研究業績

安全性予測評価部が設置された2015年度以降の研究業績(誌上発表総説・解説単行本)は以下の通りです。

誌上発表

2019年度

  • Jojima K, Yamada T, Hirose A: Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events. Fundamental Toxicological Sciences. 2019;6:327-332
  • Yamada T, Matsumoto M, Miura M, Hirose A: Case study on the use of integrated approaches to testing and assessment for testicular toxicity of ethylene glycol methyl ether (EGME)-related chemicals.OECD, Series on Testing & Assessment. 2019;308:1-75
  • Patlewicz G, Lizarraga LE, Rua D, Allen DG, Daniel AB, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus A, Matheson J, Mumtaz M, Richarz A, Ruiz P, Scarano L, Yamada T, Kleinstreuer N: Exploring current read-across applications and needs among selected U.S. Federal Agencies. Regulatory Toxicology and Pharmacology. 2019;106:197-209
  • Matsumoto M, Hirata-Koizumi M, Kawamura T, Sakuratani S, Ono A, Hirose A: Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies. Fundamental Toxicological Sciences. 2019;6:125-136
  • Igarashi T, Suzuki H, Ushida K, Matsumoto M, Inoue K, Kanno T, Miwa Y, Ishii T, Nagase T, Katsumata Y, Hirose A: Initial hazard assessment of 1,4-dichlorobutane: genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2020;112:104610, doi:10.1016/j.yrtph.2020.104610
  • Kobayashi-Tsukumo H, Oiji K, Xie D, Sawada Y, Yamashita K, Ogata S, Kojima H, Itagaki H: Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT). J Toxicol Sci. 2019;44:283-297
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
  • Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa T: Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing. Altern Lab Anim. 2019;47:140-157
  • Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C, Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M, Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D, Inoue T, Rogen EL, Kojima H, Aiba S: An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals. Toxicol In Vitro. 2020;66:104832, doi: 10.1016/j.tiv.2020.104832
  • Akimoto M, Yamamoto Y, Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay. J Appl Toxicol. 2020;40:843-854

2018年度

  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine. 2018;3:1- 15
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular network pathway of ERBB in diffusetype gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition. Journal of Clinical Epigenetics. 2018;4:2:13
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells. AIMS Cell and Tissue Engineering. 2018;2:58-77
  • Igarashi T, Serizawa H, Kobayashi K, Suzuki H, Matsumoto M, Iso T, Kawamura T, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeateddose toxicity study in rats. Regul Toxicol Pharmacol. 2018;96:64-75
  • Igarashi T, Takashima H, Takabe M, Suzuki H, Ushida K, Kawamura T, Matsumoto M, Iso T, Tanabe S, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats. Regul. Toxicol. Pharmacol. 2018;100:105-117
  • Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K: Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues. Bioorg. Med. Chem. 2019;27(8);1720–1727
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Kojima H, Ono A, Katsuoka Y, Tanabe H, Yokoyama H, Kasahara T: Cause of and countermeasures for oxidation of the cysteinederived reagent used in the amino acid derivative reactivity assay. J. Appl. Toxicol. 2019;39(2):191-208
  • Kimura Y, Watanabe M, Suzuki N, Iwaki T, Yamakage K, Saito K, Nakajima Y, Fujimura C, Ohmiya Y, Omori T, Kojima H, Aiba S: The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA). J. Toxicol. Sci. 2018;43(12):741-749
  • Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T: Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018; 39(4):187-195
  • Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V: Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol. 2018;92(2):611-617.
  • Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, RégimbaldKrnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N: International regulatory requirements for skin sensitization testing. Regul. Toxicol. Pharmacol. 2018;95:52-65
  • Narita K, Ishii Y, Vo PTH, Nakagawa F, Ogata S, Yamashita K, Kojima H, Itagaki H: Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results. J Toxicol Sci. 2018;43(3):229-240
  • Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H: Some nonsensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J. Toxicol. Sci. 2019;44(3):213-224
  • Hoffmann S, Kleinstreuer N, Alépée N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization (I): the Cosmetics Europe database. Crit. Rev. Toxicol. 2018;48(5):344-358
  • Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E , Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization (II): an assessment of defined approaches. Crit. Rev. Toxicol. 2018;48(5):359-374
  • Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: Comparison of three (Q)SAR models. Mutagenesis. 2019;34:91-100
  • Yamada T, Tanaka Y, Hasegawa R, Igarashi T, Hirose A: Male-specific prolongation of prothombin time by industrial chemicals. Fundam. Toxicol. Sci. 2018;5:75-82
  • Petkov PI, Schultz TW, Honma M. Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data. Mutagenesis. 2019;34:83-90

