研究業績(2012年以前) / Publications 1970s~2012

1. 石館 基、吉川 邦衛、祖父尼 俊雄. Ⅰ.食品添加物の変異原性試験成績 --昭和54年度厚生省試験研究費による第一次スクリーニング・データ(第一回)--. 変異原と毒性 12.

2. 石館 基、祖父尼 俊雄、吉川 邦衛. 食品添加物の変異原性試験成績(その2)--昭和55年度厚生省試験研究費による第1次スクリーニング・データ--. 変異原と毒性 4.

3. 石館 基、祖父尼 俊雄、吉川 邦衛. 食品添加物(天然を含む)の変異原性. 変異原と毒性 4.

4. 石館 基、吉川 邦衛、祖父尼 俊雄. 食品添加物の変異原性試験成績(その4)--昭和57年度厚生省試験研究費による--. トキシコロジーフォーラム 6.

5. 石館 基、祖父尼 俊雄、吉川 邦衛. 食品添加物の変異原性試験成績(その5)--昭和58年度厚生省試験研究費による--. トキシコロジーフォーラム 7.

6. 石館 基、祖父尼 俊雄、岸 美智子. 食品添加物の変異原性試験成績(その6)昭和59年度厚生省試験研究費による. トキシコロジーフォーラム 8.

7. 石館 基、滝澤 行雄、坂部 美雄、石崎 睦雄、伊藤 和敏、館 正知. 食品添加物の変異原性試験成績(その7)昭和60年度厚生省試験研究費による. トキシコロジーフォーラム 9.

8. 石館 基、滝澤 行雄、坂部 美雄、石崎 睦雄、伊藤 和敏、館 正知. 食品添加物の変異原性試験成績(その8)昭和61年度厚生省試験研究費による. トキシコロジーフォーラム 10.

9. 石館 基、滝澤 行雄、坂部 美雄、石崎 睦雄、渡部 重信、館 正知、竹本 和夫. Ⅰ.食品添加物の変異原性試験成績(その9)昭和62年度厚生省試験研究費による. トキシコロジーフォーラム 11, 663-669.

10. 安斉 美知子、鈴木 郁生、神谷 庄造、中島 利章、中舘 正弘、中村 晃忠、末吉 祥子、丹野 雅幸、宮原 誠、小田嶋 成和、石館 基. 合成化学研究部で合成した化合物の抗腫瘍効果. 衛生試験所報告 94(1976).

11. Ishidate M, Jr, Odashima S. Chromosome tests with 134 comounds on chines hamster cells in vitro – a screening for chemical carcinogens. . Mutat Res 48, 337-354 (1977).

12. Ishidate, M., Jr., Hayashi, M., Sawada, M., Matsuoka, A., Yoshikawa, K., Ono, M. & Nakadate, M. [Cytotoxicity test on medical drugs--chromosome aberration tests with Chinese hamster cells in vitro (author's transl)]. Eisei Shikenjo Hokoku, 55-61 (1978).

13. Nohmi T, Mikami S, Yamane A, Takeuchi M, Ichishima E. Cellular localization of acid carboxypeptidase in Aspergillus oryzae. Curr Microbiol 1, 25-28 (1978).

14. Sawada, M. & Ishidate, M., Jr. Colchicine-like effect of diethylstilbestrol (DES) on mammalian cells in vitro. Mutat Res 57, 175-82 (1978).

15. Watabe T, Isobe M, Yoshikawa K, Takabatake E. Studies on metabolism and toxicity of styrene. I. Biotransformation of styrene to styrene glycol via styrene oxide by rat liver microsomes. J Pharm Dyn 1, 98-104 (1978).

16. Watabe T, Isobe M, Yoshikawa K, Takabatake E. Studies on metabolism and toxicity of styrene. II. Mutagenesis in Salmonella typhimurium by metabolic activation of styrene with 3-methylcholanthrene. J Pharm Dyn 1, 301-309 (1978).

17. Watabe T, Isobe M, Sawabata T, Yoshikawa K, Yamada S, Takabatake E. Metabolism and mutagenicity of styrene. Scand J Work Environ & Health suppl 2, 142-155 (1978).

18. Yoshikawa K, Kurata H, Iwahara S, Kada T. Photodynamic action of fluorescein dyes in DNA-damage and in vitro inactivation of transforming DNA in bacteria. . Mutat Res 56, 359-365 (1978).

19. Yoshikawa K, Uchino H, Kurata H Differential mutagenicity of N-methyl-N-nitrosocarbamate insecticides in Escherichia coli strains having different DNA repair capacities. . Mutat Res 54, 283-288 (1978).

20. (石館 基)、高畠 英伍. プラスチック製食品容器に残存する諸物質の生体影響. 昭和53年度 食品衛生調査研究 (1978).

21. 石館 基. Ⅰ.染色体異常による変異原の検出法. 変異原と毒性 4(1978).

22. Maeki K, Hayashi M. On the behavior of a supernumerary chromosome observed in Graphium sarpedon (Lepidoptera: Papilionidae). . Chrom Infor Ser 27, 9-10 (1979).

23. Matsuoka, A., Hayashi, M. & Ishidate, M., Jr. Chromosomal aberration tests on 29 chemicals combined with S9 mix in vitro. Mutat Res 66, 277-90 (1979).

24. Yoshikawa, K., Nohmi, T., Harada, R., Inokawa, Y. & Ishidate, M., Jr. Differential mutagenicities of triamino benzenes against Salmonella typhimurium TA98 in the presence of S9 fractions from polychlorinated biphenyls-, phenobarbital- or 3-methylcholanthrene-pretreated rats, hamsters and mice. J Toxicol Sci 4, 317-26 (1979).

25. Yoshikawa K, Uchino H, Yamamoto M, Yamada T, Tanimura A, Kondo S. Effect of N-carboxymethyl-N-nitrosourea on viability and mutagenic response of repair-deficient strains on Escherichia coli. Gann 70, 705-708 (1979).

26. 石館 基、祖父尼 俊雄、吉川 邦衛. 28 環境汚染化学物質の変異原性並びにその試験法の開発に関する研究. (1979).

27. 内山 充、武田 明治、鈴木 隆、佐々木 久美子、石館 基、吉川 邦衛、慶田 雅洋、伊藤 誉志男. 27.モデル水系エコシステムにおける環境汚染物の動態に関する研究. (1979).

28. Evans, H. J., Ishidate, M., Jr., Leng, M., Miller, C. T., Mitelman, F. & Vogel, E. Cytogenetic damage as an endpoint in short-term assay systems for detecting environmental carcinogens. IARC Monogr Eval Carcinog Risk Chem Hum Suppl, 227-44 (1980).

29. Fujinaga, Y., Matsuto, T., Nohmi, T. & Uotani, J. [Scanning electron microscopic studies on the true diabetic cataratous lenses (author's transl)]. Nihon Ganka Gakkai Zasshi 84, 472-8 (1980).

30. Ichishima E, Turuda T, Ushijima T, Nohmi T, Suzuki S, Takeuchi M, Yamane A. Soluble and bound forms of intracellular acid carboxy peptides in Aspergillus. Curr Microbiol 4, 85-89 (1980).

31. Ishidate, M. [Hideo Kikkawa's works on eye pigment] (Jpn). Kagakushi Kenkyu 19, 129-39 (1980).

32. Ishidate, M., Jr. & Yoshikawa, K. Chromosome aberration tests with Chinese hamster cells in vitro with and without metabolic activation--a comparative study on mutagens and carcinogens. Arch Toxicol Suppl 4, 41-4 (1980).

33. Ishidate, M., Jr., Yoshikawa, K. & Sofuni, T. [Recent aspects of mutagenicity tests on chemicals in our environment (author's transl)]. Eisei Shikenjo Hokoku 98, 1-19 (1980).

34. Kawachi, T., Yahagi, T., Kada, T., Tazima, Y., Ishidate, M., Sasaki, M. & Sugiyama, T. Cooperative programme on short-term assays for carcinogenicity in Japan. IARC Sci Publ, 323-30 (1980).

35. Sofuni T, Tanabe K, Awa. Chromosome heteromorphisms in the Japanese. II. Nucleolus organizer regions of variant chromosomes in D and G groups. Hum Genet 55, 265-270 (1980).

36. Yoshikawa, K., Nakadate, M., Watabe, T., Ishidate, M., Jr. & Kondo, S. Differential mutagenicities of 6 N-nitroso-N-alkylurea derivatives in Escherichia coli strains with different DNA-repair capacities. Mutat Res 79, 319-25 (1980).

37. Yoshikawa, K., Nohmi, T., Nagahara, A., Inokawa, Y. & Ishidate, M., Jr. Stability of S9 during frozen storage in Salmonella/S9 assays. Mutat Res 74, 389-91 (1980).

38. Yoshikawa K, Isobe M, Watabe T, Takabatake E. Studies on metabolism and toxicity of styrene. (III) The effect of metabolic inactivation by rat-liver S9 on the mutagenicity of phenyloxirane toward Salmonella typhimurium. Mutat Res 78, 219-226 (1980).

39. 石館 基. WHOにおける照射食品の許可. シンポジウム:食品工業をめぐる省エネルギー下の新技術 (1980).

40. 石館 基. 変異原性試験法によるがん原性物質のスクリーニング. 昭和55年度食品衛生特殊技術講習会1 (1980).

41. 石館 基. ⅠⅤ.変異原性試験. 変異原と毒性 10(1980).

42. 石館 基. 環境変異原性物質検出法の現状とその評価

Present Status of the Screening for Environmental Mutagens and/or Carcinogens. <特別講演-2> (1980).

43. 石館 基、吉川 邦衛、祖父尼 俊雄. 生活関連化学物質に関する変異原性試験の現状とその評価. 衛生試験所報告 98(1980).

44. 藤井 正美、石館 基、長尾 美奈子、井村 伸正. 食品の中の発癌物質、変異原物質. ファルマシア 16(1980).

45. 石館 基、祖父尼 俊雄、吉川 邦衛. 22 環境汚染化学物質の変異原性並びにその試験法の開発に関する研究. (1980).

46. Ishidate, M., Jr., Yoshikawa, K., Sofuni, T., Iwahara, S., Sibuya, T., Muramatsu, S., Kitayama, S. & Matsuyama, A. Mutagenicity studies on alcohol extracts from gamma-irradiated potatoes. Radioisotopes 30, 662-8 (1981).

47. Ishidate M, Jr., Sofuni T, Yoshikawa K. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens. GANN Monograph on Cancer Res 27, 95-108 (1981).

48. M.Ishidate, Jr. Application of chromosomal aberration tests in vitro to the primary screening for chemicals with carcinogenic and/or genetic hazards. Short-term Tests for Carcinogenesis:Quo Vadis?. Proceedings of a symposium held in Montpellier on February 4-5,1981 (1981).

49. Miyata, R., Nohmi, T., Yoshikawa, K. & Ishidate, M., Jr. [Metabolic activation of p-nitrotoluene and trichloroethylene by rat-liver S9 or mouse-liver S9 fractions in Salmonella typhimurium strains (author's transl)]. Eisei Shikenjo Hokoku 99, 60-5 (1981).

50. Nohmi, T., Yoshikawa, K., Miyata, R., Nakamura, S. & Ishidate, M., Jr. Duration of S9 activity in agar overlay. Mutat Res 91, 37-9 (1981).

51. Watabe T, Ozawa N, Yoshikawa K. Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes. Biochem Pharmacol 30, 1695-1698 (1981).

52. Yoshimura H, Nakamura M, Koeda T, Yoshikawa K. Mutagenicities of carbadox and olaquindox - growth promoters for pigs. . Mutat Res 90, 49-55 (1981).

53. 宮田 ルミ子、能美 健彦、吉川 邦衛、石館 基. サルモネラ菌株を用いたラット肝及びマウス肝S9分画による p-Nitrotoluene と Trichloroethylene の代謝的活性化試験. 衛生試験所報告 99(1981).

54. 石館 基. 変異原性試験とがん原物質チェックの現状. 公衆衛生 45(1981).

55. 石館 基. 日米毒性研究協力事業による米国視察旅行を終えて. Overseas meeting and project (1981).

56. 石館 基. 変異原性と発癌性-発癌性物質のスクリーニングの立場から-. 日本薬剤師会雑誌 33(1981).

57. 石館 基. 危険性評価 --変異原性試験と生活関連物質の安全性評価--. 食品関連物質の安全性評価に関するILSI国際シンポジウム講演録 (1981).

58. 石館 基、祖父尼 俊雄、吉川 邦衛. 19 環境汚染化学物質の変異原性試験並びにその試験法の開発に関する研究. (1981).

59. Hayashi, M., Sofuni, T. & Ishidate, M., Jr. High-sensitivity in micronucleus induction of a mouse strain (MS). Mutat Res 105, 253-6 (1982).

60. Matsuoka, A., Shudo, K., Saito, Y., Sofuni, T. & Ishidate, M., Jr. Clastogenic potential of heavy oil extracts and some aza-arenes in Chinese hamster cells in culture. Mutat Res 102, 275-83 (1982).

61. Nakamura, M., Matsuo, Y., Mori, T., Okada, S., Nakayama, T., Saito, H., Ito, T., Koseki, Y., Ogawa, T., Ishihara, S., Kohsaka, K., Nakamura, K. & Ishidate, M. Failure to validate the growth of Mycobacterium leprae on M-Y 14b agar medium. Int J Lepr Other Mycobact Dis 50, 480-7 (1982).

62. Nohmi, T., Miyata, R., Yoshikawa, K. & Ishidate, M., Jr. Effects of 7, 8-benzoflavone and SKF 525-A on the enzyme-mediated mutagenicity of phenylenediamines. J Toxicol Sci 7, 61-9 (1982).

63. Nohmi T, Ichishima E. Regeneration of mycelial protoplasts of Aspergillus oryzae. Agric Biol Chem 46, 809-810 (1982).

64. Ohtaki K, Shimba H, Awa AA, Sofuni T. Comparison of type and frequency of chromosome aberrations by conventional and G-staining methods in Hiroshima atomic bomb survivors. J Radiat Res (Tokyo) 23, 441-449 (1982).

65. Yoshikawa, K., Nohmi, T., Miyata, R. & Ishidate, M., Jr. [Bacterial mutagenicity tests on irradiated foods (fish-meat cake, wiener and orange juice)]. Eisei Shikenjo Hokoku, 110-9 (1982).

66. Yoshikawa, K., Nohmi, T., Miyata, R., Ishidate, M., Jr., Ozawa, N., Isobe, M., Watabe, T., Kada, T. & Kawachi, T. Difference in liver homogenates from Donryu, Fischer, Sprague-Dawley and Wistar strains of rat in the drug-metabolizing enzyme assay and the Salmonella/hepatic S9 activation test. Mutat Res 96, 167-86 (1982).

67. 大森 義仁、戸部 満寿夫、鈴木 康雄、中路 幸男、石館 基、祖父尼 俊雄、吉川 邦衛、義平 邦利、佐谷戸 安好. 低沸点性有機塩素化合物の生体影響に関する研究. (1982).

68. 吉川 邦衛、能美 健彦、宮田 ルミ子、石館 基. 照射食品(カマボコ・ウィンナーソーセージ・ミカンジュース)の微生物に対する突然変異試験. 衛生試験所報告 100(1982).

69. 石館 基. 哺乳動物細胞を用いる検索と問題点. 日本香粧品科学会誌 6(1982).

70. 石館 基. 食品中の変異原-最近の話題から. 医学のあゆみ 122(1982).

71. 石館 基. ⅠⅠ.WHO/IPCSの最近の動き-CSSTT活動について-. 変異原と毒性 5, 588-589 (1982).

72. 石館 基. 哺乳動物細胞を用いる変異原性試験-発癌性・遺伝毒性物質の検索. 衛生化学 28, 291-304 (1982).

73. 石館 基. 哺乳動物細胞を用いる検索と問題点. 日本香粧品科学会誌 6(1982).

74. 石館 基. 変異原性試験法ガイドラインに関するOECD専門家会議(ロンドン)に出席して. 変異原と毒性 5(1982).

75. 石館 基、祖父尼 俊雄. 30.大気汚染物質の哺乳動物細胞に及ぼす細胞遺伝学的影響に関する研究. (1982).

76. 変異原性部. 医薬品、食品添加物等の変異原性の定量的評価に関する研究. 衛生試験所報告 100(1982).

77. Hayashi, M., Sofuni, T. & Ishidate, M., Jr. An application of Acridine Orange fluorescent staining to the micronucleus test. Mutat Res 120, 241-7 (1983).

78. Jr, Ishidate M. Cytogenetic screening of environmental mutagens and/or carcinogens using Chinese hamster cells in culture. Genetics & Public Health, Bionature 3A: 25-41 3A, 25-41 (1983).

79. Nohmi, T., Kawamoto, Y., Hashimoto, Y., Tanaka, A., Fujii, A. & Aono, M. [2 cases of tracheomegaly]. Masui 32, 348-51 (1983).

80. Nohmi, T., Miyata, R., Yoshikawa, K., Nakadate, M. & Ishidate, M., Jr. Metabolic activation of 2,4-xylidine and its mutagenic metabolite. Biochem Pharmacol 32, 735-8 (1983).

81. Nohmi, T., Yoshikawa, K., Nakadate, M. & Ishidate, M., Jr. Species difference in the metabolic activation of phenacetin by rat and hamster liver microsomes. Biochem Biophys Res Commun 110, 746-52 (1983).

82. Yoshikawa K, Tanaka A, Yamaha T, Kurata H. Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli. Food Chem Toxicol 21, 221-223 (1983).

83. 石館 基. 米国 Ann Arbor に Ernest H.Y. Chu教授を訪ねて. 組織培養 9, 227-229 (1983).

84. 石館 基. 変異原性試験のがん研究分野における役割. Oncologia 6, 76-89 (1983).

85. 林 真、祖父尼 俊雄、石館 基. 小核試験におけるアクリジンオレンジ蛍光染色法. トキシコロジーフォーラム 6(1983).

86. 祖父尼 俊雄、松岡 厚子. 染色体異常誘発試験における代謝活性化法について. 環境変異原研究 5, 4-6 (1983).

