Publications

Original papers (Excerpt from the Annual Report of NIHS Vol 137, 2019)

• Yokota S, Oshio S: A simple and robust quantitative analysis of retinol and retinyl palmitate using a liquid chromatographic isocratic method. J Food Drug Anal. 2018;26(2):504-11.
• Nomura Y, Ikuta S, Yokota S, Mita J, Oikawa M, Matsushima H, Amano A, Shimonomura K, Seya Y, Koike C: Evaluation of critical flicker-fusion frequency measurement methods using a touchscreen-based visual temporal discrimination task in the behaving mouse.
  Neurosci Res. 2018 Dec 5; pii: S0168-0102(18)30388-2.
• Yokota S, Shirahata T, Yusa J, Sakurai Y, Ito H, Oshio S: Long-term dietary intake of excessive vitamin A impairs spermatogenesis in mice. J Toxicol Sci. 2019;44(4):257-71.
• Ono R, Yasuhiko Y, Aisaki KI, Kitajima S, Kanno J, Hirabayashi Y: Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing.
  Communications Biology. 2019 Feb 8;2:57.
• Tanabe S, Ono R. The gene and microRNA networks of stem cells and reprogramming, AIMS Cell and Tissue Engineering. 2018;2(4): 238-245
• Mishima M, Hoffmann D, Ichihara G, Kitajima S., Shibutani M, Furukawa S, Hirose A: Derivation of acceptable daily exposure value for alanine, N,N-bis (carboxymethyl)-, trisodium salt.
  Fund Toxicol Sci. 2018;5:167-170.
• Tsuboi I, Harada T, Hirabayashi Y and Aizawa S: Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.
  Haematologica. 2019 doi: 10.3324/haematol.2018.209551. ［Epub ahead of print］
• Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S: Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats.
  Arch Toxicol. 2019 Feb 13;909-920.
• Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S: Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats.
  Arch Toxicol. 2019 Feb 13;909-920.
• Shigemoto-Mogami Y, Hoshikawa K, Sato K: Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
  Front Cell Neurosci 2018;12:494
• Yamazaki D, Kitaguchi T, Ishimura M, Taniguchi T, Yamanishi A, Saji D, Takahashi E, Oguchi M, Moriyama Y, Maeda S, Miyamoto K, Morimura K, Ohnaka H, Tashibu H, Sekino Y, Miyamoto N, Kanda Y: Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes.
  J Pharmacol Sci. 2018;136:249-256.
• Kobayashi H, Misawa T, Oba M, Hirata N, Kanda Y, Tanaka M, Matsuno K, Demizu Y: Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives.
  Chemical and Pharmaceutical Bulletin. 2018; 66: 575-580.
• Yamada S, Yamazaki D, Kanda Y: 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells.
  The Journal of Toxicological Sciences. 2018;43:727-734.
• Yamada S, Kubo Y, Yamazaki D, Sekino Y, Nomura Y, Yoshida S, Kanda Y: Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells.
  Sci Rep. 2018;8:12155.
• Yamada S, Yamazaki D, Kanda Y: Silver nanoparticles inhibit neural induction in human induced pluripotent stem cells.
  Nanotoxicology. 2018;12:836-846.
• Watari R, Kakiki M, Oshikata A, Takezawa T, Yamasaki C, Ishida Y, Tateno C, Kuroda Y, Ishida S, Kusano K: A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers.
  J Toxicol Sci. 2018;43:521-529.
• Horiuchi S, Kuroda Y, Fujii R, Kim SR, Ishida S: Deactivation of Hepatic Stellate Cells by Culturing on VECELL Inserts.
  AATEX. 2018;23:53-62.
• Inamura K, Komizu Y, Yamakuchi M Ishida S, Matsumoto Y, Matsushita T: Inhibitory effect of hybrid liposomes on the growth of liver cancer stem cells.
  Biochem Biophys Res Commun. 2019;509:268-274.
• Watari R, Kakiki M, Yamasaki C, Ishida Y, Tateno, Kuroda Y, Ishida S, Kusano K: Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and fresh hepatocytes isolated from liver humanized mice.
  Biol. Pharm. Bull. 2019;42:348-53
• Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G＊17: International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment.
  Cell Rep. 2018;24:3582-3592.
• Izumi-Nakaseko H, Hagiwara-Nagasawa M, Naito AT, Goto A, Chiba K, Sekino Y, Kanda Y, Sugiyama A: Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
  J Pharmacol Sci. 2018;137:372-380.
