Publications

2023

  • Iso T, Suzuki K, Murata Y, Hirose N, Umano T, Horibata K, Sugiyama KI, Hrose A, Masumura K, Matsumoto M: Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice. Genes Environ. 2024; 46: 7.
  • Abdallah A, Adel N, Elkerdawy AM, Tanabe S, Andres F, Pester A, Ali HH: Geom-SAC: Geometric multi-discrete soft actor critic with applications in de novo drug design. IEEE Access. 2024;12:45519-45529. doi: 10.1109/ACCESS.2024.3377289
  • Tanabe S, Boonstra E, Hong T, Quader S, Ono R, Cabral H, Aoyagi K, Yokozaki H, Perkins EJ, Sasaki H: Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes. 2023;14(11):2073. doi: 10.3390/genes14112073
  • Myden A, Stalford SA, Fowkes A, White E, Hirose A, Yamada T. Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion. Curr Res Toxicol. 2023 Sep 15:5:100124.
  • Yamazoe Y, Murayama N, Kawamura T, Yamada T. Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms. Genes Environ. 2023 Aug 7;45(1):22
  • Murata Y, Natsume M, Iso T, Shigeta Y, Hirose N, Umano T, Horibata K, Sugiyama K, Masumura K, Hirose A, Matsumoto M: In vivo mutagenicity assessment of styrene in MutaMouse liver and lung. Genes Environ. 2023; 45: 12.
  • Murata Y, Suzuki K, Shigeta Y, Iso T, Hirose N, Umano T, Horibata K, Sugiyama K, Hirose A, Masumura K, Matsumoto M: In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse. Genes Environ. 2023; 45: 29.
  • Matsumoto M, Murata Y, Hirose N, Shigeta Y, Iso T, Umano T, Hirose A. Derivation of subacute guidance values for chemical contaminants of drinking water quality standard in Japan. Regul Toxicol Pharmacol, 2023;141;105401
  • Kawashima A, Inoue K, Ushida K, Kai K, Suzuki H, Yoshida-Yamashita LS, Hirose A, Masumura K: Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japanese Chemical Substances Control Law. Fundam Toxicol Sci. 2023;10（3）:91-103.
  • Ashikaga T, Narita K, Kobayashi M, Tachibana S, Murasaki W, Suzuki M, Ambe K, Tohkin M: Skin Sensitization Potency Prediction of Ingredients in Hair Colorants Using in silico Models of Machine Learning, Journal of Japanese Cosmetic Science Society, 2023:47(1), 1–5.
  • Strickland J, Haugabrooks E, Allen DG, Balottin LB, Hirabayashi Y, Kleinstreuer NC, Kojima H, Nishizawa C, Prieto P, Ratzlaff DE, Jeong J, Lee J, Yang Y, Lin P, Sullivan K, Casey W: International regulatory uses of acute systemic toxicity data and integration of new approach methodologies, Crit Rev Toxicol. 2023;53(7):385-411. doi: 10.1080/10408444.2023.2240852.
  • Tanabe I, Yoshida K, Ishikawa S, Ishimori K, Hashizume T, Yoshimoto T, Ashikaga T: Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells, Altern Lab Anim. 2023:2611929231204823. doi: 10.1177/02611929231204823.
  • Mizumachi H,Watanabe M, Ikezumi M, Kajiwara M, Yasuda M, Mizuno M, Imai N, Sakuma M, Shibata M, Watanabe S, Motoyama J, Basketter D, Eskes C, Hoffmann S, Lehmann D, Ashikaga T, Sozu T, Takeyoshi M, Suzuki S, Miyazawa M, Kojima H: The inter-laboratory validation study of EpiSensA for predicting skin sensitization potential, J Appl Toxicol. 2023 Oct 28. doi: 10.1002/jat.4559.
  • Nishikawa A, Nagano K, Kojima H, Fukushima S, Ogawa K. Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway, J Toxicol Pathol. 2024;37(1):11-27. doi: 10.1293/tox.2023-0098
  • Aoi T, Asaka I, Akutsu H, Ito Y, Kataoka K, Kanda Y, Kojima H, Sekino Y, Suemori H, Nakagawa M, Nakamura K, Nakamura Y, Fujii M, Furue M, Yamazaki D, Japanese Working Group for Consideration of Good Cell Culture Practice: Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture, In Vitro Cellular & Developmental Biology – Animal. 12 March 2024. https://doi.org/10.1007/s11626-024-00863-w
  • Yamamoto N, Hiramatsu N, kato Y, Sato A, Kojima H, Development of an Eye Irritation Test Method Using anIn House Fabrication of a Reconstructed Human Cornea like Epithelium Model for Eye Hazard Identification, IBioengineering 2024;11(4):302. https://doi.org/10.3390/bioengineering11040302