87. 石館 基、祖父尼 俊雄、林 真、松岡 厚子、沢田 稔. 25 大気汚染物質の哺乳動物細胞に及ぼす細胞遺伝学的影響に関する研究. (1983).

88. Hayashi, M., Sofuni, T. & Ishidate, M., Jr. A pilot experiment for the micronucleus test. The multi-sampling at multi-dose levels method. Mutat Res 141, 165-9 (1984).

89. Hayashi, M., Sofuni, T. & Ishidate, M., Jr. Kinetics of micronucleus formation in relation to chromosomal aberrations in mouse bone marrow. Mutat Res 127, 129-37 (1984).

90. Ishidate, M., Jr., Sofuni, T., Yoshikawa, K., Hayashi, M., Nohmi, T., Sawada, M. & Matsuoka, A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol 22, 623-36 (1984).

91. Ishidate M, Jr., Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol 22, 623-636 (1984).

92. Nohmi, T., Yoshikawa, K., Ishidate, M., Jr., Hiratsuka, A. & Watabe, T. Mechanism of species differences in N-hydroxyphenacetin mutagenicity: the role of deacetylation by rat and hamster liver microsomes. Chem Pharm Bull (Tokyo) 32, 4525-31 (1984).

93. Nohmi, T., Yoshikawa, K., Nakadate, M., Miyata, R. & Ishidate, M., Jr. Mutations in Salmonella typhimurium and inactivation of Bacillus subtilis transforming DNA induced by phenylhydroxylamine derivatives. Mutat Res 136, 159-68 (1984).

94. Sofuni, T., Hayashi, M., Matsuoka, A., Sawada, M., Hatanaka, M. & Ishidate, M., Jr. [Cytogenetic effects of gaseous and volatile chemicals on mammalian cells in vitro and in vivo. II. Micronucleus tests in mice]. Eisei Shikenjo Hokoku, 84-90 (1984).

95. Sofuni, T., Hayashi, M., Matsuoka, A., Sawada, M., Hatanaka, M. & Ishidate, M., Jr. [Cytogenetic effects of gaseous and volatile chemicals on mammalian cells in vitro and in vivo. I. Chromosome aberration tests in cultured mammalian cells]. Eisei Shikenjo Hokoku, 77-83 (1984).

96. Sofuni, T. & Ishidate, M., Jr. Induction of chromosomal aberrations in cultured Chinese hamster cells in a superoxide-generating system. Mutat Res 140, 27-31 (1984).

97. 石館 基. 変異原性試験法ガイドラインに関する国内外の動向. 化学品安全 2(1984).

98. 石館 基. 変異原性試験法ガイドラインに関する国内外の動向. 化学品安全 2(1984).

99. 石館 基. 遺伝と癌<細胞レベルの問題点>. 現代病理学大系 9c 、腫瘍ⅠⅠⅠ (1984).

100. 祖父尼 俊雄、林 真、松岡 厚子、沢田 稔、畑中 みどり、石館 基. ガス状及び揮発性化学物質の哺乳動物細胞に対する細胞遺伝学的影響

Ⅰ.培養細胞を用いる染色体異常試験. 衛生試験所報告 102(1984).

101. 祖父尼 俊雄、林 真、松岡 厚子、沢田 稔、畑中 みどり、石館 基. ガス状及び揮発性化学物質の哺乳動物細胞に対する細胞遺伝学的影響

ⅠⅠ.マウスを用いる小核試験. 衛生試験所報告 102(1984).

102. 沢田 稔・祖父尼 俊雄、石館 基. 1,1-Dichloroethyleneの染色体異常誘発性について. 環境変異原研究 6, 149-154 (1984).

103. 能美 健彦、森本 和滋、石館 基. 環境変異原物質、環境発癌物質へのヒト曝露をモニタリングするためのドシメーター:

DNA付加物に関する会議の報告. トキシコロジーフォーラム 9(1984).

104. 石館 基、祖父尼 俊雄、林 真、松岡 厚子、沢田 稔. 21 大気汚染物質の哺乳動物細胞に及ぼす細胞遺伝学的影響に関する研究. (1984).

105. 能美 健彦、石館 基、渡部 烈. 解熱鎮痛剤フェナセチン、ブセチンの代謝活性化機構. 環境変異原研究 6, 203-209 (1984).

106. 哺乳動物試験系研究会. 小核試験 -ガイドラインの比較検討と標準プロトコールの提案(その2)-. トキシコロジーフォーラム 7(1984).

107. K.Nakajima, K.Mise &. Restriction endonuclease Eco0109 from Escherichia coli H709c with heptanucleotide recognition site 5' -PuG/GNCCPy. Gene 36, 363-367 (1985).

108. Nohmi, T., Ishidate, M., Jr., Hiratsuka, A. & Watabe, T. Mechanism of metabolic activation of the analgetic bucetin to bacterial mutagens by hamster liver microsomes. Chem Pharm Bull (Tokyo) 33, 2877-85 (1985).

109. Nohmi, T., Miyata, R., Yoshikawa, K. & Ishidate, M., Jr. [Mutagenicity tests on organic chemical contaminants in city water and related compounds. I. Bacterial mutagenicity tests]. Eisei Shikenjo Hokoku, 6O-4 (1985).

110. Slor H, Bynum GD, Jr, Lee C, Mizusawa H, Kakefuda T. Effect of DNA conformation on the binding of antibodies to benzo[a]pyrene diolepoxide DNA adducts. Gann 76, 488-495 (1985).

111. Sofuni, T., Hayashi, M., Matsuoka, A., Sawada, M., Hatanaka, M. & Ishidate, M., Jr. [Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mammalian cells]. Eisei Shikenjo Hokoku, 64-75 (1985).

112. 石館 基、吉川 邦衛、宮田 ルミ子、祖父尼 俊雄、畑中 みどり. 56.体内適用放射性医薬品の安全性に関する研究

(4)放射性医薬品の突然変異原性に関する研究. (1985).

113. 石館 基、能美 健彦、宮田 ルミ子、祖父尼 俊雄、畑中 みどり. 51.体内適用放射性医薬品の安全性に関する研究

(4)放射性医薬品の突然変異原性に関する研究. (1985).

114. 水沢 博、石館 基. 厚生省・細胞バンク計画とその現状. トキシコロジーフォーラム 8(1985).

115. 石館 基. 水道水汚染有機化合物およびその関連物質の変異原性に関する研究. 衛生試験所報告 103(1985).

116. 石館 基. 変異原性試験法の適用に関する国内外の動向. 環境変異原研究 7, 47-56 (1985).

117. 能美 健彦、宮田 ルミ子、吉川 邦衛、石館 基. 水道水汚染有機化合物およびその関連物質の変異原性に関する研究. 衛生試験所報告 103(1985).

118. 林 真、山崎 実、菊池 康基、石館 基. 小核試験結果の判定に関する背景データの利用. トキシコロジーフォーラム 8(1985).

119. 祖父尼 俊雄. 哺乳動物変異原性試験研究会ニュース. 環境変異原研究 7, 69-72 (1985).

120. 石館 基、祖父尼 俊雄、林 真、松岡 厚子、沢田 稔. 28 環境汚染物質の低濃度レベルにおける生体内変異原活性検出法の開発. (1985).

121. Ashby, J. & Ishidate, M., Jr. Clastogenicity in vitro of the Na, K, Ca and Mg salts of saccharin; and of magnesium chloride; consideration of significance. Mutat Res 163, 63-73 (1986).

122. Harasawa R, Mizusawa H, Koshimizu K. A reliable and sensitive method for detecting mycoplasma in cell culture. Microbiol Immunol 30, 919-921 (1986).

123. Ichishima E, Hanzawa S, Watanabe M, Takeuchi M. Electrophoretic heterogeneity and age-related change of serine proteinase from Aspergillus sojae. Curr Microbiol 13, 231-235 (1986).

124. Matsui, M., Mise, K., Yoshida, Y. & Ishidate, M., Jr. [Production of restriction endonucleases from various Salmonella strains of human origin]. Eisei Shikenjo Hokoku, 92-6 (1986).

125. Mise, K., Nakajima, K., Terakado, N. & Ishidate, M., Jr. Production of restriction endonucleases using multicopy Hsd plasmids occurring naturally in pathogenic Escherichia coli and Shigella boydii. Gene 44, 165-9 (1986).

126. Mizokami, K., Nohmi, T., Fukuhara, M., Takanaka, A. & Omori, Y. Purification and characterization of a form of cytochrome P-450 with high specificity for aflatoxin B1 from 3-methylcholanthrene-treated hamster liver. Biochem Biophys Res Commun 139, 466-72 (1986).

127. Mizusawa, H., Kawase, M., Sasaki, K., Harnois, M. & Ishidate, M. [Quality control of cell lines in the JCRB-cell bank]. Tanpakushitsu Kakusan Koso 31, 1470-80 (1986).

128. 石館 基、祖父尼 俊雄、林 真、松岡 厚子、沢田 稔、Hannu Norppa. 23 環境汚染物質の低濃度レベルにおける生体内変異原活性検出法の開発. (1986).

129. Sofuni, T., Hayashi, M., Matsuoka, A., Sawada, M., Hatanaka, M. & Ishidate, M., Jr. [Cytogenetic effects of diesel engine exhausts on mammalian cells in vitro and in vivo]. Eisei Shikenjo Hokoku, 97-103 (1986).

130. test, The collabolative study group for the micronucleus. Sex difference in the micronucleus test. . Mutat Res 172, 151-163 (1986).

131. 松井 道子、三瀬 勝利、吉田 洋子、石館 基. 患者由来 Salmonella の産生する制限酵素. 衛生試験所報告 104(1986).

132. 水沢 博、石館 基. 細胞バンクにおける品質管理の原則と実情. 組織培養 12, 424-428 (1986).

133. 水沢 博、石館 基. JCRB細胞バンクの設立と品質管理の現状. 凍結及び乾燥研究会会誌 32, 8-13 (1986).

134. 水沢 博、川瀬 雅子、佐々木 澄志、Marion Harnois、石館 基. JCRB細胞バンクにおける細胞株の品質管理. 蛋白質 核酸 酵素 31(1986).

135. 石館 基. 日米毒性研究協力事業による米国視察. Overseas meeting and project (1986).

136. 石館 基. 危険性評価--変異原性試験と生活関連物質の安全性評価--. 食品関連物質の安全性評価に関するISLI国際シンポジウム講演録 1986(1986).

137. 石館 基. 変異原性の強さとその評価-生活関連物質の面から-. 環境変異原研究 8, 21-30 (1986).

138. 石館 基. 生活関連化学物質に関する変異原性試験の現状. ファルマシア 22(1986).

139. 祖父尼 俊雄、林 真、松岡 厚子、沢田 稔、畑中 みどり、石館 基. ディーゼル・エンジン排出物の細胞遺伝学的影響について. 衛生試験所報告 104(1986).

140. 能美 健彦、松井 道子、石館 基. バクテリアを用いる誘発突然変異頻度の測定法. トキシコロジーフォーラム 9(1986).

141. 祖父尼 俊雄. ATCC培養細胞部門の現況. 実験医学 3(1986).

142. 石館 基、滝澤 行雄、坂部 美雄、石崎 睦雄、伊藤 和敏、館 正知. 食品添加物の変異原性試験成績(その7). トキシコロジーフォーラム 9, 628-633 (1986).

143. Fujii, K., Nomoto, K., Ishidate, M., Jr. & Nakamura, K. Chronic toxicity of charred fish meat in Wistar rats. Nutr Cancer 9, 185-93 (1987).

144. Ishidate, M., Jr. & Harnois, M. C. The clastogenicity of chemicals in cultured mammalian cells. Mutagenesis 2, 240-3 (1987).

145. Ishiwata, H., Inoue, T., Yoshihira, K., Nohmi, T. & Ishidate, M., Jr. Lack of mutagenicity of tetramethylsuccinonitrile in Salmonella typhimurium TA strains. Eisei Shikenjo Hokoku, 100-1 (1987).

146. M.Ishidate, Jr. , T.Sofuni, M.Hayashi. QUANTITIVE EVALUATION OF GENOTOXIC POTENCY OF CHEMICALS IN A BATTERY SYSTEM COMBINING WITH IN VITRO AND IN VIVO TESTS. (1987).

147. Munoz N, Hayashi M, Bang LJ, Wahrendorf J, Crespi M, Bosch FX. Effect of riboflavin, retinol, and zinc and on micronuclei of buccal mucosa and of esophagus: A randomized double-blind intervension study in China. . JNCI 79, 687-691 (1987).

148. Nohmi, T., Mizokami, K., Kawano, S., Fukuhara, M. & Ishidate, M., Jr. Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters. Jpn J Cancer Res 78, 153-61 (1987).

149. 石館 基、祖父尼 俊雄、林 真、児玉 幸夫、Hannu Norppa. 16 環境汚染物質の低濃度レベルにおける生体内変異原活性検出法の開発. (1987).

150. Sawada, M., Sofuni, T. & Ishidate, M., Jr. Cytogenetic studies on 1,1-dichloroethylene and its two isomers in mammalian cells in vitro and in vivo. Mutat Res 187, 157-63 (1987).

151. Watanabe, M., Nohmi, T. & Ishidate, M., Jr. New tester strains of Salmonella typhimurium highly sensitive to mutagenic nitroarenes. Biochem Biophys Res Commun 147, 974-9 (1987).

152. 義平 邦利、松井 道子、石館 基. ステビオサイドの最近の話題. トキシコロジーフォーラム 10, 281-289 (1987).

153. 石館 基. 短期試験法による長期毒性の予測. The Journal of Toxicological Sciences 12(1987).

154. 林 真. マウス小核試験-その特徴と評価. 環境変異原研究 9, 73-86 (1987).

155. 林 真. In vivo小核試験の基礎と応用に関する研究. 環境変異原研究 9, 3-14 (1987).

156. 水沢 博. リレーショナルデータベースソフトウェアによる文献データベースの作成と利用. 蛋白質 核酸 酵素 32(1987).

157. 水沢 博. 細胞バンクにおける情報管理システム. 蛋白質 核酸 酵素 32(1987).

158. Ashby, J., Loquet, C., Ishidate, M., Jr., Callander, R. D. & Albanese, R. Mutagenicity to bacteria, cultured cells, and rodents of the human carcinogen chlornaphazine. Environ Mol Mutagen 12, 365-74 (1988).

159. Hayashi, M., Kishi, M., Sofuni, T. & Ishidate, M., Jr. Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. Food Chem Toxicol 26, 487-500 (1988).

160. Ishidate, M., Jr. A proposed battery of tests for the initial evaluation of the mutagenic potential of medicinal and industrial chemicals. Mutat Res 205, 397-407 (1988).

161. Ishidate, M., Jr., Harnois, M. C. & Sofuni, T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res 195, 151-213 (1988).

162. Mizokami, K., Fukuhara, M., Nohmi, T., Sunouchi, M., Fujimori, K., Takanaka, A. & Omori, Y. Characterization of mixed-function oxidases and purified cytochrome P-450 of livers of house musk shrew, Suncus murinus. Drug Metab Dispos 16, 151-5 (1988).

163. Nohmi, T., Battista, J. R., Dodson, L. A. & Walker, G. C. RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. Proc Natl Acad Sci U S A 85, 1816-20 (1988).

164. Sasaki, K., Mizusawa, H. & Ishidate, M. Isolation and characterization of ras-transfected BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoyl-phorbol-13-acetate. Jpn J Cancer Res 79, 921-30 (1988).

165. Sawada, M., Sofuni, T. & Ishidate, M., Jr. Induction of chromosomal aberrations in active oxygen-generating systems. II. A study with hydrogen peroxide-resistant cells in culture. Mutat Res 197, 133-40 (1988).

166. Sofuni, T. & Ishidate, M., Jr. [Generation of active oxygen by environmental factors; mutagenicity and active oxygen species]. Tanpakushitsu Kakusan Koso 33, 2830-7 (1988).

167. Sofuni, T. & Ishidate, M., Jr. Induction of chromosomal aberrations in active oxygen-generating systems. I. Effects of paraquat in Chinese hamster cells in culture. Mutat Res 197, 127-32 (1988).

168. The collabolative study group for the micronucleus test (Sutou S, Hayashi M, Shimada H, Shibuya T, Nishi Y). Strain difference in the micronucleus test. . Mutat Res 204, 307-316 (1988).

169. Tsuchiya, T., Matuoka, A., Sekita, S., Hisano, T., Takahashi, A. & Ishidate, M., Jr. Human embryonic cell growth assay for teratogens with or without metabolic activation system using microplate. Teratog Carcinog Mutagen 8, 265-72 (1988).

170. Yoshida T, Kawase M, Sasaki K, Mizusawa H, Ishidate M, Jr., Takeuchi M. Comparative studies on the sensitivity of three methods for detecting mycoplasma contamination in cell culture. . Bull JFCC 4, 9-15 (1988).

171. 石館 基. CHL-突然変異・細胞毒性アッセイ-. 蛋白質 核酸 酵素 33(1988).

172. 石館 基. 遺伝毒性 変異原性試験による生活関連物質の安全性評価. トキシコロジーフォーラム 11(1988).

173. 祖父尼 俊雄、石館 基. 変異原性と活性酸素. 蛋白質 核酸 酵素 33(1988).

174. 林 真、祖父尼 俊雄、石館 基. マウス小核試験の統計処理. トキシコロジーフォーラム 11(1988).

175. 石館 基、松井 道子、渡辺 雅彦、松井 恵子. 27.γ線照射した柑橘類等の変異原性に関する研究

-照射グレープフルーツジュースの微生物に対する突然変異試験-. (1988).

176. 石館 基、祖父尼 俊雄、松岡 厚子、沢田 稔、松田 良枝. 25.γ線照射した柑橘類等の変異原性に関する研究

-照射グレープフルーツジュースの哺乳類培養細胞を用いる染色体異常試験-. (1988).

177. 石館 基、祖父尼 俊雄、松岡 厚子、沢田 稔、松田 良枝. 26.γ線照射した柑橘類等の変異原性に関する研究

-照射グルコースの哺乳類培養細胞を用いる染色体異常試験-. (1988).

178. Battista, J. R., Nohmi, T., Donnelly, C. E. & Walker, G. C. Amino acid similarities to other proteins offer insights into roles of UmuD and UmuC in mutagenesis. Genome 31, 594-6 (1989).

