Publications

2019

  • Jojima K, Yamada T, Hirose A: Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events. Fundamental Toxicological Sciences. 2019;6:327-332
  • Yamada T, Matsumoto M, Miura M, Hirose A: Case study on the use of integrated approaches to testing and assessment for testicular toxicity of ethylene glycol methyl ether (EGME)-related chemicals.OECD, Series on Testing & Assessment. 2019;308:1-75
  • Patlewicz G, Lizarraga LE, Rua D, Allen DG, Daniel AB, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus A, Matheson J, Mumtaz M, Richarz A, Ruiz P, Scarano L, Yamada T, Kleinstreuer N: Exploring current read-across applications and needs among selected U.S. Federal Agencies. Regulatory Toxicology and Pharmacology. 2019;106:197-209
  • Matsumoto M, Hirata-Koizumi M, Kawamura T, Sakuratani S, Ono A, Hirose A: Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies. Fundamental Toxicological Sciences. 2019;6:125-136
  • Igarashi T, Suzuki H, Ushida K, Matsumoto M, Inoue K, Kanno T, Miwa Y, Ishii T, Nagase T, Katsumata Y, Hirose A: Initial hazard assessment of 1,4-dichlorobutane: genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2020;112:104610, doi:10.1016/j.yrtph.2020.104610
  • Kobayashi-Tsukumo H, Oiji K, Xie D, Sawada Y, Yamashita K, Ogata S, Kojima H, Itagaki H: Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT). J Toxicol Sci. 2019;44:283-297
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
  • Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa T: Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing. Altern Lab Anim. 2019;47:140-157
  • Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C, Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M, Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D, Inoue T, Rogen EL, Kojima H, Aiba S: An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals. Toxicol In Vitro. 2020;66:104832, doi: 10.1016/j.tiv.2020.104832
  • Akimoto M, Yamamoto Y, Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay. J Appl Toxicol. 2020;40:843-854

2018

  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine. 2018;3:1- 15
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular network pathway of ERBB in diffusetype gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition. Journal of Clinical Epigenetics. 2018;4:2:13
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells. AIMS Cell and Tissue Engineering. 2018;2:58-77
  • Igarashi T, Serizawa H, Kobayashi K, Suzuki H, Matsumoto M, Iso T, Kawamura T, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeateddose toxicity study in rats. Regul Toxicol Pharmacol. 2018;96:64-75
  • Igarashi T, Takashima H, Takabe M, Suzuki H, Ushida K, Kawamura T, Matsumoto M, Iso T, Tanabe S, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats. Regul. Toxicol. Pharmacol. 2018;100:105-117
  • Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K: Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues. Bioorg. Med. Chem. 2019;27(8);1720–1727
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Kojima H, Ono A, Katsuoka Y, Tanabe H, Yokoyama H, Kasahara T: Cause of and countermeasures for oxidation of the cysteinederived reagent used in the amino acid derivative reactivity assay. J. Appl. Toxicol. 2019;39(2):191-208
  • Kimura Y, Watanabe M, Suzuki N, Iwaki T, Yamakage K, Saito K, Nakajima Y, Fujimura C, Ohmiya Y, Omori T, Kojima H, Aiba S: The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA). J. Toxicol. Sci. 2018;43(12):741-749
  • Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T: Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018; 39(4):187-195
  • Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V: Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol. 2018;92(2):611-617.
  • Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, RégimbaldKrnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N: International regulatory requirements for skin sensitization testing. Regul. Toxicol. Pharmacol. 2018;95:52-65
  • Narita K, Ishii Y, Vo PTH, Nakagawa F, Ogata S, Yamashita K, Kojima H, Itagaki H: Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results. J Toxicol Sci. 2018;43(3):229-240
  • Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H: Some nonsensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J. Toxicol. Sci. 2019;44(3):213-224
  • Hoffmann S, Kleinstreuer N, Alépée N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization (I): the Cosmetics Europe database. Crit. Rev. Toxicol. 2018;48(5):344-358
  • Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E , Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization (II): an assessment of defined approaches. Crit. Rev. Toxicol. 2018;48(5):359-374
  • Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: Comparison of three (Q)SAR models. Mutagenesis. 2019;34:91-100
  • Yamada T, Tanaka Y, Hasegawa R, Igarashi T, Hirose A: Male-specific prolongation of prothombin time by industrial chemicals. Fundam. Toxicol. Sci. 2018;5:75-82
  • Petkov PI, Schultz TW, Honma M. Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data. Mutagenesis. 2019;34:83-90

