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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_9 |
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5. Pesticides
It is reported that farming mothers' sons have higher
hypospadias risk. Weidner et al. (1998) conducted a case-control
study on the relationship of farm or gardening work of parents
with the prevalence of hypospadias and cryptorchidism of their
children using Danish population, patients and infertility
databases (6,177 cases with cryptorchidism and 23,273 subjects
as the control). Data indicate a higher risk for gardening
mothers (RR = 1.67, 95% CI = 1.14-2.47). Farming mothers gave a
higher but not significant risk (RR = 1.28, 95% CI = 0.94-1.73).
Farming or gardening work of fathers had no effect (RR = 1.08,
95% CI = 0.93-1.24 for farming, RR = 1.28, 95% CI = 0.80-2.04
for gardening). On the other hand, a study by Kristensen et al.
(1997) on congenital malformation frequency in farming,
gardening and stockbreeding families based on Norwegian birth,
population and agriculture registries found no significant
increase in cryptorchidism risk (OR = 0.77, 95% CI = 0.58-1.03),
while exposure to pesticide was linked with higher risk (OR =
1.70, 95% CI = 1.16-2.50 for pesticide purchase; OR = 2.32, 95%
CI = 1.34-4.01 for pesticide purchase and vegetable growing).
Wang et al. (2002) conducted a case-control study on 99 boys
with cryptorchidism (1-14 years of age, left for 30 cases, right
27, both 42), with two control cases matched with each case.
Data obtained in interviews using a uniform questionnaire form
revealed a significant increase of odds ratio (OR = 12.79, 95%
CI = 2.90-56.43) for subjects whose fathers had been
occupationally exposed to pesticides.
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