179. Fukuhara, M., Nohmi, T., Mizokami, K., Sunouchi, M., Ishidate, M., Jr. & Takanaka, A. Characterization of three forms of cytochrome P-450 inducible by 3-methylcholanthrene in Golden hamster livers with special reference to aflatoxin B1 activation. J Biochem 106, 253-8 (1989).

180. Hayashi, M., Sofuni, T., Kodama, Y., Ishidate, M., Jr. & Tamura, H. Micronucleus test with 1-beta-D-arabinofuranosylcytosine administered by intraperitoneal injection and oral gavage. Mutat Res 223, 345-8 (1989).

181. Hayashi, M., Yoshimura, I., Sofuni, T. & Ishidate, M., Jr. A procedure for data analysis of the rodent micronucleus test involving a historical control. Environ Mol Mutagen 13, 347-56 (1989).

182. Hayashi M, Sutou S, Shimada H, Sato S, Sasaki YF, Wakata A. Difference between intraperitoneal and oral gavage application in the micronucleus test. The 3rd collaborative study by CSGMT/JEMS.MMS. Collaborative Study Group for the Micronucleus Test/Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan. . Mutat Res 223, 329-344 (1989).

183. Ishidate, M., Jr. & Odagiri, Y. Negative micronucleus tests on caprolactam and benzoin in ICR/JCL male mice. Mutat Res 224, 357-9 (1989).

184. M.Ishidate, Jr. In Vitro Chromosomal Aberration Test - Current Status. Chromosomal Aberrations Basic and Applied Aspects (1989).

185. Matsui, M., Matsui, K., Nohmi, T., Mizusawa, H. & Ishidate, M. [Mutagenicity of steviol: an analytical approach using the Southern blotting system]. Eisei Shikenjo Hokoku, 83-7 (1989).

186. Matsuoka, A., Hirosawa, A., Natori, S., Iwasaki, S., Sofuni, T. & Ishidate, M., Jr. Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes. II. Chromosomal aberration tests with cultured mammalian cells. Mutat Res 215, 179-85 (1989).

187. Watanabe, M., Ishidate, M., Jr. & Nohmi, T. A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100. Mutat Res 216, 211-20 (1989).

188. 佐々木 澄志、田中 憲穂、水沢 博、石館 基. 癌遺伝子v-Ha-rasを導入したBALB 3T3 細胞株(Bhas42)を用いる発癌プロモーター検索系の開発. 環境変異原研究 11(1989).

189. 松井 道子、松井 恵子、能美 健彦、水沢 博、石館 基. Steviolによる突然変異誘発機構に関する研究-Southern blotting法による解析-. 衛生試験所報告 107(1989).

190. 石館 基. 環境化学物質の染色体異常試験. OLYMPUS MICROSCOPE REVIEW 16(1989).

191. 渡辺 雅彦、能美 健彦、石館 基. ニトロアレーン、芳香族アミンに高感受性を示す Salmonella typhimurium TA98,TA100 の新しい誘導株の樹立. 環境変異原研究 11(1989).

192. Ashby, J., Ishidate, M., Jr., Stoner, G. D., Morgan, M. A., Ratpan, F. & Callander, R. D. Studies on the genotoxicity of beryllium sulphate in vitro and in vivo. Mutat Res 240, 217-25 (1990).

193. Battista, J. R., Nohmi, T., Donnelly, C. E. & Walker, G. C. Genetic analyses of cellular functions required for UV mutagenesis in Escherichia coli. Basic Life Sci 52, 269-75 (1990).

194. Battista, J. R., Ohta, T., Nohmi, T., Sun, W. & Walker, G. C. Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis. Proc Natl Acad Sci U S A 87, 7190-4 (1990).

195. Einisto, P., Nohmi, T., Watanabe, M. & Ishidate, M., Jr. Sensitivity of Salmonella typhimurium YG1024 to urine mutagenicity caused by cigarette smoking. Mutat Res 245, 87-92 (1990).

196. Fukuhara, K., Miyata, N., Matsui, M., Matsui, K., Ishidate, M., Jr. & Kamiya, S. Synthesis, chemical properties and mutagenicity of 1,6- and 3,6-dinitrobenzo[a]pyrenes. Chem Pharm Bull (Tokyo) 38, 3158-61 (1990).

197. H.Norppa, M.Hayashi, J.Maki-Paakkanen & M.Sorsa. THE MICRONUCLEUS ASSAY IN LYMPHOCYTES. Mutation and the Environment, Part B: 207-216 (1990).

198. Hayashi, M., Morita, T., Kodama, Y., Sofuni, T. & Ishidate, M., Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat Res 245, 245-9 (1990).

199. Hitotsumachi, S., Kimura, Y., Nakajima, Y., Hayashi, M. & Ishidate, M., Jr. Micronucleus test on quinacrine dihydrochloride in mice: a comparison of dosage regimens. Mutat Res 234, 141-5 (1990).

200. Matsuoka, A., Matsui, M., Miyata, N., Sofuni, T. & Ishidate, M., Jr. Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro. Mutat Res 241, 125-32 (1990).

201. Nohmi, T., Battista, J. R., Ohta, T., Igras, V., Sun, W. & Walker, G. C. Antimutagenic effect of umuD mutant plasmids: isolation and characterization of umuD mutants reduced in their ability to promote UV mutagenesis in Escherichia coli. Basic Life Sci 52, 417-21 (1990).

202. Sakai, A., Sasaki, K., Mizusawa, H. & Ishidate, M., Jr. Effects of quercetin, a plant flavonol, on the two-stage transformation in vitro. Teratog Carcinog Mutagen 10, 333-40 (1990).

203. Sasaki, K., Mizusawa, H., Ishidate, M. & Tanaka, N. Transformation of ras transfected BALB 3T3 clone (Bhas 42) by promoters: Application for screening and specificity of promoters. Toxicol In Vitro 4, 657-9 (1990).

204. Sasaki, K., Mizusawa, H., Ishidate, M. & Tanaka, N. Establishment of a highly reproducible transformation assay of a ras-transfected BALB 3T3 clone by treatment with promoters. Basic Life Sci 52, 411-6 (1990).

205. Shimada, H., Satake, S., Itoh, S., Hattori, C., Hayashi, M. & Ishidate, M., Jr. Multiple-dosing effects of benzo[a]pyrene in the mouse bone marrow micronucleus test. Mutat Res 234, 179-81 (1990).

206. Sofuni, T., Matsuoka, A., Sawada, M., Ishidate, M., Jr., Zeiger, E. & Shelby, M. D. A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture. Mutat Res 241, 175-213 (1990).

207. test, Collaborative study group for the micronucleus. The mammalian mutagenesis study group of the Environmental Mutagen Society, Japan (CSGMT/JEMS・MMS): Single versus multiple dosing in the micronucleus test: the summary of the fouth collaborative study by CSGMT/JEMS・MMS, . Mutat Res 234, 205-222 (1990).

208. Watanabe, M., Ishidate, M., Jr. & Nohmi, T. Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels. Mutat Res 234, 337-48 (1990).

209. Watanabe, M., Ishidate, M., Jr. & Nohmi, T. Nucleotide sequence of Salmonella typhimurium nitroreductase gene. Nucleic Acids Res 18, 1059 (1990).

210. Yamada M, Makino K, Shinagawa H, Nakata A Regulation of the phosphate regulon of Escherichia coli: Properties of phoR deletion mutants and subcellular localization of PhoR protein,. Mol Gen Genet 220, 366-372 (1990).

211. 能美 健彦、渡辺 雅彦、Pirkko Einisto、松岡 厚子、祖父尼 俊雄、石館 基. 遺伝子工学的手法を用いた新しいサルモネラ指標菌株の開発. 環境変異原研究 12, 57-65 (1990).

212. 国立衛生試験所安全性生物試験研究センター & 祖父尼 俊雄・松岡 厚子・鈴木 孝昌・林 真. リンパ球の分裂中期細胞集積法に関する研究. (1990).

213. 国立衛生試験所安全性生物試験研究センター変異遺伝部 & (祖父尼 俊雄・能美 健彦・松井 道子・渡辺 雅彦・松井 恵子). 大量照射した食品成分の変異原性に関する研究:照射グルコースの微生物を用いる遺伝子突然変異試験. (1990).

214. 石館 基、祖父尼 俊雄. 化学物質のリスクアセスメント確立のための第2回日米学術会議 -リスクアセスメント手法等の改善と確立に関する研究-. 環境変異原研究 12, 305-308 (1990).

215. 祖父尼 俊雄. 哺乳動物試験に影響を及ぼす要因の解析とその協力研究の推進(平成元年度学会奨励賞受賞者論文). 環境変異原研究 12, 11-22 (1990).

216. 国立衛生試験所:療品部・代謝生化学部・有機化学部・変異遺伝部(石館 基・能美 健彦・松井 道子). 動物実験結果から化学物質の低濃度曝露時のヒトに対する影響を推定するための毒物動態学的研究. (1990).

217. Asita, A. O., Matsui, M., Nohmi, T., Matsuoka, A., Hayashi, M., Ishidate, M., Jr., Sofuni, T., Koyano, M. & Matsushita, H. Mutagenicity of wood smoke condensates in the Salmonella/microsome assay. Mutat Res 264, 7-14 (1991).

218. Einisto, P., Watanabe, M., Ishidate, M., Jr. & Nohmi, T. Mutagenicity of 30 chemicals in Salmonella typhimurium strains possessing different nitroreductase or O-acetyltransferase activities. Mutat Res 259, 95-102 (1991).

219. Gichner T, Holy A, Spassova M, Veleminsky J, Gruz P The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium. . Mutagenesis 6, 55-58 (1991).

220. Hakura, A., Morimoto, K., Sofuni, T. & Nohmi, T. Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase. J Bacteriol 173, 3663-72 (1991).

221. Hayashi, M., Nakadate, M., Osada, T., Ishibe, T., Tanaka, S., Maekawa, A., Sofuni, T., Nakata, Y., Kanoh, N., Hashiba, S. & et al. A fact database for toxicological data at the National Institute of Hygienic Sciences, Japan. Environ Health Perspect 96, 57-60 (1991).

222. Hayashi, M., Sofuni, T. & Morita, T. Simulation study of the effects of multiple treatments in the mouse bone marrow micronucleus test. Mutat Res 252, 281-7 (1991).

223. Heddle JA, Cimino MC, Hayashi M, Romagna F, Shelby MD, Tucker JD, Vanparys PH, MacGregor JT. Micronuclei as an index of cytogenetic damage: Past, present and future. Env. Mol Mutaen 18, 277-291 (1991).

224. indholm C, Norppa H, Hayashi M, Sorsa M. Induction of micronuclei and anaphase aberrations by cytochalasin B in human lymphocyte cultures,. Mutat Res 260, 369-375 (1991).

225. Ishidate, M. [The recollections of "vitacampher" development] (Jpn). Yakushigaku Zasshi 26, 121-42 (1991).

226. Ishidate, M. [The recollections of "vitacampher" development]. Yakushigaku Zasshi 26, 121-42 (1991).

227. Ishidate, M., Jr., Sofuni, T. & Nohmi, T. Quantitative evaluation on the genotoxic potency of chemicals. J Toxicol Sci 16 Suppl 1, 83-92 (1991).

228. Juricek M, Gruz P, Veleminsky J, Stanek J, Kefurt K, Moravcova J, Jary J. Mutagenic activity of 6-azido deoxyhexoses and azido alcohols in Salmonella typhimurium and its inhibition by a structure-similar carbon source in the medium. . Mutat Res 251, 13-20 (1991).

229. Marsh, L., Nohmi, T., Hinton, S. & Walker, G. C. New mutations in cloned Escherichia coli umuDC genes: novel phenotypes of strains carrying a umuC125 plasmid. Mutat Res 250, 183-97 (1991).

230. Matsuoka, A., Sofuni, T., Miyata, N. & Ishidate, M., Jr. Clastogenicity of 1-nitropyrene, dinitropyrenes, fluorene and mononitrofluorenes in cultured Chinese hamster cells. Mutat Res 259, 103-10 (1991).

231. Nakadate, M., Hayashi, M., Sofuni, T., Kamata, E., Aida, Y., Osada, T., Ishibe, T., Sakamura, Y. & Ishidate, M., Jr. The expert system for toxicity prediction of chemicals based on structure-activity relationship. Environ Health Perspect 96, 77-9 (1991).

232. Nohmi, T. [The molecular mechanism of UV-induced mutagenesis in Escherichia coli]. Tanpakushitsu Kakusan Koso 36, 1911-25 (1991).

233. Nohmi, T., Hakura, A., Nakai, Y., Watanabe, M., Murayama, S. Y. & Sofuni, T. Salmonella typhimurium has two homologous but different umuDC operons: cloning of a new umuDC-like operon (samAB) present in a 60-megadalton cryptic plasmid of S. typhimurium. J Bacteriol 173, 1051-63 (1991).

234. Sasaki, K., Mizusawa, H., Ishidate, M. & Tanaka, N. Gene transfer into mammalian cells by rapid freezing. In Vitro Cell Dev Biol 27, 86-8 (1991).

235. Sawada, M., Sofuni, T. & Ishidate, M., Jr. Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity. Mutat Res 264, 37-41 (1991).

236. Sawada, M., Sofuni, T. & Ishidate, M., Jr. Isolation of a menadione-resistant subclone from Chinese hamster lung (CHL) cells in culture. Mutat Res 249, 7-17 (1991).

237. Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M., Jr., Brusick, D., Ashby, J. & Myhr, B. C. International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. Mutat Res 257, 147-205 (1991).

238. Shelby MD, Sofuni T. Toxicology testing requirements and the U.S.-Japan collaborative study on in vitro tests for chromosomal aberrations. Environ Health Perspect 94, 255-259 (1991).

239. Ueda T, Hayashi M, Koide N , Sofuni T, Kobayashi J. Preliminary examination of the mutagenicity test using embryo cells of rose bitterling, Rhodeus ocellatus ocellatus. Chrom Inf Serv 51, 2-14 (1991).

240. Yoshida T, Yanai N, Kawase M, Mizusawa H, Takeuchi M. Characgerization of fastidious strains of Mycoplasma hyorhinis isolated from cell cultures. . IFO Res Commun 15, 5-14 (1991).

241. Yoshimura I, Hayashi M. On the use of historical controls in the analysis of labroratory data. . Statistical Medicine 10, 839-841 (1991).

242. 祖父尼 俊雄、能美 健彦、松井 道子、渡辺 雅彦、山田 雅巳、松井 恵子. 24.大量照射した食品成分の変異原性に関する研究 照射アミノ酸の微生物を用いる遺伝子突然変異試験. (1991).

243. 能美 健彦. 微生物を用いる変異原性試験データ集:その読み方と総括. 微生物を用いる変異原性試験データ集:11-22 (1991).

244. 能美 健彦. エームス・テストの原理と新しいサルモネラ試験菌株の開発. 微生物を用いる変異原性試験データ集:23-36 (1991).

245. 能美 健彦. 誤りがちDNA修復の分子機構-大腸菌のUmuD, UmuC, RecA, DNA複製酵素と紫外線誘発突然変異-. 蛋白質核酸酵素 36(1991).

246. 中村 晃忠、土屋 利江、五十嵐 良明、寺尾  男、沢田 純一、高橋 惇、鈴木 和博、森本 和滋、奥平 和穂、岩田 & 雅彦, 神谷 庄造、宮田 直樹、福原 潔、祖父尼 俊雄、能美 健彦、渡辺 修永. 動物実験結果から化学物質の低濃度曝露時のヒトに対する影響を推定するための毒物動態学的研究. (1991).

247. 祖父尼 俊雄. 変異原性試験. 水道協会雑誌 第60巻第5号(第680号), 24-34 (1991).

248. 祖父尼 俊雄. 小核試験. ファルマシア 27, 907-910 (1991).

249. 祖父尼 俊雄、松岡 厚子、鈴木 孝昌、林 真. 127.リンパ球の分裂中期細胞集積法に関する研究. (1991).

250. 林 真. 小核試験の最近の動向 教育講演「環境変異原のヒトへの新しいリスク解析法」. 環境変異原研究 13, 89-96 (1991).

251. Asita, A. O., Hayashi, M., Kodama, Y., Matsuoka, A., Suzuki, T. & Sofuni, T. Micronucleated reticulocyte induction by ethylating agents in mice. Mutat Res 271, 29-37 (1992).

252. Hayashi, M., Kodama, Y., Awogi, T., Suzuki, T., Asita, A. O. & Sofuni, T. The micronucleus assay using peripheral blood reticulocytes from mitomycin C- and cyclophosphamide-treated rats. Mutat Res 278, 209-13 (1992).

253. Hayashi, M., Norppa, H., Sofuni, T. & Ishidate, M., Jr. Flow cytometric micronucleus test with mouse peripheral erythrocytes. Mutagenesis 7, 257-64 (1992).

254. Hayashi, M., Norppa, H., Sofuni, T. & Ishidate, M., Jr. Mouse bone marrow micronucleus test using flow cytometry. Mutagenesis 7, 251-6 (1992).

255. Honma, M., Kataoka, E., Ohnishi, K., Ohno, T., Takeuchi, M., Nomura, N. & Mizusawa, H. A new DNA profiling system for cell line identification for use in cell banks in Japan. In Vitro Cell Dev Biol 28A, 24-8 (1992).

256. Honma, M., Mitani, K., Mizusawa, H., Sofuni, T., Muramatsu, M. & Kominami, R. A new VNTR-type RFLP probe (ChdTC-114) on chromosome 20p (D20S72). Hum Mol Genet 1, 554 (1992).

257. Honma, M., Mitani, K., Mizusawa, H., Sofuni, T., Muramatsu, M. & Kominami, R. A new VNTR-type RFLP probe (lambda TM-18) on chromosome 1 (D1S157). Hum Mol Genet 1, 554 (1992).

258. Honma, M., Mitani, K., Mizusawa, H., Sofuni, T., Muramatsu, M. & Kominami, R. A new VNTR-type RFLP probe (ChdTC-15) on chromosome 12 (D12S65). Hum Mol Genet 1, 555 (1992).

259. Ishidate, M., Jr. Comment on the US EPA recommendation for genotoxicity guidelines on chemicals. Mutat Res 272, 79-80 (1992).

