研究業績

安全性予測評価部が設置された2015年度以降の研究業績（誌上発表、総説・解説、単行本）は以下の通りです。

誌上発表

2023年度

Iso T, Suzuki K, Murata Y, Hirose N, Umano T, Horibata K, Sugiyama KI, Hrose A, Masumura K, Matsumoto M: Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice. Genes Environ. 2024; 46: 7.
Abdallah A, Adel N, Elkerdawy AM, Tanabe S, Andres F, Pester A, Ali HH: Geom-SAC: Geometric multi-discrete soft actor critic with applications in de novo drug design. IEEE Access. 2024;12:45519-45529. doi: 10.1109/ACCESS.2024.3377289
Tanabe S, Boonstra E, Hong T, Quader S, Ono R, Cabral H, Aoyagi K, Yokozaki H, Perkins EJ, Sasaki H: Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes. 2023;14(11):2073. doi: 10.3390/genes14112073
Myden A, Stalford SA, Fowkes A, White E, Hirose A, Yamada T. Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion. Curr Res Toxicol. 2023 Sep 15:5:100124.
Yamazoe Y, Murayama N, Kawamura T, Yamada T. Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms. Genes Environ. 2023 Aug 7;45(1):22
Murata Y, Natsume M, Iso T, Shigeta Y, Hirose N, Umano T, Horibata K, Sugiyama K, Masumura K, Hirose A, Matsumoto M: In vivo mutagenicity assessment of styrene in MutaMouse liver and lung. Genes Environ. 2023; 45: 12.
Murata Y, Suzuki K, Shigeta Y, Iso T, Hirose N, Umano T, Horibata K, Sugiyama K, Hirose A, Masumura K, Matsumoto M: In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse. Genes Environ. 2023; 45: 29.
Matsumoto M, Murata Y, Hirose N, Shigeta Y, Iso T, Umano T, Hirose A. Derivation of subacute guidance values for chemical contaminants of drinking water quality standard in Japan. Regul Toxicol Pharmacol, 2023;141;105401
Kawashima A, Inoue K, Ushida K, Kai K, Suzuki H, Yoshida-Yamashita LS, Hirose A, Masumura K: Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japanese Chemical Substances Control Law. Fundam Toxicol Sci. 2023;10（3）:91-103.
Ashikaga T, Narita K, Kobayashi M, Tachibana S, Murasaki W, Suzuki M, Ambe K, Tohkin M: Skin Sensitization Potency Prediction of Ingredients in Hair Colorants Using in silico Models of Machine Learning, Journal of Japanese Cosmetic Science Society, 2023:47(1), 1–5.
Strickland J, Haugabrooks E, Allen DG, Balottin LB, Hirabayashi Y, Kleinstreuer NC, Kojima H, Nishizawa C, Prieto P, Ratzlaff DE, Jeong J, Lee J, Yang Y, Lin P, Sullivan K, Casey W: International regulatory uses of acute systemic toxicity data and integration of new approach methodologies, Crit Rev Toxicol. 2023;53(7):385-411. doi: 10.1080/10408444.2023.2240852.
Tanabe I, Yoshida K, Ishikawa S, Ishimori K, Hashizume T, Yoshimoto T, Ashikaga T: Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells, Altern Lab Anim. 2023:2611929231204823. doi: 10.1177/02611929231204823.
Mizumachi H,Watanabe M, Ikezumi M, Kajiwara M, Yasuda M, Mizuno M, Imai N, Sakuma M, Shibata M, Watanabe S, Motoyama J, Basketter D, Eskes C, Hoffmann S, Lehmann D, Ashikaga T, Sozu T, Takeyoshi M, Suzuki S, Miyazawa M, Kojima H: The inter-laboratory validation study of EpiSensA for predicting skin sensitization potential, J Appl Toxicol. 2023 Oct 28. doi: 10.1002/jat.4559.
Nishikawa A, Nagano K, Kojima H, Fukushima S, Ogawa K. Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway, J Toxicol Pathol. 2024;37(1):11-27. doi: 10.1293/tox.2023-0098
Aoi T, Asaka I, Akutsu H, Ito Y, Kataoka K, Kanda Y, Kojima H, Sekino Y, Suemori H, Nakagawa M, Nakamura K, Nakamura Y, Fujii M, Furue M, Yamazaki D, Japanese Working Group for Consideration of Good Cell Culture Practice: Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture, In Vitro Cellular & Developmental Biology – Animal. 12 March 2024. https://doi.org/10.1007/s11626-024-00863-w
Yamamoto N, Hiramatsu N, kato Y, Sato A, Kojima H, Development of an Eye Irritation Test Method Using anIn House Fabrication of a Reconstructed Human Cornea like Epithelium Model for Eye Hazard Identification, IBioengineering 2024;11(4):302. https://doi.org/10.3390/bioengineering11040302

2022年度

Murayama N, Yamada T, Yamazoe Y. Application of CYP1A2-Template system to understand metabolic processes in the safety assessment. Food Safety, 2022, 10, 129-139.
Sakai S, Tahara M, Kubota R, Kawakami T, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Volatile organic compounds. Sci Total Environ 2022;838:156400.
Kubota R, Obama T, Kawakami T, Sakai S, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Total content and migration of metals. Sci Total Environ 2022;842:156705.
Yamamoto Y, Fujita M, Watanabe S, Yamaga H, Wakabayashi K , Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within - and bet ween- laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay（ADRA） using a 0.5 mg/ml test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories. J Appl Toxicol 2022;42:1078-90.
Kawakami T, Sakai S, Obama T, Kubota R, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Rubber additives and related compounds. Sci Total Environ 2022;840:156716.
Nishi I, Kawakami T, Sakai S, Obama T, Kubota R, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Polyaromatic hydrocarbons and related compounds. Sci Total Environ 2022;842:156684.
Sugaya N, Inoue K, Tahara M, Kawakami T: Analysis and risk assessment of vinyl chloride emitted from aerosol products. J Environ Sci Health Part A, 2023;58,284-94.
Isano Y, Fujita H, Murakami K, NiS, Kurotaki Y, Takano T, Isoda Y, Matsuda R, Nakamura F, Nishitai Y, Ochirkhuyag N., Inoue K, Kawakami H, Okubo Y, Ueno K, Fujie T, Ota H: Transparent and Breathable Ion Gel Based Sensors toward Multimodal Sensing Ability. Adv Mater Technol. 2022;7（11）:2200209.
Honma M, Yamada M, Yasui M, Horibata K, Sugiyama K, Masumura K: Genotoxicity assessment of food-flavoring chemicals used in Japan. Toxicol Rep. 2022;9 :1008-1012 .
Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Perkins EJ, Yokozaki H, Sasaki H: Regulation of Epithelial-Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction. Onco. 2023;3（1）:13-25.
Kawashima A, Inoue K, Ushida K, Kai K, Suzuki H, Matsumoto M, Masumura K, Hirose A: Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law. Fundam Toxicol Sci. 2022;9（4）:123-133.
Yamada T, Kawamura T, Tsujii S, Miura M, Ohata H, Katsutani K, Matsumoto M, Hirose A: Formation and evaluation of mechanism-based chemical categories for regulatory read-across assessment of repeated-dose toxicity: a case of hemolytic anemia. Regul Toxicol Pharmacol. 2022;136:105275.
Yamada T, Katsutani K, Maruyama T, Kawamura T, Yamazaki H, Murayama N, Tong W, Yamazoe Y, Hirose A: Combined risk assessment of food derived coumarin with in silico approaches. Food Safety. 2022;10:73-82.
Fujita M, Nakashima N, Wanibuchi S, Yamamoto Y, Kojima H, Ono A, Kasahara T: Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach. J Appl Toxicol. 2023;43（3）:446-457.
Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Yamamoto K, Sugiyama M, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Aizawa S, Nakagawa S, Hagino S, Hatao M: A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients. Curr Res Toxicol. 2022;4:100100.
Kimura Y, Yasuno R, Iwaki T, Fujimura C, Ohmiya Y, Nakajima Y, Omori T, Corsini E, Inoue T , Rogen EL , Kojima H, Aiba S: An international validation study of the interleukin-2 luciferase leukocyte toxicity test （IL-2 Luc LTT） to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay（ IL-2 Luc assay）. Toxicol In Vitro. 2023;88:105535.
Fukuhara K, Nakanishi I, Imai K, Mizuno M, Matsumoto K, Ohno A: DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe Coordination. Antioxidants（Basel）, 2023;12（2）:225.