2022

  • Murayama N, Yamada T, Yamazoe Y. Application of CYP1A2-Template system to understand metabolic processes in the safety assessment. Food Safety, 2022, 10, 129-139.
  • Sakai S, Tahara M, Kubota R, Kawakami T, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Volatile organic compounds. Sci Total Environ 2022;838:156400.
  • Kubota R, Obama T, Kawakami T, Sakai S, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Total content and migration of metals. Sci Total Environ 2022;842:156705.
  • Yamamoto Y, Fujita M, Watanabe S, Yamaga H, Wakabayashi K , Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within - and bet ween- laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay（ADRA） using a 0.5 mg/ml test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories. J Appl Toxicol 2022;42:1078-90.
  • Kawakami T, Sakai S, Obama T, Kubota R, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Rubber additives and related compounds. Sci Total Environ 2022;840:156716.
  • Nishi I, Kawakami T, Sakai S, Obama T, Kubota R, Inoue K, Ikarashi Y: Characterization of synthetic turf rubber granule infill in Japan: Polyaromatic hydrocarbons and related compounds. Sci Total Environ 2022;842:156684.
  • Sugaya N, Inoue K, Tahara M, Kawakami T: Analysis and risk assessment of vinyl chloride emitted from aerosol products. J Environ Sci Health Part A, 2023;58,284-94.
  • Isano Y, Fujita H, Murakami K, NiS, Kurotaki Y, Takano T, Isoda Y, Matsuda R, Nakamura F, Nishitai Y, Ochirkhuyag N., Inoue K, Kawakami H, Okubo Y, Ueno K, Fujie T, Ota H: Transparent and Breathable Ion Gel Based Sensors toward Multimodal Sensing Ability. Adv Mater Technol. 2022;7（11）:2200209.
  • Honma M, Yamada M, Yasui M, Horibata K, Sugiyama K, Masumura K: Genotoxicity assessment of food-flavoring chemicals used in Japan. Toxicol Rep. 2022;9 :1008-1012 .
  • Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Perkins EJ, Yokozaki H, Sasaki H: Regulation of Epithelial-Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction. Onco. 2023;3（1）:13-25.
  • Kawashima A, Inoue K, Ushida K, Kai K, Suzuki H, Matsumoto M, Masumura K, Hirose A: Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law. Fundam Toxicol Sci. 2022;9（4）:123-133.
  • Yamada T, Kawamura T, Tsujii S, Miura M, Ohata H, Katsutani K, Matsumoto M, Hirose A: Formation and evaluation of mechanism-based chemical categories for regulatory read-across assessment of repeated-dose toxicity: a case of hemolytic anemia. Regul Toxicol Pharmacol. 2022;136:105275.
  • Yamada T, Katsutani K, Maruyama T, Kawamura T, Yamazaki H, Murayama N, Tong W, Yamazoe Y, Hirose A: Combined risk assessment of food derived coumarin with in silico approaches. Food Safety. 2022;10:73-82.
  • Fujita M, Nakashima N, Wanibuchi S, Yamamoto Y, Kojima H, Ono A, Kasahara T: Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach. J Appl Toxicol. 2023;43（3）:446-457.
  • Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Yamamoto K, Sugiyama M, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Aizawa S, Nakagawa S, Hagino S, Hatao M: A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients. Curr Res Toxicol. 2022;4:100100.
  • Kimura Y, Yasuno R, Iwaki T, Fujimura C, Ohmiya Y, Nakajima Y, Omori T, Corsini E, Inoue T , Rogen EL , Kojima H, Aiba S: An international validation study of the interleukin-2 luciferase leukocyte toxicity test （IL-2 Luc LTT） to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay（ IL-2 Luc assay）. Toxicol In Vitro. 2023;88:105535.
  • Fukuhara K, Nakanishi I, Imai K, Mizuno M, Matsumoto K, Ohno A: DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe Coordination. Antioxidants（Basel）, 2023;12（2）:225.