2017年度

  • Horibe A, Odashima S, Hamasuna N, Morita T, Hayashi M: Weight of contribution of in vitro chromosomal aberration assay for evaluation of pesticides: Experience of risk assessment at the Food Safety Commission of Japan. Regul Toxicol Pharmacol. 2018:95:133-41
  • Tsukumo H , Matsunari N , Yamashita K , Kojima H, Itagaki H: Lipopolysaccharide interferes with the use of the human Cell Line Activation Test to determine the allergic potential of proteins. J Pharmacol Toxicol Methods. 2018; 92:34-42.
  • Matsumoto M, Furukawa M, Kobayashi K, Iso T, Igarashi T, Yamada T, Hirose A: A 28-day repeated oral-dose toxicity study of insecticide synergist N- (2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2.2.2]oct5-ene-2,3-dicarboximide in rats. Fundam Toxicol Sci. 2018;5:1-11
  • Narita K, Vo PTH, Yamamoto K, Kojima H, Itagaki H: Preventing false-negatives in the in vitro skin sensitization testing of acid anhydrides using interleukin-8 release assays. Toxicol In Vitro. 2017;Aug 42:69-75.
  • Akagi T, Nagura M, Hiura A, Kojima H, Akashi M: Construction of Three-Dimensional Dermo-Epidermal Skin Equivalents Using Cell Coating Technology and Their Utilization as Alternative Skin for Permeation Studies and Skin Irritation Tests. Tissue Eng Part A. 2017; 23(11-12):481-490.
  • Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H: Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42(4):499-507
  • Arakawa H Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T: Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40(7):967-974
  • Tanabe S, Kobayashi K, Matsumoto M, Serizawa H, Igarashi T, Yamada T, Hirose A: Toxicity of repeated 28-day oral administration of acenaphthylene in rats. Fundam Toxicol Sci. 2017;4:247-259
  • Tanabe S, Ohara M, Ito M, Noda A, Kobayashi K, Matsumoto M, Hirose A: Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats.Fundam Toxicol Sci. 2017;4:207-218
  • Fukuhara K, Ohno A, Kikura-Hanajiri R: A metabolic study on the biochemical effects of chiral illegal drugs in rats using 1 H-NMR spectroscopy.Yakugaku Zasshi. 2017;137(9):1147-1154
  • Yamada T, Hirose A: Case study on the use of an integrated approach to testing and assessment for the repeated-dose toxicity of phenolic benzotriazoles, Organisation for Economic Co-operation and Development (OECD), Series on Testing & Assessment No. 271. 1-44, 2017.
  • Miyazaki H, Yamashita K, Uchino T, Takezawa T, Kojima H: Development of a Novel in Vitro Skin Sensitization Test Method using a Collagen Vitrigel Membrane Chamber, AATEX, 2017;22(2):141-154.
  • 小島肇, 西川秋佳: 日本動物実験代替法評価センター平成28年度報告, AATEX-JaCVAM, 2017; 6(1), 51-55.

