研究業績 / Recent Publications

  1. Wada K, Katoh Y, Ohnuma-Koyama A, Takahashi N, Yamada M, Matsumoto K: 2-Nitroanisole-induced oxidative DNA damage in Salmonella typhimurium and in rat urinary bladder cells. Mutat Res; 816-7:18-23 (2017).
  2. Horibata K, Ukai A, Ogata A, Nakae D, Ando H, Kubo Y, Nagasawa A, Yuzawa K, Honma M. Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats. Genes Environ. 39, 4 (2017)
  3. Yamada M. Preface. Mutat Res. 811, 1-2 (2016)
  4. Kimoto T, Horibata K, Miura D, Chikura S, Okada Y, Ukai A, Itoh S, Nakayama S, Sanada H, Koyama N, Muto S, Uno Y, Yamamoto M, Suzuki Y, Fukuda T, Goto K, Wada K, Kyoya T, Shigano M, Takasawa H, Hamada S, Adachi H, Uematsu Y, Tsutsumi D, Hori H, Kikuzuki R, Ogiwara Y, Yoshida I, Maeda A, Narumi K, Fujiishi Y, Morita T, Yamada M, Honma M. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals. Mutat Res. 811, 3-15 (2016)
  5. Horibata K, Ukai A, Honma M., Evaluation of mutagenicity of acrylamide using RBC Pig-a and PIGRET assays by single peroral dose in rats. Mutat Res. 811, 54-59 (2016)
  6. Johnson GE, Yamamoto M, Suzuki Y, Adachi H, Kyoya T, Takasawa H, Horibata K, Tsutsumi E, Wada K, Kikuzuki R, Yoshida I, Kimoto T, Maeda A, Narumi K. Measuring reproducibility of dose response data for the Pig-a assay using covariate benchmark dose analysis. Mutat Res. 811, 135-139 (2016)
  7. Horibata K, Ukai A, Ishikawa S, Sugano A, Honma M. Monitoring genotoxicity in patients receiving chemotherapy for cancer: application of the PIG-A assay. Mutat Res. 808, 20-26 (2016)
  8. Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T. Dose-dependent de novo germline mutations detected by whole-exome sequencing in progeny of ENU-treated male gpt delta mice. Mutat Res. 810, 30-39 (2016)
  9. Suzuki T, Yasui M, Honma M. Mutator phenotype and DNA double-strand break repair in BLM helicase-deficient human cells. Mol Cell Biol. 36, 2877-2889 (2016)
  10. Suzuki T, Grúz P, Honma M, Adachi N, Nohmi T. The role of DNA polymerase ζ in translesion synthesis across bulky DNA adducts and cross-links in human cells.Mutat Res. 791-792, 35-41 (2016)
  11. Sassa A, Kanemaru Y, Kamoshita N, Honma M, Yasui M. Mutagenic consequences of cytosine alterations site-specifically embedded in the human genome. Genes Environ. 38,17 (2016).
  12. Cao Y, Yang L, Feng N, Shi O, Xi J, You X, Yin C, Yang H, Horibata K, Honma M, Qian B, Weng W, Luan Y. A population study using the human erythrocyte PIG-A assay. Environ Mol Mutagen. 57, 605-614 (2016)
  13. Sugiyama KI, Furusawa H, Shimizu M, Grúz P, Honma M. Epigenetic mutagen as histone modulator can be detected by yeast flocculation. Mutagenesis. 31, 687-693 (2016)
  14. Manganelli S, Benfenati E, Manganaro A, Kulkarni S, Barton-Maclaren TS, Honma M. New quantitative structure-activity relationship models improve predictability of Ames mutagenicity for aromatic azo compounds.Toxicol Sci. 153, 316-26 (2016)
  15. 本間正充 ゲノム上に起きたDNA損傷の運命をターゲットミュータジェネシスにより追跡する.日本がん疫学・分子疫学研究会 News Letter 114, 11-12 (2016)
  16. 本間正充 食品添加物等の遺伝毒性リスク評価法.食品衛生学雑誌 57(1)J12-J15 (2016)
  17. Suzuki T, Grúz P, Honma M, Adachi N, Nohmi T. Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses.DNA Repair (Amst) 45. 34-43 (2016)
  18. Petko I. Petkov, Terry W. Schultz, E. Maria Donner, Masamitsu Honma, Takeshi Morita, Shuichi Hamada, Akihiro Wakata, Masayuki Mishima, Jiro Maniwa, Milen Todorov, Elena Kaloyanova, Stefan Kotov, Ovanes G. Mekenyan, Integrated Approach to Testing and Assessment for Predicting Rodent Genotoxic Carcinogenesity.Journal of Applied Toxicology 36, 1536-1550 (2016)