2021

  • Fujita M, Yamamoto Y, Wanibuchi S, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay （ADRA） using 4mM test chemical solution: Results of ring-study implementation from five participating laboratories. J Appl Toxicol 2022;42:318-33.
  • Cui H, Soga K, Tamehiro N, Adachi R, Hachisuka A, Hirose A, Kondo K, Nishimaki-Mogami T: Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages. Biochem Pharmacol. 2021;188:114580.
  • Petkov PI, Ivanova H, Honma M, Yamada T, Morita T, Furuhama A, Kotov S, Kaloyanova E, Dimitrova G, Mekenyan O: Differences between in vitro and in vivo genotoxicity due to metabolism: The role of kinetics. Computat Toxicol. 2022;22:100222.
  • Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Yokozaki H, Sasaki H: Molecular network analysis of RNA viral infection pathway in diffuse- and intestinal-type gastric cancer. Fundam Toxicol Sci. 2022;9（2）:37-46.
  • Iso T, Natsume M, Murata Y, Shigeta Y, Hirose N, Umano T, Horibata K, Masumura K, Sugiyama K, Matsumoto M, Hirose A: Absence of in vivo mutagenicity of 4,4'-oxybis（benzenesulfonohydrazide） in liver and glandular stomach of Muta TM mice. Fundam Toxicol Sci. 2022;9（2）:31-36.
  • Ohno A, Okiyama Y, Hirose A, Fukuhara K: The Position of the Nitro Group Affects the Mutagenicity of Nitroarenes. Toxicol Appl Pharmacol. 2022;441;115974.
  • Watanabe-Matsumoto S, Yoshida K, Meiseki Y, Ishida S, Hirose A, Yamada T: A physiologically based kinetic modeling of ethyl tert-butyl ether in humans - An illustrative application of quantitative structure-property relationship and Monte Carlo simulation. J Toxicol Sci. 2022;47（2）:77-87.
  • Fujita M, Yamamoto Y, Wanibuchi S, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: The within- and between-laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4mM test chemical solution: Results of ring study implemented at five participating laboratories. J Appl Toxicol. 2022;42（2）:318-333.
  • Yamamoto Y, Fujita M, Watanabe S, Yamaga H, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Takeuchi K, Kamiya K, Kawakami T, Kojima K, Sozu T, Kojima H, Kasahara T, Ono A: Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay （ADRA） using a 0.5 mg/ mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories. J Appl Toxicol. 2022;42（6）:1078-1090.
  • Imamura M, Yamamoto Y, Fujita M, Wanibuchi S, Nakashima N, Kojima H, Ono A, Kasahara T: Applicability of ADRA （4mM） for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events. J Appl Toxicol. 2022; in press.
  • Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M. Establishment of a Threshold of Toxicological Concern Concept for Skin Sensitization by in Vitro/in Silico Approaches 日本香粧品学会誌. 2021;45（4）:331-5.
  • Kojima H: Alternatives to animal testing. Impact. 2021;44-45.
  • Narita K, Okutomi H, Kawakami K, Sui H, Basketter D, Ashikaga T: Behavior of Chemical Respiratory Sensitizers in in Vitro Methods for Skin Sensitization. AATEX. 2021;26（1）:9-18.