2016年度

  • Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H: Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells. 2016;8:384-95
  • Yamamoto N, Kato Y, Sato A, Hiramatsu N, Yamashita H, Ohkuma M, Miyachi E, Horiguchi M, Hirano K, Kojima H: Establishment of a new immortalized human corneal epithelial cell line(iHCE-NY1)for use in evaluating eye irritancy by in vitro test methods. In Vitro Cell Dev Biol Anim. 2016; 52(7):742-8
  • Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M: Evaluation o f the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogen. Mutation Research. 2016;802:1-29
  • Fujita Y, Morita T, Matsumura S, Kawamoto T, Itoh Y, Nishiyama N, Honda H: Comprehensive retrospective evaluation o f existing in vitro chromosomal aberration test data by cytotoxicity index transformation. Mutation Research. 2016;802:38-49
  • Morita T, Uneyama C: Genotoxicity assessment of 4-methylimidazole: Regulatory perspectives. Genes and Environment. 2016;38:20
  • Hirata-Koizumi M, Ise R, Kato H, Matsuyama T, Nishimaki-Mogami T, Takahashi M, Ono A, Ema M, Hirose A: Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α(PPARα) activity of an ultraviolet absorber, 2-(2’-hydroxy-3’,5’-di-tert-butylphenyl)benzotriazole, as possible mechanism of their toxicity and the gender differences. J Toxicol Sci. 2016;41:693-700
  • Matsumoto M, Todo H, Akiyama T, HirataKoizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K: Risk assessment of skin lightening cosmetics containing hydroquinone. Regul Toxicol Pharmacol. 2016;81:128-35
  • Uchino T, Kuroda Y, Ishida S, Yamashita K, Miyazaki H, Oshikata A, Shimizu K, Kojima H, Takezawa T, Akiyama T, Ikarashi Y: Increase of β2-integrin on adhesion of THP-1 cells to collagen vitrigel membrane, Biosci Biotechnol Biochem. 2016;4:1-6

2015年度

  • Kato H, Fujii S, Takahashi M, Matsumoto M, Hirata-Koizumi M, Ono A, Hirose A: Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats. Environ Toxicol. 2015;30:1235-43.
  • Morita T, Uno Y, Honma M, Kojima H, Hayashi M, Tice RC, Corvi R, Schechtman L: The JaCVAM International Validation Study on the in vivo Comet Assay: Selection of Test Chemicals. Mutat Res. 2015;786-788:14-44.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Burlinson B, Escobar P, Kraynak AR, Nakagawa Y, Nakajim M, Pant K, Asano N, Lovell D, Morita T, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutat Res. 2015;786-788:3-13.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Beevers C, Boeck MB, Burlinson B, Hobbs CH, Kitamoto S, Kraynakl AR, McNamee J, Nakagawa Y, Pant K, Plappert-Helbig U, Priestley C, Takasawa H, Wada K, Wirnitzer U, Asano N, Escobar P, Lovell D, Morita T, Nakajima M, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutat Res. 2015;786-788:45-76.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Recommended protocols for the liver micronucleus test: report of the IWGT working group. Mutat Res. 2015;783:13-8.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Micronucleus test in rodent tissues other than liver or erythrocytes: Report of the IWGT working group. Mutat Res. 2015;783:19-22.
  • MacGregor JT, Frötschl R, White PA3, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V, Johnson GE: IWGT Report on Quantitative Approaches to Genotoxicity Risk Assessment I. Methods and metrics for defining exposure-response  relationships  and  points  of departure (PoDs). Mutat Res. 2015;783:55-65.
  • MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Johnson GE,Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V: IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-ofdeparture (PoD) metrics in definingacceptable exposure limits and assessing human risk. Mutat Res. 2015;783:66-78
  • Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S1, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A*, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M: Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) ‒ Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2015;780-781:2-17.
  • Hirata-Koizumi M, Fujii S, Hina K, Matsumoto M, Takahashi M, Ono A, Hirose A:  Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl  carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid. Fundam Toxicol Sci. 2015;2:177-90
  • Ono A, Kobayashi K, Serizawa H, Kawamura T, Kato H, Matsumoto M, Takahashi M, Hirata-Koizumi M, Matsushima Y, Hirose A: A repeated dose 28-day oral toxicity study of b-bromostyrene in rats. Fundam Toxicol Sci. 2015;2:191‒200.
  • Okamura H, Abe H, Hasegawa-Baba Y, Saito K, Sekiya F, Hayashi S, Mirokuji Y, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T: The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1384-96.
  • Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokawa M, Watanabe W: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice. Environ. Toxicol Pharmacol. 2015;39:879-86.
  • Watanabe H, Tamura I, Abe R, Takanobu H, Nakamura A, Suzuki T, Hirose A, Nishimura T, Tatarazako N: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2015;35:996-1006.
  • Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G: A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure. Regul Toxicol Pharmacol. 2015;73:770-9
  • Yamaguchi H, Kojima H, Takezawa T: Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals. J Appl Toxicol. 2016;36(8):1025-37.
  • Kojima H: The use of 3-D models as alternatives to animal testing. Altern Lab Anim. 2015;43(4):P40-3.
  • Speit G, Kojima H, Burlinson B, Collins AR, Kasper P, Plappert-Helbig U, Uno Y, Vasquez M, Beevers C, De Boeck M, Escobar PA, Kitamoto S, Pant K Pfuhler S, Tanaka J, Levy DD: Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT). Mutat Res Genet Toxicol Environ Mutagen. 2015;783:6-12