  19. E. Benfenati, M. Belli, T. Borges, E. Casimiro, J. Cester, A. Fernandez, G. Gini, M. Honma, M. Kinzl, R. Knauf, A. Manganaro, E. Mombelli, M. I. Petoumenou, M. Paparella, P. Paris & G. Raitano, Results of a round-robin exercise on read-across. SAR and QSAR in Environmental Research 27, 371-384 (2016)
  20. Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T. Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice. Gene & Environ. 38, 10 (2016)
  21. Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M. Evaluation of the sensitivity and specificity of in vivo erythrocytemicronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens.Mutat. Res. 802, 1-29 (2016)
  22. Ahlberg E, Amberg A, Beilke LD, Bower D, Cross KP, Custer L, Ford KA, Van Gompel J, Harvey J, Honma M, Jolly R, Joossens E, Kemper RA, Kenyon M, Kruhlak N, Kuhnke L, Leavitt P, Naven R, Neilan C, Quigley DP, Shuey D, Spirkl HP, Stavitskaya L, Teasdale A, White A, Wichard J, Zwickl C, Myatt GJ. Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity. Regul Toxicol Pharmacol. 13, 1-12 (2016)
  23. Amberg A, Beilke L, Bercu J, Bower D, Brigo A, Cross KP, Custer L, Dobo K, Dowdy E, Ford KA, Glowienke S, Van Gompel J, Harvey J, Hasselgren C, Honma M, Jolly R, Kemper R, Kenyon M, Kruhlak N, Leavitt P, Miller S, Muster W, Nicolette J, Plaper A, Powley M, Quigley DP, Reddy MV, Spirkl HP, Stavitskaya L, Teasdale A, Weiner S, Welch DS, White A, Wichard J, Myatt GJ. Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses. Regul Toxicol Pharmacol. 77, 13-24 (2016)
  24. Sugiyama K, Yamada M, Awogi T, Hakura A, The strains recommended for use in the bacterial reverse mutation test (OECD guideline 471) can be certified as non-genetically modified organisms. Genes and Environment. 38:2 (2016).
  25. Honma, M., Evaluation of the in vivo genotoxicity of Allura Red AC (Food Red No. 40).Food and Chemical Toxicology. 84, 270-275 (2015).
  26. 本間正充:第1章 ICH M7の適用範囲と既存ガイドラインとの関連性 「ICH M7 変異原性不純物の開発段階からの評価・管理と申請/CTD記載法」サイエンステクノロジー (2015)
  27. 本間正充:1.3遺伝毒性試験法「衛生試験法・注解」金原出版格式会社(日本薬学会編)(2015)
  28. Masumura K, Sakamoto Y, Kumita W, Honma M, Nishikawa A, Nohmi T, Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents. Genes and Environment 37:24 (2015).
  29. Sassa A, Kamoshita N, Kanemaru Y, Honma M, Yasui M, Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. PLoS One. 10(11):e0142218 (2015).
  30. Barber C, Amberg A, Custer L, Dobo KL, Glowienke S, Van Gompel J, Gutsell S, Harvey J, Honma M, Kenyon MO, Kruhlak N, Muster W, Stavitskaya L, Teasdale A, Vessey J, Wichard J., Establishing best practise in the application of expert review of mutagenicity under ICH M7. Regul Toxicol Pharmacol. 73, 367-377 (2015)
  31. Canipa S, Cayley A, Drewe WC, Williams RV, Hamada S, Hirose A, Honma M, Morita T. Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing. Mutagenesis 31, 17-25 (2015)
  32. Kanemaru Y, Suzuki T, Niimi N, Grúz P, Matsumoto K, Adachi N, Honma M, Nohmi T. Catalytic and non-catalytic roles of DNA polymerase κ in the protection of human cells against genotoxic stresses. Environ Mol Mutagen. ;56:650-62(2015)
  33. Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Res. 43, 6359-72 (2015)
  34. Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Beevers C, Boeck MD, Burlinson B, Hobbs CA, Kitamoto S, Kraynak AR, McNamee J, Nakagawa Y, Pant K, Plappert-Helbig U, Priestley C, Takasawa H, Wada K, Wirnitzer U, Asano N, Escobar PA, Lovell D, Morita T, Nakajima M, Ohno Y, Hayashi M. JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutat Res Genet Toxicol Environ Mutagen. 786-788:45-76 (2015)
  35. Morita T, Uno Y, Honma M, Kojima H, Hayashi M, Tice RR, Corvi R, Schechtman L. The JaCVAM international validation study on the in vivo comet assay: Selection of test chemicals. Mutat Res Genet Toxicol Environ Mutagen. 786-788, 14-44 (2015)