  • Kojima H, Nakada T, Yagami A, Todo H, Nishimura J, Yagi M, Sugiyama M, Yamamoto K, Ikarashi Y, Sakaguchi H, Yamaguchi M, Hirota M, Ikeda H, Imai N, Hatao M: A Step-by-Step Approach for Assessing Human Skin Irritation Without Animal Testing for Quasi-Drugs and Cosmetic Products. Applied in vitro Toxicology. 2021;7（3）.
  • Nishida H, Ohtake T, Ashikaga T, Hirota M, Onoue S, Seto Y, Tokura Y, Kouzuki H: In chemico sequential testing strategy for assessing the photoallegic potential. Toxicol In Vitro. 2021;77:105245.
  • Dent MP, Vaillancourt E, Thomas RS, Carmichael PL, Ouedraogo G, Kojima H, Barroso J, Ansell J, Barton-Maclaren TS, Bennekou SH, Boekelheide K, Ezendam J, Field J, Fitzpatrick S, Hatao M, Kreiling R, Lorencini M, Mahony C, Montemayor B, Mazaro-Costa R, Oliveira J, Rogiers V, Smegal D, Taalman R, Tokura Y, Verma R, Willett C, Yang C: Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients. Regul Toxicol Pharmacol. 2021;125:105026.
  • Ambe K, Suzuki M, Ashikaga T, Tohkin M: Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost Regul Toxicol Pharmacol. 2021;125:105019.
  • Liao CC, Wu CY, Lin MH, Hsieh FK, Hsu LT, Chang SY, Chen KJ, Huang HT, Hsu HC, Lin CH, Lin PJ, Lai HM, Kojima H, Todo H, Lin SJ, Li JH, Chen W: Validation study of a new reconstructed human epidermis model EPiTRI for in vitro skin irritation test according to OECD guidelines. Toxicol In Vitro. 2021;75:105197.
  • Lee B-M, Lee SH, Yamada T, Park S, Wang Y, Kim K-B, Kwon S: Read-across approaches: Current applications and regulatory acceptance in Korea, Japan, and China. J. Toxicol. Environ. Health. A. 2021, 1-14.
  • Yamada T, Kawamura T, Maruyama T, Kurimoto M, Yamamoto H, Katsutani N, Hirose A: Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals. Fundam Toxicol Sci. 2021;8:195-204.
  • Yamada T, Miura M, Kawamura T, Ushida K, Inoue K, Kuwagata M, Katsutani N, Hirose A: Constructing a developmental and reproductive toxicity database of chemicals （DART NIHS DB） for integrated approaches to testing and assessment. J Toxicol Sci. 2021;46:531-538.
  • Tanabe S, Quader S, Ono R, Cabral H, Aoyagi K, Hirose A, Yokozaki H, Sasaki H: Cell cycle regulation and DNA damage response networks in diffuse- and intestinal-type gastric cancer. Cancers. 2021;13:5786.
  • Matsumoto M, Takano M, Takabe M, Yamaguchi N, Iso T, Shigeta Y, Murata Y, Hirose N, Inoue K, Hirose A: Initial hazard assessment of ethyl （dimethyl）（tetradecyl）ammonium ethyl sulfate: Genotoxicity tests and combined repeated-dose and reproductive/developmental toxicity screening in rats. Regul Toxicol Pharmacol. 2021;122:104914.
  • Matsumoto M, Fujii S, Hirose N, Iso T, Shigeta Y, Murata Y, Inoue K. Hirose A. Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats. Fundam Toxicol Sci. 2021;8（4）:103-116.
  • Inoue K, Shigeta Y, Umemura T, Nishiura H, Hirose A. Application of the benchmark dose method to the incidence data for various pathological findings and its validation analysis. Shokuhin Eiseigaku Zasshi. 2021;62（2）:56-64.