• Toyoda T, Matsushita K, Morikawa T, Yamada T, Miyoshi N, Ogawa K: Distinct differences in the mechanisms of mucosal damage and γ-H2AX formation in the rat urinary bladder treated with o-toluidine and o-anisidine.
  Arch Toxicol. 2019;93:753-62.
• Akagi J, Cho YM, Mizuta Y, Toyoda T, Ogawa K: Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats.
  Food Chem Toxicol. 2018;122:80-6.
• Yang Q, Yasuda T, Choi E, Toyoda T, Roland JT, Uchida E, Yoshida H, Seto Y, Goldenring JR, Nomura S: MEK inhibitor reverses metaplasia and allows re-emergence of normal lineages in Helicobacter pylori-infected gerbils.
  Gastroenterology. 2019;156:577-81.
• Toyoda T, Totsuka Y, Matsushita K, Morikawa T, Miyoshi N, Wakabayashi K, Ogawa K: γ-H2AX formation in the urinary bladder of rats treated with two norharman derivatives obtained from o-toluidine and aniline.
  J Appl Toxicol. 2018;38:537-43.
• Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S: Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure.
  J Invest Dermatol. 2018;138:2550-7.
• Funahashi S, Okazaki Y, Nagai H, Chew SH, Ogawa K, Toyoda T, Cho YM, Toyokuni S: Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.
  J Toxicol Pathol. 2019;32:19-26.
• Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T: Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin.
  J Toxicol Pathol. 2018;31:179-88.
• Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T: Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2 -deficient gpt delta mice.
  J Toxicol Pathol. 2018;31:169-78.
• Hirata T, Cho YM, Suzuki I, Toyoda T, Akagi J, Nakamura Y Numasawa S, Ogawa K: 4-Methylthio-3-butenyl isothiocyanate (MTBITC) induced apoptotic cell death and G2/M cell cycle arrest via ROS production in human esophageal epithelial cancer cells.
  J Toxicol Sci. 2019;44:73-81.
• Toyoda T, Cho YM, Akagi J, Mizuta Y, Matsushita K, Nishikawa A, Imaida K, Ogawa K: A 13-week subchronic toxicity study of acetaminophen using an obese rat model.
  J Toxicol Sci. 2018;43:423-33.
• Akagi J, Cho YM, Mizuta Y, Tatebe C, Sato K, Ogawa K: Subchronic toxicity evaluation of isoeugenyl methyl ether in F344/DuCrj rats by 13-week oral administration.
  Regul Toxicol Pharmacol. 2019;102:34-39.
• Matsushita K, Toyoda T, Morikawa T, Takahashi M, Inoue K, Ogawa K: A 13-week subchronic toxicity study of 2-ethylbutanal in F344 rats.
  Regul Toxicol Pharmacol. 2018;100:118-26.
• Takasu S, Yokoo Y, Ishii Y, Kijima A, Ogawa K, Umemura T: Molecular pathological differences in global gene expression between two sustained proliferative lesions, nodular regenerative hepatocellular hyperplasia and hepatocellular adenoma, in mice.
  Toxicol Pathol. 2019;47:44-52.
• Matsushita K, Takasu S, Kuroda K, Ishii Y, Kijima A, Ogawa K, Umemura T: Mechanisms underlying exacerbation of osmotic nephrosis caused by pre-existing kidney injury.
  Toxicol Sci. 2018;165:420-30.
• Ambe K, Ishihara K, Ochibe T, Ohya K, Tamura S, Inoue K, Yoshida M, Tohkin M: In silico prediction of chemical-induced hepatocellular hypertrophy using molecular descriptors.
  Toxicol Sci. 2018;162:667-75.
• Gi M, Fujioka M, Kakehashi A, Okuno T, Masumura K, Nohmi T, Matsumoto M, Omori M, Wanibuchi H, Fukushima S: In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats.
  Arch Toxicol 2018; 92:3207-3221.
• Kato M, Sugiyama K, Fukushima T, Miura Y, Awogi T, Hikosaka S, Kawakami K, Nakajima M, Nakamura M, Sui H, Watanabe K, Hakura A: Negative and positive control ranges in the bacterial reverse mutation test: JEMS/BMS collaborative study.
  Genes Environ. 2018; 40:1-13.