  36. Uno Y, Kojima H, Omori T, Corvi R, Honma M, Schechtman LM, Tice RR, Burlinson B, Escobar PA, Kraynak AR, Nakagawa Y, Nakajima M, Pant K, Asano N, Lovell D, Morita T, Ohno Y, Hayashi M. JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results. Mutat Res Genet Toxicol Environ Mutagen. 786-788:3-13 (2015)
  37. Hamada S, Ohyama W, Takashima R, Shimada K, Matsumoto K, Kawakami S, Uno F, Sui H, Shimada Y, Imamura T, Matsumura S, Sanada H, Inoue K, Muto S, Ogawa I, Hayashi A, Takayanagi T, Ogiwara Y, Maeda A, Okada E, Terashima Y, Takasawa H, Narumi K, Wako Y, Kawasako K, Sano M, Ohashi N, Morita T, Kojima H, Honma M, Hayashi M. Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) – Mammalian Mutagenicity Study Group (MMS). Mutat Res Genet Toxicol Environ Mutagen. 780-781:2-17 (2015)
  38. Martus HJ, Hayashi M, Honma M, Kasper P, Gollapudi B, Mueller L, Schoeny R, Uno Y, Kirkland DJ, Summary of major conclusions from the 6th International Workshop on Genotoxicity Testing (IWGT), Foz do Iguacu, Brazil, Mutat. Res., 783, 1-5 (2015)
  39. Yauk CL, Aardema MJ, Benthem VJ, Bishop JB, Dearfield KL, DeMarini DM, Dubrova YE, Honma M, Lupski JR, Marchetti F, Meistrich ML, Pacchierotti F, Stewart J, Waters MD, Douglas GR. Approaches for Identifying Germ Cell Mutagens: Report of the 2013 IWGT Workshop on Germ Cell Assays. Mutat. Res., 783, 36-54 (2015)
  40. Petkov PI, Patlewicz G, Schultz TW, Honma M, Todorov M, Kotov S, Dimitrov SD, Donner EM, Mekenyan OG, A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? Regul. Tox. Pharm., 72, 17-25 (2015)
  41. Zeiger E, Gollapudi B, Aardema MJ, Auerbach S, Boverhof D, Custer L, Dedon P, Honma M, Ishida S, Kasinski AL, Kim JH, Manjanatha MG, Marlowe J, Pfuhler S, Pogribny I, Slikker W, Stankowski LF Jr, Tanir JY, Tice R, van Benthem J, White P, Witt KL, Thybaud V. Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report. Environ Mol Mutagen. 56, 277-85 (2015)
  42. Aoki Y, Akiko A, Sugawara Y, Hiyoshi-Arai K, Goto S, Masumura K, Nohmi T, Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages, Genes and Environment, 37:7 (2015)
  43. Kuroda K, Hibi D, Ishii Y, Yokoo Y, Takasu S, Kijima A, Matsushita K, Masumura K, Kodama Y, Yanai T, Sakai H, Nohmi T, Ogawa K, Umemura T, Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice, Toxicol Sci, 144, 65-76 (2015)
  44. Gollapudi BB, Lynch AM, Heflich RH, Dertinger SD, Dobrovolsky VN, Froetschl R, Horibata K, Kenyon MO, Kimoto T, Lovell DP, Stankowski LF Jr, White PA, Witt KL, Tanir JY, The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup, Mutat Res Genet Toxicol Environ Mutagen, 1, 23-35 (2015)
  45. Horibata K, Kono S, Ishigami C, Zhang X, Aizawa M, Kako Y, Ishii T, Kosaki R, Saijo M, Tanaka K, Constructive rescue of TFIIH instability by an alternative isoform of XPD derived from a mutated XPD allele in mild but not severe XP-D/CS, J Hum Genet, 60, 259-65 (2015)
  46. Matsuda T, Matsuda S, Yamada M, Mutation assay using single-molecule real-time (SMRTTM) sequencing technology, Genes and Environment, 37: 15 (2015)
  47. Yasui M, Kamoshita N, Nishimura T, Honma M, Mechanism of induction of binucleated cells by multiwalled carbon nanotubes as revealed by live-cell imaging analysis, Genes and Environment, 37: 6 (2015)
  48. Sugiyama K, Takamune M, Furusawa H, Honma M, Human DNA methyltransferase gene-transformed yeasts display an inducible flocculation inhibited by 5-aza-2'-deoxycytidine, Biochem Biophys Res Commun, 456, 689-694 (2015)