2021年度

Fujita M, Yamamoto Y, Wanibuchi S, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay （ADRA） using 4mM test chemical solution: Results of ring-study implementation from five participating laboratories. J Appl Toxicol 2022;42:318-33.
Cui H, Soga K, Tamehiro N, Adachi R, Hachisuka A, Hirose A, Kondo K, Nishimaki-Mogami T: Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages. Biochem Pharmacol. 2021;188:114580.
Petkov PI, Ivanova H, Honma M, Yamada T, Morita T, Furuhama A, Kotov S, Kaloyanova E, Dimitrova G, Mekenyan O: Differences between in vitro and in vivo genotoxicity due to metabolism: The role of kinetics. Computat Toxicol. 2022;22:100222.
Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Yokozaki H, Sasaki H: Molecular network analysis of RNA viral infection pathway in diffuse- and intestinal-type gastric cancer. Fundam Toxicol Sci. 2022;9（2）:37-46.
Iso T, Natsume M, Murata Y, Shigeta Y, Hirose N, Umano T, Horibata K, Masumura K, Sugiyama K, Matsumoto M, Hirose A: Absence of in vivo mutagenicity of 4,4'-oxybis（benzenesulfonohydrazide） in liver and glandular stomach of Muta TM mice. Fundam Toxicol Sci. 2022;9（2）:31-36.
Ohno A, Okiyama Y, Hirose A, Fukuhara K: The Position of the Nitro Group Affects the Mutagenicity of Nitroarenes. Toxicol Appl Pharmacol. 2022;441;115974.
Watanabe-Matsumoto S, Yoshida K, Meiseki Y, Ishida S, Hirose A, Yamada T: A physiologically based kinetic modeling of ethyl tert-butyl ether in humans - An illustrative application of quantitative structure-property relationship and Monte Carlo simulation. J Toxicol Sci. 2022;47（2）:77-87.
Fujita M, Yamamoto Y, Wanibuchi S, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4mM test chemical solution: Results of ring study implemented at five participating laboratories. J Appl Toxicol. 2022;42（2）:318-333.
Yamamoto Y, Fujita M, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay （ADRA） using a 0.5 mg/ mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories. J Appl Toxicol. 2022;42（6）:1078-1090.
Imamura M, Yamamoto Y, Fujita M, Wanibuchi S, Nakashima N, Kojima H, Ono A, Kasahara T: Applicability of ADRA （4mM） for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events. J Appl Toxicol. 2022; in press.
Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M. Establishment of a Threshold of Toxicological Concern Concept for Skin Sensitization by in Vitro/in Silico Approaches 日本香粧品学会誌. 2021;45（4）:331-5.
Kojima H: Alternatives to animal testing. Impact. 2021;44-45.
Narita K, Okutomi H, Kawakami K, Sui H, Basketter D, Ashikaga T: Behavior of Chemical Respiratory Sensitizers in in Vitro Methods for Skin Sensitization. AATEX. 2021;26（1）:9-18.
Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Sugiyama M, Yamamoto K, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Ikeda H, Imai N, Hatao M: A Step-by-Step Approach for Assessing Human Skin Irritation Without Animal Testing for Quasi-Drugs and Cosmetic Products. Applied in vitro Toxicology. 2021;7（3）.
Nishida H, Ohtake T, Ashikaga T, Hirota M, Onoue S, Seto Y, Tokura Y, Kouzuki H: In chemico sequential testing strategy for assessing the photoallegic potential. Toxicol In Vitro. 2021;77:105245.
Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, Yang C: Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients. Regul Toxicol Pharmacol. 2021;125:105026.
Ambe K, Suzuki M, Ashikaga T, Tohkin M: Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost Regul Toxicol Pharmacol. 2021;125:105019.
Liao CC, Wu CY, Lin MH, Hsieh FK, Hsu LT, Chang SY, Chen KJ, Huang HT, Hsu HC, Lin CH, Lin PJ, Lai HM, Kojima H, Todo H, Lin SJ, Li JH, Chen W: Validation study of a new reconstructed human epidermis model EPiTRI for in vitro skin irritation test according to OECD guidelines. Toxicol In Vitro. 2021;75:105197.
Lee B-M, Lee SH, Yamada T, Park S, Wang Y, Kim K-B, Kwon S: Read-across approaches: Current applications and regulatory acceptance in Korea, Japan, and China. J. Toxicol. Environ. Health. A. 2021, 1-14.
Yamada T, Kawamura T, Maruyama T, Kurimoto M, Yamamoto H, Katsutani N, Hirose A: Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals. Fundam Toxicol Sci. 2021;8:195-204.
Yamada T, Miura M, Kawamura T, Ushida K, Inoue K, Kuwagata M, Katsutani N, Hirose A: Constructing a developmental and reproductive toxicity database of chemicals （DART NIHS DB） for integrated approaches to testing and assessment. J Toxicol Sci. 2021;46:531-538.
Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Yokozaki H, Sasaki H: Cell cycle regulation and DNA damage response networks in diffuse- and intestinal-type gastric cancer. Cancers. 2021;13:5786.
Matsumoto M, Takano M, Takabe M, Yamaguchi N, Iso T, Shigeta Y, Murata Y, Hirose N, Inoue K, Hirose A: Initial hazard assessment of ethyl （dimethyl）（tetradecyl）ammonium ethyl sulfate: Genotoxicity tests and combined repeated-dose and reproductive/developmental toxicity screening in rats. Regul Toxicol Pharmacol. 2021;122:104914.
Matsumoto M, Fujii S, Hirose N, Iso T, Shigeta Y, Murata Y, Inoue K. Hirose A. Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats. Fundam Toxicol Sci. 2021;8（4）:103-116.
Inoue K, Shigeta Y, Umemura T, Nishiura H, Hirose A. Application of the benchmark dose method to the incidence data for various pathological findings and its validation analysis. Shokuhin Eiseigaku Zasshi. 2021;62（2）:56-64.

2020年度

Akimoto M , Yamamoto Y , Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Yu, Horie N, Fujimoto K, Kusakari K,Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: The effect of dimethyl sulfoxide （DMSO） on the oxidation of cysteine-derivative nucleophilic reagent when using acetonitrile containing DMSO as an solvent in the Amino acid Derivative Reactivity Assay（ADRA）. J Appl Toxicol 2020;40:843-54.
Igarashi Y, Takahashi M, Tsutsumi T, Inoue K, Akiyama H: Monitoring Analysis of Perfluoroalkyl Substances and F-53B in Bottled Water, Tea and Juice Samples by LC-MS/MS. Chem Pharm Bull 2021;69:286-290.
Takahashi M, Yada M, Morimoto K, Nemoto S, Akiyama H, Inoue K: Simultaneous determination of alachlor and its metabolites in bovine tissues, milk and egg by liquid chromatography-tandem mass spectrometry. SSC plus 2020;4:68-76.
Takahashi M, Nishizaki Y, Masumoto N, Sugimoto N, Sato K, Inoue K: Quantification of tea-derived catechins without the requirement for respective calibration curves by single reference liquid chromatography based on relative molar sensitivity. J. Sci. Food Agric., ［Epub ahead of print］