• You X, Ando T, Xi J, Cao Y, Liu W, Zhang X, Honma M, Masumura K, Luan Y: Gene mutation and micronucleus assays in gpt delta mice treated with 2,2’,4,4’-tetrabromodiphenyl ether.
  Mutagenesis. 2018; 33:153-160.
• Suzuki T, Matsumoto K, Honma M, Nohmi T: Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens.
  Mutat Res. 2018; 828:10-14.
• Grúz P, Shimizu M, Yamada M, Sugiyama K, Honma M: Opposing roles of Y-family DNA polymerases in lipid peroxide mutagenesis at the hisG46 target in the Ames test.
  Mutat Res. 2018; 829-830:43-49
• Myatt GJ, Ahlberg E, Akahori Y, Allen D, Amberg A, Anger LT, Aptula A, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Burden N, Cammerer Z, Cronin MTD, Cross KP, Custer L, Dettwiler M, Dobo K, Ford KA, Fortin MC, Gad-McDonald SE, Gellatly N, Gervais V, Glover KP, Glowienke S, Van Gompel J, Gutsell S, Hardy B, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Hughes K, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kim MT, Kruhlak NL, Kulkarni SA, Kummerer K, Leavitt P, Majer B, Masten S, Miller S, Moser J, Mumtaz M, Muster W, Neilson L, Oprea TI, Patlewicz G, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Ruiz P, Schilter B, Serafimova R, Simpson W, Stavitskaya L, Stidl R, Suarez-Rodriguez D, Szabo DT, Teasdale A, Trejo-Martin A, Valentin JP, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Hasselgren C. : In silico toxicology protocols.
  Regul Toxicol Pharmacol. 2018; 96:1-17.
• Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S: Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.
  Environ Mol Mutagen. 2018; 59:529-538.
• Benfenati E, Golbamaki A, Raitano G, Roncaglioni A, Manganelli S, Lemke F, Norinder U, Lo Piparo E, Honma M, Manganaro A, Gini G: A large comparison of integrated SAR/QSAR models of the Ames test for mutagenicity.
  SAR QSAR Environ Res. 2018; 29:591-611.
• Kohara A, Matsumoto M, Hirose A, Hayashi M, Honma M, Suzuki T: Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays.
  Genes Environ. 2018; 40:18.
• Yamada M, Honma M: Summarized data of genotoxicity tests for designated food additives in Japan.
  Genes Environ. 2018; 40:27.
• Yatagai F, Honma M, Dohmae N, Ishioka N: Biological effects of space environmental factors: A possible interaction between space radiation and microgravity.
  Life Sci Space Res. 2019; 20:113-123.
• Honma M, Kitazawa A, Cayley A, Williams RV, Barber C, Hanser T, Saiakhov R, Chakravarti S, Myatt GJ, Cross KP, Benfenati E, Raitano G, Mekenyan O, Petkov P, Bossa C, Benigni R, Battistelli CL, Giuliani A, Tcheremenskaia O, DeMeo C, Norinder U, Koga H, Jose C, Jeliazkova N, Kochev N, Paskaleva V, Yang C, Daga PR, Clark RD, Rathman J: Improvement of quantitative structure-activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project.
  Mutagenesis. 2019; 34:3-16.
• Fukuchi J, Kitazawa A, Hirabayashi K, Honma M: A practice of expert review by read-across using QSAR Toolbox.
  Mutagenesis. 2019; 34:49-54.
• Amberg A, Anger LT, Bercu J, Bower D, Cross KP, Custer L, Harvey JS, Hasselgren C, Honma M, Johnson C, Jolly R, Kenyon MO, Kruhlak NL, Leavitt P, Quigley DP, Miller S, Snodin D, Stavitskaya L, Teasdale A, Trejo-Martin A, White AT, Wichard J, Myatt GJ.: Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?
  Mutagenesis. 2019; 34:67-82.
• Petkov PI, Schultz TW, Honma M, Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data.
  Mutagenesis. 2019; 34:83-90.
• Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: comparison of three (Q)SAR models.
  Mutagenesis. 2019; 34:91-100.
• Tennant RE, Guesné SJ, Canipa S, Cayley A, Drewe WC, Honma M, Masumura K, Morita T, Stalford SA, Williams RV: Extrapolation of in vitro structural alerts for mutagenicity to the in vivo endpoint.
  Mutagenesis. 2019; 34:111-121.