260. Iwakura K, Tamura H, Matsumoto A, Ajimi S, Ogura S, Kakimoto K, Mtsumoto T, Hayashi M. Micronucleus assays on 5-fluorouracil and 6-mercaptopurine with mouse peripheral blood reticulocytes. Mutat Res 278, 131-137 (1992).

261. Kataoka, E., Honma, M., Ohnishi, K., Sofuni, T. & Mizusawa, H. Application of highly polymorphic DNA markers to the identification of HeLa cell sublines. In Vitro Cell Dev Biol 28A, 553-6 (1992).

262. Kishi M, Horiguchi Y, Awogi T, Suzuki T, Asita AO, Sofuni T. Validation of the mouse peripheral blood micronucleus assay usig acridine orange supravital staining with urethane. . Mutat Res 278, 205-208 (1992).

263. Matsuoka, A., Yamazaki, N., Suzuki, T., Hayashi, M. & Sofuni, T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat Res 272, 223-36 (1992).

264. Nakamura, A., Kawasaki, Y., Takada, K., Aida, Y., Kurokama, Y., Kojima, S., Shintani, H., Matsui, M., Nohmi, T., Matsuoka, A. & et al. Difference in tumor incidence and other tissue responses to polyetherurethanes and polydimethylsiloxane in long-term subcutaneous implantation into rats. J Biomed Mater Res 26, 631-50 (1992).

265. Nohmi, T., Yamada, M., Watanabe, M., Murayama, S. Y. & Sofuni, T. Roles of Salmonella typhimurium umuDC and samAB in UV mutagenesis and UV sensitivity. J Bacteriol 174, 6948-55 (1992).

266. Oda, Y., Shimada, T., Watanabe, M., Ishidate, M., Jr. & Nohmi, T. A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM1011 having a high nitroreductase activity. Mutat Res 272, 91-9 (1992).

267. Oda Y Shimada T, Watanabe M, Nohmi T. A sensitive system (umu test) for the detection of mutagenic nitroarenes in Salmonella typhimurium strain possessing elevted nitroreductase. Wat Sci Tech 25, 279-284 (1992).

268. Sai, K., Hayashi, M., Takagi, A., Hasegawa, R., Sofuni, T. & Kurokawa, Y. Effects of antioxidants on induction of micronuclei in rat peripheral blood reticulocytes by potassium bromate. Mutat Res 269, 113-8 (1992).

269. Sasaki, K., Mizusawa, H., Ishidate, M. & Tanaka, N. Regulation of G418 selection efficiency by cell-cell interaction in transfection. Somat Cell Mol Genet 18, 517-27 (1992).

270. Sofuni T, Yoshida MC. Combined use of several mitogens for mitotic stimulation to human lymphocytes. J Radiat Res (Tokyo) 33 Suppl, 222-230 (1992).

271. Suzuki, T., Tamai, K., Kodama, Y., Asita, A. O., Matsuoka, A., Sofuni, T., Kurita, M., Ohtsuki, H., Hiwatashi, T. & Hayashi, M. Micronucleus induction in mouse peripheral reticulocytes by 7,12-dimethylbenz[a]anthracene. Mutat Res 278, 169-73 (1992).

272. T, Sofuni. Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: Preface. . Mutat Res 278, 81 (1992).

273. T.Sofuni. IN VITRO DETECTION OF CHROMOSOMAL ABERRATIONS. In Vitro Methods of Toxicology (1992).

274. test, The collaborative study group for the micronucleus. Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: the summary report of the 5th collaborative study by CSGMT/JEMS.MMS. . Mutat Res 278, 83-98 (1992).

275. Ueda T, Hayashi M, Ohtsuka Y, Nakamura T, Kobayashi J, Sofuni T A preliminary study of the micronucleus test by acridine orange fluorescent staining compared with chromosomal aberration test using fish erythropoietic and embryonic cells. . Wat Sci Tech 25, 235-240 (1992).

276. Watanabe, M., Sofuni, T. & Nohmi, T. Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms. J Biol Chem 267, 8429-36 (1992).

277. Yamada, M., Sofuni, T. & Nohmi, T. Preferential induction of AT-TA transversion, but not deletions, by chlorambucil at the hisG428 site of Salmonella typhimurium TA102. Mutat Res 283, 29-33 (1992).

278. Yoshihara K, Itaya A, Hironaka T, Sakuramoto S, Tanaka Y, Tsuyuki M, Inada Y, Kamiya T, Ohnishi K, Honma M, Kataoka E, Mizusawa H, Uchida M, Uchida K, Miwa M. Poly (ADP ribose) polymerse defective mtutant cell clone of mouse L1210 cells. . Exp Cell Res 200, 126-134 (1992).

279. 中村 晃忠、土屋 利江、高橋 惇、落合 宏美、管 健一郎、片野 美樹、宮田 直樹、福原 潔、祖父尼 俊雄、能美 健彦、渡辺 雅彦. 15.動物実験結果から化学物質の低濃度曝露時のヒトに対する影響を推定するための毒物動態学的研究. (1992).

280. 鈴木 孝昌. トランスジェニックマウスの変異原性試験への応用. 変異原性試験 1(2), 3-18 (1992).

281. 祖父尼 俊雄. 染色体の構造異常. 変異原性試験 1(4), 235-241 (1992).

282. 祖父尼 俊雄、松岡 厚子、本間 正充、鈴木 孝昌、林 真. 128.リンパ球の分裂中期細胞集積法に関する研究. 国立機関原子力試験研究成果報告書(平成3年度), 128-1~128-10 (1992).

283. 祖父尼 俊雄、林 真、松岡 厚子、山崎 奈緒美. 29.大量照射した食品成分の変異原性に関する研究-照射グルコースの細胞遺伝学的研究-. (1992).

284. 中村 晃忠、佐藤 道夫、小嶋 茂雄、新谷 英晴、矢上 健、祖父尼 俊雄、能美 健彦、松井 道子、吉井 文男. 74.人工透析器の放射線滅菌による生体適合性の変化に関する研究(第二報). (1992).

285. 祖父尼 俊雄、山本 勝彦、石崎 睦雄、渡辺 重信、真坂 敬三、竹本 和夫. 食品添加物の変異原性試験成績(その10)-昭和63年度厚生省試験研究費による-. 変異原性試験 1(1), 46-52 (1992).

286. A.Matsuoka, N.Yamazaki, T.Suzuki, M.Hayashi and T.Sofuni. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutation Res. 272, 223-236 (1993).

287. Bai L, Kondo Y, Honma M, Namba M Immortalization of normal human fibroblasts by treatment with 4-nitroquinoline 1-oxide. . Int J Cancer 53, 451-456 (1993).

288. Gruz P, Juricek M, Zak P, Veleminsky J. Mutagenicity of 3-azido-1,2-propanediol and 9-(3-azido-2-hydroxypropyl)-adenine in repair deficient strains of Escherichia coli. . Mutat Res 303, 1-9 (1993).

289. Hagiwara, Y., Watanabe, M., Oda, Y., Sofuni, T. & Nohmi, T. Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity. Mutat Res 291, 171-80 (1993).

290. Harasawa R, Mizusawa H, Nozawa K, Nakagawa Y. Asada K, Kato I. Detection and tentative identification of dominant mycoplasma species in cell culture by restriction anaysis of the 16S-23S rRNA intergenic spacr regions. Res Microbiol 144, 489-493 (1993).

291. Honma, M., Kataoka, E., Ohnishi, K., Kikuno, T., Hayashi, M., Sofuni, T. & Mizusawa, H. Detection of recombinational mutations in cultured human cells by Southern blot analysis with minisatellite DNA probes. Mutat Res 286, 165-72 (1993).

292. Honma, M., Mitani, K., Mizusawa, H., Hayashi, M., Sofuni, T., Muramatsu, M. & Komonami, R. A new VNTR polymorphism at locus D1S340. Hum Mol Genet 2, 1329 (1993).

293. Kim SR, Funayama N, Komano T. Nucleotide sequence and chaaracterization of the traABCD region of IncII plasmid R64. J Bacteriol 175, 5035-5042 (1993).

294. M, Hayashi. Overview of in vivo micronucleus and chromosomal aberration assays. . MMS Commun Suppl 2, 45-54 (1993).

295. Matsuoka A, Horikawa K, Yamazaki N, Sera N, Sofuni T, Tokiwa H Chromosomal aberrations induced in vitro by 3,7- and 3,9-dinitrofluoranthene. . Mutat Res 298, 255-259 (1993).

296. Miura, K. F., Hatanaka, M., Otsuka, C., Satoh, T., Takahashi, H., Wakabayashi, K., Nagao, M. & Ishidate, M., Jr. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a carcinogenic pyrolysate, induces chromosomal aberrations in Chinese hamster lung fibroblasts in vitro. Mutagenesis 8, 349-54 (1993).

297. Nohmi, T., Hakura, A., Nakai, Y., Watanabe, M., Yamada, M., Murayama, S. Y. & Sofuni, T. The two umuDC-like operons, samAB and umuDCST, in Salmonella typhimurium: the umuDCST operon may reduce UV-mutagenesis-promoting ability of the samAB operon. Basic Life Sci 61, 247-55 (1993).

298. Oda, Y., Yamazaki, H., Watanabe, M., Nohmi, T. & Shimada, T. Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O-acetyltransferase and nitroreductase activities. Environ Mol Mutagen 21, 357-64 (1993).

299. Suzuki, T., Hayashi, M., Sofuni, T. & Myhr, B. C. The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice. Mutat Res 285, 219-24 (1993).

300. Suzuki T, Hayashi M, Sofuni T Current aspects of transgenic mice for mutation research -Importance of the positive selection system-. . MMS Commun Suppl 2 7, 31-38 (1993).

301. T, Sofuni. Japanese guidelines for mutagenicity testing. Ministry of Agriculture, Forestry and Fisheries; Ministry of Health and Welfare; Ministry of Labor. . Environ Mol Mutagen 21, 2-7; 46-57 (1993).

302. T.Nohmi, M.Yamada, M.Watanabe, M.Matsui, S.Y.Murayama and T.Sofuni. Two umuDC-like operons in Salmonella typhimurium: Their roles in UV mutagenesis. In Shima et al.(eds) "Frontiers of Photobiology", Elsevier Science Publishers B.V. 369-374(1993).

303. Takeuchi M, Yoshida T, Satoh M, Kuno H, Mizusawa H, Ohno T. Survey of mycoplasma contamination in animal cell lines collected by three cell banks in Japan. . Bull JFCC 9, 13-18 (1993).

304. Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H Comparative mapping of the primate immunoglobulin Ce1 gene homologous to IGHE by FISH. . Hum Genome Mapping WS 93, 110 (1993).

305. Watanabe, M., Sofuni, T. & Nohmi, T. Comparison of the sensitivity of Salmonella typhimurium strains YG1024 and YG1012 for detecting the mutagenicity of aromatic amines and nitroarenes. Mutat Res 301, 7-12 (1993).

306. Yamada, M., Hakura, A., Sofuni, T. & Nohmi, T. New method for gene disruption in Salmonella typhimurium: construction and characterization of an ada-deletion derivative of Salmonella typhimurium TA1535. J Bacteriol 175, 5539-47 (1993).

307. 中村 晃忠、土屋 利江、高橋 惇、L. Drummond、宮田 直樹、福原 潔、祖父尼 俊雄、能美 健彦、渡辺 雅彦. 動物実験結果から化学物質の低濃度曝露時のヒトに対する影響を推定するための毒物動態学的研究. 国立機関公害防止等試験研究成果報告書(平成4年度), 14-1~14-27 (1993).

308. 能美 健彦. ニトロアレーン、芳香族アミンに高感受性を示すサルモネラ菌株の開発. 環境変異原研究 15, 1-11 (1993).

309. 能美 健彦. 環境変異原検出系・評価系の開発. 環境変異原研究 15, 203-212 (1993).

310. 祖父尼 俊雄. 変異原性試験 -分子生物学技術を使った動物実験代替法(2)-. 遺伝 47(6), 27-32 (1993).

311. 祖父尼 俊雄. 環境物質の変異原性の検出法. 薬局 44(12), 23-29 (1993).

312. 水沢 博、本間 正充、野村 信夫. 培養細胞株におけるクロスカルチャーコンタミネーションの防止とDNAプロファイリング(前半). 組織培養 19(13), 494-498 (1993).

313. 水沢 博、本間 正充、野村 信夫. 培養細胞株におけるクロスカルチャーコンタミネーションの防止とDNAプロファイリング(後半). 組織培養 19(14), 543-546 (1993).

314. 祖父尼 俊雄、松岡 厚子、本間 正充、鈴木 孝昌、林 真. リンパ球の分裂中期細胞集積法に関する研究. 国立機関原子力試験研究成果報告書(平成4年度), 125-1~125-6 (1993).

315. 祖父尼 俊雄、宮部 正樹、石崎 睦雄、渡辺 重信、真坂 敬三、河村 太郎. 食品添加物の変異原性試験成績(その11)-平成元年度厚生省試験研究費による-. 変異原性試験 2(1), 19-28 (1993).

316. 能美 健彦、渡辺 雅彦、山田 雅巳、祖父尼 俊雄、小田 美光. 高感受性サルモネラ・テスター株開発のストラテジー:薬物代謝酵素遺伝子の導入とDNA修復酵素遺伝子の破壊. 環境変異原研究 15, 13-21 (1993).

317. Galloway, S. M., Aardema, M. J., Ishidate, M., Jr., Ivett, J. L., Kirkland, D. J., Morita, T., Mosesso, P. & Sofuni, T. Report from working group on in vitro tests for chromosomal aberrations. Mutat Res 312, 241-61 (1994).

318. Gatehouse, D., Haworth, S., Cebula, T., Gocke, E., Kier, L., Matsushima, T., Melcion, C., Nohmi, T., Ohta, T., Venitt, S. & et al. Recommendations for the performance of bacterial mutation assays. Mutat Res 312, 217-33 (1994).

319. Hayashi, M., Hashimoto, S., Sakamoto, Y., Hamada, C., Sofuni, T. & Yoshimura, I. Statistical analysis of data in mutagenicity assays: rodent micronucleus assay. Environ Health Perspect 102 Suppl 1, 49-52 (1994).

320. Hayashi, M., Maki-Paakkanen, J., Tanabe, H., Honma, M., Suzuki, T., Matsuoka, A., Mizusawa, H. & Sofuni, T. Isolation of micronuclei from mouse blood and fluorescence in situ hybridization with a mouse centromeric DNA probe. Mutat Res 307, 245-51 (1994).

321. Hayashi M, Tice RR, MacGregor JT, Anderson D, Blakey DH, Kirsh-Volders M, Oleson FB, Jr., Pacchierotti F, Romagna F, Shimada H, et al. . In vivo rodent erythrocyte micronucleus assay. . Mutat Res 312, 293-304 (1994).

322. Honma, M., Mizusawa, H., Sasaki, K., Hayashi, M., Ohno, T., Tanaka, N. & Sofuni, T. Demonstration by DNA fingerprint analysis of genomic instability in mouse BALB 3T3 cells during cell transformation. Mutat Res 304, 167-79 (1994).

323. Kirkland DJ, Galloway SM, Sofuni T International Workshop on Standardisation of Genotoxicity Test Procedures. Summary of major conclusions. Mutat Res 312, 205-209 (1994).

324. Komano T, Kim SR, Yoshida T, Nisioka T. DNA rearrangement of the shufflon determines recipient specificity in liquid mating of IncI1 plasmid R64. J Mol Biol 243, 6-9 (1994).

325. M.Hayashi, S.Sutou, M.Yajima and T.Morita. Editorial. MMS Com. 2, 59-60 (1994).

326. M.Yamada, H, Shinagawa, K.Makino, M.Amemura, T.Sato and A.Nakata. Single transduction in the phosphate regulon of Echerichia coli: Dual functions of PhoR as a protein kinase and a protein phosphatase. In A.Torriani-Govini et al.(eds), Phosphate in microorganisms: Cellular and molecular biology, American Soc. Microbiol., Washington DC, 285-289 (1994).

327. Matsuoka, A., Tucker, J. D., Hayashi, M., Yamazaki, N. & Sofuni, T. Chromosome painting analysis of X-ray-induced aberrations in human lymphocytes in vitro. Mutagenesis 9, 151-5 (1994).

328. Miyano-Kurosaki N, Nakashima H, Ichiyama K, Inazawa K, Tabata H, Tanabe H, Ohnishi K, Mizusawa H, Ohshiro Y, Yamamoto H A novel assay system for anti-huma immunodificiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937. Microbiol. Immunol 38, 813-818 (1994).

329. Nohmi, T., Abe, S., Tansho, S. & Yamaguchi, H. Suppression of anti-Candida activity of murine and human neutrophils by glucocorticoids. Microbiol Immunol 38, 977-82 (1994).

330. Ohno Y, Kaneko T, Kobayashi T, Inoue T, Kuroiwa Y, Yoshida T, Momma J, Hayashi M, Akiyama J, Atsumi T, Chiba K Endo T, Fujii A, Kakishima H, Kojima H, Masamoto K, Masuda M, Matsukawa S, Ohkoshi K, Okada J, Sakamoto K, Takano K, Takanaka A First-phase validation of the in vitro eye irritation tests for cosmetic ingredients. . In Vitro Toxicol 7, 89-94 (1994).

331. Sobue G, Ueno-Natsukari I, Okamoto H, Connell TA, Aizawa I, Mizoguchi K, Honma M, Ishikawa G, Mitsuma T, Natsukari N. Phenotypic heterogeneity of an adult from of adenoleukodystrophy in monozygotic twins. . Ann Neurol 36, 912-915 (1994).

332. Suzuki, T., Hayashi, M. & Sofuni, T. Initial experiences and future directions for transgenic mouse mutation assays. Mutat Res 307, 489-94 (1994).

333. T.Sofuni, M.Hayashi and. The micronucleus assay with rodent peripheral blood and acridine orange supravital standing. In G.Obe and A.T.Natarajan (eds),Chromosomal alterations, Springer-Verlag, Berlin, Heidelberg, 203-213 (1994).

334. Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H Regional assignment of the human immunoglobulin processed pseudogene C epsilon 3 (IGHEP2) to 9p24.2-->p24.1 by fluorescence in situ hybridization. Cytogenet Cell Genet 66, 93-95 (1994).

