    [ISBN: 978-4254340310]
  • 北嶋 聡:“トキシコロジー (第3版)”, 食品,食品添加物,食品汚染物質,飼料添加物・汚染物質,(一社)日本毒性学会教育委員会編集,株式会社朝倉書店,東京,pp.79-91(2018)
    [ISBN: 978-4254340310]

平成28年度(2016)

  • Furukawa Y, Tanemura K, Igarashi K, Ideta-Otsuka M, Aisaki K, Kitajima S, Kitagawa M, Kanno J: Learning and memory deficits in male adult mice treated with a benzodiazepine sleep-inducing drug during the juvenile period. Front Neurosci 2016: 10: 339.
    [doi 10.3389/fnins.2016.00339]
  • Tsuboi I, Harada T, Hirabayashi Y, Kanno J, Aizawa S: Differential Regulation of Lympho-Myelopoiesis by Stromal Cells in the Early and Late Phases in BALB/c Mice Repeatedly Exposed to Lipopolysaccharide. Biol Pharm Bull.2016; 39: 1939-1947
    [doi 10.1248/bpb.b16-00375]
  • Takeda K, Kou I, Kawakami N, Iida A, Nakajima M, Ogura Y, Imagawa E, Miyake N, Matsumoto N, Yasuhiko Y, Sudo H, Kotani T, Nakamura M, Matsumoto M, Watanabe K, Ikegawa S: Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis. Hum Mutat. 2017:38(3):317-323.
    [doi 10.1002/humu.23168]
  • 高橋祐次:高分散型小型全身曝露吸入システムによるマウス吸入毒性-ヒトの現実的な曝露シナリオに基づいたナノマテリアルの吸入毒性評価の迅速化と効率化に向けて-. 医学のあゆみ,2016:259(3),234-240.
  • 平成27年度(2015)

    • Kanno J: Biomechanism-based innovation of toxicology by the fundamental concept of "Signal Toxicity". Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2015;(133):21-8.
    • Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K: Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid. Stem Cell Reports. 2015: 8;5(6):996-1009.
      [doi 10.1016/j.stemcr.2015.10.012]
    • Ono R, Ishii M, Fujihara Y, Kitazawa M, Usami T, Kaneko-Ishino T, Kanno J, Ikawa M, Ishino F: Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes. Sci Rep. 2015;5:12281
      [doi 10.1038/srep12281]
    • Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y0, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H: Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos. A patient-based study. Cancer Sci. 2015:106(7):825-32.
      [doi 10.1111/cas.12687]
    • Hirabayashi Y, Tsuboi I, Kuramoto K, Kusunoki Y, Inoue T: Cell cycle of primitive hematopoietic progenitors decelerated in senescent mice is reactively accelerated after 2-Gy whole-body irradiation. Exp Biol Med (Maywood).2016; 241: 485-492.
      [doi 10.1177/1535370215625472]
    • Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, Shterev I, Sempowski G, Macchiarini F, Nakachi K, Kunugi KC, Hammer CG, Dewerd LA: An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned. Int J Radiat Biol.2016; 92: 59-70
      [doi 10.3109/09553002.2015.1106024]
    • Fujimoto N, Kanno J: Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17β-estradiol in C57BL mice. J Steroid Biochem Mol Biol. 2016;158:56-62.
      [doi 10.1016/j.jsbmb.2016.01.011]

    平成26年度(2014)

    • 相﨑健一,北嶋 聡,菅野 純:シリーズ:日本毒性学会との連携(1)~遺伝子の発現からみた毒性学 中毒研究 2014;27:358-63
    • Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J: Ubiquitin acetylation inhibits polyubiquitin chain elongation. EMBO Rep. 2015;16:192-201.
      [doi 10.15252/embr.201439152]
    • Tanaka M, Aisaki K, Kitajima S, Igarashi K, Kanno J, Nakamura T: Gene expression response to EWS–FLI1 in mouse embryonic cartilage. Genomics Data 2014;2:296–298.
      [doi 10.1016/j.gdata.2014.09.003]
    • Tanaka M, Yamazaki Y, Kanno Y, Igarashi K, Aisaki K, Kanno J, Nakamura T: Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. J Clin Invest. 2014;124:3061-74.
      [doi 10.1172/JCI72399]
    • Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y7, Morohashi KI, Sugawara A: Identification of myelin transcription factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific demethylase 1 (LSD1) Complex. J Biol Chem. 2014;289(26):18152-62.
      [doi 10.1074/jbc.M114.566448]
    • Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H: Size- and shape-dependent pleural translocation, deposition, fibrogenesis and mesothelial proliferation by multi-walled carbon nanotubes. Cancer Sci. (2014);105(7):763-9.
      [doi 10.1111/cas.12437]
    • Hirabayashi Y, Tsuboi I, Nakachi K, Kusunoki Y, Inoue T: Experimentally induced, synergistic late effects of a single dose of radiation and aging: significance in LKS fraction as compared with mature blood cells. J Appl Toxicol.2015; 35: 230-240.
      [doi 10.1002/jat.3088]
    • Mie Naruse, Ryuichi Ono, Masahito Irie, Kenji Nakamura, Tamio Furuse, Toshiaki Hino, Kanako Oda, Misho Kashimura, Ikuko Yamada, Shigeharu Wakana, Minesuke Yokoyama, Fumitoshi Ishino and Tomoko Kaneko-Ishino: Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition Development 2014 Dec;141(24):4763-71.
      [doi 10.1242/dev.114520]