• Aoki Y, Nakajima D, Matsumoto M, Yagishita M, Matsumoto M, Yanagisawa R, Goto S, Masumura K, Nohmi T: Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area.
  Genes Environ. 2018; 40:25.
• Hori H, Shimoyoshi S, Tanaka Y, Momonami A, Masumura K, Yamada M, Fujii W, Kitagawa Y: Integration of micronucleus tests with a gene mutation assay in F344 gpt delta transgenic rats using benzo [a]pyrene.
  Mutat Res. 2019; 837:1-7.
• Aoki Y, Matsumoto M, Matsumoto M, Masumura K, Nohmi T: Mutant frequency is not increased in mice orally exposed to sodium dichromate.
  Food Safety. 2019; 7:2-10.
• Amberg A, Andaya RV, Anger LT, Barber C, Beilke L, Bercu J, Bower D, Brigo A, Cammerer Z, Cross KP, Custer L, Dobo K, Gerets H, Gervais V, Glowienke S, Gomez S, Van Gompel J, Harvey J, Hasselgren C, Honma M, Johnson C, Jolly R, Kemper R, Kenyon M, Kruhlak N, Leavitt P, Miller S, Muster W, Naven R, Nicolette J, Parenty A, Powley M, Quigley DP, Reddy MV, Sasaki JC, Stavitskaya L, Teasdale A, Trejo-Martin A, Weiner S, Welch DS, White A, Wichard J, Woolley D, Myatt GJ. 6: Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses.
  Regul Toxicol Pharmacol. 2019; 102:53-64.
• Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine. 2018;3:1-15
• Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular network pathway of ERBB in diffuse-type gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition.
  Journal of Clinical Epigenetics. 2018;4:2:13
• Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells.
  AIMS Cell and Tissue Engineering. 2018;2:58-77
• Igarashi T, Serizawa H, Kobayashi K, Suzuki H, Matsumoto M, Iso T, Kawamura T, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats.
  Regul Toxicol Pharmacol. 2018;96:64-75
• Igarashi T, Takashima H, Takabe M, Suzuki H, Ushida K, Kawamura T, Matsumoto M, Iso T, Tanabe S, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats．
  Regul. Toxicol. Pharmacol. 2018;100:105-117
• Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K: Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues.
  Bioorg. Med. Chem. 2019;27(8);1720–1727
• Fujita M, Yamamoto Y, Watanabe S, Sugawara T , Wakabayashi K , Tahara Y , Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Kojima H, Ono A, Katsuoka Y, Tanabe H, Yokoyama H, Kasahara T: Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay.
  J. Appl. Toxicol. 2019 Feb;39(2):191-208
• Kimura Y, Watanabe M, Suzuki N, Iwaki T, Yamakage K, Saito K, Nakajima Y, Fujimura C, Ohmiya Y, Omori T, Kojima H, Aiba S: The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA).
  J. Toxicol. Sci. 2018;43(12):741-749
• Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T: Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates.
  Biopharm Drug Dispos. 2018; Apr;39 (4):187-195
• Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, Régimbald-Krnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N: International regulatory requirements for skin sensitization testing.
  Regul. Toxicol. Pharmacol. 2018 Jun;95:52-65
• Narita K, Ishii Y, Vo PTH, Nakagawa F, Ogata S, Yamashita K, Kojima H, Itagaki H: Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results.
  J Toxicol Sci. 2018;43(3):229-240
• Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H: Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells.
  J. Toxicol. Sci. 2019;44(3):213-224
• Hoffmann S, Kleinstreuer N, Alepee N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kuhnl J, Lalko JF, Martinozzi-Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D: Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database.
  Crit Rev Toxicol.48(5):344-358.
• Kleinstreuer NC, Hoffmann S, Alepee N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Gobel C, Kern PS, Klaric M, Kuhnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E, Zang Q, Petersohn D: Non-animal methods to predict skin sensitization (II): an assessment of defined approaches.
  Crit Rev Toxicol.48(5):359-374.
• Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: Comparison of three (Q)SAR models.
  Mutagenesis. 2019;34:91-100
• Yamada T, Tanaka Y, Hasegawa R, Igarashi T, Hirose A: Male-specific prolongation of prothombin time by industrial chemicals.
  Fundam. Toxicol. Sci. 2018;5:75-82
• Petkov PI, Schultz TW, Honma M. Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data.
  Mutagenesis. 2019;34:83-90

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