2019年度

Abdelgied M, El-Gazzar AM, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H ,Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Abdou KA, Takahashi S, Alexande DB, Tsuda H: Carcinogenic effect of potassium octatitanate（POT） fibers in the lung and pleura of male Fischer344 rats after intrapulmonary administration. Part Fibre Toxicol 2019 2;16（1）:34.
Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y , Kanno J , Abdelhamid M , Tsuda H ,Takahashi S: Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344rats. Arch Toxicol 2019;93（4）:909-920.
Mizoi K, Fukai Y, Matsumoto E, Koyama S, Ishida S, Kojima H, Ogihara T: Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction．Fundamental Toxicological Sciences. 2020;7:9-14
Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C , Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M,Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D,Inoue T, Rogen EL, Kojima H, Aiba S: An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxinc effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals. Toxicol In Vitro. 2020;66:104832, 国立医薬品食品衛生研究所報告第138号（2020） j.tiv.2020.104832
Jojima K, Yamada T, Hirose A: Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events. Fundamental Toxicological Sciences. 2019;6:327-332
Yamada T, Matsumoto M, Miura M, Hirose A: Case study on the use of integrated approaches to testing and assessment for testicular toxicity of ethylene glycol methyl ether (EGME)-related chemicals．OECD, Series on Testing & Assessment. 2019;308:1-75
Patlewicz G, Lizarraga LE, Rua D, Allen DG, Daniel AB, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus A, Matheson J, Mumtaz M, Richarz A, Ruiz P, Scarano L, Yamada T, Kleinstreuer N: Exploring current read-across applications and needs among selected U.S. Federal Agencies. Regulatory Toxicology and Pharmacology. 2019;106:197-209
Matsumoto M, Hirata-Koizumi M, Kawamura T, Sakuratani S, Ono A, Hirose A: Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies. Fundamental Toxicological Sciences. 2019;6:125-136
Igarashi T, Suzuki H, Ushida K, Matsumoto M, Inoue K, Kanno T, Miwa Y, Ishii T, Nagase T, Katsumata Y, Hirose A: Initial hazard assessment of 1,4-dichlorobutane: genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2020;112:104610, doi:10.1016/j.yrtph.2020.104610
Kobayashi-Tsukumo H, Oiji K, Xie D, Sawada Y, Yamashita K, Ogata S, Kojima H, Itagaki H: Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT). J Toxicol Sci. 2019;44:283-297
Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa T: Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing. Altern Lab Anim. 2019;47:140-157
Akimoto M, Yamamoto Y, Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay. J Appl Toxicol. 2020;40:843-854

2018年度

Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine. 2018;3:1- 15
Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular network pathway of ERBB in diffusetype gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition． Journal of Clinical Epigenetics. 2018;4:2:13
Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells． AIMS Cell and Tissue Engineering. 2018;2:58-77
Igarashi T, Serizawa H, Kobayashi K, Suzuki H, Matsumoto M, Iso T, Kawamura T, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeateddose toxicity study in rats. Regul Toxicol Pharmacol. 2018;96:64-75
Igarashi T, Takashima H, Takabe M, Suzuki H, Ushida K, Kawamura T, Matsumoto M, Iso T, Tanabe S, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats. Regul. Toxicol. Pharmacol. 2018;100:105-117
Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K: Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues. Bioorg. Med. Chem. 2019;27（8）;1720–1727
Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Kojima H, Ono A, Katsuoka Y, Tanabe H, Yokoyama H, Kasahara T: Cause of and countermeasures for oxidation of the cysteinederived reagent used in the amino acid derivative reactivity assay. J. Appl. Toxicol. 2019;39（2）:191-208
Kimura Y, Watanabe M, Suzuki N, Iwaki T, Yamakage K, Saito K, Nakajima Y, Fujimura C, Ohmiya Y, Omori T, Kojima H, Aiba S: The performance of an in vitro skin sensitisation test, IL-8 Luc assay （OECD442E）, and the integrated approach with direct peptide reactive assay （DPRA）. J. Toxicol. Sci. 2018;43（12）:741-749
Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T: Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018; 39（4）:187-195
Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V: Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol. 2018;92(2):611-617.
Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, RégimbaldKrnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N: International regulatory requirements for skin sensitization testing. Regul. Toxicol. Pharmacol. 2018;95:52-65
Narita K, Ishii Y, Vo PTH, Nakagawa F, Ogata S, Yamashita K, Kojima H, Itagaki H: Improvement of human cell line activation test （h-CLAT） using short-time exposure methods for prevention of false-negative results. J Toxicol Sci. 2018;43（3）:229-240
Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H: Some nonsensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J. Toxicol. Sci. 2019;44（3）:213-224
Hoffmann S, Kleinstreuer N, Alépée N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization （I）: the Cosmetics Europe database. Crit. Rev. Toxicol. 2018;48（5）:344-358
Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E , Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization （II）: an assessment of defined approaches. Crit. Rev. Toxicol. 2018;48（5）:359-374
Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: Comparison of three （Q）SAR models. Mutagenesis. 2019;34:91-100
Yamada T, Tanaka Y, Hasegawa R, Igarashi T, Hirose A: Male-specific prolongation of prothombin time by industrial chemicals. Fundam. Toxicol. Sci. 2018;5:75-82
Petkov PI, Schultz TW, Honma M. Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data. Mutagenesis. 2019;34:83-90

2017年度

Horibe A, Odashima S, Hamasuna N, Morita T, Hayashi M: Weight of contribution of in vitro chromosomal aberration assay for evaluation of pesticides: Experience of risk assessment at the Food Safety Commission of Japan. Regul Toxicol Pharmacol. 2018:95:133-41
Tsukumo H , Matsunari N , Yamashita K , Kojima H, Itagaki H: Lipopolysaccharide interferes with the use of the human Cell Line Activation Test to determine the allergic potential of proteins. J Pharmacol Toxicol Methods. 2018; 92:34-42.
Matsumoto M, Furukawa M, Kobayashi K, Iso T, Igarashi T, Yamada T, Hirose A: A 28-day repeated oral-dose toxicity study of insecticide synergist N- （2-ethylhexyl）-1-isopropyl-4-methylbicyclo［2.2.2］oct5-ene-2,3-dicarboximide in rats. Fundam Toxicol Sci. 2018;5:1-11
Narita K, Vo PTH, Yamamoto K, Kojima H, Itagaki H: Preventing false-negatives in the in vitro skin sensitization testing of acid anhydrides using interleukin-8 release assays. Toxicol In Vitro. 2017;Aug 42:69-75.
Akagi T, Nagura M, Hiura A, Kojima H, Akashi M: Construction of Three-Dimensional Dermo-Epidermal Skin Equivalents Using Cell Coating Technology and Their Utilization as Alternative Skin for Permeation Studies and Skin Irritation Tests. Tissue Eng Part A. 2017; 23（11-12）:481-490.
Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H: Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42（4）:499-507
Arakawa H Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T: Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40（7）:967-974
Tanabe S, Kobayashi K, Matsumoto M, Serizawa H, Igarashi T, Yamada T, Hirose A: Toxicity of repeated 28-day oral administration of acenaphthylene in rats. Fundam Toxicol Sci. 2017;4:247-259
Tanabe S, Ohara M, Ito M, Noda A, Kobayashi K, Matsumoto M, Hirose A: Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats．Fundam Toxicol Sci. 2017;4:207-218
Fukuhara K, Ohno A, Kikura-Hanajiri R: A metabolic study on the biochemical effects of chiral illegal drugs in rats using 1 H-NMR spectroscopy．Yakugaku Zasshi. 2017;137（9）:1147-1154
Yamada T, Hirose A: Case study on the use of an integrated approach to testing and assessment for the repeated-dose toxicity of phenolic benzotriazoles, Organisation for Economic Co-operation and Development （OECD）, Series on Testing & Assessment No. 271. 1-44, 2017.
Miyazaki H, Yamashita K, Uchino T, Takezawa T, Kojima H: Development of a Novel in Vitro Skin Sensitization Test Method using a Collagen Vitrigel Membrane Chamber, AATEX, 2017;22(2):141-154.
小島肇, 西川秋佳: 日本動物実験代替法評価センター平成28年度報告, AATEX-JaCVAM, 2017; 6(1), 51-55.