    平成25年度(2013)

    • Ohba T, Xu J, Alexander DB, Yamada A, Kanno J, Hirose A, Tsuda H, Imaizumi Y: MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents. J Toxicol Sci. 2014;39(3):499-505.
      [doi 10.2131/jts.39.499]
    • Janesick A, Nguyen TT, Aisaki KI, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B: Active repression by RARγ signaling is required for vertebrate axial elongation. Development 2014;141(11):2260-70.
      [doi 10.1242/dev.103705]
    • Numano T, Xu J, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Kanno J, Hirose A, Tsuda H, Suzu, M: Comparative Study of Toxic Effects of Anatase and Rutile Type Nanosized Titanium Dioxide Particles in vivo and in vitro. Asian Pac J Cancer Prev. 2014:15(2):929-35.
      [doi 10.7314/APJCP.2014.15.2.929]
    • Kondoh S, Inoue K, Igarashi K, Sugizaki H, Shirode-Fukuda Y, Inoue E, Yu T, Takeuchi JK, Kanno J, Bonewald LF, Imai Y: Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice. Bone, 2014:60:68-77.
      [doi 10.1016/j.bone.2013.12.005]
    • Xu J, Futakuchi M, Alexander DB, Fukamachi K, Numano T, Suzui M, Shimizu H, Omori T, Kanno J, Hirose A, Tsuda H: Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles. Arch Toxicol. 2014;88(1):65-75
      [doi 10.1007/s00204-013-1086-5]
    • Hirabayashi Y: Radiation-induced, cell cycle-related gene expression in aging hematopoietic stem cells: enigma of their recovery. Annals of the New York Academy of Sciences. 2014:1310:69-73.
      [doi 10.1111/nyas.12401]
    • Taquahashi Y, Ogawa Y, Takagi A, Tsuji M, Morita K, Kanno J: An improved dispersion method of multi-wall carbon nanotube for inhalation toxicity studies of experimental animals. J Toxicol Sci. 2013;38(4):619-28.
      [doi 10.2131/jts.38.619]
    • Kanno J, Aisaki K, Igarashi K, Kitajima S, Matsuda N, Morita K, Tsuji M, Moriyama N, Furukawa Y, Otsuka M, Tachihara E, Nakatsu N, Kodama Y: Oral administration of pentachlorophenol induces interferon signaling mRNAs in C57BL/6 male mouse liver. J Toxicol Sci. 2013:38(4):643-54.
      [doi 10.2131/jts.38.643]
    • Okuno Y, Ohtake F, Igarashi K, Kanno J, Matsumoto T, Takada I, Kato S, Imai Y: Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase. Diabetes. 2013:62(5):1426-1434.
      [doi 10.2337/db12-0628]
    • Si Y, Inoue K, Igarashi K, Kanno J, Imai Y: Autoimmune regulator, Aire, is a novel regulator of chondrocyte differentiation. Biochem Biophys Res Commun. 2013;437(4):579-84.
      [doi 10.1016/j.bbrc.2013.07.001]
    • Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J: Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo. Developmental Biology 2013:380:172-184.
      [doi 10.1016/j.ydbio.2013.05.020]
    • 髙橋祐次:“動物実験代替安全性試験プロトコル集(The Protocols for the Alternative Toxicological Testings)”,第15章 急性毒性試験,小島肇夫監修, (株)シーエムシー出版,東京,pp187-197 (2013)
      [ISBN: 978-4-7813-0792-3]