335. Tice RR, Hayashi M, MacGregor JT, Anderson D, Blakey DH, Holden HE, Kirsch-Volders M, Oleson FB Jr., Pacchierotti F, Preston RJ, Romagna F, Shimada H, Sutou S, Vannier B. Report from the working group on the in vivo mammlaian bone marrow chromosomal aberration test. Mutat Res 312, 305-312 (1994).

336. Ushijima, T., Hosoya, Y., Ochiai, M., Kushida, H., Wakabayashi, K., Suzuki, T., Hayashi, M., Sofuni, T., Sugimura, T. & Nagao, M. Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice. Carcinogenesis 15, 2805-9 (1994).

337. Watanabe, M., Igarashi, T., Kaminuma, T., Sofuni, T. & Nohmi, T. N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes. Environ Health Perspect 102 Suppl 6, 83-9 (1994).

338. Watanabe, M., Matsuoka, A., Yamazaki, N., Hayashi, M., Deguchi, T., Nohmi, T. & Sofuni, T. New sublines of Chinese hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferases or Salmonella typhimurium O-acetyltransferase: comparison of the sensitivities to nitroarenes and aromatic amines using the in vitro micronucleus test. Cancer Res 54, 1672-7 (1994).

339. Watanabe, M., Nohmi, T. & Ohta, T. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: II. Base substitution mutagenesis. Mutat Res 314, 39-49 (1994).

340. Watanabe, M., Nohmi, T. & Ohta, T. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: I. Frameshift mutagenesis. Mutat Res 314, 27-37 (1994).

341. 村上 博子、伊藤 啓、望月 正隆、山田 雅巳、能美 健彦. 酢酸塩緩衝液によるN-ニトロソアルキル尿素の変異原性抑制の Salmonella typhimurium YG71 系を用いた解析. 変異原性試験 3(3), 167-171 (1994).

342. 祖父尼 俊雄、林 真、松岡 厚子、本間 正充、鈴木 孝昌. 水生生物の細胞遺伝毒性を指標とした水質汚染モニタリング法の開発に関する研究. 国立機関公害防止試験研究成果報告書(平成5年度), 18-1~18-14 (1994).

343. 祖父尼 俊雄、山本 勝彦、石崎 睦雄、渡辺 重信、真坂 敬三、河村 太郎、滝澤 行雄. 食品添加物の変異原性試験成績(その12) -平成2年度厚生省試験研究費による-. 変異原性試験 3(4), 206-215 (1994).

344. 杉木 靖子、山崎 奈緒美、松岡 厚子、鈴木 孝昌、林 真、祖父尼 俊雄. In vitro 染色体異常試験における濃度設定のための細胞毒性試験方法の比較. Environ.Mutagen Res.Commun. 16, 37-43 (1994).

345. 林 真、鈴木 孝昌、祖父尼 俊雄. 遺伝子突然変異と小核誘発の同時検出系 The concomitant detection of gene mutation and micronucleus. Environ.Mutagen Res.Commun. 16, 67-77 (1994).

346. 林 裕造、祖父尼 俊雄. 化学物質の発癌性評価における変異原性試験の役割 -その現状と将来展望-. J.Toxicol.Sci. 19, 103-110 (1994).

347. 祖父尼 俊雄、松岡 厚子、鈴木 孝昌、林 真. リンパ球の分裂中期細胞集積法に関する研究 放射線による染色異常の高速自動解析システムに関する研究. 原子力基盤技術総合的研究(クロスオーバー研究:放射線リスク評価・低減化)第1期(平成元年4月~6年3月)最終報告書, 67-92 (1994).

348. 祖父尼 俊雄、松岡 厚子、本間 正充、鈴木 孝昌、林 真. リンパ球の分裂中期細胞集積法に関する研究. 国立機関原子力試験研究成果報告書(平成5年度), 121-1~121-4 (1994).

349. 林 真. 小核実験の将来 -特集・小核実験をめぐって(5). 変異原性試験 3(1), 55-63 (1994).

350. 能美 健彦、太田 敏博. 微生物突然変異試験. Environ.Mut.Res.Commun. 16, 137-140 (1994).

351. 祖父尼 俊雄、林 真、山崎 奈緒美、鈴木 孝昌、本間 正充、杉木 靖子. 培養細胞を用いる小核試験 -労働省委託研究班(平成5年度)報告書から-. 変異原性試験 3(4), 238-266 (1994).

352. (CSGMT), The collaborative study group for the micronucleus test. Protocol recommended by the CSGMT/JEMS・MMS for the short-term mouse peripheral blood micronucleus test. Mutagenesis 10, 153-159 (1995).

353. (JEMS), The collaborative study group for the micronucleus test (CSGMT) of the MMS of the Environmental Mutagen Society of Japan. Individual data in the results of the 7th collaborative study organized by CSGNT/JEMSMMS. MMS Commun 3, 117-131 (1995).

354. Harasawa R, Mizusawa H Demonstration and genotyping of pestivirus RNA from mammalian cell lines Microbiol Immunol 39, 979-985 (1995).

355. Hayashi, M. & Sofuni, T. A reaction to 'A sequential approach to testing with the rodent bone marrow micronucleus assay'. Mutat Res 331, 173-4 (1995).

356. Hayashi, M. & Sofuni, T. The need for three dose levels to detect genotoxic chemicals in in vivo rodent assays. Mutat Res 327, 247-51 (1995).

357. Honma M, Little JB Recombinogenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells. Carcinogenesis 16, 1717-1722 (1995).

358. Kikuno, T., Honma, M., Ogura, S., Mizusawa, H., Hayashi, M. & Sofuni, T. DNA fingerprint analysis in chemically mutagenized Chinese hamster lung cells. Mutat Res 338, 87-93 (1995).

359. Komano T, Kim SR, Yoshida T, Nisioka T. Mating variation by DNA inversions of shufflon in plasmid R64. Advanced Biophysics 31, 181-193 (1995).

360. Maki-Paakkanen, J., Hayashi, M., Suzuki, T., Tanabe, H., Honma, M. & Sofuni, T. Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons. Mutagenesis 10, 513-6 (1995).

361. Morita T, Shinohara N, Honma M and Tokue. Establishment and characterization of a new cell line from human bladder cancer (JMSU1). . Urol Res 23, 143-149 (1995).

362. Nohmi, T., Abe, S., Dobashi, K., Tansho, S. & Yamaguchi, H. Suppression of anti-Candida activity of murine neutrophils by progesterone in vitro: a possible mechanism in pregnant women's vulnerability to vaginal candidiasis. Microbiol Immunol 39, 405-9 (1995).

363. Nohmi, T., Yamada, M., Matsui, K., Watanabe, M. & Sofuni, T. Specific disruption of samAB genes in a 60-megadalton cryptic plasmid of Salmonella typhimurium. Mutat Res 329, 1-9 (1995).

364. Nohmi, T., Yamada, M., Matsui, M., Matsui, K., Watanabe, M. & Sofuni, T. Involvement of umuDCST genes in nitropyrene-induced -CG frameshift mutagenesis at the repetitive CG sequence in the hisD3052 allele of Salmonella typhimurium. Mol Gen Genet 247, 7-16 (1995).

365. Oda, Y., Yamazaki, H., Watanabe, M., Nohmi, T. & Shimada, T. Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity. Mutat Res 334, 145-56 (1995).

366. Ohno Y, Kaneko T, Kobayashi T, Inoue T, Kuroiwa Y, Yoshida T, Momma J, Hayashi M, Akiyama J, Atsumi T, Chiba K Endo T, Fujii A, Kakishima H, Kojima H, Masamoto Y, Masuda M, Matsukawa K, Ohkoshi K, Okada J, Sakamoto K, Takano K, Suzuki T, Takanaka A First-phase inter-laboratory validtion of the in vitro eye irritation tests for cosmetic ingredients: (1) Overview, organization and results of the validation study. . Altern Animal Test Experiment 3, 123-136 (1995).

367. Ono, T., Miyamura, Y., Ikehata, H., Yamanaka, H., Kurishita, A., Yamamoto, K., Suzuki, T., Nohmi, T., Hayashi, M. & Sofuni, T. Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age. Mutat Res 338, 183-8 (1995).

368. Sato S, Taketomi M, Nakajima M, Kitazawa M, Shimada H, Itouh S, Igarashi M, Higashikuni N, Sutou S, Sasaki YF, Hayashi M, Sofuni T et al. Effect of aging on spontaneous micronucleus frequencies in peripheral blood of mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS・MMS Mutat Res 338, 51-57 (1995).

369. Suzuki, T., Hayashi, M., Hakura, A., Asita, A. O., Kodama, Y., Honma, M. & Sofuni, T. Combination effects of clastogens in the mouse peripheral blood micronucleus assay. Mutagenesis 10, 31-6 (1995).

370. Suzuki T, Hayashi M, Myhr B, Sofuni T. Diethylnitrosamine is mutagenic in liver but not in bone marrow of lacZ transgenic mice (Muta Mouse ). MMS Commun Suppl 2 3, 33-39 (1995).

371. Suzuki T, Hayashi M, Honma M, Sofuni T. Micronucleus induction by monocrotaline in mouse peripheral blood. MMS Commun 3, 81-85 (1995).

372. T, Masui. Establishment of an outgrowth culture system to study growth regulation of normal human epithelim. . In Vitro Cell Dev Biol-animal 31, 440-446 (1995).

373. Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H Comparative mapping of the immunoglobulin C epsilon 1 gene (IGHE) in five species of nonhuman primates by fluorescence in situ hybridization. Cytogenet Cell Genet 70, 239-242 (1995).

374. Ushijima T, Hosoya Y, Suzuki T, Sofuni T, Sugimura T, Nagao M A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity. Mutat Res 334, 283-292 (1995).

375. Yamada, M., Sedgwick, B., Sofuni, T. & Nohmi, T. Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6-methylguanine. J Bacteriol 177, 1511-9 (1995).

376. Zhang, L. S., Honma, M., Hayashi, M., Suzuki, T., Matsuoka, A. & Sofuni, T. A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test. Mutat Res 347, 105-15 (1995).

377. 能美 健彦. 突然変異誘発を促進する遺伝子群:大腸菌umuDC遺伝子とそのホモローグ. 放射線生物研究 30, 157-176 (1995).

378. 祖父尼 俊雄、林 真、松岡 厚子、本間 正充、鈴木 孝昌. 水生生物の細胞遺伝毒性を指標とした水質汚染モニタリング法の開発に関する研究. 国立機関公害防止等試験研究成果報告書(平成6年度), 16-1~16-19 (1995).

379. 林 真、鈴木 孝昌、祖父尼 俊雄. 複合効果の理論的考察-In Vivo 小核誘発性について-. Environ.Mutagen Res.Commun. 17, 93-98 (1995).

380. 祖父尼 俊雄、能美 健彦、松井 道子. 変異細胞の選択技術の確立と突然変異の塩基配列の解析に関する研究. 国立機関原子力試験研究成果報告書(平成6度), 117-1~117-7 (1995).

381. Abe, S., Ohnishi, M., Nohmi, T., Katoh, M., Tansho, S. & Yamaguchi, H. A glucocorticoid antagonist, mifepristone affects anti-Candida activity of murine neutrophils in the presence of prednisolone in vitro and experimental candidiasis of prednisolone-treated mice in vivo. FEMS Immunol Med Microbiol 13, 311-6 (1996).

382. Ashby J, Waters MD, Preston J, Adler ID, Douglas GR, Fielder R, Shelby MD, Anderson D, Sofuni T, Gopalan HN, Becking G, Sonich-Mullin C. IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens. Mutat Res 352, 153-157 (1996).

383. assay, The collaborative study group for the transgenic mouse mutaion. Mammalian mutagenesis study group of the Environmental Mutagen Society of Japan: Organ variation in the mutagenicity of ethylnitrosourea in Muta mouse: Results of the collaborative study on the transgenic mutation assay by JEMS/MMS. . Environ Mol Mutagen 28, 363-375 (1996).

384. Ceccotti S, Aquilina G, Macpherson P, Yamada M, Karran P, Bignami M. Processing of O6-methylguanine by mismatch correction in human cell extracts. Curr Biol 6, 1528-1531 (1996).

385. Gruz, P., Matsui, K., Sofuni, T. & Nohmi, T. Construction of a new system for separate expression of mutagenesis proteins: the abilities to promote UV mutagenesis and interchangeability of MucA', MucB, SamA' and SamB proteins in Salmonella typhimurium. Mutat Res 354, 157-70 (1996).

386. Honma, M., Hayashi, M., Ohno, T., Mizusawa, H., Saijo, K. & Sofuni, T. Heterogeneity of the Y chromosome following long-term culture of the human lung cancer cell line A549. In Vitro Cell Dev Biol Anim 32, 262-4 (1996).

387. 山田 雅巳 and Peter Karran. ヒト細胞におけるミスマッチ修復の分子機構. 実験医学 14, 11-7 (1996).

388. Kondo K, Asano N, Hitotsumachi S, Kikuchi Y, Kondo Y, Miyamae Y, shimada H, Hayashi M MMS Osaka workshop, 1995 Case studies to evaluate genotoxicity test data based on the ICH consensus. . MMS Commun 4, 29-73 (1996).

389. Matsui, M., Matsui, K., Kawasaki, Y., Oda, Y., Noguchi, T., Kitagawa, Y., Sawada, M., Hayashi, M., Nohmi, T., Yoshihira, K., Ishidate, M., Jr. & Sofuni, T. Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis 11, 573-9 (1996).

390. Matsui, M., Sofuni, T. & Nohmi, T. Regionally-targeted mutagenesis by metabolically-activated steviol: DNA sequence analysis of steviol-induced mutants of guanine phosphoribosyltransferase (gpt) gene of Salmonella typhimurium TM677. Mutagenesis 11, 565-72 (1996).

391. Matsuoka, A., Yamada, K., Hayashi, M. & Sofuni, T. Chromosomal aberrations detected by chromosome painting in lymphocytes from cancer patients given high doses of therapeutic X-rays. J Radiat Res 37, 257-65 (1996).

392. Matsuoka, A., Yamakage, K., Kusakabe, H., Wakuri, S., Asakura, M., Noguchi, T., Sugiyama, T., Shimada, H., Nakayama, S., Kasahara, Y., Takahashi, Y., Miura, K. F., Hatanaka, M., Ishidate, M., Jr., Morita, T., Watanabe, K., Hara, M., Odawara, K., Tanaka, N., Hayashi, M. & Sofuni, T. Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay "unique positive' NTP carcinogens. Mutat Res 369, 243-52 (1996).

393. Nohmi, T., Abe, S., Katoh, M., Yamamoto, T. & Yamaguchi, H. [Augmented ability of spleen cells to produce interferons and prevention from lethal infection of herpes simplex virus in mice orally treated with Enterococcus faecalis preparation, FK-23]. Yakugaku Zasshi 116, 323-8 (1996).

394. Nohmi, T., Katoh, M., Suzuki, H., Matsui, M., Yamada, M., Watanabe, M., Suzuki, M., Horiya, N., Ueda, O., Shibuya, T., Ikeda, H. & Sofuni, T. A new transgenic mouse mutagenesis test system using Spi- and 6-thioguanine selections. Environ Mol Mutagen 28, 465-70 (1996).

395. Nonaka M, Omura H, Sofuni T, Hayashi M. Kojic acid did not induce micronuclei in mouse bone marrow hematopoietic cells. . MMS Commun 4, 109-112 (1996).

396. Oka H, Ohuchida A, Suzuki T, Sofuni T, Hayashi M. Hydrazine monohydrochloride and 1,2-dimethyl-hydrazine dihydrochloride induce micronuclei in rats. . MMS Commun 4, 99-107 (1996).

397. Otsuka, C., Miura, K. F. & Ishidate, M., Jr. The possible role of acetyltransferase in the induction of cytogenetic effects by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in cultured Chinese hamster cells. Mutat Res 371, 23-8 (1996).

398. Otsuka, C., Miura, K. F., Satoh, T., Hatanaka, M., Wakabayashi, K. & Ishidate, M., Jr. Cytogenetic effects of a food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-beta]pyridine (PhIP), and its metabolite, 2-hydroxyamino-1-methy-6-phenylimidazo[4,5-beta]pyridine (N-OH-PhIP), on human and Chinese hamster cells in vitro. Mutat Res 367, 115-21 (1996).

399. Sato S, Taketomi M, Nakajima J, Kitazawa M, Shimada H, Sasaki YF, Hayashi M, Sofuni T et al. Effect of aging on spontaneous micronucleus frequencis in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS・MMS. . Mutat Res 361, 287-288 (1996).

400. Satonaka, K., Ohashi, K., Nohmi, T., Yamamoto, T., Abe, S., Uchida, K. & Yamaguchi, H. Prophylactic effect of Enterococcus faecalis FK-23 preparation on experimental candidiasis in mice. Microbiol Immunol 40, 217-22 (1996).

401. Sofuni, T., Honma, M., Hayashi, M., Shimada, H., Tanaka, N., Wakuri, S., Awogi, T., Yamamoto, K. I., Nishi, Y. & Nakadate, M. Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study. Mutagenesis 11, 349-55 (1996).

402. Sofuni, T., Suzuki, T. & Hayashi, M. Initial consideration for use of transgenic mutation assays in a regulatory submission. Environ Mol Mutagen 28, 443-6 (1996).

403. Suzuki, T., Hayashi, M., Ochiai, M., Wakabayashi, K., Ushijima, T., Sugimura, T., Nagao, M. & Sofuni, T. Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice. Mutat Res 369, 45-9 (1996).

404. Suzuki, T., Itoh, T., Hayashi, M., Nishikawa, Y., Ikezaki, S., Furukawa, F., Takahashi, M. & Sofuni, T. Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice. Environ Mol Mutagen 28, 348-53 (1996).

405. T, Sofuni. How will the genotoxicity guidelines for pharmaceuticals be changed by the ICH agreement. J Toxicol Sci 21, 461-464 (1996).

406. T.Suzuki, M.Honma, T.Sofuni and M.Hayashi. Micronucleus induction by cis -diamminedichloroplatinum(Ⅱ)(cisplatin) assessed in mouse preipheral blood. MMS Commun. 4(1), 13-18 (1996).

407. Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H Molecular anatomy of human chromosome 9: comparative mapping of the immunoglobulin processed pseudogene C epsilon 3 (IGHEP2) in primates. . Cytogenet Cell Genet 73, 92-96 (1996).

408. Watanabe M, Zingg BC, Mohrenweiser HW. Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus. Am J Hum Genet 58, 308-316 (1996).

409. Zhang, L. S., Honma, M., Matsuoka, A., Suzuki, T., Sofuni, T. & Hayashi, M. Chromosome painting analysis of spontaneous and methyl methanesulfonate-induced trifluorothymidine-resistant L5178Y cell colonies. Mutat Res 370, 181-90 (1996).

410. Zhang LS, Honma M, Sofuni T, Matsuoka A, Suzuki T, Hayashi M. The induction of micronuclei and gene mutaions in L5178Y mouse lymphoma cells by hydroquinone and diethylstilbestol: A comparison of short- and long-term treatments. MMS Commun 4, 113-120 (1996).

411. 祖父尼 俊雄、林 真、松岡 厚子、本間 正充、鈴木 孝昌. 水生生物の細胞遺伝毒性を指標とした水質汚染モニタリング法の開発に関する研究. 国立衛生試験所安全性生物試験研究センター 変異遺伝部 (1996).

412. 祖父尼 俊雄. 放射線誘発染色体異常および突然変異の解析の高精度化:染色体ペインティング法と遺伝子導入系の利用. 原子力工業 42, 9-13 (1996).

413. 本間 正充、林 真、祖父尼 俊雄. ヒトリンパ球細胞株のtkを利用した欠失型、組み換え型突然変異 (Deletional and recombinational mutations at heterozygous thymidine kinase (tk) locus in human lymphoblastoid cells). Environ.Mutagen Res. 18, 107-111 (1996).

414. 林 真. 小核試験による評価法. 水環境学会誌 19, 775-779 (1996).

415. 祖父尼 俊雄、能美 健彦、松井 道子、増村 健一、金秀良、鈴木 任. 114.変異細胞の選択技術の確立と突然変異の塩基配列の解析に関する研究. 国立機関原子力試験研究成果報告書(平成7年度), 114-1~114-14 (1996).

416. 田辺 秀之、祖父尼 俊雄、水沢 博. Comparative Genomic Hybridization(CGH)法による細胞ゲノム解析 (Comparative genomic hybridization for genomic analyses of gells). 組織培養 22, 194-198 (1996).

417. Arai, K., Morishita, K., Shinmura, K., Kohno, T., Kim, S. R., Nohmi, T., Taniwaki, M., Ohwada, S. & Yokota, J. Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene 14, 2857-61 (1997).

418. authors, T.Ohno and 98 co-. A validation study in Japan on five different cytotoxicity assays. In:van Zutphen, L.F.M. and Balls, M.(Eds.) Animal alternatives, welfare and ethics Elsevier Science B.V., 1145-1154 (1997).

419. Galloway, S. M., Sofuni, T., Shelby, M. D., Thilagar, A., Kumaroo, V., Kaur, P., Gulati, D., Putman, D. L., Murli, H., Marshall, R., Tanaka, N., Anderson, B., Zeiger, E. & Ishidate, M., Jr. Multilaboratory comparison of in vitro tests for chromosome aberrations in CHO and CHL cells tested under the same protocols. Environ Mol Mutagen 29, 189-207 (1997).

420. Hauschke D, Hayashi M, Lin KK, Lovell DP, Robinson WD, Yoshimura I. Recommendations for biostatistics of mutagenicity studies. . Drug Inform J 31, 323-326 (1997).

421. Honma, M., Hayashi, M., Hackman, P. & Sofuni, T. Chlorambucil-induced structural changes in the gpt gene of AS52 cells. Mutat Res 389, 199-205 (1997).

422. Honma, M., Hayashi, M. & Sofuni, T. Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells. Mutat Res 374, 89-98 (1997).

423. Honma, M., Zhang, L. S., Hayashi, M., Takeshita, K., Nakagawa, Y., Tanaka, N. & Sofuni, T. Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells. Mol Cell Biol 17, 4774-81 (1997).

424. Inoue A, Yokomori K, Tanabe H, Mizusawa H, Sofuni T, Hayashi Y, Tsuchida Y, Shimatake H. Extensive genetic heterogeneity in the neuroblastoma cell line NB(TU)1. . Int J Cancer 72, 1070-1077 (1997).

425. Josephy, P. D., Gruz, P. & Nohmi, T. Recent advances in the construction of bacterial genotoxicity assays. Mutat Res 386, 1-23 (1997).

426. Kim, S. R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T. & Ohmori, H. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc Natl Acad Sci U S A 94, 13792-7 (1997).

427. Kim SR, Komano T. The plasmid R64 thin pilus identified as a type IV plus. J Bacteriol 179, 3594-3603 (1997).

428. Kobayashi, S., Nishimura, M., Shimada, Y., Suzuki, F., Matsuoka, A., Sakamoto, H., Hayashi, M., Sofuni, T., Sado, T. & Ogiu, T. Increased sensitivity of scid heterozygous mice to ionizing radiation. Int J Radiat Biol 72, 537-45 (1997).

429. Li-gun J, Osada M, Ishioka C, Gamo M, Ikawa S, Suzuki T Shimodaira H, Niitani T, Kudo T, Akiyama M, Kimura N, Matuo M, Mizusawa H, Tanaka N, Koyama H, Namba M, Kanamaru R, Kuroki T. Screening the p53 status of human cell lines using a yeast functional assay. Mol Carcinogen 19, 243-253 (1997).

430. Matsuoka, A., Ozaki, M., Takeshita, K., Sakamoto, H., Glatt, H. R., Hayashi, M. & Sofuni, T. Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79. Mutagenesis 12, 365-72 (1997).

431. Moggs JG, Szymkowski DE, Yamada M, Karran P, Wood RD. Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts. Nuc Acids Res 25, 480-490 (1997).

432. Morita, T., Asano, N., Awogi, T., Sasaki, Y. F., Sato, S., Shimada, H., Sutou, S., Suzuki, T., Wakata, A., Sofuni, T. & Hayashi, M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group. Mutat Res 389, 3-122 (1997).

433. Nishikawa, A., Furukawa, F., Kasahara, K., Lee, I. S., Suzuki, T., Hayashi, M., Sofuni, T. & Takahashi, M. Comparative study on organ-specificity of tumorigenicity, mutagenicity and cell proliferative activity induced by dimethylnitrosamine in Big Blue mice. Cancer Lett 117, 143-7 (1997).

434. Okonogi H, Ushijima T, Zhang XB, Heddle JA, Suzuki T, Sofuni T, Felton JS, Tucker JD, Sugimura T, Nagao M. Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents. . Carcinogenesis 18, 745-748 (1997).

435. Ono T, Ikehata H, Hosoi Y, Shung BS, Kurishita A, Wang X, Yamamoto K, Suzuki T, Sofuni T. X-ray- and ultraviolet-radiation-induced mutations in Muta mouse. Radiation Research 148, 123-128 (1997).

436. Piegorsh WW, Lockhart AC, Carr GJ, Margolin BH, Brooks T, Douglas GR, Liegibel, UM, Suzuki T, Thybaud V, van Delft JHM, Gorelick NJ Sources of variablitity in data from a positve selection lacZ transgenic mouse mutaion assay: An interlaboratory study. Mutat Res 388, 249-289 (1997).

437. Sasaki, Y. F., Izumiyama, F., Nishidate, E., Ishibashi, S., Tsuda, S., Matsusaka, N., Asano, N., Saotome, K., Sofuni, T. & Hayashi, M. Detection of genotoxicity of polluted sea water using shellfish and the alkaline single-cell gel electrophoresis (SCE) assay: a preliminary study. Mutat Res 393, 133-9 (1997).

438. Satoh, T., Tsuruga, H., Yabuta, N., Ishidate, M., Jr. & Nojima, H. Assignment of the human CDC21 (MCM4) gene to chromosome 8q11.2. Genomics 46, 525-6 (1997).

439. Sofuni T, Wilcox P, Shimada H, Clements J, Honma M, Clive D, Green M, Thybaud V, San RH, Elliott BM, Muller L. Mouse lymphoma workshop: Victoria, British Columbia, Canada, March 27, 1996 protocol issues regarding the use of the Microwell Method of the Mouse Lymphoma Assay. . Environ Mol Mutagen 29, 434-438 (1997).

440. Suzuki, M., Matsui, K., Yamada, M., Kasai, H., Sofuni, T. & Nohmi, T. Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds. Mutat Res 393, 233-46 (1997).

441. Suzuki M, Matsui K, Yamada M, Kasai H, Sofuni T, Nohmi T Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds. . Mutat Res 393, 233-246 (1997).

442. Suzuki, T., Hayashi, M., Wang, X., Yamamoto, K., Ono, T., Myhr, B. C. & Sofuni, T. A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice (Muta Mouse). Mutat Res 395, 75-82 (1997).

443. Suzuki, T., Itoh, S., Takemoto, N., Yajima, N., Miura, M., Hayashi, M., Shimada, H. & Sofuni, T. Ethyl nitrosourea and methyl methanesulfonate mutagenicity in sperm and testicular germ cells of lacZ transgenic mice (Muta Mouse). Mutat Res 388, 155-63 (1997).

444. Suzuki T, Hayashi M, Wang X, Yamamoto K, Ono T, Myhr BC, Sofuni T A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice (Muta Mouse). . Mutat Res 395, 75-82 (1997).

445. Suzuki T, Itoh S, Takemoto N, Yajima N, Miura M, Hayashi M, Shimada H, Sofuni T. Ethyl nitrosourea and methyl methanesulfonate mutagenicity in sperm and testicular germ cells of lacZ transgenic mice (Muta Mouse). Mutat Res 388, 155-163 (1997).

446. Yamada, M., Espinosa-Aguirre, J. J., Watanabe, M., Matsui, K., Sofuni, T. & Nohmi, T. Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538. Mutat Res 375, 9-17 (1997).

447. Yamada, M., Matsui, K., Sofuni, T. & Nohmi, T. New tester strains of Salmonella typhimurium lacking O6-methylguanine DNA methyltransferases and highly sensitive to mutagenic alkylating agents. Mutat Res 381, 15-24 (1997).

448. Yamada M, Espinosa-Aguirre JJ, Watanabe M, Matsui K, Sofuni T, Nohmi T Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538. . Mutat Res 375, 9-17 (1997).

449. Yamada M, Matsui K, Sofuni T, Nohmi T. New tester strains of Salmonella typhimurium lacking O6-methylguanine DNA methyltransferases and highly sensitive to mutagenic alkylating agents. Mutat Res 381, 15-24 (1997).

450. Yamada M, O’Regan E, Brown R, Karran P Selective recognition of cisplatin-DNA adduct by human mismatch repair proteins. . Nuc Acids Res 25, 491-495 (1997).

451. 祖父尼 俊雄、林 真、松岡 厚子、本間 正充、鈴木 孝昌. 水質汚染モニタリング法のための遺伝毒性を指標としたバイオセンサー系の開発. 環境保全研究成果集(平成8年度) 12, 1-22 (1997).

452. 林 真、渡辺 烈、島田 弘康. レギュラトリサイエンスにおける変異原性試験. Environ.Mutagen Res. 19, 111-115 (1997).

453. 祖父尼 俊雄、林 真、本間 正充. 変異細胞の選択技術の確立と突然変異の塩基配列の解析に関する研究. 国立医薬品食品衛生研究所 変異遺伝部 研究期間平成6年度~10年度, 116-1~116-7 (1997).

454. Adler I-D, Bootman J, Favor J, Hook G, Schriever-Schwemmer G, Welzl G, Whorton E, Yoshimura I, Hayashi M. Recommendations for statistical designs of in vivo mutagenicity tests with regard to subsequent statistical anaysis. Mutat Res 417, 19-30 (1998).

455. Asano N, Katsuma Y, Tamura H, Higashikuni N, Hayashi M An automated new technique for scoring the rodent micronucleus assay: computerized image analysis of acridine orange supravitally stained peripheral blood cells. . Mutat Res 404, 149-154 (1998).

456. Gruz, P., Matsui, K., Sofuni, T. & Nohmi, T. Roles of the mutagenesis proteins SamA'B and MucA'B in chemically induced frameshift mutagenesis in Salmonella typhimurium hisD3052. Mutat Res 398, 33-42 (1998).

457. Hayashi, M., Honma, M. & Sofuni, T. Dilution series for test chemicals in the mouse lymphoma mutation assay. Mutat Res 415, 165-6 (1998).

458. Hayashi, M., Ueda, T., Uyeno, K., Wada, K., Kinae, N., Saotome, K., Tanaka, N., Takai, A., Sasaki, Y. F., Asano, N., Sofuni, T. & Ojima, Y. Development of genotoxicity assay systems that use aquatic organisms. Mutat Res 399, 125-33 (1998).

459. Ishidate, M., Jr., Miura, K. F. & Sofuni, T. Chromosome aberration assays in genetic toxicology testing in vitro. Mutat Res 404, 167-72 (1998).

460. Itagaki H, Ohno T, Hatao M, Hayasaka A, Hayashi M et al. . Validation study on five cytotoxicity assays by JSAAE-V. Details of the crystal violet staining assay. . Altern Animal Test Experiment 5, 87-98 (1998).

461. Itagaki H, Ohno T, Hatao M, Hattori C, Hayasaka A, Hayashi M et al. . Validation study on five cytotoxicity assays by JSAAE-VII. Details of the MTT assay. . Altern Animal Test Experiment 5, 119-130 (1998).

462. Kohno, T., Shinmura, K., Tosaka, M., Tani, M., Kim, S. R., Sugimura, H., Nohmi, T., Kasai, H. & Yokota, J. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 16, 3219-25 (1998).

463. Matsuoka, A., Matsuura, K., Sakamoto, H., Hayashi, M. & Sofuni, T. Spindle disturbances induced by benzo[a]pyrene and 7, 12-dimethylbenz[a]anthracene in a Chinese hamster cell line (V79-MZ) and the stability of the numerical chromosome aberrations that follow. Mutat Res 419, 1-12 (1998).

464. MatsuokaA, Hayashi M, Sofuni T In vitro clastogenicity of 19 organic chemicals found in contaminated water and 7 structurally related chemicals. . Environ Mutagen Res 20, 159-165 (1998).

465. Miyamae Y, Yamamoto M, Sasaki YF, Kobayashi H, Igarashi-Soga M, Shimoi K, Hayashi M Evaluation of a tissue homogenization technique that isolates nuclei for the in vivo single cell gel electrophoresis (comet ) assay: A collaborative study by five laboratories. Mutat Res 418, 131-140 (1998).

466. Miyata, Y., Saeki, K., Kawazoe, Y., Hayashi, M., Sofuni, T. & Suzuki, T. Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice. Mutat Res 414, 165-9 (1998).

467. Morita T, Hayashi M 1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay , but is in mouse liver micronucleus assay. . Environ Mol Mutagen 32, 269-280 (1998).

468. Nagao M, Fujita H, Ochiai M, Wakabayashi K, Sofuni T, Matsushima T, Sugimura T, Ushijima T No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. . Mutat Res 400, 251-257 (1998).

469. Ochiai M, Ishida K, Ushijima T, Suzuki T, Sofuni T, Sugimura T, Nagao M DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity. . Mutagenesis 13, 381-384 (1998).

470. Ohno T, Asakura M, Awogi T, Futamura Y, Harihara A, Hayashi M Validation study on five cytotoxicity assays by JSAAE-I. Overview of the study and analyses of variations of ED50 values. . Altern Animal Test Experiment 5, 1-38 (1998).

471. Ohno T, futamura Y, harihara A, Hatao M, Hayashi M et al. . Validation study on five cytotoxicity assays by JSAAE-VI. Details of the LDH release assay. . Altern Animal Test Experiment 5, 99-118 (1998).

472. Ohno T, Futamura Y, Harihara A, Hatao M, Hayasaka A, Hayashi M et al. . Validation study on five cytotoxicity assays by JSAAE-VIII. Details of the neutral red uptake assay. . Altern Animal Test Experiment 5, 131-145 (1998).

473. Omori T, Saijo K, Kato M, Hayasi M, Itagaki H, et al. . Validation study on five cytotoxicity assays by JSAAE-II. Statistical analysis. . Altern Animal Test Experiment 5, 39-58 (1998).

474. Omori T, Saijo K, Kato M, Itagaki H, Hayasi M et al. . Validation study on five cytotoxicity assays by JSAAE-III. Quality of collected data files. . Altern Animal Test Experiment, 59-73 (1998).

475. Suzuki, A., Kushida, H., Iwata, H., Watanabe, M., Nohmi, T., Fujita, K., Gonzalez, F. J. & Kamataki, T. Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines. Cancer Res 58, 1833-8 (1998).

476. Suzuki, T., Miyata, Y., Saeki, K., Kawazoe, Y., Hayashi, M. & Sofuni, T. In vivo mutagenesis by the hepatocarcinogen quinoline in the lacZ transgenic mouse: evidence for its in vivo genotoxicity. Mutat Res 412, 161-6 (1998).

477. T, Sofuni. Harmonization of genotoxicity testing requirements for pharmaceuticals. . J Toxicol Sci 23 Suppl 2, 262-264 (1998).

478. Tanaka N, Asakura M, hattori C, Hayasaka A, Hayashi M et al. . Validation study on five cytotoxicity assays by JSAAE-IV. Details of the colony formation assay. . Altern Animal Test Experiment 5, 74-86 (1998).

479. Tani, M., Shinmura, K., Kohno, T., Shiroishi, T., Wakana, S., Kim, S. R., Nohmi, T., Kasai, H., Takenoshita, S., Nagamachi, Y. & Yokota, J. Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage. Mamm Genome 9, 32-7 (1998).

480. Wakata A, Miyamae Y, Sato S, Suzuki T, Morita T, AsanoN, Awogi T, Kondo K, Hayashi M Evaluation of the rat micronucleus test with bone marrow and peripheal blood: Summary of the 9th collaborative study by CSGMT/JEMS・MMS. . Environ Mol Mutagen 32, 84-100 (1998).