2016年度

Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H: Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells. 2016;8:384-95
Yamamoto N, Kato Y, Sato A, Hiramatsu N, Yamashita H, Ohkuma M, Miyachi E, Horiguchi M, Hirano K, Kojima H: Establishment of a new immortalized human corneal epithelial cell line（iHCE-NY1）for use in evaluating eye irritancy by in vitro test methods. In Vitro Cell Dev Biol Anim. 2016; 52（7）:742-8
Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M: Evaluation o f the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogen. Mutation Research. 2016;802:1-29
Fujita Y, Morita T, Matsumura S, Kawamoto T, Itoh Y, Nishiyama N, Honda H: Comprehensive retrospective evaluation o f existing in vitro chromosomal aberration test data by cytotoxicity index transformation. Mutation Research. 2016;802:38-49
Morita T, Uneyama C: Genotoxicity assessment of 4-methylimidazole: Regulatory perspectives. Genes and Environment. 2016;38:20
Hirata-Koizumi M, Ise R, Kato H, Matsuyama T, Nishimaki-Mogami T, Takahashi M, Ono A, Ema M, Hirose A: Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α（PPARα) activity of an ultraviolet absorber, 2-（2’-hydroxy-3’,5’-di-tert-butylphenyl）benzotriazole, as possible mechanism of their toxicity and the gender differences. J Toxicol Sci. 2016;41:693-700
Matsumoto M, Todo H, Akiyama T, HirataKoizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K: Risk assessment of skin lightening cosmetics containing hydroquinone. Regul Toxicol Pharmacol. 2016;81:128-35
Uchino T, Kuroda Y, Ishida S, Yamashita K, Miyazaki H, Oshikata A, Shimizu K, Kojima H, Takezawa T, Akiyama T, Ikarashi Y: Increase of β2-integrin on adhesion of THP-1 cells to collagen vitrigel membrane, Biosci Biotechnol Biochem. 2016;4:1-6

2015年度

Kato H, Fujii S, Takahashi M, Matsumoto M, Hirata-Koizumi M, Ono A, Hirose A: Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats. Environ Toxicol. 2015;30:1235-43.
Morita T, Uno Y, Honma M, Kojima H, Hayashi M, Tice RC, Corvi R, Schechtman L: The JaCVAM International Validation Study on the in vivo Comet Assay: Selection of Test Chemicals. Mutat Res. 2015;786-788:14-44.
Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Burlinson B, Escobar P, Kraynak AR, Nakagawa Y, Nakajim M, Pant K, Asano N, Lovell D, Morita T, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutat Res. 2015;786-788:3-13.
Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Beevers C, Boeck MB, Burlinson B, Hobbs CH, Kitamoto S, Kraynakl AR, McNamee J, Nakagawa Y, Pant K, Plappert-Helbig U, Priestley C, Takasawa H, Wada K, Wirnitzer U, Asano N, Escobar P, Lovell D, Morita T, Nakajima M, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutat Res. 2015;786-788:45-76.
Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Recommended protocols for the liver micronucleus test: report of the IWGT working group. Mutat Res. 2015;783:13-8.
Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Micronucleus test in rodent tissues other than liver or erythrocytes: Report of the IWGT working group. Mutat Res. 2015;783:19-22.
MacGregor JT, Frötschl R, White PA3, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V, Johnson GE: IWGT Report on Quantitative Approaches to Genotoxicity Risk Assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs). Mutat Res. 2015;783:55-65.
MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Johnson GE,Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V: IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-ofdeparture (PoD) metrics in definingacceptable exposure limits and assessing human risk. Mutat Res. 2015;783:66-78
Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S1, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A＊, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M: Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) ‒ Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2015;780-781:2-17.
Hirata-Koizumi M, Fujii S, Hina K, Matsumoto M, Takahashi M, Ono A, Hirose A: Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid. Fundam Toxicol Sci. 2015;2:177-90
Ono A, Kobayashi K, Serizawa H, Kawamura T, Kato H, Matsumoto M, Takahashi M, Hirata-Koizumi M, Matsushima Y, Hirose A: A repeated dose 28-day oral toxicity study of b-bromostyrene in rats. Fundam Toxicol Sci. 2015;2:191‒200.
Okamura H, Abe H, Hasegawa-Baba Y, Saito K, Sekiya F, Hayashi S, Mirokuji Y, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T: The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1384-96.
Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokawa M, Watanabe W: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice. Environ. Toxicol Pharmacol. 2015;39:879-86.
Watanabe H, Tamura I, Abe R, Takanobu H, Nakamura A, Suzuki T, Hirose A, Nishimura T, Tatarazako N: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2015;35:996-1006.
Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G: A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure. Regul Toxicol Pharmacol. 2015;73:770-9
Yamaguchi H, Kojima H, Takezawa T: Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals. J Appl Toxicol. 2016;36(8):1025-37.
Kojima H: The use of 3-D models as alternatives to animal testing. Altern Lab Anim. 2015;43(4):P40-3.
Speit G, Kojima H, Burlinson B, Collins AR, Kasper P, Plappert-Helbig U, Uno Y, Vasquez M, Beevers C, De Boeck M, Escobar PA, Kitamoto S, Pant K Pfuhler S, Tanaka J, Levy DD: Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT). Mutat Res Genet Toxicol Environ Mutagen. 2015;783:6-12

総説・解説

2023年度

Tanabe S: Role of eIF2 Signaling in Cancer and its Relationship with Coronavirus. Adv Clin Med Res. 2024;5(1):73. doi: 10.52793/ACMR.2024.5(1)-73
Esterhuizen M, Park C-B, Kim YJ, Kim T-Y, Yoon H, Andres F, Rodriguez-Rodriguez R, Tanabe S: A Perspective on the Role of Physiological Stresses in Cancer, Diabetes and Cognitive Disease as Environmental Diseases. Front Mol Biosci. 2023;10:1274221 doi: 10.3389/fmolb.2023.1274221
Tanabe S, Beaton D, Chauhan V, Choi I, Choi J, Clerbaux L-A, Coppola L, Dumont A, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Garcia-Reyero N, Goralczyk A, Huliganga E, Kim Y-J, Klose J, La Rocca C, Landesmann B, Mally A, Murugadoss S, Omeragic E, Ouédraogo G, Pereira J, Sadi B, Schaffert A, Song Y, Sovadinova I, Stöger T, Tollefsen KE, Wittwehr C, Yauk C: Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference. ALTEX - Alternatives to animal experimentation. 2023;40(4):689–693 doi: 10.14573/altex.2307041
田邊思帆里: がん細胞及びRNAウィルス感染分子ネットワーク制御機構の解明について. 細胞. 2023;55(12):32-34
Tanabe S: A Role of SPINK1 in Cancer. Adv Clin Med Res. 2023;4(2):53 doi: 10.52793/ACMR.2023.4(2)-53
山田隆志, 丸山（薦田）多恵子. 化学物質のヒト健康影響評価に資するリードアクロス -行政リスク評価への適用を目指して- , CICSJ Bulletin 2023, Vo.41, No.1, 6-10.
山田隆志, 丸山（薦田）多恵子, 広瀬明彦, 医薬品の生態毒性評価を支援するデータベースとin silico予測手法, 医薬品医療機器レギュラトリーサイエンス, 2023, 54 巻, 6 号, p. 525-531, https://doi.org/10.51018/pmdrs.54.6_525