2020

  • Akimoto M , Yamamoto Y , Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Yu, Horie N, Fujimoto K, Kusakari K,Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: The effect of dimethyl sulfoxide （DMSO） on the oxidation of cysteine-derivative nucleophilic reagent when using acetonitrile containing DMSO as an solvent in the Amino acid Derivative Reactivity Assay（ADRA）. J Appl Toxicol 2020;40:843-54.
  • Igarashi Y, Takahashi M, Tsutsumi T, Inoue K, Akiyama H: Monitoring Analysis of Perfluoroalkyl Substances and F-53B in Bottled Water, Tea and Juice Samples by LC-MS/MS. Chem Pharm Bull 2021;69:286-290.
  • Takahashi M, Yada M, Morimoto K, Nemoto S, Akiyama H, Inoue K: Simultaneous determination of alachlor and its metabolites in bovine tissues, milk and egg by liquid chromatography-tandem mass spectrometry. SSC plus 2020;4:68-76.
  • Takahashi M, Nishizaki Y, Masumoto N, Sugimoto N, Sato K, Inoue K: Quantification of tea-derived catechins without the requirement for respective calibration curves by single reference liquid chromatography based on relative molar sensitivity. J. Sci. Food Agric., ［Epub ahead of print］

2019

  • Abdelgied M, El-Gazzar AM, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H ,Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Abdou KA, Takahashi S, Alexande DB, Tsuda H: Carcinogenic effect of potassium octatitanate（POT） fibers in the lung and pleura of male Fischer344 rats after intrapulmonary administration. Part Fibre Toxicol 2019 2;16（1）:34.
  • Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y , Kanno J , Abdelhamid M , Tsuda H ,Takahashi S: Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344rats. Arch Toxicol 2019;93（4）:909-920.
  • Mizoi K, Fukai Y, Matsumoto E, Koyama S, Ishida S, Kojima H, Ogihara T: Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction．Fundamental Toxicological Sciences. 2020;7:9-14
  • Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
  • Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C , Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M,Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D,Inoue T, Rogen EL, Kojima H, Aiba S: An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxinc effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals. Toxicol In Vitro. 2020;66:104832, 国立医薬品食品衛生研究所報告第138号（2020） j.tiv.2020.104832
  • Jojima K, Yamada T, Hirose A: Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events. Fundamental Toxicological Sciences. 2019;6:327-332
  • Yamada T, Matsumoto M, Miura M, Hirose A: Case study on the use of integrated approaches to testing and assessment for testicular toxicity of ethylene glycol methyl ether (EGME)-related chemicals．OECD, Series on Testing & Assessment. 2019;308:1-75
  • Patlewicz G, Lizarraga LE, Rua D, Allen DG, Daniel AB, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus A, Matheson J, Mumtaz M, Richarz A, Ruiz P, Scarano L, Yamada T, Kleinstreuer N: Exploring current read-across applications and needs among selected U.S. Federal Agencies. Regulatory Toxicology and Pharmacology. 2019;106:197-209
  • Matsumoto M, Hirata-Koizumi M, Kawamura T, Sakuratani S, Ono A, Hirose A: Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies. Fundamental Toxicological Sciences. 2019;6:125-136
  • Igarashi T, Suzuki H, Ushida K, Matsumoto M, Inoue K, Kanno T, Miwa Y, Ishii T, Nagase T, Katsumata Y, Hirose A: Initial hazard assessment of 1,4-dichlorobutane: genotoxicity tests, 28-day repeated-dose toxicity test, and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2020;112:104610, doi:10.1016/j.yrtph.2020.104610
  • Kobayashi-Tsukumo H, Oiji K, Xie D, Sawada Y, Yamashita K, Ogata S, Kojima H, Itagaki H: Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT). J Toxicol Sci. 2019;44:283-297
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A: The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol. 2019;39:1492-1505
  • Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa T: Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing. Altern Lab Anim. 2019;47:140-157
  • Akimoto M, Yamamoto Y, Watanabe S, Yamaga H, Yoshida K, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kamiya K, Kojima K, Kawakami T, Kojima H, Ono A, Kasahara T, Fujita M: Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay. J Appl Toxicol. 2020;40:843-854

