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平成18年度

Miyazaki, T., Yoshioka, S., Aso, Y. : Physical Stability of amorphous acetanilide derivatives imporoved by polymer excipients
Chem. Pharm. Bull., 54, 1207-1210 (2006).

　

　

平成17年度

S.Yoshioka, T. Miyazaki, Y.Aso. b-relaxation of insulin molecule in lyophilized formulations containing trehalose or dextran as a determinant of chemical reacivity. 

Pharm. Res. Accepted (2006). 

　

Aso, Y., Yoshioka, S.: Molecular Mobility of Nifedipine-PVP and Phenobarbital-PVP Solid Dispersions as Measured by ¹³C-NMR Spin-Lattice Relaxation Time. 

J.Pharm. Sci., 95, 318-325 (2006)

　

S.Yoshioka, Y.Aso, T. Miyazaki, Negligible contribution of molecular mobility to the degradation rate of insulin lyophilized with poly(vinylpyrrolidone). 

J. Pharm. Sci., 95: 939-943 (2006).

　

S.Yoshioka, Y.Aso, Comparison of the glass transition temperature and fragility parameter of isomalto-olygomer predicted by molecular dynamics simulations with those measured by differential scanning calorimetry. 

Chem. Pharm. Bull. 53:1443-1445 (2005). 

　

S.Yoshioka, Y.Aso, A quantitative assessment of the significance of molecular mobility as a determinant for the stability of lyophilized insulin formulations. 

Pharm. Res. 22: 1358-1364 (2005). 

　

　

　

平成16年度

S.Yoshioka, Y.Aso, Glass transition-Related Changes in Molecular Mobility below Glass Transition Temperature of Freeze-dried Formulations, as Measured by Dielectric Spectroscopy and Solid State NMR. J.Pharm. Sci., 94:275-287 (2005). 

　

Aso, Y. and Yoshioka, S.: Effect of Freezing Rate on Physical Stability of Lyophilized Cationic Liposomes
Chem. Pharm. Bull., 53, 301-304 (2005).

　

Miyazaki, T, Yoshikao, S., Aso, Y., Kojima, S.: Ability of polyvinylpyrrolidone and polyacrylic acid to inhibit the crystallization of amorphous acetaminophen.

J. Pharm. Sci. 93, 2710-2717 (2004).

平成15年度

Yoshioka, S., Aso, Y., Kojima, S.: Temperature- and glass transition temperature-dependence of biomolecular reaction rates in lyophilized formulations described by Adam-Gibbs-Vogel equation

J.Pharm. Sci., 93, 1062-1069 (2004)

Abstract

　

Aso, Y., Yoshioka, S., Kojima, S.: Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions

J. Pharm. Sci., 93, 384-391 (2004)

Abstract

　

Yoshioka, S., Aso, Y., Kojima, S.: Molecular mobility of lyophilized poly(vinylpyrrolidone) and methyl cellulose as determined by the laboratory and rotating frame spin-lattice relaxation time of ¹H and ¹³C

Chem. Pharm. Bull., 51, 1289-1292 (2003)

Abstract

　

Yoshioka, S., Tajima, S., Aso, Y., Kojima, S.: Inactivation and aggregation of b-galactosidase in lyophilized formulation described by Kohlraushu-Williams-Watts Streched exponential function

Pharm. Res., 20, 1655-1660 (2003)

Abstract

　

Sumie Yoshioka, Yukio Aso and Shigeo Kojima: Prediction of Glass Transition Temperature of Freeze-Dried Formulations by Molecular Dynamics Simulation. 

Pharm. Res., 20, 873-878 (2003)

Abstract

　

　

平成14年度

　

Yoshioka, S., Aso, Y. and Kojima S.: " Different molecular motions in lyophilized protein formulations as determined by laboratory and rotating frame spin-lattice relaxation times."

J. Pharm. Sci., 91, 2203-2210 (2002)

　

Yoshioka, S., Aso, Y., Kojima, S. and Cappuccino N. F.  : A comparison of the analysis of covariance (AMCOVA) and range-based approaches for assessing batch-to-batch variability of the stability of pharmaceutical products.

Chem.Pharm.Bull., 50, 881-883 (2002)

　

阿曽幸男、吉岡澄江、小嶋茂雄：凍結乾燥製剤の安定性に及ぼす水の影響

低温生物工学会誌　48、42-46　(2002)

　

Aso,Y., Yoshioka,S., Zhang, J. and Zografi, G. : Effect of water on the molecular mobility of sucrose and poly(vinylpyrrolidone) in a colyophilized formulation as measured by ¹³C–NMR relaxation time.

Chem.Pharm.Bull., 50,　822-826 (2002)

　

　

平成13年度

　

Yoshioka, S., Aso, Y. and Kojima, S.:"Usefulness of Kohlraush-Williams-Watts Stretched Exponential Function to Describe Protein Aggregation in Lyophilized Formulations and Temperature Dependence Near the Glass Transition Temperature."

Pharm. Res., 18, 256-260 (2001)

　

Aso, Y., Yoshioka S. and Kojima S.:"Explanation of the Crystallization Rate of Amorphous Nifedipine and Phenobarbital from Their Molecular Mobility as Measured by ¹³C NMR Relaxation Time and the Relaxation Time Obtained from the Heating Rate Dependence of T_g."