2022年度

杉山圭一，増村健一：ゲノム不安定性評価を見据えた遺伝毒性研究の新潮流．日本薬理学雑誌 2022;157:265-70.
Tanabe S: PYGO in Cancer Pathway. Adv Clin Med Res. 2023;4（1）:48.
Bajard L, Adamovsky O, Audouze K, Baken K , Barouki R, Beltman JB , Beronius A ,Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, Fitz Gerald R E , Gundacker C , Hernández A F ,Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L: Application of AOPs to assist regulatory assessment of chemical risks – case studies, needs and recommendations. Environ Res. 2023;217:114650.
Tanabe S: Relationship between immune checkpoint inhibitors and myocarditis. Adv Clin Med Res. 2023;3（4）:41.
Tanabe S: Relationship between coronavirus infection and immune checkpoint inhibitors. Adv Clin Med Res. 2023;3（3）:37.
Tanabe S, O’Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, Fitz Gerald R: Reactive Oxygen Species in the Adverse Outcome Pathway Framewok: Toward Creation of Harmonized Consensus Key Events. Front Toxicol. 2022; 4:887135.
Tanabe S: Relationship between COVID-19 vaccines and myocarditis. Adv Clin Med Res. 2023;3（2）:30.
山田隆志：Cefic LRI/ILSI Europe Joint WorkshopでのCarcinogen Dose Response Data base for Threshold of Toxicological Concern（TTC）の概要ならびにTTCに関する近年の国際動向. イルシー. 2022;150:4-12.
足利太可雄：免疫毒性に関するAdverse Outcome Pathway（AOP）の開発およびその活用状況について. レギュラトリーサイエンス学会誌. 2022;12（2）:221-231.
小島肇：医薬部外品承認申請における動物実験代替法の利用と留意点. 日本香粧品学会誌. 2022;46（1）:30-36.
足利太可雄：化粧品・医薬部外品の安全性評価に関する動物実験代替法の研究動向. FRAGRANCE JOURNAL. 2022;7:76-80.
小島肇：序論：AMED-MPS事業の現状と今後の展望. 医薬品医療機器レギュラトリーサイエンス. 2022;53（5）:386.
小島肇，渡辺美香：一般財団法人食品薬品安全センターにおける代替法研究. 秦野研究所年報. 2022;45:8-17.
髙橋祐次，中村るりこ，山城朋子，小島肇：ヒト表皮モデルを用いた皮膚腐食性試験代替法評価報告書. AATEX-JaCVAM. 2022;11（1）:1-12.
山本直樹，佐々木正治，竹内小苗，波多野浩太，原範子，山下晴洋，小島肇：眼刺激性試験代替法 Vitrigel-EIT法評価報告書. AATEX-JaCVAM. 2022;11（1）:13-28.
山本直樹，佐々木正治，竹内小苗，波多野浩太，山下晴洋，小島肇：眼刺激性試験代替法 SIRC-CVS:TEA法評価報告書. AATEX-JaCVAM. 2022;11（1）:29-41.
足利太可雄，小島肇，平林容子：日本動物実験代替法評価センター（Ja CVAM）令和3 4 年度報告書. AATEX-JaCVAM. 2022;11（1）:42-49.
小島肇：食品添加物の動物を用いない安全性評価のSystematic reviewに関する研究. 日本食品化学研究振興財団第28回（令和3年度）研究成果報告書. 2022;9-14.
小島肇：化粧品原料としてのタンパク質・ペプチド等の安全性評価. Cosmetic Stage. 2023:2:1-6.
小島肇：化学物質の毒性評価方法の現状と今後. 化学物質と環境. 2023:178:1-4.
小島肇, 平林容子: 創薬開発に期待されるNew Approach Methodの行政的な受け入れについて, 日薬理誌, 2023:158,269-272. doi:10.1254/fpj.22154
小島肇: 動物実験代替法に関する国際機関の動向, 医学のあゆみ, 2023:285(9),777-780.
足利太可雄: 化粧品・医薬部外品の安全性評価代替法の現状と将来, フレグランスジャーナル, 2023:7,10-15.
小島肇: 医薬部外品・化粧品の安全性評価に動物実験代替法の活用と推進を図るためのガイダンス, 日皮協ジャーナル, 2023:46(1), 46-52.
相場節也, 足利太可雄: 世界初！日本におけるOECD 免疫毒性テストガイドラインの開発について, ImmunoTox Letter, 2023:28(2)(通巻56号),14-18.
小島肇: 食品添加物の動物実験を用いない安全性評価のSystematic reviewに関する研究第2報, 日本食品化学研究振興財団　第29回（令和4年度）研究成果報告書. 2023;37-47.

2021年度

Nishikawa A, Nagano K, Kojima H, Ogawa K: A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity. Regul Toxicol Pharmacol. 2021;123:104937.
Tanabe S, Beaton D, Chauhan V , Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant TW, Garcia-Reyero N, Helm JS, Huliganga E, Jacobsen NR, Kay JE, Kim Y-J, Klose J, La Rocca C, Luettich K, Mally A, O'Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE Vogel U, Yepiskoposyan H, Yauk C: Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX - Alternatives to animal experimentation. 2022;39（2）:336-338.
Clerbaux L-A, Amigó N, Amorim MJ, Bal-Price A, Batista Leite S, Beronius A, Bezemer GFG, Bostroem A-C, Carusi A, Coecke S, Concha R, Daskalopoulos EP, Debernardi F, Edrosa E, Edwards SW, Filipovska J, Garcia-Reyero N, Gavins FNE, Halappanavar S, Hargreaves AJ , Hogberg HT , Huynh MT , Jacobson D, Josephs-Spaulding J, Kim YJ, Kong HJ, Krebs CE, Lam A, Landesmann B, Layton A, Lee YO, Macmillan DS, Mantovani A, Margiotta-Casaluci L, Martens M, Masereeuw R, Mayasich SA, Mei LM, Mortensen H Munoz Pineiro A, Nymark P, Ohayon E, Ojasi J, Paini A, Parissis N, Parvatam S, Pistollato F , Sachana M , Sørli JB , Sullivan KM , Sund J , Tanabe S, Tsaioun K, Vinken M, Viviani L, Waspe J, Willett C, Wittwehr C: COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop. ALTEX - Alternatives to animal experimentation. 2022;39（2）:322-335.
Tanabe S, Hirose A, Yamada T: Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy. OECD Series on Adverse Outcome Pathways. 2021, No. 17.
Tanabe S: Involvement of reactive oxygen species （ROS） and coagulation network in coronaviral infection. Adv Clin Med Res. 2021;2（2）:21.
Tanabe S : EMT Mechanism , Lung Cancer Metastasis, and microRNA. Front Mol Biosci. 2021;8:731788.
Tanabe S: Editorial: Protein Functional Changes and Signaling Transduction in Cancer Stem Cells. Front Oncol. 2021;11:761678.
Tanabe S: RNA Signaling in Microenvironment. Adv Clin Med Res. 2021;2（2）:19.
田邊思帆里：エクソソームによる細胞集団内RNAシグナルパスウェイ． Drug Delivery System. 2021;36（4）:241-247.
Tanabe S, Perkins EJ, Ono R, Sasaki H: Artificial intelligence in gastrointestinal diseases. Artif Intell Gastroenterol. 2021;2（3）:69-76.
足利太可雄：In vitro/in silico試験による皮膚感作性の毒性学的懸念の閾値（TTC）コンセプトの確立. Cosmetology. 2021;29:62-66.
浅野哲秀，笠松俊夫，北本幸子，山本美佳，小島肇：Bhas 42細胞形質転換試験法（Bhas 42 CTA）評価報告書. AATEX-JaCVAM. 2021;10（1）:1-26.
小野敦，井口泰泉，青柳智子，足利太可雄，北嶋聡，児玉進：エストロゲン受容体（ER）結合親和性化学物質の検出のための，ヒト組み換えエストロゲン受容体（hrER）in vitro試験法に関する性能準拠試験法ガイドライン（TG493）評価報告書. AATEX-JaCVAM. 2021;10（1）:27-48.
小野敦，井口泰泉，青柳智子，足利太可雄，北嶋聡，児玉進：エストロゲン受容体（ER）結合親和性化学物質の検出のための，ヒト組み換えエストロゲン受容体（hrER）in vitro試験法に関する性能準拠試験法ガイドライン（TG493）評価報告書. AATEX-JaCVAM. 2021;10（1）:27-48.
小島幸一，足利太可雄，安達玲子，佐藤一博，瀬崎拓人，武吉正博，福山朋季：皮膚感作性試験代替法 Interleukin-8 Reporter Gene Assay（IL-8 Luc assay）評価報告書. AATEX-JaCVAM. 2021;10（1）:49-68.
足利太可雄，小島肇，平林容子：日本動物実験代替法評価センター（Ja CVAM）令和2年度報告書. AATEX-JaCVAM. 2021;10（1）:69-76.
小島肇：医薬部外品の承認申請における動物実験代替法利用における最近の動向. COSMETIC STAGE. 2021;12:32-39.
Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle D, Tong L, Tong W, Eijnden-van-Raaij JVD, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W: Emerging technologies and their impact on regulatory science. Exp Biol Med （Maywood）. 2022;247（1）:1-75.