総説・解説

2019年度

  • 田邊思帆里,広瀬明彦,Maurice Whelan,山田隆志:遺伝子ネットワーク解析による分子パスウェイ解明及びAOP開発状況について. YAKUGAKU ZASSHI. 2020;140:485-489
  • Tanabe S: Quest of EMT and CSC.Journal of Clinical and Medical Research. 2019;1:1-2
  • Tanabe S: The potential stem cell source for the future.Journal of Dentistry and Oral Biology. 2019;4:1156
  • Tanabe S: Crossroad of Molecular Networks and Disease Treatment.Journal of Clinical and Medical Research. 2020;2:1-3
  • 田邊思帆里,山田隆志:分子パスウェイ経路による有害性発現予測に関するOECD等の取り組みについて. YAKUGAKU ZASSHI. 2020;140:479-480
  • 小島肇: 化粧品の安全性評価における国内外の動向. フレグランスジャーナル2019;9:17-22
  • 荻原琢男, 細野麻友, 小島 肇: ヒト肝細胞の3次元培養スフェロイドモデルの新展開, 日本薬理学雑誌 2019;153(5):235-241.
  • Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A: Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020. doi:10.14573/altex.2001241.
  • Kojima H: Use of non-animal test methods in the safety assessment of chemicals.
    Translat Regulat Sci. 2019;1:66-72
  • 小島肇, 足利太可雄,平林容子: 日本動物実験代替法評価センター平成30年度報告.
    AATEX-JaCVAM. 2019;8:35-41
  • 小島幸一, 足利太可雄, 安達玲子, 佐藤一博, 武吉正博, 福山朋季: In Vitro皮膚感作性試験:U937 Cell Line Activation Test (U-SENSTM).AATEX-JaCVAM. 2019;8:1-16
  • 山本直樹, 佐々木正浩, 竹内小苗, 波多野浩太, 森村智美, 小島肇: 再構築ヒト角膜様上皮モデル法(RhCE法) LabCyte CORNEA-MODEL24眼刺激性試験(LabCyte-CORNEA-MODEL24 EIT) 評価報告書.AATEX-JaCVAM. 2019;8:27-34
  • 山田隆志,足利太可雄,小島肇,広瀬明彦: AOP (Adverse Outcome Pathway; 有害性発現経路)に基づいた化学物質の安全性評価へ向けたチャレンジ.YAKUGAKU ZASSHI. 2020;140:481-484
  • Tachibana K, Kass GEN, Ono A, Yamada T, Tong W, Doerge DR, Yamazoe Y: A Summary Report of FSCJ Workshop "Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments". Food Safety. 2019;7:83-89
  • 広瀬明彦: 許容一日曝露量の基本的な考え方.製剤機械技術学会誌. 2019;28:365-370
  • 広瀬明彦: PDE設定における毒性学的な基本概念について.PHARM TECH JAPAN. 2019;35:2309-2312

