DIVISION OF GENETICS AND MUTAGENESIS

Many chemical substances exist in our living environment, and the number is increasing every year. Some classes of chemical substances affect a gene causing cancers and hereditary diseases which are so-called "Genotoxic Chemicals".

The mission of Division of Genetics and Mutagenesis is to identify genotoxic chemicals, i.e., hazard identification, and evaluate the risk to humans, i.e., risk assessment, and remove or reduce them from our environment through administrative regulations, if necessary, thereby assuring the integrity of human genome. In addition, we have tried to provide an understanding for genomic instability associated with epigenetic changes.

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Prediction of genotoxicity by in silico / QSAR

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Analyses on chemical-induced genotoxicity and molecular mechanism of mutagenesis using microorganisms, etc.

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Gene mutation test (left, upper right) and micronucleus test (lower right) using cultured human cells

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Genotoxicity test and research using animals

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