2020年度

足利太可雄，小島肇夫，平林容子：日本動物実験代替法評価センター（JaCVAM）令和元年度報告書 AATEX-JaCVAM 2020;9（1）:58-64.
Tanabe S: Cancer recognition of artificial intelligence. Artif Intell Cancer. 2021;2:1-6.
Tanabe S: How can artificial intelligence and humans work together to fight against cancer? Artif Intell Cancer. 2020;1:45-50.
Tanabe S: The therapeutic mechanism of COVID-19. J Clin Med Res. 2020;2:1-3.
Garcia-Chica J, Paraiso WKD, Tanabe S, Serra D, Herrero L, Casals N, Garcia J, Ariza X, Quader S, Rodriguez-Rodriguez R: An overview of nanomedicines for neuron targeting. Nanomedicine. 2020;15:1617-1636.
Tanabe S, Quader S, Cabral H, Ono R: Interplay of EMT and CSC in cancer and the potential therapeutic strategies. Front Pharmacol. 2020;11:904.
Tanabe S: Cellular internalization and RNA regulation of RNA virus. Adv Clin Med Res. 2020;1:1-3.
Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesné C, Cronin MTD , De Knecht J , Dietrich DR, Escher SE, Fitzpatrick S, Flannery B, Herzler M, Hougaard Bennekou S, Hubesch B, Kamp H, Kisitu J, Kleinstreuer N, Kovarich S, Leist M, Maertens A, Nugent K, Pallocca G, Pastor M, Patlewicz G, Pavan M, Presgrave O, Smirnova L, Schwarz M, Yamada T, Hartung T: Internationalization of read-across as a validated new approach method （NAM） for regulatory toxicology. ALTEX. 2020; 37（4）: 579- 606.
小島肇：世界の化粧品における安全性評価の現状と日本の立ち位置−今後の代替法の見通し. フレグランスジャーナル. 2020;9:30-36.
小島肇：OECD試験法ガイドライン開発におけるCERIの国際貢献. CERI NEWS. 2020;90:2-3.
小島肇：AOP及びIATAに基づく安全性評価手法の進捗 JETOC 40周年記念誌. 2020;71-101.
山本直樹，小島肇，佐々木正治，竹内小苗，波多野浩太，森村智美：2018年改定 OECD TG438ニワトリ眼球を用いた眼刺激性試験（Isolated Chicken Eye Test: ICE法）．AATEX-JaCVAM. 2020;9（1）, 35-42.
小島幸一，足利太可雄，安達玲子，佐藤一博，瀬崎拓人，武吉正博，福山朋季：皮膚感作性試験代替法：ARE-Nrf2 luciferase LuSens Test Method（LuSens 法）．AATEX-JaCVAM. 2020;9（1）, 43-57.
尾上誠良，上月裕一，豊田明美，笛木修，細井一弘，小島肇夫，足利太可雄，小野寺博志：光安全性評価の現状と課題 YAKUGAKU ZASSHI. 2021;141:111-124.

2019年度

青井貴之，浅香勲，阿久津英憲，伊藤弓弦，片岡健，諫田泰成，小島肇，関野祐子，末森博文，中川誠人，中村和昭，中村幸夫，藤井万紀子，古江―楠田美保，山崎大樹：「多能性幹細胞培養の留意点」の提案．Tiss. Cult. Res. Commun. 2019;38:135-43
田邊思帆里，広瀬明彦，Maurice Whelan，山田隆志：遺伝子ネットワーク解析による分子パスウェイ解明及びAOP開発状況について. YAKUGAKU ZASSHI. 2020;140:485-489
Tanabe S: Quest of EMT and CSC．Journal of Clinical and Medical Research. 2019;1:1-2
Tanabe S: The potential stem cell source for the future．Journal of Dentistry and Oral Biology. 2019;4:1156
Tanabe S: Crossroad of Molecular Networks and Disease Treatment．Journal of Clinical and Medical Research. 2020;2:1-3
田邊思帆里，山田隆志：分子パスウェイ経路による有害性発現予測に関するOECD等の取り組みについて. YAKUGAKU ZASSHI. 2020;140:479-480
小島肇: 化粧品の安全性評価における国内外の動向. フレグランスジャーナル 2019;9:17-22
荻原琢男, 細野麻友, 小島肇: ヒト肝細胞の3次元培養スフェロイドモデルの新展開, 日本薬理学雑誌 2019;153(5):235-241.
Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A: Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020. doi:10.14573/altex.2001241.
Kojima H: Use of non-animal test methods in the safety assessment of chemicals. Translat Regulat Sci. 2019;1:66-72
小島肇, 足利太可雄，平林容子: 日本動物実験代替法評価センター平成30年度報告. AATEX-JaCVAM. 2019;8:35-41
小島幸一, 足利太可雄, 安達玲子, 佐藤一博, 武吉正博, 福山朋季: In Vitro皮膚感作性試験:U937 Cell Line Activation Test (U-SENSTM)．AATEX-JaCVAM. 2019;8:1-16
山本直樹, 佐々木正浩, 竹内小苗, 波多野浩太, 森村智美, 小島肇: 再構築ヒト角膜様上皮モデル法(RhCE法) LabCyte CORNEA-MODEL24眼刺激性試験(LabCyte-CORNEA-MODEL24 EIT) 評価報告書．AATEX-JaCVAM. 2019;8:27-34
山田隆志，足利太可雄，小島肇，広瀬明彦: AOP (Adverse Outcome Pathway; 有害性発現経路）に基づいた化学物質の安全性評価へ向けたチャレンジ．YAKUGAKU ZASSHI. 2020;140:481-484
Tachibana K, Kass GEN, Ono A, Yamada T, Tong W, Doerge DR, Yamazoe Y: A Summary Report of FSCJ Workshop "Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments". Food Safety. 2019;7:83-89
広瀬明彦: 許容一日曝露量の基本的な考え方．製剤機械技術学会誌. 2019;28:365-370
広瀬明彦: PDE設定における毒性学的な基本概念について．PHARM TECH JAPAN. 2019;35:2309-2312