2017

  • Horibe A, Odashima S, Hamasuna N, Morita T, Hayashi M: Weight of contribution of in vitro chromosomal aberration assay for evaluation of pesticides: Experience of risk assessment at the Food Safety Commission of Japan. Regul Toxicol Pharmacol. 2018:95:133-41
  • Tsukumo H , Matsunari N , Yamashita K , Kojima H, Itagaki H: Lipopolysaccharide interferes with the use of the human Cell Line Activation Test to determine the allergic potential of proteins. J Pharmacol Toxicol Methods. 2018; 92:34-42.
  • Matsumoto M, Furukawa M, Kobayashi K, Iso T, Igarashi T, Yamada T, Hirose A: A 28-day repeated oral-dose toxicity study of insecticide synergist N- (2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2.2.2]oct5-ene-2,3-dicarboximide in rats. Fundam Toxicol Sci. 2018;5:1-11
  • Narita K, Vo PTH, Yamamoto K, Kojima H, Itagaki H: Preventing false-negatives in the in vitro skin sensitization testing of acid anhydrides using interleukin-8 release assays. Toxicol In Vitro. 2017;Aug 42:69-75.
  • Akagi T, Nagura M, Hiura A, Kojima H, Akashi M: Construction of Three-Dimensional Dermo-Epidermal Skin Equivalents Using Cell Coating Technology and Their Utilization as Alternative Skin for Permeation Studies and Skin Irritation Tests. Tissue Eng Part A. 2017; 23(11-12):481-490.
  • Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H: Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42(4):499-507
  • Arakawa H Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T: Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40(7):967-974
  • Tanabe S, Kobayashi K, Matsumoto M, Serizawa H, Igarashi T, Yamada T, Hirose A: Toxicity of repeated 28-day oral administration of acenaphthylene in rats. Fundam Toxicol Sci. 2017;4:247-259
  • Tanabe S, Ohara M, Ito M, Noda A, Kobayashi K, Matsumoto M, Hirose A: Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats.Fundam Toxicol Sci. 2017;4:207-218
  • Fukuhara K, Ohno A, Kikura-Hanajiri R: A metabolic study on the biochemical effects of chiral illegal drugs in rats using 1 H-NMR spectroscopy.Yakugaku Zasshi. 2017;137(9):1147-1154
  • Yamada T, Hirose A: Case study on the use of an integrated approach to testing and assessment for the repeated-dose toxicity of phenolic benzotriazoles, Organisation for Economic Co-operation and Development (OECD), Series on Testing & Assessment No. 271. 1-44, 2017.
  • Miyazaki H, Yamashita K, Uchino T, Takezawa T, Kojima H: Development of a Novel in Vitro Skin Sensitization Test Method using a Collagen Vitrigel Membrane Chamber, AATEX, 2017;22(2):141-154.

2016

  • Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H: Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells. 2016;8:384-95
  • Yamamoto N, Kato Y, Sato A, Hiramatsu N, Yamashita H, Ohkuma M, Miyachi E, Horiguchi M, Hirano K, Kojima H: Establishment of a new immortalized human corneal epithelial cell line(iHCE-NY1)for use in evaluating eye irritancy by in vitro test methods. In Vitro Cell Dev Biol Anim. 2016; 52(7):742-8
  • Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M: Evaluation o f the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogen. Mutation Research. 2016;802:1-29
  • Fujita Y, Morita T, Matsumura S, Kawamoto T, Itoh Y, Nishiyama N, Honda H: Comprehensive retrospective evaluation o f existing in vitro chromosomal aberration test data by cytotoxicity index transformation. Mutation Research. 2016;802:38-49
  • Morita T, Uneyama C: Genotoxicity assessment of 4-methylimidazole: Regulatory perspectives. Genes and Environment. 2016;38:20
  • Hirata-Koizumi M, Ise R, Kato H, Matsuyama T, Nishimaki-Mogami T, Takahashi M, Ono A, Ema M, Hirose A: Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α(PPARα) activity of an ultraviolet absorber, 2-(2’-hydroxy-3’,5’-di-tert-butylphenyl)benzotriazole, as possible mechanism of their toxicity and the gender differences. J Toxicol Sci. 2016;41:693-700
  • Matsumoto M, Todo H, Akiyama T, HirataKoizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K: Risk assessment of skin lightening cosmetics containing hydroquinone. Regul Toxicol Pharmacol. 2016;81:128-35
  • Uchino T, Kuroda Y, Ishida S, Yamashita K, Miyazaki H, Oshikata A, Shimizu K, Kojima H, Takezawa T, Akiyama T, Ikarashi Y: Increase of β2-integrin on adhesion of THP-1 cells to collagen vitrigel membrane, Biosci Biotechnol Biochem. 2016;4:1-6

