誌上発表 戻る
平成20年度
Aso, Y.,
Yoshioka, S., Miyazaki, T., Kawanishi, T.: Feasibility of 19F-NMR
for assessing the molecular mobility of flufenamic acid in solid dispersions.
Chem. Pharm. Bull., 57, 61-64 (2009).
Miyazaki T., Sivaprakasam K., Tantry J., Suryanarayanan R.:
Physical characterization of dibasic calcium phosphate dihydrate and
anhydrate.
J. Pharm. Sci., 98, 905-916 (2009).
Yoshioka, S., Aso, Y., Kawanishi, T.:
Wide-Ranging Molecular Mobilities of Water in Active Pharmaceutical Ingredient
(API) Hydrates as Determined by NMR Relaxation Times.
J. Pharm. Sci., 97, 4258-4268
(2008).
平成19年度
Aso, Y., Yoshioka, S.: Correlation between molecular mobility and chemical stability during storage of amorphous pharmaceuticals.
J. Pharm. Sci., 96, 960-981 (2007).
Aso, Y., Yoshioka, S., Miyazaki, T.,
Kawanishi, T., Tanaka, K., Kitamura, S., Takakura, A., Hayashi, T., Muranushi,
N.: Miscibility of nifedipine and hydrophilic polymers as measured by 1H-NMR
spin-lattice relaxation.
Chem. Pharm. Bull., 55, 1227-1231 (2007).
Maitani, Y.*, Aso, Y., Yamada, A.*,
Yoshioka, S.: Effect of sugars on storage stability of lyophilized liposome/DNA
complexes with high transfection efficiency.
Int. J. Pharm., 356, 69-75 (2008).
平成18年度
Yoshioka, S., Miyazaki, T., Aso, Y.,
Kawanishi, T.: Significance of local mobility in aggregation of b-galactosidase
lyophilized with trehalose, sucrose or stachyose.
Pharm. Res, 24,
0724-0741 (2007)
Yoshioka, S., Miyazaki, T., Aso, Y.: Degradation
Rate of Lyophilized Insulin, Exhibiting an Apparent Arrhenius Behavior around
Glass Transition Temperature Regardless of Significant Contribution of
Molecular Mobility
J. Pharm. Sci., 95, 2684-2691 (2006).
Yoshioka, S., Miyazaki, T., Aso, Y.: b-relaxation of
insulin molecule in lyophilized formulations containing trehalose or dextran as
a determinant of chemical reactivity
Pharm. Res, 23, 961-966 (2006).
Miyazaki, T., Yoshioka, S., Aso, Y. :
Physical Stability of amorphous acetanilide derivatives imporoved by polymer
excipients
Chem. Pharm. Bull., 54, 1207-1210 (2006).
平成17年度
Aso, Y., Yoshioka, S.: Molecular Mobility of Nifedipine-PVP and Phenobarbital-PVP Solid Dispersions as Measured by 13C-NMR Spin-Lattice Relaxation Time.
J.Pharm. Sci., 95, 318-325 (2006)
S.Yoshioka, Y.Aso, T. Miyazaki, Negligible contribution of molecular mobility to the degradation rate of insulin lyophilized with poly(vinylpyrrolidone).
J. Pharm. Sci., 95: 939-943 (2006).
S.Yoshioka, Y.Aso, Comparison of the glass transition temperature and fragility parameter of isomalto-olygomer predicted by molecular dynamics simulations with those measured by differential scanning calorimetry.
Chem. Pharm. Bull. 53:1443-1445 (2005).
S.Yoshioka, Y.Aso, A quantitative assessment of the significance of molecular mobility as a determinant for the stability of lyophilized insulin formulations.
Pharm. Res. 22: 1358-1364 (2005).
平成16年度
S.Yoshioka, Y.Aso, Glass transition-Related Changes in Molecular Mobility below Glass Transition Temperature of Freeze-dried Formulations, as Measured by Dielectric Spectroscopy and Solid State NMR. J.Pharm. Sci., 94:275-287 (2005).
Aso, Y. and Yoshioka, S.: Effect of
Freezing Rate on Physical Stability of Lyophilized Cationic Liposomes
Chem. Pharm. Bull., 53, 301-304 (2005).
Miyazaki, T, Yoshikao, S., Aso, Y., Kojima, S.: Ability of polyvinylpyrrolidone and polyacrylic acid to inhibit the crystallization of amorphous acetaminophen.
J. Pharm. Sci. 93, 2710-2717 (2004).
平成15年度
Yoshioka, S., Aso, Y., Kojima, S.: Temperature- and glass transition temperature-dependence of biomolecular reaction rates in lyophilized formulations described by Adam-Gibbs-Vogel equation
J.Pharm. Sci., 93, 1062-1069 (2004)