This experimental animal facility has approved by the Health Science Center for Accreditation of Laboratory Animal Care, Japan as a facility corresponding to various animal experiments used for testing and research to ensure the safety and effectiveness of various substances such as chemicals, foods, and medicines. Experimental animals are maintained in environmentally controlled specific-pathogen-free (SPF) rooms. Also, there are equipped high-fidelity inhalation system, chemical safety rooms, and biological safety rooms. All the experimental protocols are reviewed and approved based on the related laws by the Interdisciplinary Monitoring Committee for Proper Animal Use and Welfare of Experimental Animals, a peer review panel established at NIHS.