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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_7 |
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4) Ecological study
Sandau et al. (2002) measured concentrations of PCB,
hydroxylated PCB metabolite (4-HO-HpCS) and pentachlorophenol
(PCP) in cord blood samples from neonates in 3 areas in Quebec,
of which two were highly exposed to PCB via marine product-based
diet (Inuit people in Nunavik and subsistence fishermen around
Lower North Shore of the Gulf of St. Laurence), and one was a
southern Quebec urban center where PCB exposure was at
background level. The main chlorinated phenolic compound in all
regions was PCP. The mean PCP concentration was 1670 pg/g (range
628-7680 pg/g wet weight). The PCP levels were not significantly
different among regions. The ratio of PCP to CB-153
concentration ranged from 0.72 to 42.3. The total HO-PCB
concentrations in plasma were 553 (238-1750), 286 (103-788), and
234 (147-464) pg/g wet weight for the Lower North Shore, Nunavik,
and the southern Québec groups, respectively. Lower North Shore
samples showed the highest total plasma PCB (sum of 49
congeners) level of 2710 pg/g wet weight, compared with 1510 and
843 pg/g wet weight in Nunavik and southern Quebec,
respectively. The total HO-PCBs and total PCB concentrations
(log transformed) were significantly correlated (r = 0.62, p <
0.001). In Nunavik and Lower North Shore samples, free thyroxine
(T4) concentrations (log transformed) were inversely correlated
with the total chlorinated phenolic compounds (total PCP and
total HO-PCBs ; r = -0.47, p = 0.01, n = 20) and were not
correlated with any PCB congeners or total PCBs.
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