2018

  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: PTCH1 pathway network model in diffuse-type gastric cancer and epithelial-mesenchymal transition. Journal of Stem Cell Research and Medicine. 2018;3:1- 15
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular network pathway of ERBB in diffusetype gastric cancer, mesenchymal stem cells and epithelial-mesenchymal transition． Journal of Clinical Epigenetics. 2018;4:2:13
  • Tanabe S, Aoyagi K, Yokozaki H, Sasaki H: Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells． AIMS Cell and Tissue Engineering. 2018;2:58-77
  • Igarashi T, Serizawa H, Kobayashi K, Suzuki H, Matsumoto M, Iso T, Kawamura T, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeateddose toxicity study in rats. Regul Toxicol Pharmacol. 2018;96:64-75
  • Igarashi T, Takashima H, Takabe M, Suzuki H, Ushida K, Kawamura T, Matsumoto M, Iso T, Tanabe S, Inoue K, Ono A, Yamada T, Hirose A: Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats. Regul. Toxicol. Pharmacol. 2018;100:105-117
  • Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K: Synthesis and Radical-Scavenging Activity of C-Methylated Fisetin Analogues. Bioorg. Med. Chem. 2019;27（8）;1720–1727
  • Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y , Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Kojima H, Ono A, Katsuoka Y, Tanabe H, Yokoyama H, Kasahara T: Cause of and countermeasures for oxidation of the cysteinederived reagent used in the amino acid derivative reactivity assay. J. Appl. Toxicol. 2019;39（2）:191-208
  • Kimura Y, Watanabe M, Suzuki N, Iwaki T, Yamakage K, Saito K, Nakajima Y, Fujimura C, Ohmiya Y, Omori T, Kojima H, Aiba S: The performance of an in vitro skin sensitisation test, IL-8 Luc assay （OECD442E）, and the integrated approach with direct peptide reactive assay （DPRA）. J. Toxicol. Sci. 2018;43（12）:741-749
  • Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T: Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018; 39（4）:187-195
  • Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V: Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol. 2018;92(2):611-617.
  • Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, RégimbaldKrnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N: International regulatory requirements for skin sensitization testing. Regul. Toxicol. Pharmacol. 2018;95:52-65
  • Narita K, Ishii Y, Vo PTH, Nakagawa F, Ogata S, Yamashita K, Kojima H, Itagaki H: Improvement of human cell line activation test （h-CLAT） using short-time exposure methods for prevention of false-negative results. J Toxicol Sci. 2018;43（3）:229-240
  • Mitachi T, Kouzui M, Maruyama R, Yamashita K, Ogata S, Kojima H, Itagaki H: Some nonsensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J. Toxicol. Sci. 2019;44（3）:213-224
  • Hoffmann S, Kleinstreuer N, Alépée N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization （I）: the Cosmetics Europe database. Crit. Rev. Toxicol. 2018;48（5）:344-358
  • Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E , Zang Q, Petersohn D: Nonanimal methods to predict skin sensitization （II）: an assessment of defined approaches. Crit. Rev. Toxicol. 2018;48（5）:359-374
  • Morita T, Shigeta Y, Kawamura T, Fujita Y, Honda H, Honma M: In silico prediction of chromosome damage: Comparison of three （Q）SAR models. Mutagenesis. 2019;34:91-100
  • Yamada T, Tanaka Y, Hasegawa R, Igarashi T, Hirose A: Male-specific prolongation of prothombin time by industrial chemicals. Fundam. Toxicol. Sci. 2018;5:75-82
  • Petkov PI, Schultz TW, Honma M. Yamada T, Kaloyanova E, Mekenyan OG: Validation of the performance of TIMES genotoxicity models with EFSA pesticide data. Mutagenesis. 2019;34:83-90