  49. Wakasugi M, Sasaki T, Matsumoto M, Nagaoka M, Inoue K, Inobe M, Horibata K, Tanaka K, Matsunaga T, Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells, J Biol Chem, 289, 28730-7 (2014)
  50. Onami S, Cho YM, Toyoda T, Horibata K, Ishii Y, Umemura T, Honma M, Nohmi T, Nishikawa A, Ogawa K, Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats, Mutagenesis, 29, 295-302 (2014)
  51. Matsumoto, M., Masumori, S., Hirata-Koizumi, M., Ono, A., Honma, M., Yokoyama, K. and Hirose, A., Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice. Mutat Res Genet Toxicol Environ Mutagen., 775-776, 94-98 (2014)
  52. Morita, T., Miyajima, A., Hatano, A., Honma, M.: Effects of the proposed top concentration limit on an in vitro chromosomal aberration test to assay sensitivity or to reduce the number of false positives, Mutation Research, 769, 34–49 (2014)
  53. Takeiri A, Wada NA, Motoyama S, Matsuzaki K, Tateishi H, Matsumoto K, Niimi N, Sassa A, Grúz P, Masumura K, Yamada M, Mishima M, Jishage K, Nohmi T, In vivo evidence that DNA polymerase kappa is responsible for error-free bypass across DNA cross-links induced by mitomycin C, DNA Repair, 24, 113-121 (2014)
  54. Horibata K, Ukai A, Honma M, Evaluation of rats' in vivo genotoxicity induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt assays, Genes and Enviromment, 36, 199-202 (2014)
  55. Sassa A, Suzuki T, Kanemaru Y, Niimi N, Fujimoto H, Katafuchi A, Grúz P, Yasui M, Gupta RC, Johnson F, Ohta T, Honma M, Adachi N, Nohmi T, In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ, DNA Repair, 15, 21-28 (2014)
  56. Yasui M, Kanemaru Y, Kamoshita N, Suzuki T, Arakawa T, Honma M, Tracing the fates of site-specifically introduced DNA adducts in the human genome, DNA Repair, 15, 11-20 (2014)
  57. Grúz P, Sassa A, Hosoda A, Yamagishi H, Usui Y, Shimizu M, Exclusive induction of G:C to A:T transitions by 3-azido-1,2-propanediol in yeast, Mutation Res, 760, 73-76 (2014)
  58. Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, Masumura K, Watanabe M, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T, Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats, Mutagenesis, 29, 27-36 (2014)
  59. Horibata K, Ukai A, Kimoto T, Suzuki T, Kamoshita N, Masumura K, Nohmi T, Honma M, Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays, Environ Mol Mutagen, 54, 747-754 (2013)
  60. Kawamura Y, Hayashi H, Kurata Y, Hiratsuka K, Masumura K, Nohmi T, Evaluation of the genotoxicity of tamoxifen in the liver and kidney of F344 gpt delta transgenic rat in 3-week and 13-week repeated dose studies, Toxicology, 312, 56-62 (2013)
  61. Sugiyama K, Yamazaki R, Kinoshita M, Kamata Y, Tani F, Minai Y, Sugita-Konishi Y, Inhibitory effect of citrinin on lipopolisaccharide-induced nitric oxide production by mouse macrophage cells, Mycotoxin Res, 29, 229-234 (2013)
  62. Kimura A, Miyata A, Honma M, A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells, Mutagenesis, 28, 583-590 (2013)
  63. Shah N, Montes de Oca M, Jover-Cobos M, Tanamoto K, Muroi M, Sugiyama K, Davies NA, Mookerjee RP, Dhar DK, Jalan R, Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure, Liver Transpl, 19, 751-761 (2013)
  64. Kimoto T, Horibata K, Chikura S, Hashimoto K, Itoh S, Sanada H, Muto S, Uno Y, Yamada M, Honma M, Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody, Mutat Res, 755, 126-134 (2013)
  65. Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS, DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation, EMBO J, 32, 2172-2185 (2013)
  66. Pfuhler S, Elespuru R, Aardema MJ, Doak SH, Maria Donner E, Honma M, Kirsch-Volders M, Landsiedel R, Manjanatha M, Singer T, Kim JH, Genotoxicity of nanomaterials: refining strategies and tests for hazard identification, Environ Mol Mutagen, 54, 229-239 (2013)