2018年度

  • Tanabe S, Ono R: The gene and microRNA networks of stem cells and reprogramming. AIMS Cell and Tissue Engineering. 2018;2:238-245
  • Tanabe S: Wnt signaling and epithelial-mesenchymal transition network in cancer. Research Journal of Oncology. 2018;2:2:3
  • Tanabe S: Molecular Network and Cancer. Research Journal of Oncology. 2018;2:1:3
  • 小島肇:化学物質や医薬品などの安全性評価に用いる動物実験代替法の技術開発の現状と展望. イルシーJapan, 2018;136, 23-31.
  • 小島肇:幹細胞を用いた化粧品安全性評価への応用. Cosmetic Stage, 2019;13(3)26-30.
  • 小島肇: 厚労省ガイダンスを踏まえた今後の動物実験代替法活用の在り方,Cosmetic Stage, 2018;6, 1-9
  • 小島肇:化学物質の毒性評価方法の現状と今後, 化学物質と環境.エコケミストリー研究会, 2019;154, 1-3.
  • 高橋祐次, 中村るりこ, 須方督夫, 小島 肇: ヒト表皮モデルを用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):1-20.
  • 高橋祐次, 中村るりこ, 須方督夫, 小島 肇: 経皮電気抵抗試験を用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):21-30.
  • 高橋祐次, 中村るりこ, 須方督夫, 小島 肇: In vitro膜バリア試験を用いた皮膚腐食性試験代替法の評価報告書, AATEX-JaCVAM, 2018;7(1):31-38.
  • 山本直樹, 佐々木正治, 竹内小苗, 波多野浩太, 森村智美, 小島 肇: 再構築ヒト角膜様上皮モデル法(RhCE法) Skin EthicTM HCE/Sを用いた眼刺激性試験(Skin EthicTM HCE EIT)評価報告書, AATEX-JaCVAM, 2018;7(1):39-45.
  • 小島肇,西川秋佳: 日本動物実験代替法評価センター 平成29年度報告. AATEX-JaCVAM, 2018; 7(1):65-70.
  • Dent M, Amaral RT, Da Silva PA, Ansell J, Boisleve F, Hatao M, Hirose A, Kasai Y, Kern P, Kreiling R, Milstein S, Montemayor B , Oliveira J , Richarz A, Taalman R , Vaillancourt E, Verma R, OʼReilly Cabral Posada NV, Weiss C, Kojima H: Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients. Computational Toxicology. 2018;7:20-26
  • Chesnut M, Yamada T, Adams T, Knight D, Kleinstreuer N, Kass G, Luechtefeld T, Hartung T: Regulatory acceptance of read-across. ALTEX. 2018; 35:413-419