2017

  • Horibe A, Odashima S, Hamasuna N, Morita T, Hayashi M: Weight of contribution of in vitro chromosomal aberration assay for evaluation of pesticides: Experience of risk assessment at the Food Safety Commission of Japan. Regul Toxicol Pharmacol. 2018:95:133-41
  • Tsukumo H , Matsunari N , Yamashita K , Kojima H, Itagaki H: Lipopolysaccharide interferes with the use of the human Cell Line Activation Test to determine the allergic potential of proteins. J Pharmacol Toxicol Methods. 2018; 92:34-42.
  • Matsumoto M, Furukawa M, Kobayashi K, Iso T, Igarashi T, Yamada T, Hirose A: A 28-day repeated oral-dose toxicity study of insecticide synergist N- （2-ethylhexyl）-1-isopropyl-4-methylbicyclo［2.2.2］oct5-ene-2,3-dicarboximide in rats. Fundam Toxicol Sci. 2018;5:1-11
  • Narita K, Vo PTH, Yamamoto K, Kojima H, Itagaki H: Preventing false-negatives in the in vitro skin sensitization testing of acid anhydrides using interleukin-8 release assays. Toxicol In Vitro. 2017;Aug 42:69-75.
  • Akagi T, Nagura M, Hiura A, Kojima H, Akashi M: Construction of Three-Dimensional Dermo-Epidermal Skin Equivalents Using Cell Coating Technology and Their Utilization as Alternative Skin for Permeation Studies and Skin Irritation Tests. Tissue Eng Part A. 2017; 23（11-12）:481-490.
  • Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H: Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42（4）:499-507
  • Arakawa H Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T: Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40（7）:967-974
  • Tanabe S, Kobayashi K, Matsumoto M, Serizawa H, Igarashi T, Yamada T, Hirose A: Toxicity of repeated 28-day oral administration of acenaphthylene in rats. Fundam Toxicol Sci. 2017;4:247-259
  • Tanabe S, Ohara M, Ito M, Noda A, Kobayashi K, Matsumoto M, Hirose A: Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats．Fundam Toxicol Sci. 2017;4:207-218
  • Fukuhara K, Ohno A, Kikura-Hanajiri R: A metabolic study on the biochemical effects of chiral illegal drugs in rats using 1 H-NMR spectroscopy．Yakugaku Zasshi. 2017;137（9）:1147-1154
  • Yamada T, Hirose A: Case study on the use of an integrated approach to testing and assessment for the repeated-dose toxicity of phenolic benzotriazoles, Organisation for Economic Co-operation and Development （OECD）, Series on Testing & Assessment No. 271. 1-44, 2017.
  • Miyazaki H, Yamashita K, Uchino T, Takezawa T, Kojima H: Development of a Novel in Vitro Skin Sensitization Test Method using a Collagen Vitrigel Membrane Chamber, AATEX, 2017;22(2):141-154.

2016

  • Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H: Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells. 2016;8:384-95
  • Yamamoto N, Kato Y, Sato A, Hiramatsu N, Yamashita H, Ohkuma M, Miyachi E, Horiguchi M, Hirano K, Kojima H: Establishment of a new immortalized human corneal epithelial cell line（iHCE-NY1）for use in evaluating eye irritancy by in vitro test methods. In Vitro Cell Dev Biol Anim. 2016; 52（7）:742-8
  • Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M: Evaluation o f the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogen. Mutation Research. 2016;802:1-29
  • Fujita Y, Morita T, Matsumura S, Kawamoto T, Itoh Y, Nishiyama N, Honda H: Comprehensive retrospective evaluation o f existing in vitro chromosomal aberration test data by cytotoxicity index transformation. Mutation Research. 2016;802:38-49
  • Morita T, Uneyama C: Genotoxicity assessment of 4-methylimidazole: Regulatory perspectives. Genes and Environment. 2016;38:20
  • Hirata-Koizumi M, Ise R, Kato H, Matsuyama T, Nishimaki-Mogami T, Takahashi M, Ono A, Ema M, Hirose A: Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α（PPARα) activity of an ultraviolet absorber, 2-（2’-hydroxy-3’,5’-di-tert-butylphenyl）benzotriazole, as possible mechanism of their toxicity and the gender differences. J Toxicol Sci. 2016;41:693-700
  • Matsumoto M, Todo H, Akiyama T, HirataKoizumi M, Sugibayashi K, Ikarashi Y, Ono A, Hirose A, Yokoyama K: Risk assessment of skin lightening cosmetics containing hydroquinone. Regul Toxicol Pharmacol. 2016;81:128-35
  • Uchino T, Kuroda Y, Ishida S, Yamashita K, Miyazaki H, Oshikata A, Shimizu K, Kojima H, Takezawa T, Akiyama T, Ikarashi Y: Increase of β2-integrin on adhesion of THP-1 cells to collagen vitrigel membrane, Biosci Biotechnol Biochem. 2016;4:1-6