481. Wang, X., Suzuki, T., Itoh, T., Honma, M., Nishikawa, A., Furukawa, F., Takahashi, M., Hayashi, M., Kato, T. & Sofuni, T. Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice. Mutagenesis 13, 625-30 (1998).

482. Watanabe, M., Nishino, T., Takio, K., Sofuni, T. & Nohmi, T. Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem 273, 23922-8 (1998).

483. 祖父尼 俊雄、能美 健彦、山田 雅巳、増村 健一. 118.変異細胞の選択技術の確立と突然変異の塩基配列の解析に関する研究. 国立機関原子力試験研究成果報告書(平成6-10年度), 118-1~118-4 (1998).

484. 祖父尼 俊雄、林 真、松岡 厚子、本間 正充、鈴木 孝昌. 水質汚染モニタリング法のための遺伝毒性を指標としたバイオセンサー系の開発. 環境保全研究成果集(平成9年度) 12, 1-23 (1998).

485. 祖父尼 俊雄. Genotoxicityの翻訳は遺伝毒性でよいのか?. Environ.Mutagen Res. 20, 69-70 (1998).

486. 谷所 達幸、八木 利仁、岩崎 浩一、下位 香代子、木苗 直秀、林 真、祖父尼 俊雄. 魚類の小核試験を用いる沿岸水域の汚染モニタリング. Environ.Mutagen Res. 20, 1-9 (1998).

487. Studies on Kar ayotype evolution in higher primates in relation to human chromosome 14 and 9 by Comparative mapping of immunoglobulin C genes with fluorescence in situ hybridization

(FISH法による免疫グロブリンC遺伝子の比較マッピングに基づいたヒト及び高等霊長類における14番および9番染色体の核型進化に関する研究). 国立医薬品食品衛生研究所報告 117(1999).

488. Espinosa-Aguirre, J. J., Yamada, M., Matsui, K., Watanabe, M., Sofuni, T. & Nohmi, T. New O-acetyltransferase-deficient Ames Salmonella strains generated by specific gene disruption. Mutat Res 439, 159-69 (1999).

489. Heddle, J. A., Glickman, B. W., Nohmi, T. & van Steeg, H. Preface. Environ Mol Mutagen 34, 71 (1999).

490. Honma, M., Hayashi, M., Shimada, H., Tanaka, N., Wakuri, S., Awogi, T., Yamamoto, K. I., Kodani, N., Nishi, Y., Nakadate, M. & Sofuni, T. Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test. Mutagenesis 14, 5-22 (1999).

491. Honma, M., Zhang, L. Z., Sakamoto, H., Ozaki, M., Takeshita, K., Momose, M., Hayashi, M. & Sofuni, T. The need for long-term treatment in the mouse lymphoma assay. Mutagenesis 14, 23-9 (1999).

492. Horiguchi, M., Masumura, K., Ikehata, H., Ono, T., Kanke, Y., Sofuni, T. & Nohmi, T. UVB-induced gpt mutations in the skin of gpt delta transgenic mice. Environ Mol Mutagen 34, 72-9 (1999).

493. Kamataki, T., Suzuki, A., Kushida, H., Iwata, H., Watanabe, M., Nohmi, T. & Fujita, K. Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines. Cancer Lett 143, 113-6 (1999).

494. Kobayashi H, Hayashi M. Classification and evaluation of comets in single cell gel electrophoresis assay(コメット法における泳道像の分類と評価). (1999).

495. M, Honma. 内分泌撹乱化学物質がもたらす遺伝的不安定性 -組み換え型遺伝子突然変異について-. 21, 281-285 (1999).

496. Masumura, K., Matsui, K., Yamada, M., Horiguchi, M., Ishida, K., Watanabe, M., Ueda, O., Suzuki, H., Kanke, Y., Tindall, K. R., Wakabayashi, K., Sofuni, T. & Nohmi, T. Mutagenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the new gpt delta transgenic mouse. Cancer Lett 143, 241-4 (1999).

497. Masumura, K., Matsui, M., Katoh, M., Horiya, N., Ueda, O., Tanabe, H., Yamada, M., Suzuki, H., Sofuni, T. & Nohmi, T. Spectra of gpt mutations in ethylnitrosourea-treated and untreated transgenic mice. Environ Mol Mutagen 34, 1-8 (1999).

498. Matsuoka, A., Matsuura, K., Sakamoto, H., Hayashi, M. & Sofuni, T. A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test. Mutagenesis 14, 385-9 (1999).

499. Matsushima, T., Hayashi, M., Matsuoka, A., Ishidate, M., Jr., Miura, K. F., Shimizu, H., Suzuki, Y., Morimoto, K., Ogura, H., Mure, K., Koshi, K. & Sofuni, T. Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis 14, 569-80 (1999).

500. Muller L, Kikuchi Y, Probst G, Schechtman L, Shimada H, Sofuni T, Tweats D. ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact. Mutat Res 436, 195-225 (1999).

501. Nishikawa, T., Haresaku,M., Adachi,K., Masuda,M., Hayashi,M. Study of a rat skin in vivo micronucleus test: data generated by mitomycin C and methyl methanesulfonate. Mutation Research 444, 159-166 (1999).

502. Nohmi, T., Suzuki, M., Masumura, K., Yamada, M., Matsui, K., Ueda, O., Suzuki, H., Katoh, M., Ikeda, H. & Sofuni, T. Spi(-) selection: An efficient method to detect gamma-ray-induced deletions in transgenic mice. Environ Mol Mutagen 34, 9-15 (1999).

503. Ohno, Y., Kaneko,T.,Inoue,T.,Morikawa,Y.,Yoshida,T.,Fujii,A.,Masuda,M.,Ohno,T.,Hayashi,M.,Momma,J.,Uchiyama,T.,Chiba,K.,Ikeda,N.,Imanishi,Y.,Itakagaki,H.,Kakishima,H.,Kasai,Y.,Kusrishita,A.,Kojima,H.,Matsukawa,K.,Nakamura,T.,Ohkoshi,K.,Okumura,H.,Saijo,K.,Sakamoto,K.,Suzuki,T.,Takano,K.,Tatsumi,H.,Tani,N.,Usami,M.,and Watanabe,R. Interlaboratory Validation of the In Vitro Eye Irritation Tests for Cosmetic Ingredients. (1) Overview of the Validation Study and Draize Scores for the Evaluation of the Tests. Toxicology in Vitro 13, 73-98 (1999).

504. Okada, N., Masumura, K., Nohmi, T. & Yajima, N. Efficient detection of deletions induced by a single treatment of mitomycin C in transgenic mouse gpt delta using the Spi(-) selection. Environ Mol Mutagen 34, 106-11 (1999).

505. Saitoh, M., Umemura, T., Kawasaki, Y., Momma, J., Matsushima, Y., Sakemi, K., Isama, K., Kitajima, S., Ogawa, Y., Hasegawa, R., Suzuki, T., Hayashi, M., Inoue, T., Ohno, Y., Sofuni, T., Kurokawa, Y. & Tsuda, M. Toxicity study of a rubber antioxidant, mixture of 2-mercaptomethylbenzimidazoles, by repeated oral administration to rats. Food Chem Toxicol 37, 777-87 (1999).

506. Saotome, K., Sofuni, T. & Hayashi, M. A micronucleus assay in sea urchin embryos. Mutat Res 446, 121-7 (1999).

507. Satoh, T., Yamamoto, K., Miura, K. F., Sasaki, K. & Ishidate, M., Jr. Application of laser scanning cytometry to the analysis of chromosomal aberrations induced by benzo[a]pyrene in CHO-WBLT cells. Cytometry 35, 363-8 (1999).

508. Sofuni T, Hayashi M, Matsuoka A, Honma M, and Suzuki T. 水質汚染モニタリングのための遺伝毒性を指標としたバイオセンサー系の開発 Development of a Genotoxic Bioassay system to Monitor Water Pollution. (1999).

509. Sui, H., Suzuki, M., Yamada, M., Hara, T., Kawakami, K., Shibuya, T., Nohmi, T. & Sofuni, T. Effects of O (6)-alkylguanine-DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice. Environ Mol Mutagen 34, 221-6 (1999).

510. Suzuki, T., Uno, Y., Idehara, K., Baba, T., Maniwa, J., Ohkouchi, A., Wang, X., Hayashi, M., Sofuni, T., Tsuruoka, M., Miyajima, H. & Kondo, K. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res 444, 269-81 (1999).

511. Suzuki T, Itoh S, Nakajima M, Hachiya N, Hara T Target organ and time-course in the mutagenicity of five carcinogens in Muta™Mouse: A summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS. . Mutation Res 444, 259-268 (1999).

512. Tanabe, H., Takada,Y., Minegishi,D., Kurematsu,M., Masui,T., Mizusawa,H. CELL LINE INDIVIDUALIZATION BY STR MULTIPLEX SYSTEM IN THE CELL BANK FOUND CROSS-CONTAMINATION BETWEEN ECV304 AND EJ-1/T24. Tiss.Cult.Res.Commun. 18, 329-338 (1999).

513. Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H. Studies on karyotype evolution in higher primates in relation to human chromosome 14 and 9 by comparative mapping of immunoglobulin C epsilon genes with fluorescence in situ hybridization. . Bull Natl Health Sci (Eikenhoukoku) 117, 77-90 (1999).

514. Tanaka, T., Satoh, T., Onozawa, Y., Kohroki, J., Itoh, N., Ishidate, M., Jr., Muto, N. & Tanaka, K. Apoptosis during iron chelator-induced differentiation in F9 embryonal carcinoma cells. Cell Biol Int 23, 541-50 (1999).

515. Uchiyama, T., Akiyama,J., Miyai,E., Sakamoto,K., Takino,Y., Ohnuma,M., Ohkoshi,K., Okamoto,Y., Morito,Y., Kojima,H., Okumura,H., Sawamura,J., Ikeda,N., Sumida,Y., Chiba,K., Makino,I., Kawakami,K., Yamamoto,R., Torishima,H.,Yanase,H., Miyajima,A., Sunouchi,M., Hayashi,M and Ohno,Y. Interlaboratory Validation of the In Vitro Eye Irritation Tests for Cosmetic Ingredients (7) Evaluation of Cytotoxicity Test by CornePack. Toxicology in Vitro 13, 163-173 (1999).

516. Wagner, J., Gruz, P., Kim, S. R., Yamada, M., Matsui, K., Fuchs, R. P. & Nohmi, T. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis. Mol Cell 4, 281-6 (1999).

517. 水沢 博、田辺 秀之、増井 徹、高田 容子、榑松 美治、峯岸 大輔、吉田 東歩、佐藤 元信、竹内 昌男、阿部 武丸、原沢 亮. 技術情報「細胞培養系に混入するウシウイルス性下痢ウイルス(BVDV)のRT-PCR法による検出」. (1999).

518. Gopala, K., Hayashi,M. In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutation Research 455, 155-166 (2000).

519. Hayashi M, MacGregor JT, Gatehouse DG, Adler ID, Blakey DH, Dertinger SD, Krishna G, Morita T, Russo A, Sutou S In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. . Environ Mol Mutagen 35, 234-252 (2000).

520. Heddle, J. A., Dean, S., Nohmi, T., Boerrigter, M., Casciano, D., Douglas, G. R., Glickman, B. W., Gorelick, N. J., Mirsalis, J. C., Martus, H. J., Skopek, T. R., Thybaud, V., Tindall, K. R. & Yajima, N. In vivo transgenic mutation assays. Environ Mol Mutagen 35, 253-9 (2000).

521. Honma, M., Momose, M., Tanabe, H., Sakamoto, H., Yu, Y., Little, J. B., Sofuni, T. & Hayashi, M. Requirement of wild-type p53 protein for maintenance of chromosomal integrity. Mol Carcinog 28, 203-14 (2000).

522. Horiguchi M, Masumura K, Nohmi T UVB-induced mutations in the skin of gpt delta transgenic mouse: a novel transgenic mouse mutagensis assay. Env Sci 7, 249-258 (2000).

523. Itoh, T., Suzuki, T., Nishikawa, A., Furukawa, F., Takahashi, M., Xue, W., Sofuni, T. & Hayashi, M. In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice. Mutat Res 468, 19-25 (2000).

524. Kawasaki K, Suzuki1 T, Ueda M, Ichihashi M, Reguer G, Yamasaki H. CC to TT mutation in the mitochondrial DNA of normal skin: relationship to ultraviolet light exposure. . Mutat Res 468, 35-43 (2000).

525. Kirkland, D. J., Hayashi, M., MacGregor, J. T., Muller, L., Schechtman, L. & Sofuni, T. Summary of major conclusions from the International Workshop on Genotoxicity Test Procedures. Environ Mol Mutagen 35, 162-6 (2000).

526. Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Eastmond, D., Fenech, M., Ishidate, M., Jr., Lorge, E., Norppa, H., Surralles, J., von der Hude, W. & Wakata, A. Report from the In Vitro Micronucleus Assay Working Group. Environ Mol Mutagen 35, 167-72 (2000).

527. Krishna G, Hayashi M In vivo rodent micronucleus assay: protocol, conduct and data interpretation. . Mutat Res 455, 155-166 (2000).

528. Kushida, H., Fujita, K., Suzuki, A., Yamada, M., Endo, T., Nohmi, T. & Kamataki, T. Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase. Carcinogenesis 21, 1227-32 (2000).

529. Kushida, H., Fujita, K., Suzuki, A., Yamada, M., Nohmi, T. & Kamataki, T. Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108. Mutat Res 471, 135-43 (2000).

530. Kusunoki, Y, Kyoizumi, S, Honma, M, Kubo, Y, Ohnishi, H, Hayashi, T and Seyama, T NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecule. J Immunol, 165, 3555-3563 (2000).

531. Masumura, K., Matsui, K., Yamada, M., Horiguchi, M., Ishida, K., Watanabe, M., Wakabayashi, K. & Nohmi, T. Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G:C deletions beside runs of identical bases. Carcinogenesis 21, 2049-56 (2000).

532. Matsuoka, A., Sakamoto,H., Tadokoro,S., Tada,A., Terao,Y., Nukaya,H., Wakabayashi,K. The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity. Mutatuin Research 464, 161-167 (2000).

533. Minowa, O., Arai, T., Hirano, M., Monden, Y., Nakai, S., Fukuda, M., Itoh, M., Takano, H., Hippou, Y., Aburatani, H., Masumura, K., Nohmi, T., Nishimura, S. & Noda, T. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A 97, 4156-61 (2000).

534. Moore, M. M., Honma, M., Clements, J., Awogi, T., Bolcsfoldi, G., Cole, J., Gollapudi, B., Harrington-Brock, K., Mitchell, A., Muster, W., Myhr, B., O'Donovan, M., Ouldelhkim, M. C., San, R., Shimada, H. & Stankowski, L. F., Jr. Mouse lymphoma thymidine kinase locus gene mutation assay: International Workshop on Genotoxicity Test Procedures Workgroup Report. Environ Mol Mutagen 35, 185-90 (2000).

535. Muller L, Sofuni T. Appropriate levels of cytotoxicity for genotoxicity tests using mammalian cells in vitro. . Environ Mol Mutagen 35, 202-205 (2000).

536. Nishikawa A, Furukawa F, Kasahara K, Ikezaki S, Itoh T, Suzuki T, Uchida K, Kurihara M, Hayashi M, Miyata N, Hirose M. Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice. Cancer Lett 148, 81-86 (2000).

537. Nohmi, T. [Development of novel genotoxicity assays by genetic engineering methods]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku, 1-20 (2000).

538. Nohmi, T., Suzuki, T. & Masumura, K. Recent advances in the protocols of transgenic mouse mutation assays. Mutat Res 455, 191-215 (2000).

539. Shinmura, K., Yamaguchi, S., Saitoh, T., Takeuchi-Sasaki, M., Kim, S. R., Nohmi, T. & Yokota, J. Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA. Nucleic Acids Res 28, 4912-8 (2000).

540. Sofuni, T., Hayashi, M., Nohmi, T., Matsuoka, A., Yamada, M. & Kamata, E. Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat Res 464, 97-104 (2000).

541. Suzuki, T., Wang, X., Miyata, Y., Saeki, K., Kohara, A., Kawazoe, Y., Hayashi, M. & Sofuni, T. Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse). Mutat Res 456, 73-81 (2000).

542. Tanabe H, Nakagawa Y, Minegishi D, Hashimoto K, Tanaka N, Oshimura M, Sofuni T, Mizusawa H. Human monochromosome hybrid cell panel characterized by FISH in the JCRB/HSRRB. . Chromosome Res 8(4), 319-334 (2000).

543. Wagner, J., Fujii, S., Gruz, P., Nohmi, T. & Fuchs, R. P. The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity. EMBO Rep 1, 484-8 (2000).

544. Wagner, J. & Nohmi, T. Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity. J Bacteriol 182, 4587-95 (2000).

545. Yatagai, F., Nohmi, T., Kusakabe, M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe, T., Kuniya, K., Hanaoka, F. & Yano, Y. Mutation induction by heavy ion irradiation of gpt delta transgenic mice. Biol Sci Space 14, 172-3 (2000).

546. 林 真、松井 道子、石井 健二、川崎 通昭. 厚生省等による食品添加物の変異原性評価データシート. Environ.Mutagen Res. 22(2000).

547. ヒト培養細胞:科学と倫理のジレンマ. 2001科学(岩波書店) 71(2001).

548. Abril, N., Luque-Romero, F. L., Yamada, M., Nohmi, T. & Pueyo, C. The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity. Mutat Res 497, 111-21 (2001).

549. Fujita, K., Nakayama, K., Yamazaki, Y., Tsuruma, K., Yamada, M., Nohmi, T. & Kamataki, T. Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase. Environ Mol Mutagen 38, 329-38 (2001).

550. Gruz, P., Pisani, F. M., Shimizu, M., Yamada, M., Hayashi, I., Morikawa, K. & Nohmi, T. Synthetic activity of Sso DNA polymerase Y1, an archaeal DinB-like DNA polymerase, is stimulated by processivity factors proliferating cell nuclear antigen and replication factor C. J Biol Chem 276, 47394-401 (2001).