2017年度

  • Tanabe S: Molecular markers and networks for cancer and stem cells.J Embryol Stem Cell Res. 2017;1:1
  • 小島 肇: 化粧品・医薬部外品の安全性評価のための動物実験代替法開発の現状と課題. フレグランスジャーナル 2017;7:12-16.
  • 小島 肇:医薬品食品領域での動物愛護管理法の現在と未来.NPO動物実験関係者連絡協議会 第 5 回シンポジウム 報告書「動物愛護管理法」の過去・現在・未来 2017;15-20.
  • 小島 肇:動物実験代替法開発の現状と今後の課題. 医薬品医療機器レギュラトリーサイエンス 2017;48(9):600-607.
  • 井上治久,小島 肇,澤田光平,谷憲三郎,山本恵司,畠賢一郎:再生医療技術を用いた創薬支援ツールの意義と展望. 再生医療 2017;16(3):9-16.
  • 小島 肇:化学物質の安全性評価に利用されるインビトロアッセイ(in vitro試験)法. 生物工学会誌 2017;95:455-460.
  • 小島 肇,西川秋佳:日本動物実験代替法評価センター 平成28年度報告. AATEX-JaCVAM 2017;6(1):51-55.
  • 小島 肇: 動物を用いない代替法の新しい胎動. 日本薬理学雑誌 2018;151(2):52-55.

2016年度

  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Regulation of CTNNB1 signaling in gastric cancer and stem cells. World J Gastrointest Oncol. 2016;8:592-8
  • 小島肇:VICHセッション5所感. JVPA Digest. 2016;55:19
  • 小島肇:日本で開発または評価されたOECDテストガイドライン.生物化学的測定研究会年報 2016;20
  • 小島肇:医薬品,医薬部外品,化粧品の安全性評価に用いることができる代替法.薬剤学 2016;76(4):243-6
  • 小島肇:皮膚毒性評価に関する最近の話題,評価方法. 第17回日本毒性学会生涯教育講習会テキスト 2016;89- 108
  • 小島肇:医薬品に係わる新添加物の安全性評価.月刊ファームステージ 2016;16(6):1
  • 小島肇,西川秋佳:日本動物実験代替法評価センター(JaCVAM)平成27年度報告書. AATEX-JaCVAM. 2016;5(1):45-56
  • 小島肇:皮膚細胞を用いた最新のin vitro安全性評価 研究.Cosmetic Stage. 2016;12:1-4
  • 大内淳子,山田隆志:化粧品安全性評価のためのコンピュータ予測モデルの活用. Cosmetic Stage. 2016;10:1-8
  • Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A: Biologyinspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX. 2016;33(3):272-321
  • Barroso J, Ahn IY, Caldeira C, Carmichael PL, Casey W, Coecke S, Curren R, Desprez B, Eskes C, Griesinger C, Guo J, Hill E, Roi AJ, Kojima H, Li J, Lim CH, Moura W, Nishikawa A, Park H, Peng S, Presgrave O, Singer T, Sohn SJ, Westmoreland C, Whelan M, Yang X, Yang Y, Zuang V.: International Harmonization and Cooperation in the Validation of Alternative Methods, Advance in Experimental Medicine and Biology, 2016;856:343-386.

2015年度

  • 森田健:LD50値による毒性評価手法の変遷. 中毒研究 2015;28:388-91.
  • 松本真理子,清水将史,宮地繁樹,菅谷芳雄,広瀬明彦:OECD化学物質共同評価プログラム:第6回化学物質共同評価会議概要. 化学生物総合管理 2015;10:37-45
  • 高橋美加,松本真理子,宮地繁樹,菅谷芳雄,長谷川隆一,小林克己,平田睦子,小野敦,広瀬明彦: OECD化学物質対策の動向(第26報)-第6回OECD 化学物質共同評価会議(2014年パリ). 化学生物総合管理 2015;11:28-36.
  • 小島肇:化粧品原料に対する安全性規制の世界動向. Cosmetic Stage 2015;9(4):1-9.
  • 小島肇:化粧品等の接触皮膚炎を起こす物質を評価するための動物実験代替法について. アレルギーの臨床 2015;35(5):436-40.
  • Kojima H, Kasamatsu T: Regulatory science-JEMS symposium in 2014. Genes and Environment 2015;37:12.
  • 小島肇:昨今の皮膚毒性評価法の動向.谷本学校毒性質問箱 2015;17:8-14.
  • 小島肇:動物実験代替法の変遷と最新動向.日本香粧品学会誌 創立40周年記念 2015;39:72-5
  • 小島肇:日本動物実験代替法評価センター(JaCVAM) の紹介並びに我が国における動物実験代替法の現状. LABIO 21 2015;62:42-4.
  • 小島肇,西川秋佳:日本動物実験代替法評価センター(JaCVAM)平成26年度報告. AATEX-JaCVAM 2015;4(1):30-8
  • Yamazoe Y, Yamada T, Mitsumori K: Embryo- and testicular-toxicities of methoxyacetate and the related: a review on possible roles of one-carbon  transfer and histone modification. Food Safety 2015;3:92-107.
  • Tanabe S: Overview of gene regulation in stem cell network to identify therapeutic targets utilizing genome databases. Insights Stem Cells. 2015;1:1.
  • Tanabe S: Signaling involved in stem cell reprogramming and differentiation. World J Stem Cells. 2015;7:992-8.
  • Tanabe S, Komatsu M, Aoyagi K, Yokozaki H, Sasaki H: Implications of epithelial-mesenchymal transition in gastric cancer. Transl Gastrointest Cancer. 2015;4:258-64.
  • Tanabe S: Origin of cells and network information. World J Stem Cells. 2015;7:535-40.