2018年度

Tanabe S, Ono R: The gene and microRNA networks of stem cells and reprogramming． AIMS Cell and Tissue Engineering. 2018;2:238-245
Tanabe S: Wnt signaling and epithelial-mesenchymal transition network in cancer. Research Journal of Oncology. 2018;2:2:3
Tanabe S: Molecular Network and Cancer. Research Journal of Oncology. 2018;2:1:3
小島肇：化学物質や医薬品などの安全性評価に用いる動物実験代替法の技術開発の現状と展望．イルシーJapan, 2018;136, 23-31.
小島肇：幹細胞を用いた化粧品安全性評価への応用. Cosmetic Stage, 2019;13（3）26-30.
小島肇: 厚労省ガイダンスを踏まえた今後の動物実験代替法活用の在り方，Cosmetic Stage, 2018;6, 1-9
小島肇：化学物質の毒性評価方法の現状と今後, 化学物質と環境．エコケミストリー研究会, 2019;154, 1-3.
高橋祐次, 中村るりこ, 須方督夫, 小島　肇: ヒト表皮モデルを用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):1-20.
高橋祐次, 中村るりこ, 須方督夫, 小島　肇: 経皮電気抵抗試験を用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):21-30.
高橋祐次, 中村るりこ, 須方督夫, 小島　肇: In vitro膜バリア試験を用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):31-38.
山本直樹, 佐々木正治, 竹内小苗, 波多野浩太, 森村智美, 小島　肇: 再構築ヒト角膜様上皮モデル法(RhCE法) Skin EthicTM HCE/Sを用いた眼刺激性試験(Skin EthicTM HCE EIT)評価報告書, AATEX-JaCVAM, 2018;7(1):39-45.
小島肇，西川秋佳: 日本動物実験代替法評価センター平成29年度報告． AATEX-JaCVAM, 2018; 7（1）:65-70.
Dent M, Amaral RT, Da Silva PA, Ansell J, Boisleve F, Hatao M, Hirose A, Kasai Y, Kern P, Kreiling R, Milstein S, Montemayor B , Oliveira J , Richarz A, Taalman R , Vaillancourt E, Verma R, OʼReilly Cabral Posada NV, Weiss C, Kojima H: Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients. Computational Toxicology. 2018;7:20-26
Chesnut M, Yamada T, Adams T, Knight D, Kleinstreuer N, Kass G, Luechtefeld T, Hartung T: Regulatory acceptance of read-across. ALTEX. 2018; 35:413-419

2017年度

Tanabe S: Molecular markers and networks for cancer and stem cells．J Embryol Stem Cell Res. 2017;1:1
小島肇: 化粧品・医薬部外品の安全性評価のための動物実験代替法開発の現状と課題．フレグランスジャーナル 2017;7:12-16.
小島肇：医薬品食品領域での動物愛護管理法の現在と未来．NPO動物実験関係者連絡協議会第 5 回シンポジウム報告書「動物愛護管理法」の過去・現在・未来 2017;15-20.
小島肇：動物実験代替法開発の現状と今後の課題．医薬品医療機器レギュラトリーサイエンス 2017;48（9）:600-607.
井上治久，小島肇，澤田光平，谷憲三郎，山本恵司，畠賢一郎：再生医療技術を用いた創薬支援ツールの意義と展望．再生医療 2017;16（3）:9-16.
小島肇：化学物質の安全性評価に利用されるインビトロアッセイ（in vitro試験）法．生物工学会誌 2017;95:455-460.
小島肇，西川秋佳：日本動物実験代替法評価センター平成28年度報告． AATEX-JaCVAM 2017;6（1）:51-55.
小島肇: 動物を用いない代替法の新しい胎動. 日本薬理学雑誌 2018;151（2）:52-55.

2016年度

Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Regulation of CTNNB1 signaling in gastric cancer and stem cells. World J Gastrointest Oncol. 2016;8:592-8
小島肇：VICHセッション5所感． JVPA Digest. 2016;55:19
小島肇：日本で開発または評価されたOECDテストガイドライン．生物化学的測定研究会年報　2016;20
小島肇：医薬品，医薬部外品，化粧品の安全性評価に用いることができる代替法．薬剤学　2016;76（4）:243-6
小島肇：皮膚毒性評価に関する最近の話題，評価方法. 第17回日本毒性学会生涯教育講習会テキスト　2016;89- 108
小島肇：医薬品に係わる新添加物の安全性評価．月刊ファームステージ　2016;16（6）:1
小島肇，西川秋佳：日本動物実験代替法評価センター（JaCVAM）平成27年度報告書． AATEX-JaCVAM. 2016;5（1）:45-56
小島肇：皮膚細胞を用いた最新のin vitro安全性評価研究．Cosmetic Stage. 2016;12:1-4
大内淳子，山田隆志：化粧品安全性評価のためのコンピュータ予測モデルの活用． Cosmetic Stage. 2016;10:1-8
Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A: Biologyinspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX. 2016;33（3）:272-321
Barroso J, Ahn IY, Caldeira C, Carmichael PL, Casey W, Coecke S, Curren R, Desprez B, Eskes C, Griesinger C, Guo J, Hill E, Roi AJ, Kojima H, Li J, Lim CH, Moura W, Nishikawa A, Park H, Peng S, Presgrave O, Singer T, Sohn SJ, Westmoreland C, Whelan M, Yang X, Yang Y, Zuang V.: International Harmonization and Cooperation in the Validation of Alternative Methods, Advance in Experimental Medicine and Biology, 2016;856:343-386.

2015年度

森田健：LD50値による毒性評価手法の変遷. 中毒研究 2015;28:388-91.
松本真理子，清水将史，宮地繁樹，菅谷芳雄，広瀬明彦：OECD化学物質共同評価プログラム：第6回化学物質共同評価会議概要．化学生物総合管理 2015;10:37-45
高橋美加，松本真理子，宮地繁樹，菅谷芳雄，長谷川隆一，小林克己，平田睦子，小野敦，広瀬明彦： OECD化学物質対策の動向（第26報）－第6回OECD 化学物質共同評価会議（2014年パリ）．化学生物総合管理 2015;11:28-36.
小島肇：化粧品原料に対する安全性規制の世界動向. Cosmetic Stage 2015;9(4):1-9.
小島肇：化粧品等の接触皮膚炎を起こす物質を評価するための動物実験代替法について．アレルギーの臨床 2015;35(5):436-40.
Kojima H, Kasamatsu T: Regulatory science-JEMS symposium in 2014. Genes and Environment 2015;37:12.
小島肇：昨今の皮膚毒性評価法の動向．谷本学校毒性質問箱 2015;17:8-14.
小島肇：動物実験代替法の変遷と最新動向．日本香粧品学会誌創立40周年記念 2015;39:72-5
小島肇：日本動物実験代替法評価センター（JaCVAM) の紹介並びに我が国における動物実験代替法の現状． LABIO 21 2015;62:42-4.
小島肇，西川秋佳：日本動物実験代替法評価センター（JaCVAM）平成26年度報告． AATEX-JaCVAM 2015;4(1):30-8
Yamazoe Y, Yamada T, Mitsumori K: Embryo- and testicular-toxicities of methoxyacetate and the related: a review on possible roles of one-carbon transfer and histone modification. Food Safety 2015;3:92-107.
Tanabe S: Overview of gene regulation in stem cell network to identify therapeutic targets utilizing genome databases. Insights Stem Cells. 2015;1:1.
Tanabe S: Signaling involved in stem cell reprogramming and differentiation. World J Stem Cells. 2015;7:992-8.
Tanabe S, Komatsu M, Aoyagi K, Yokozaki H, Sasaki H: Implications of epithelial-mesenchymal transition in gastric cancer. Transl Gastrointest Cancer. 2015;4:258-64.
Tanabe S: Origin of cells and network information. World J Stem Cells. 2015;7:535-40.

