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Advisory Committee on Health Effects of Endocrine Disruptors
The Supplement II to the Intermediary Report
1.4.2.2_9 |
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[Results]
1. Polychlorinated biphenyls (PCB)
Mol et al. (2002) studied association of sex differentiation in
boys with prenatal exposure to PCBs by examining 196 boys, born
in three Faroese hospitals during a 21-month period from March
1986 on, for the development of puberty at 14 years of age.
Examination included presence of sperm in morning urine samples
(spermaturia), Tanner stages, testicular size, sex hormone
concentrations and PCB level in cord blood. Spermaturia was
associated with puberty markers but not with prenatal PCB
exposure. Twenty cases out of 196 showed abnormality in testicle
development (19 with cryptorchidism, 1 with torsion of testis)
but cord blood PCB level showed no significant difference
between this group (1.99 ng/g on an average) and the 176 normal
cases (1.85 ng/g).
2. 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,pf-DDE)
Longnecker et al. (2002) conducted a nested case-control study
in the Collaborative Perinatal Project in 1959-66 in which a
case group consisting of 219 cases of cryptorchidism, 199 of
hypospadias and 167 of polythelia was compared with a control
group of 552 subjects. Mothers' serum DDE concentrations were
quartered after correction for the recovery ratio of the gas
chromatograph, and the lowest quartile (< 21.4 Ęg/l) was used as
a reference. The odds ratios for cryptorchidism, hypospadias and
polythelia in the highest quartile ( 85.6 Ęg/l) were 1.3 (95%
CI = 0.7-2.4), 1.2 (95% CI = 0.6-2.4) and 1.9 (95% CI = 0.9-4.0)
after correction for race, triglyceride level and cholesterol
level. No significant difference was observed.
3. Other organochlorine compounds
Hosie et al. (2000) compared accumulation of 26 organochlorine
compounds in fat of 18 cryptorchidism patients (average 4.2
years old) and 30 subjects as the control (average 3.5 years
old) in Germany. The patients showed high accumulation of
heptachlor epoxide (HCE) (P = 0.009) and hexachlorobenzene (HCB)
(P = 0.012). Other compounds did not show significant
correlation.
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