単行本

2019年度

  • Kojima H, Sakai Y, Tanaka N: “Japanese Contributions to the Development of Alternative Test Methods”, Section 2: Contributions From Countries, Regions and Organisations, The History of Alternative Test Methods in Toxicology, Edited by Michael Balls, Robert Combes and Andrew Worth, Elsevier, Netherlands, pp.79-85 (2019)
  • Landsiedel R, Gamo M, Hirose A: “The Role of In Vivo Screening Studies in Assessing Manufactured Nanomaterials”, In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials, Takebayashi T, Landsiedel R, Gamo M eds, In Current Topics in Environmental Health and Preventive Medicine, Springer (Springer Nature Singapore Pte Ltd), pp.1-21 (2019)

2018年度

  • Tanabe S: “Peripheral Membrane Proteins”, Chapter 1: Invitation for Peripheral Membrane Proteins.Editor: Tanabe S, ISBN: 978-1-78923-513-5, InTechOpen Ltd.,United Kingdom, pp.1-4(2018)
  • 小島肇:“臓器チップの技術と開発動向”,動物実験代替法としての臓器チップへの期待,(株)シーエムシー出版,東京,pp.6-13(2018)
  • 小島肇:“肌/皮膚,毛髪と化粧品科学”,化粧品の安全性評価-動物実験代替法の利用,(株)薬事日報社,東京,pp.263-274(2018)
  • 小島肇:“皮膚の安全性・有用性評価法”,第 1 章 3 次元皮膚モデルにおける評価モデルの作製と評価,第1節 3 次元皮膚モデル作製のノウハウ,(株)技術情報協会,東京,pp.3-13(2018)
  • 小島肇:“創薬のための細胞利用技術の最新動向と市場”,第 1 章 利用できる細胞の種類,細胞ソース,第1節 in vitro実験の重要性と培養細胞の選択方法,(株)シーエムシー・リサーチ,pp.3-6(2018)
  • 小島肇:“創薬のための細胞利用技術の最新動向と市場”,第 1 章 3 次元皮膚モデルにおける評価モデルの作製と評価,第1節  3次元皮膚モデル作製のノウハウ,皮膚の安全性・有用性評価法,(株)シーエムシー・リサーチ,pp.211-214(2018)
  • Kojima H, Ikarashi Y, Nakada T, Yagami A, Sugibayashi K, Todo H, Hoshino Y, Iizuka N, Nakamura T, Sekizawa S, Shinoda K, Yagi M, Araki D, Sakaguchi H, Sasa H, Sugiyama M: “Alternatives to Animal Testing”,Guidance on the Use of Alternative Test Methods for the Safety Assessment of Cosmetics and Quasi-Drugs, Springer, Singapore, pp.63-68(2019)
  • 山田隆志:“皮膚の安全性・有用性評価法”,第 4 章 皮膚の安全性・毒性評価におけるインシリコの活用,第3節 OECDにおけるQSAR,AOPの開発状況,(株)技術情報協会,東京,pp.151-157(2018)

