薬理部 DIVISION OF PHARMACOLOGY

Effects of chemicals including medicines on central and peripheral nerve systems are investigated pharmacologically and physiologically. Research on drug metabolism and disposition is also conducted for appropriate use of those chemicals. This division engaged in establishment of various guidelines (e.g. drug metabolism and disposition, drug-drug interaction etc.), in evaluation of alternative methods and in domestic and international committees and conferences for regulation of a wide variety of chemicals.

The effects on the central nervous system
A: Ca2+ imaging system
B: Primary culture of dopamine neurons
C: Newborn cells in the cultured neonatal forebrain slice
D: Effects of niflumic acid on GLAST current

We investigate the effects of drugs and other chemicals on the function of the cardiovascular system at the molecular, cellular and pharmacological levels.

Non-freezed human hepatocytes which are used for drug metabolism study

The amount of an administered chemical and its metabolites in the blood, tissues, feces and urine collected from the experimental animals are determined, and its relationship to the toxicity is investigated.
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