J. Pharm. Sci., 90, 798-806 (2001)

　

Aso, Y., Yoshioka, S. and Kojima, S.:"Feasibility of Using Isothermal Microcalorimetry to Evaluate the Physical Stability of Amorphous Nifedipine and Phenobarbital."

Thermochimica Acta, 380, 199-204 (2001).

　

平成12年度

　

Aso, Y., Yoshioka S. and Kojima S.:"Relationship between the Crystallization Rates of Amorphous Nifedipine, Phenobarbital and Flopropione, and their Molecular Mobility as Measured by their Enthalpy Relaxation and ¹H-NMR Relaxation Times."
J. Pharm. Sci. 89 (3), 408-416 (2000).

Effect of polymer excipient on the enzyme activity of lyophilized bilirubin oxidase and b-galactosidase formulation.
Chem. Pharm. Bull. 48, 283-285 (2000).

Izutsu, K., Kojima, S.: Freeze-concentration separates proteins and polymer excipients into different amorphous phase.
Pharm. Res., 17, 1316-1322 (2000).

伊豆津健一、小嶋茂雄：凍結濃縮による生体高分子の相分離と共存分子の影響
低温生物工学会誌 46,91-94 (2000).

Yoshioka, S., Aso, Y. and Kojima, S.: Temperature dependence of bimolecular reactions associated with molecular mobility in lyophilized formulation.

Pharm. Res., 17, 925-929 (2000).

吉岡澄江、阿曽幸男、小嶋茂雄：タンパク質凍結乾燥製剤の安定性に及ぼす分子運動性の影響に関する検討
低温生物工学会誌 46,8-11 (2000).

　

　

平成11年度

　

Molecular mobility of protein in lyophilized formulations linked to the molecular mobility of polymer excipients, as determined by high resolution ¹³C solid state NMR.
Pharm. Res., 16, 1621-1625 (1999).

Swelling behavior and drug release of amphiphilic N-isopropylacrylamide terpolymer xerogels depending on polymerization method: g-irradiation polymerization and redox initiated polymerization.
Chem. Pharm. Bull. 47, 579-581 (1999).

Thermary controlled protein release from gelatin-dextran hydrogels.
Rad. Phys. Chem. 55, 179-183 (1999).

The effect of excipient on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature.
Pharm. Res., 16, 135-140 (1999).

　

Yoshioka, S., Aso, Y. and Kojima, S.:"Usefulness of Kohlraush-Williams-Watts Stretched Exponential Function to Describe Protein Aggregation in Lyophilized Formulations and Temperature Dependence Near the Glass Transition Temperature."

Pharm. Res., 18, 256-260 (2001)

　

Aso, Y., Yoshioka S. and Kojima S.:"Explanation of the Crystallization Rate of Amorphous Nifedipine and Phenobarbital from Their Molecular Mobility as Measured by ¹³C NMR Relaxation Time and the Relaxation Time Obtained from the Heating Rate Dependence of T_g."

J. Pharm. Sci., 90, 798-806 (2001)

　

Aso, Y., Yoshioka, S. and Kojima, S.:"Feasibility of Using Isothermal Microcalorimetry to Evaluate the Physical Stability of Amorphous Nifedipine and Phenobarbital."

Thermochimica Acta, 380, 199-204 (2001).

　

Aso, Y., Yoshioka S. and Kojima S.:"Relationship between the Crystallization Rates of Amorphous Nifedipine, Phenobarbital and Flopropione, and their Molecular Mobility as Measured by their Enthalpy Relaxation and ¹H-NMR Relaxation Times."
J. Pharm. Sci. 89 (3), 408-416 (2000).

Yoshioka, S., Aso Y., Kojima S. and Tanimoto T.:Effect of polymer excipient on the enzyme activity of lyophilized bilirubin oxidase and b-galactosidase formulation.
Chem. Pharm. Bull. 48, 283-285 (2000).

Izutsu, K., Kojima, S.: Freeze-concentration separates proteins and polymer excipients into different amorphous phase.
Pharm. Res., 17, 1316-1322 (2000).

伊豆津健一、小嶋茂雄：凍結濃縮による生体高分子の相分離と共存分子の影響
低温生物工学会誌 46,91-94 (2000).

Yoshioka, S., Aso, Y. and Kojima, S.: Temperature dependence of bimolecular reactions associated with molecular mobility in lyophilized formulation.

Pharm. Res., 17, 925-929 (2000).

吉岡澄江、阿曽幸男、小嶋茂雄：タンパク質凍結乾燥製剤の安定性に及ぼす分子運動性の影響に関する検討
低温生物工学会誌 46,8-11 (2000).

　

Molecular mobility of protein in lyophilized formulations linked to the molecular mobility of polymer excipients, as determined by high resolution ¹³C solid state NMR.
Pharm. Res., 16, 1621-1625 (1999).

Swelling behavior and drug release of amphiphilic N-isopropylacrylamide terpolymer xerogels depending on polymerization method: g-irradiation polymerization and redox initiated polymerization.
Chem. Pharm. Bull. 47, 579-581 (1999).

Thermary controlled protein release from gelatin-dextran hydrogels.
Rad. Phys. Chem. 55, 179-183 (1999).

The effect of excipient on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature.
Pharm. Res., 16, 135-140 (1999).

　

　

　

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