2017年度

  • Kojima H, Katoh M: “Alternatives for dermal toxicitytesting”, Part I: Skin irritation, 5: In vitro skinirritation assay with the LabCyte EPI-MODEL, Editors: Eskes C, Vliet E, Maibach M, Springer, Switzerland, pp.73-80 (2017)
  • Kojima H, Hosoi K, Onoue S: “Alternatives for dermal toxicity testing”, Part IV: UV-induced effects(phototoxicity and photoallergy), 34: Reactive oxygen species assay for evaluating phototoxicity potential, Editors: Eskes C, Vliet E, Maibach M, Springer, Switzerland, pp.477-482 (2017)
  • Kojima H: “Skin permeation and disposition of therapeutic and cosmeceutical compounds”, Part V: Selection of topically applied chemical candidates, 26: In vitro evaluation for skin toxicity, Editor: Sugibayashi K, Springer, Japan, pp.297-304(2017)
  • Kojima H: “Skin permeation and disposition of therapeutic and cosmeceutical compounds”, Part V: Selection of topically applied chemical candidates, 27: Related Topics: Safety Evaluation and Alternatives to Animal Testing for Skin Toxicity, Editor: Sugibayashi K, Springer, Japan, pp.305-311(2017)
  • 小島 肇:“トキシコロジー(第3版)”, 6 .標的臓器と毒性発現,6.10皮膚・粘膜毒性,日本毒性学会教育委員会編,(株)朝倉書店,東京,pp.279-286(2018)
  • 小島 肇:“トキシコロジー(第3版)”,8 .動物実験代替法,日本毒性学会教育委員会編,(株)朝倉書店,東京,pp.320-325(2018)
  • 広瀬明彦:“トキシコロジー(第 3 版)”,4.6 ナノマテリアル,日本毒性学会教育委員会編,(株)朝倉書店,東京,pp.107-112(2018)
  • 広瀬明彦:“ICH Q 3 D元素不純物/Q 3 C残留溶媒の許容限度値/試験法設定と適切な管理手法”,第 2 章ICH Q 3 Dにおける毒性評価の考え方と許容限度値の設定,サイエンス&テクノロジー,pp.21-29(2017)

2016年度

  • 小島肇:“機能性化粧品素材-素材開発と安全性-”,第2章 化粧品開発に関わる安全性評価,医薬部外品申請における安全性評価方針,正木仁監修,(株)シーエムシー出版,東京,pp.62-9(2016)
  • 小島肇:“有用性化粧品の処方とその活用(普及版)”,第14章 総合評価の方法,鈴木正人監修,(株)シーエムシー出版,東京,pp.147-51(2016)
  • Kojima H: “Validation of Alternative Methods for Toxicity Testing”, Advances in Experimental Medicine and Biology 856, Chapter 14: International Harmonization and Cooperation in the Validation of Alternative Methods, Editors: Chantra Eskes, Maurice Whelan, Springer, Netherland, pp.343-86(2016)
  • Kojima H: “Cosmetic Science and Technology: Theoretical Principles and Applications”, Chapter 51: Safety Assessment of Cosmetic Ingredients, Editors: Kazutami Sakamoto, Robert Lochhead, Howard Maibach, Yuji Yamashita, Elsevier. Netherland, pp.793-803(2017)

2015年度

  •  小島肇:“経皮吸収型製剤開発における基礎と実務への応用”,第4章 経費吸収の測定・評価および安全性試験,第1節 動物愛護管理法と日臨床試験,杉林堅次監修,(株)情報機構,東京,pp.71-83(2015)