2015

  • Kato H, Fujii S, Takahashi M, Matsumoto M, Hirata-Koizumi M, Ono A, Hirose A: Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats. Environ Toxicol. 2015;30:1235-43.
  • Morita T, Uno Y, Honma M, Kojima H, Hayashi M, Tice RC, Corvi R, Schechtman L: The JaCVAM International Validation Study on the in vivo Comet Assay: Selection of Test Chemicals. Mutat Res. 2015;786-788:14-44.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Burlinson B, Escobar P, Kraynak AR, Nakagawa Y, Nakajim M, Pant K, Asano N, Lovell D, Morita T, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutat Res. 2015;786-788:3-13.
  • Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Beevers C, Boeck MB, Burlinson B, Hobbs CH, Kitamoto S, Kraynakl AR, McNamee J, Nakagawa Y, Pant K, Plappert-Helbig U, Priestley C, Takasawa H, Wada K, Wirnitzer U, Asano N, Escobar P, Lovell D, Morita T, Nakajima M, Ohno Y, Hayashi M: JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutat Res. 2015;786-788:45-76.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Recommended protocols for the liver micronucleus test: report of the IWGT working group. Mutat Res. 2015;783:13-8.
  • Uno Y, Morita T, Luijten M, Beevers C, Hamada S, Itoh S, Ohyama W, Takasawa H: Micronucleus test in rodent tissues other than liver or erythrocytes: Report of the IWGT working group. Mutat Res. 2015;783:19-22.
  • MacGregor JT, Frötschl R, White PA3, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V, Johnson GE: IWGT Report on Quantitative Approaches to Genotoxicity Risk Assessment I. Methods and metrics for defining exposure-response  relationships  and  points  of departure (PoDs). Mutat Res. 2015;783:55-65.
  • MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernandez L, Johnson GE,Kasamatsu T, Levy D, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V: IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-ofdeparture (PoD) metrics in definingacceptable exposure limits and assessing human risk. Mutat Res. 2015;783:66-78
  • Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S1, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A＊, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M: Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) ‒ Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2015;780-781:2-17.
  • Hirata-Koizumi M, Fujii S, Hina K, Matsumoto M, Takahashi M, Ono A, Hirose A:  Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl  carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid. Fundam Toxicol Sci. 2015;2:177-90
  • Ono A, Kobayashi K, Serizawa H, Kawamura T, Kato H, Matsumoto M, Takahashi M, Hirata-Koizumi M, Matsushima Y, Hirose A: A repeated dose 28-day oral toxicity study of b-bromostyrene in rats. Fundam Toxicol Sci. 2015;2:191‒200.
  • Okamura H, Abe H, Hasegawa-Baba Y, Saito K, Sekiya F, Hayashi S, Mirokuji Y, Maruyama S, Ono A, Nakajima M, Degawa M, Ozawa S, Shibutani M, Maitani T: The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1384-96.
  • Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokawa M, Watanabe W: Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice. Environ. Toxicol Pharmacol. 2015;39:879-86.
  • Watanabe H, Tamura I, Abe R, Takanobu H, Nakamura A, Suzuki T, Hirose A, Nishimura T, Tatarazako N: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2015;35:996-1006.
  • Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G: A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure. Regul Toxicol Pharmacol. 2015;73:770-9
  • Yamaguchi H, Kojima H, Takezawa T: Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals. J Appl Toxicol. 2016;36(8):1025-37.
  • Kojima H: The use of 3-D models as alternatives to animal testing. Altern Lab Anim. 2015;43(4):P40-3.
  • Speit G, Kojima H, Burlinson B, Collins AR, Kasper P, Plappert-Helbig U, Uno Y, Vasquez M, Beevers C, De Boeck M, Escobar PA, Kitamoto S, Pant K Pfuhler S, Tanaka J, Levy DD: Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT). Mutat Res Genet Toxicol Environ Mutagen. 2015;783:6-12