  67. T. Matsuda, M. Takamune, Y. Matsuda, M. Yamada, A pilot study for the mutation assay using a high-throughput DNA sequencer, Genes and Environment 35, 53-56 (2013)
  68. P. Grúz, T. Nohmi, Expression and activity of human DNA polymerase η in Escherichia coli, Genes and Environment 35, 10-20 (2013)
  69. A. Sassa, N. Kamoshita, T. Matsuda, Y. Ishii, I. Kuraoka, T. Nohmi, T. Ohta, M. Honma, M. Yasui, Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases, Mutagenesis 28, 81-88 (2013)
  70. M. Yamada, M. Shimizu, A. Katafuchi, P. Grúz, S. Fujii, Y. Usui, R.P. Fuchs, T. Nohmi, Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains, Mol Microbiol, 86, 1364-75 (2012)
  71. M. Honma, T. Takahashi, S. Asada, Y. Nakagawa, A. Ikeda, K. Yamakage, In vitro clastogenicity and phototoxicity of fullerene (C(60)) nanomaterials in mammalian cells, Mutat Res. 749, 97-100 (2012)
  72. T. Nohmi, M. Honma, M. Yamada, K. Masumura, M. Yasui, K. Horibata, S. Fukushima, 2nd International Symposium on Genotoxic and Carcinogenic Thresholds, Genes and Environment 34, 141-145 (2012)
  73. T. Nohmi, M. Yamada, K. Masumura, In vivo Approaches to Identify Mutations and in vitro Research to Reveal Underlying Mechanisms of Genotoxic Thresholds, Genes and Environment 34, 146-152 (2012)
  74. A.D. Bailey, L.T. Gray, T. Pavelitz, J.C. Newman, K. Horibata, K. Tanaka, A.M. Weiner, The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells, DNA repair, 11, 488-501 (2012)
  75. X. Zhang, K. Horibata, M. Saijo, C. Ishigami, A. Ukai, S.I. Kanno, H. Tahara, E.G. Neilan, M. Honma, T. Nohmi, A. Yasui, K. Tanaka, Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair, Nature Genetics, 44, 593-597 (2012)
  76. G. Xing, X. Qia, M. Chen, Y. Wu, J. Yao, L. Gong, T. Nohmi, Y. Luan, J. Ren, Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney, Mutat Res, 743, 52–58 (2012)
  77. O.G. Mekenyan, P.I. Petkov, S.V. Kotov, S. Stoeva, V.B. Kamenska, S.D. Dimitrov, M. Honma, M. Hayashi, R. Benigni, E.M. Donner, G. Patlewicz, Investigating the relationship between in vitro-in vivo genotoxicity: Derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism, Chem Res Toxicol, 25, 277-96 (2012)
  78. F. Yatagai, M. Honma, A. Ukai, K. Ohmori, H. Suzuki, T. Shimizu, A. Takahashi, T. Ohnishi, N. Dohmae, N. Ishioka, Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells, Advance in Space Research 49, 479-485 (2012)
  79. T. Kamigaito, T. Noguchi, K. Narumi, R. Takashima, S. Hamada, H. Sanada, M. Hasuko, H. Hayashi, K. Masumura, T. Nohmi, Evaluation of the in vivo mutagenicity of nickel subsulfide in the lung of F344 gpt delta transgenic rats exposed by intratracheal instillation: A collaborative study for the gpt delta transgenic rat mutation assay, Genes and Environment, 34, 34-44 (2012)
  80. H. Sui, R. Ohta, T. Shiragiku, A. Akahori, K. Suzuki, M. Nakajima, H. Hayashi, K. Masumura, T. Nohmi, Evaluation of in vivo mutagenicity by 2,4-diaminotoluene and 2,6-diaminotoluene in liver of F344 gpt delta transgenic rat dosed for 28 days: A collaborative study of the gpt delta transgenic rat mutation assay, Genes and Environment, 34, 25-33 (2012)
  81. Y. Kawamura, H. Hayashi, O. Tajima, S. Yamada, T. Takayanagi, H. Hori, W. Fujii, K. Masumura, T. Nohmi, Evaluation of the genotoxicity of aristolochic acid in the kidney and liver of F344 gpt delta transgenic rat using a 28-day repeated-dose protocol: A collaborative study of the gpt delta transgenic rat mutation assay, Genes and Environment, 34, 18-24 (2012)

2012年以前の研究業績

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