2015

  • Kato H, Fujii S, Takahashi M, Matsumoto M, Hirata-Koizumi M, Ono A, Hirose A: Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats. Environ Toxicol. 2015;30:1235-43.
  • Morita T, Uno Y, Honma M, Kojima H, Hayashi M, Tice RC, Corvi R, Schechtman L: The JaCVAM International Validation Study on the in vivo Comet Assay: Selection of Test Chemicals. Mutat Res. 2015;786-788:14-44.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Burlinson B, Escobar P, Kraynak AR, Nakagawa Y, Nakajim M, Pant K, Asano N, Lovell D, Morita T, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutat Res. 2015;786-788:3-13.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Beevers C, Boeck MB, Burlinson B, Hobbs CH, Kitamoto S, Kraynakl AR, McNamee J, Nakagawa Y, Pant K, Plappert-Helbig U, Priestley C, Takasawa H, Wada K, Wirnitzer U, Asano N, Escobar P, Lovell D, Morita T, Nakajima M, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutat Res. 2015;786-788:45-76.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Recommended protocols for the liver micronucleus test: report of the IWGT working group. Mutat Res. 2015;783:13-8.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Micronucleus test in rodent tissues other than liver or erythrocytes: Report of the IWGT working group. Mutat Res. 2015;783:19-22.
  • MacGregor JT, Frötschl R, White PA3, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V, Johnson GE: IWGT Report on Quantitative Approaches to Genotoxicity Risk Assessment I. Methods and metrics for defining exposure-response  relationships  and  points  of departure (PoDs). Mutat Res. 2015;783:55-65.
  • MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Johnson GE,Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V: IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-ofdeparture (PoD) metrics in definingacceptable exposure limits and assessing human risk. Mutat Res. 2015;783:66-78
  • Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S1, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A*, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M: Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) ‒ Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2015;780-781:2-17.
  • Hirata-Koizumi M, Fujii S, Hina K, Matsumoto M, Takahashi M, Ono A, Hirose A:  Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl  carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid. Fundam Toxicol Sci. 2015;2:177-90
  • Ono A, Kobayashi K, Serizawa H, Kawamura T, Kato H, Matsumoto M, Takahashi M, Hirata-Koizumi M, Matsushima Y, Hirose A: A repeated dose 28-day oral toxicity study of b-bromostyrene in rats. Fundam Toxicol Sci. 2015;2:191‒200.
  • Okamura H, Abe H, Hasegawa-Baba Y, Saito K, Sekiya F, Hayashi S, Mirokuji Y, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T: The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1384-96.
  • Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokawa M, Watanabe W: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice. Environ. Toxicol Pharmacol. 2015;39:879-86.
  • Watanabe H, Tamura I, Abe R, Takanobu H, Nakamura A, Suzuki T, Hirose A, Nishimura T, Tatarazako N: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2015;35:996-1006.
  • Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G: A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure. Regul Toxicol Pharmacol. 2015;73:770-9
  • Yamaguchi H, Kojima H, Takezawa T: Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals. J Appl Toxicol. 2016;36(8):1025-37.
  • Kojima H: The use of 3-D models as alternatives to animal testing. Altern Lab Anim. 2015;43(4):P40-3.
  • Speit G, Kojima H, Burlinson B, Collins AR, Kasper P, Plappert-Helbig U, Uno Y, Vasquez M, Beevers C, De Boeck M, Escobar PA, Kitamoto S, Pant K Pfuhler S, Tanaka J, Levy DD: Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT). Mutat Res Genet Toxicol Environ Mutagen. 2015;783:6-12