This division is in charge of affairs in human health risk assessment associated with the potential effects by various chemicals (chemicals in foods, drinking water, drugs, cosmetics and personal care products) exposure and conducts related researches which include development of toxicity databases and methods for risk assessment and management. Also, the division supports the establishment of the new test guidelines for alternative toxicity methods as a secretariat of the Japanese Center for the Validation of Alternative Methods (JaCVAM) and develops in silico prediction system such as the Quantitative Structure Activity Relationship (QSAR). The division also contributes the international activities under the OECD chemicals assessment programs and International Programme on Chemical Safety (IPCS).