単行本

2022年度

Tanabe S: Epithelial-Mesenchymal Transition and Cancer Stem Cells. “Cancer Stem Cell Markers and Related Network Pathways”, ed. by Shihori Tanabe, Springer Nature, Cham, Switzerland. pp.41-9 （2023）
Tanabe S: Microenvironment of Cancer Stem Cells. “Cancer Stem Cell Markers and Related Network Pathways”, ed. by Shihori Tanabe, Springer Nature, Cham, Switzerland. pp.103-124（2023）
Quader S, Tanabe S, Cabral H: Abnormal Glycosylation in Cancer Cell sand Cancer Stem Cells as a Therapeutic Target. “Cancer Stem Cell Markers and Related Network Pathways”, ed. by Shihori Tanabe, Springer Nature, Cham, Switzerland. pp.141-156（2023）
小島肇：“皮膚の安全性・製品の安全性に関連する試験の基礎と注意点”第7章医薬品・医療機器・医薬部外品における皮膚の安全性評価試験と代替試験法の状況，監修:関東裕美，（株）情報機構，東京，pp.117-131（2023）
小島肇: "動物実験代替法とNew Approach Methodologiesの開発・利用動向" 第１編　総論　第1章　動物実験代替法にかかわる国際機関の動向, 監修:小島肇, (株)シーエムシー出版, 東京, pp.1-6 (2023).
山田隆志： Next Generation Risk Assessmentへの期待と課題（動物実験代替法とNew Approach Methodsの開発・利用動向. 監修：小島肇夫), (株)シーエムシー出版, pp.7-13 (2023)

2021年度

Tanabe S, Sachana M, Fitz Gerald R: “Reproductive and Developmental Toxicology, 3rd ed.”, Chapter 4. Adverse Outcome Pathways in reproductive and developmental toxicology, ed., Ramesh C. Gupta, Elsevier Inc./Academic Press, San Diego, pp.63-72 （2022）

2020年度

広瀬明彦：E&L不純物の安全性評価の考え方．医薬品不純物における評価及び管理戦略・運用の実際．サイエンス＆テクノロジー，pp.165-179（2020）

2019年度

相崎健一，阿部裕，石井雄二，井上薫，小川久美子，小野竜一，北嶋聡，工藤由起子，久保田浩樹，小島肇，佐藤恭子，杉本直樹，杉山圭一，高木篤也，高橋雄，髙橋祐次，多田敦子，建部千絵，田邊思帆里，曺永晩，豊田武士，西崎雄三，平林容子，広瀬明彦，本間正充，増村健一，増本直子，六鹿元雄，安井学（分担執筆又は編集）：“第9版食品添加物公定書解説書”，川西徹，穐山浩，河村葉子，佐藤恭子監修，廣川書店，東京（2019）
Kojima H, Sakai Y, Tanaka N: “Japanese Contributions to the Development of Alternative Test Methods”, Section 2: Contributions From Countries, Regions and Organisations, The History of Alternative Test Methods in Toxicology, Edited by Michael Balls, Robert Combes and Andrew Worth, Elsevier, Netherlands, pp.79-85 (2019)
Landsiedel R, Gamo M, Hirose A: “The Role of In Vivo Screening Studies in Assessing Manufactured Nanomaterials”, In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials, Takebayashi T, Landsiedel R, Gamo M eds, In Current Topics in Environmental Health and Preventive Medicine, Springer (Springer Nature Singapore Pte Ltd), pp.1-21 (2019)

2018年度

Tanabe S: “Peripheral Membrane Proteins”, Chapter 1: Invitation for Peripheral Membrane Proteins．Editor: Tanabe S, ISBN: 978-1-78923-513-5, InTechOpen Ltd.,United Kingdom, pp.1-4（2018）
小島肇：“臓器チップの技術と開発動向”，動物実験代替法としての臓器チップへの期待，（株）シーエムシー出版，東京，pp.6-13（2018）
小島肇：“肌／皮膚，毛髪と化粧品科学”，化粧品の安全性評価－動物実験代替法の利用,（株）薬事日報社，東京，pp.263-274（2018）
小島肇：“皮膚の安全性・有用性評価法”，第 1 章 3 次元皮膚モデルにおける評価モデルの作製と評価，第1節 3 次元皮膚モデル作製のノウハウ，（株）技術情報協会，東京，pp.3-13（2018）
小島肇：“創薬のための細胞利用技術の最新動向と市場”，第 1 章利用できる細胞の種類，細胞ソース，第1節 in vitro実験の重要性と培養細胞の選択方法，（株）シーエムシー・リサーチ，pp.3-6（2018）
小島肇：“創薬のための細胞利用技術の最新動向と市場”，第 1 章 3 次元皮膚モデルにおける評価モデルの作製と評価，第1節 3次元皮膚モデル作製のノウハウ，皮膚の安全性・有用性評価法，（株）シーエムシー・リサーチ，pp.211-214（2018）
Kojima H, Ikarashi Y, Nakada T, Yagami A, Sugibayashi K, Todo H, Hoshino Y, Iizuka N, Nakamura T, Sekizawa S, Shinoda K, Yagi M, Araki D, Sakaguchi H, Sasa H, Sugiyama M: “Alternatives to Animal Testing”，Guidance on the Use of Alternative Test Methods for the Safety Assessment of Cosmetics and Quasi-Drugs, Springer, Singapore, pp.63-68（2019）
山田隆志：“皮膚の安全性・有用性評価法”，第 4 章皮膚の安全性・毒性評価におけるインシリコの活用，第3節 OECDにおけるQSAR，AOPの開発状況，（株）技術情報協会，東京，pp.151-157（2018）

2017年度

Kojima H, Katoh M: “Alternatives for dermal toxicitytesting”, Part I: Skin irritation, 5: In vitro skinirritation assay with the LabCyte EPI-MODEL, Editors: Eskes C, Vliet E, Maibach M, Springer, Switzerland, pp.73-80 （2017）
Kojima H, Hosoi K, Onoue S: “Alternatives for dermal toxicity testing”, Part IV: UV-induced effects（phototoxicity and photoallergy）, 34: Reactive oxygen species assay for evaluating phototoxicity potential, Editors: Eskes C, Vliet E, Maibach M, Springer, Switzerland, pp.477-482 （2017）
Kojima H: “Skin permeation and disposition of therapeutic and cosmeceutical compounds”, Part V: Selection of topically applied chemical candidates, 26: In vitro evaluation for skin toxicity, Editor: Sugibayashi K, Springer, Japan, pp.297-304（2017）
Kojima H: “Skin permeation and disposition of therapeutic and cosmeceutical compounds”, Part V: Selection of topically applied chemical candidates, 27: Related Topics: Safety Evaluation and Alternatives to Animal Testing for Skin Toxicity, Editor: Sugibayashi K, Springer, Japan, pp.305-311（2017）
小島肇：“トキシコロジー（第３版）”， 6 ．標的臓器と毒性発現，6.10皮膚・粘膜毒性，日本毒性学会教育委員会編，（株）朝倉書店，東京，pp.279-286（2018）
小島肇：“トキシコロジー（第３版）”，8 ．動物実験代替法，日本毒性学会教育委員会編，（株）朝倉書店，東京，pp.320-325（2018）
広瀬明彦：“トキシコロジー（第３版）”，4.6 ナノマテリアル，日本毒性学会教育委員会編，（株）朝倉書店，東京，pp.107-112（2018）
広瀬明彦：“ICH Q 3 D元素不純物／Q 3 C残留溶媒の許容限度値／試験法設定と適切な管理手法”，第 2 章ICH Q 3 Dにおける毒性評価の考え方と許容限度値の設定，サイエンス＆テクノロジー，pp.21-29（2017）

2016年度

小島肇：“機能性化粧品素材－素材開発と安全性－”，第2章化粧品開発に関わる安全性評価，医薬部外品申請における安全性評価方針，正木仁監修，（株）シーエムシー出版，東京，pp.62-9（2016）
小島肇：“有用性化粧品の処方とその活用（普及版）”，第14章総合評価の方法，鈴木正人監修，（株）シーエムシー出版，東京，pp.147-51（2016）
Kojima H: “Validation of Alternative Methods for Toxicity Testing”, Advances in Experimental Medicine and Biology 856, Chapter 14: International Harmonization and Cooperation in the Validation of Alternative Methods, Editors: Chantra Eskes, Maurice Whelan, Springer, Netherland, pp.343-86（2016）
Kojima H: “Cosmetic Science and Technology: Theoretical Principles and Applications”, Chapter 51: Safety Assessment of Cosmetic Ingredients, Editors: Kazutami Sakamoto, Robert Lochhead, Howard Maibach, Yuji Yamashita, Elsevier. Netherland, pp.793-803（2017）

2015年度

小島肇：“経皮吸収型製剤開発における基礎と実務への応用”，第4章　経費吸収の測定・評価および安全性試験，第1節　動物愛護管理法と日臨床試験，杉林堅次監修，（株）情報機構，東京，pp.71-83（2015）