平成14年度以前の誌上発表

　

平成14年度

Yoshioka, S., Aso, Y. and Kojima S.: "Different molecular motions in lyophilized protein formulations as determined by laboratory and rotating frame spin-lattice relaxation times."

J. Pharm. Sci., 91, 2203-2210 (2002)

　

Yoshioka, S., Aso, Y., Kojima, S. and Cappuccino N. F.  : A comparison of the analysis of covariance (AMCOVA) and range-based approaches for assessing batch-to-batch variability of the stability of pharmaceutical products.

　

阿曽幸男、吉岡澄江、小嶋茂雄：凍結乾燥製剤の安定性に及ぼす水の影響

低温生物工学会誌　48、42-46　(2002)

　

Aso,Y., Yoshioka,S., Zhang, J. and Zografi, G. : Effect of water on the molecular mobility of sucrose and poly(vinylpyrrolidone) in a colyophilized formulation as measured by ¹³C–NMR relaxation time.

Chem.Pharm.Bull., 50,　822-826 (2002)

　

平成13年度

Yoshioka, S., Aso, Y. and Kojima, S.:"Usefulness of Kohlraush-Williams-Watts Stretched Exponential Function to Describe Protein Aggregation in Lyophilized Formulations and Temperature Dependence Near the Glass Transition Temperature."

Pharm. Res., 18, 256-260 (2001)

　

Aso, Y., Yoshioka S. and Kojima S.:"Explanation of the Crystallization Rate of Amorphous Nifedipine and Phenobarbital from Their Molecular Mobility as Measured by ¹³C NMR Relaxation Time and the Relaxation Time Obtained from the Heating Rate Dependence of T_g."

J. Pharm. Sci., 90, 798-806 (2001)

　

Aso, Y., Yoshioka, S. and Kojima, S.:"Feasibility of Using Isothermal Microcalorimetry to Evaluate the Physical Stability of Amorphous Nifedipine and Phenobarbital."

Thermochimica Acta, 380, 199-204 (2001).

　

平成12年度

Aso, Y., Yoshioka S. and Kojima S.:"Relationship between the Crystallization Rates of Amorphous Nifedipine, Phenobarbital and Flopropione, and their Molecular Mobility as Measured by their Enthalpy Relaxation and ¹H-NMR Relaxation Times."
J. Pharm. Sci. 89 (3), 408-416 (2000).

Effect of polymer excipient on the enzyme activity of lyophilized bilirubin oxidase and b-galactosidase formulation.
Chem. Pharm. Bull. 48, 283-285 (2000).

Izutsu, K., Kojima, S.: Freeze-concentration separates proteins and polymer excipients into different amorphous phase.
Pharm. Res., 17, 1316-1322 (2000).

伊豆津健一、小嶋茂雄：凍結濃縮による生体高分子の相分離と共存分子の影響
低温生物工学会誌 46,91-94 (2000).

Yoshioka, S., Aso, Y. and Kojima, S.: Temperature dependence of bimolecular reactions associated with molecular mobility in lyophilized formulation.

Pharm. Res., 17, 925-929 (2000).