551. Hamada, S., Sutou,S., Morita,T., Wakata,A., Asanami,S., Hosoya,S., Ozawa,S., Kondo,K., Nakajima,M., Shimada,H., Osawa,K., Kondo,Y., Asano,N., Sato,S., Yamura,H., Yajima,N., Marshall,R., Moore,C., Blakey,H.D., Schechtman,M,L.,Weaver,L,J., Torous,K,D.,Proudlock,R., Ito,S., Namiki,C., and Hayashi,M. Evaluation of the Rodent Micronucleus Assay by a 28-Day Treatment Protocol:Summary Of the 13th Collaborative Study by The Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan(JEMS)-Mammalian Mutagenicity Study Group (MMS). Environmental and Molecular Mutagenesis 37, 93-110 (2001).

552. Hamada S, Yamasaki KI, Nakanishi S, Omori T, Serikawa T, Hayashi M Evaluation of the general suitability of the rat for the micronucleus assay: the effect of cyclophosphamide in 14 strains. . Mutat Res 495, 127-34 (2001).

553. Honma, M. Recombinational DNA repair and maintenance of genomic integrity mediated by p53. Environ.Mutagen Res. 23, 15-21 (2001).

554. Honma, M., Sofuni,T. The Mouse Lymphoma Assay (MLA) Using the Microwell Method. (2001).

555. Honma, M., Momose, M., Sakamoto, H., Sofuni, T. & Hayashi, M. Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction. Mutat Res 493, 101-14 (2001).

556. Horiguchi, M., Masumura, K. I., Ikehata, H., Ono, T., Kanke, Y. & Nohmi, T. Molecular nature of ultraviolet B light-induced deletions in the murine epidermis. Cancer Res 61, 3913-8 (2001).

557. Imamura O, Fujita K, Shimamoto A, Tanabe H, Takeda S, Furuichi Y, Matsumoto T. Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells. Oncogene 20, 1143-1151 (2001).

558. Ishikawa KS, Masui T, Ishikawa K, Shiojiri N. Immunolocalization of hepatocyte growth factor and its receptor (c-Met) during mouse liver development. . Histochem Cell Biol 116, 453-62 (2001).

559. Iwashita S, Itoh T, Takeda H, Sugimoto Y, Takahashi I, Nobukuni T, Sezaki M, Masui T, Hashimoto K Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1. Gene 268, 59-66 (2001).

560. Kim, S. R., Matsui, K., Yamada, M., Gruz, P. & Nohmi, T. Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli. Mol Genet Genomics 266, 207-15 (2001).

561. Kohara, A., Suzuki, T., Honma, M., Hirano, N., Ohsawa, K., Ohwada, T. & Hayashi, M. Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (MutaMouse). Mutat Res 491, 211-20 (2001).

562. Masters JR, Thomson JA, Daly-Burns B, Reid YA, Dirks WG, Packer P, Toji LH, Ohno T, Tanabe H, Arlett CF, Kelland LR, Harrison M, Virmani A, Ward TH, Ayres KL, Debenham PG Short tandem repeat profiling provides an international reference standard for human cell lines. . Proc Natl Acad Sci U S A 98, 8012-7 (2001).

563. Nishikawa, A., Suzuki, T., Masumura, K., Furukawa, F., Miyauchi, M., Nakamura, H., Son, H. Y., Nohmi, T., Hayashi, M. & Hirose, M. Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis. J Exp Clin Cancer Res 20, 111-5 (2001).

564. Ohmori, H., Friedberg, E. C., Fuchs, R. P., Goodman, M. F., Hanaoka, F., Hinkle, D., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., Prakash, L., Prakash, S., Todo, T., Walker, G. C., Wang, Z. & Woodgate, R. The Y-family of DNA polymerases. Mol Cell 8, 7-8 (2001).

565. Swiger, R. R., Cosentino, L., Masumura, K. I., Nohmi, T. & Heddle, J. A. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo. Environ Mol Mutagen 37, 297-303 (2001).

566. Tanabe H, Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Cremer C, Cremer T Evolutionary conserved 3D positioning of orthologous chromosomes and chromosome segments in primate lymphoblastoid cell nuclei. Annales de Genetique 44, s120 (2001).

567. Tokuzen, R., Iwahori, Y., Asamoto, M., Iigo, M., Hasegawa, F., Satoh, T., Ishidate, M., Jr. & Tsuda, H. Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors. Pathol Int 51, 65-71 (2001).

568. Yatagai, F., Nohmi, T., Kusakabe, M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe, T., Kuniya, K., Hanaoka, F. & Yano, Y. Mutation induction by heavy-ion irradiation of gpt delta transgenic mice. Phys Med 17 Suppl 1, 192-3 (2001).

569. 水沢 博、増井 徹、田辺 秀之. ヒト培養細胞:科学と倫理のジレンマ ヒト培養細胞の個別識別の重要性とヒト遺伝子解析研究資源の匿名性に関する問題. 科学 (Science Journal KAGAKU) 71(2001).

570. Honma, M., Tadokoro, S., Sakamoto, H., Tanabe, H., Sugimoto, M., Furuichi, Y., Satoh, T., Sofuni, T., Goto, M. & Hayashi, M. Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. Mutat Res 520, 15-24 (2002).

571. Kohara, A., Suzuki, T., Honma, M., Ohwada, T. & Hayashi, M. Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse). Mutat Res 515, 63-72 (2002).

572. Kohara, A., Suzuki, T., Honma, M., Oomori, T., Ohwada, T. & Hayashi, M. Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse). Mutat Res 515, 73-83 (2002).

573. Kusakabe, H., Yamakage, K., Wakuri, S., Sasaki, K., Nakagawa, Y., Watanabe, M., Hayashi, M., Sofuni, T., Ono, H. & Tanaka, N. Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals. Mutat Res 517, 187-98 (2002).

574. Masumura, K., Kuniya, K., Kurobe, T., Fukuoka, M., Yatagai, F. & Nohmi, T. Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation. Environ Mol Mutagen 40, 207-15 (2002).

575. Moore, M. M., Honma, M., Clements, J., Harrington-Brock, K., Awogi, T., Bolcsfoldi, G., Cifone, M., Collard, D., Fellows, M., Flanders, K., Gollapudi, B., Jenkinson, P., Kirby, P., Kirchner, S., Kraycer, J., McEnaney, S., Muster, W., Myhr, B., O'Donovan, M., Oliver, J., Ouldelhkim, M. C., Pant, K., Preston, R., Riach, C., San, R., Shimada, H. & Stankowski, L. F., Jr. Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000. Environ Mol Mutagen 40, 292-9 (2002).

576. Morimoto, S., Goto, S., Kato, T., Izumi, M., Komiyama-Kobayashi, M., Fukunishi, N., Honma, M., Hanaoka, F. & Yatagai, F. Cellular responses to low dose heavy-ion exposure in human cells. Radiat Prot Dosimetry 99, 253-4 (2002).

577. Morimoto, S., Honma, M. & Yatagai, F. Sensitive detection of LOH events in a human cell line after C-ion beam exposure. J Radiat Res 43 Suppl, S163-7 (2002).

578. Morimoto, S., Kato, T., Honma, M., Hayashi, M., Hanaoka, F. & Yatagai, F. Detection of genetic alterations induced by low-dose X rays: analysis of loss of heterozygosity for TK mutation in human lymphoblastoid cells. Radiat Res 157, 533-8 (2002).

579. Morimoto S, Honma M, Yatagai F Effect of p53 codon 237 mutation on X-ray induced HPRT mutation. . Environ Mutagen Res 24, 17-21 (2002).

580. Nishikawa T, Haresaku M, Fukushima A, Nakamura T, Adachi K, Masuda M, Hayashi M. Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens. . Mutat Res 513, 93-102 (2002).

581. Noda, Y., Suzuki, T., Kohara, A., Hasegawa, A., Yotsuyanagi, T., Hayashi, M., Sofuni, T., Yamanaka, K. & Okada, S. In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse. Mutat Res 513, 205-12 (2002).

582. Nohmi, T. [Drug discovery based on genomic information]. Rinsho Byori 50, 694-7 (2002).

583. Ohyama W, Gonda M, Miyajima H, Kondo K, Noguchi T, Yoshida J, Hatakeyama S, Watabe E, Ueno Y, Hayashi M, Tokumitsu T. Collaborative validation study of the in vivo micronucleus test using mouse colonic epithelial cells. Mutat Res 518, 39-45 (2002).

584. Omori, T., Honma, M., Hayashi, M., Honda, Y. & Yoshimura, I. A new statistical method for evaluation of L5178Ytk(+/-) mammalian cell mutation data using microwell method. Mutat Res 517, 199-208 (2002).

585. Satoh T, Hatanaka M, Yamamoto K, Kuro-o M, Sofuni T. Application of mFISH for the analysis of chemically-induced chromosomal aberrations: a model for the formation of triradial chromosomes. . Mutat Res 504, 57-65 (2002).

586. T, Masui. An outgrowth culture system of normal human epithelium: an in vitro model to study the coordination of cellular migration and proliferation. . Methods in Molecular Biology, 188, 213-226 (2002).

587. Tanabe H, Haberman FA, Solovei I, Cremer M, Cremer H Non-random radial arrangements of interphase chromosome territories: Evolutionay condiderations and functionalimplications. . Mutat Res 504, 37-45 (2002).

588. Tanabe H, Müller S Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Solovei I, Cremer C, Cremer T Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc Natl Acad Sci U S A 99, 4424-4429 (2002).

589. Wakuri, S., Takahashi,A., Hayashi,M., Tanaka,N. Cytotoxicity Test with Waters from Sakawa River and Its Tributaries. Jounal of Japan Society on Water Environment 25, 669-674 (2002).

590. Yamada, K., Suzuki,T., Kohara,A., Hayashi,M., Hakura,A., Mizutani,T., Saeki,K. Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro. Mutation Research 521, 187-200 (2002).

591. Yatagai, F., Kurobe, T., Nohmi, T., Masumura, K., Tsukada, T., Yamaguchi, H., Kasai-Eguchi, K. & Fukunishi, N. Heavy-ion-induced mutations in the gpt delta transgenic mouse: effect of p53 gene knockout. Environ Mol Mutagen 40, 216-25 (2002).

592. Yatagai, F., Morimoto, S., Goto, S., Kato, T., Honma, M. & Hanaoka, F. Mutation induction in human cells after low dose X ray exposure. Radiat Prot Dosimetry 99, 241-3 (2002).

593. Yatagai, F., Morimoto, S., Kato, T. & Honma, M. [LOH analysis for estimating genetic influences by space environments]. Biol Sci Space 16, 140 (2002).

594. 能美 健彦. 変異原性試験で何がわかるか:21世紀の展望. Environ Mutagen Res. 24, 75-80 (2002).

595. 能美 健彦. 微生物由来のトランスリージョンDNAポリメラーゼ. Environ Mutagen Res. 24, 153-159 (2002).

596. 鈴木 孝昌. 環境変異原研究の光と陰:これから進むべき道. Environ.Mutagen Res. 24, 179-184 (2002).

597. 本間 正充. ほ乳類細胞におけるDNA二本鎖切断修復と、P53によるゲノム安定化機構. Environ.Mutagen Res. 24, 161-167 (2002).

598. 日本薬学会. ファルマシア 38(2002).

599. Fenech M, Bonassi S, Turner J, Lando C, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Bigatti MP, Bolognesi C, Cao J, De Luca G, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hadjidekova VV, Hrelia P, Jaworska A, Joksic G, Krishnaja AP, Lee TK, Martelli A, McKay MJ, Migliore L, Mirkova E, Muller WU, Odagiri Y, Orsiere T, Scarfi MR, Silva MJ, Sofuni T, Surralles J, Trenta G, Vorobtsova I, Vral A, Zijno A Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. . Mutat Res 534, 45-64 (2003).

600. Furuno-Fukushi, I., Masumura, K., Furuse, T., Noda, Y., Takahagi, M., Saito, T., Hoki, Y., Suzuki, H., Wynshaw-Boris, A., Nohmi, T. & Tatsumi, K. Effect of Atm disruption on spontaneously arising and radiation-induced deletion mutations in mouse liver. Radiat Res 160, 549-58 (2003).

601. Gruz, P., Shimizu, M., Pisani, F. M., De Felice, M., Kanke, Y. & Nohmi, T. Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus. Nucleic Acids Res 31, 4024-30 (2003).

602. Hamada S, Nakajima K, Namiki C, Serikawa T, Hayashi M. Sex differences in the chemical induction of micronuclei in the rat. . Environ Mutagen Res 25, 33-37 (2003).

603. Hamada S, Nakajima K, Serikawa T, Hayashi M The effect of aging on the results of the rat micronucleus assay. . Mutagenesis 18, 273-5 (2003).

604. Hayashi, H., Kondo, H., Masumura, K., Shindo, Y. & Nohmi, T. Novel transgenic rat for in vivo genotoxicity assays using 6-thioguanine and Spi- selection. Environ Mol Mutagen 41, 253-9 (2003).

605. Honma, M., Izumi, M., Sakuraba, M., Tadokoro, S., Sakamoto, H., Wang, W., Yatagai, F. & Hayashi, M. Deletion, rearrangement, and gene conversion; genetic consequences of chromosomal double-strand breaks in human cells. Environ Mol Mutagen 42, 288-98 (2003).

606. Itoh, T., Kuwahara,T., Suzuki,T., Hayashi,M., Ohnishi,Y. Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cll gene in lambda/lacZ transgenic mice. Mutation Research 539, 99-108 (2003).

607. Itoh, T., Kuwahara,T., Suzuki,T., Hayashi,M., Ohnishi,Y. Regional mutagenicity of heterocyclic amines in the intestine:mutation analysis of the cll gene in lambda/lacZ transgenic mice. Mutation Research 539, 99-108 (2003).

608. Iwashita S, Osada N, Itoh T, Sezaki M, Oshima K, Hashimoto E, Kitagawa-Arita Y, Takahashi I, Masui T, Hashimoto K, Makalowski W A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1. . Mol Biol Evol 20, 1556-63 (2003).

609. Kirkland, D. J., Hayashi, M., MacGregor, J. T., Muller, L., Schechtman, L. M. & Sofuni, T. Summary of major conclusions. Mutat Res 540, 123-5 (2003).

610. Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Eastmond, D., Fenech, M., Ishidate, M., Jr., Kirchner, S., Lorge, E., Morita, T., Norppa, H., Surralles, J., Vanhauwaert, A. & Wakata, A. Report from the in vitro micronucleus assay working group. Mutat Res 540, 153-63 (2003).

611. Liu, S. X., Cao, J., Yuan, J., Huang, P., Shua, P. Q. & Honma, M. [Effects of total alkaloids of Tripterygium hypoglaucum Hutch on tk gene of mouse lymphoma cells]. Zhongguo Zhong Yao Za Zhi 28, 954-7 (2003).

612. Masumura, K., Horiguchi, M., Nishikawa, A., Umemura, T., Kanki, K., Kanke, Y. & Nohmi, T. Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice. Mutat Res 541, 91-102 (2003).

613. Masumura, K., Totsuka, Y., Wakabayashi, K. & Nohmi, T. Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse. Carcinogenesis 24, 1985-93 (2003).

614. Moore, M. M., Honma, M., Clements, J., Bolcsfoldi, G., Cifone, M., Delongchamp, R., Fellows, M., Gollapudi, B., Jenkinson, P., Kirby, P., Kirchner, S., Muster, W., Myhr, B., O'Donovan, M., Oliver, J., Omori, T., Ouldelhkim, M. C., Pant, K., Preston, R., Riach, C., San, R., Stankowski, L. F., Jr., Thakur, A., Wakuri, S., Yoshimura, I. & Mouse Lymphoma Assay, Workgroup. Mouse lymphoma thymidine kinase gene mutation assay: International Workshop on Genotoxicity Tests Workgroup report--Plymouth, UK 2002. Mutat Res 540, 127-40 (2003).

615. Saotome K, Hayashi M. Application of a sea urchin micronucleus assay to monitoring aquatic pollution: influence of sample osmolality. . Mutagenesis 18, 73-6 (2003).

616. Sharma S, Oomizu S, Kakeya T, Masui T, Takeuchi S, Takahashi S. Gene expression and the physiological role of transforming growth factor-alpha in the mouse pituitary. . Zoolog Sci 20, 83-9 (2003).

617. Shibata, A., Masutani, M., Nozaki, T., Kamada, N., Fujihara, H., Masumura, K., Nakagama, H., Sugimura, T., Kobayashi, S., Suzuki, H. & Nohmi, T. Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation. Environ Mol Mutagen 41, 370-2 (2003).

618. Shimizu, M., Gruz, P., Kamiya, H., Kim, S. R., Pisani, F. M., Masutani, C., Kanke, Y., Harashima, H., Hanaoka, F. & Nohmi, T. Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep 4, 269-73 (2003).

619. Takeiri, A., Mishima, M., Tanaka, K., Shioda, A., Ueda, O., Suzuki, H., Inoue, M., Masumura, K. & Nohmi, T. Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice. Chem Res Toxicol 16, 171-9 (2003).

620. Thybaud, V., Dean, S., Nohmi, T., de Boer, J., Douglas, G. R., Glickman, B. W., Gorelick, N. J., Heddle, J. A., Heflich, R. H., Lambert, I., Martus, H. J., Mirsalis, J. C., Suzuki, T. & Yajima, N. In vivo transgenic mutation assays. Mutat Res 540, 141-51 (2003).

621. Yamamura, E., Nunoshiba, T., Nohmi, T. & Yamamoto, K. Hydrogen peroxide-induced microsatellite instability in the Escherichia coli K-12 endogenous tonB gene. Biochem Biophys Res Commun 306, 570-6 (2003).

622. 高井 明徳、石川 卓、林 真、上野 紘一. フナおよびオイカワの赤血球を用いた小核試験による河川の汚染モニタリングへの適用の可能性. 生活衛生 47(2003).

623. 林 真. 日本環境変異原学会に何がもとめられているか. 環境変異原学会 25(2003).

624. 林 真、鈴木 孝昌、小原 有弘、本間 正充. 遺伝子変化を指標とした環境化学物質による発がんリスク評価および気候究明のための手法の開発に関する研究. (2003).

625. Arlt, V. M., Zhan, L., Schmeiser, H. H., Honma, M., Hayashi, M., Phillips, D. H. & Suzuki, T. DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse. Environ Mol Mutagen 43, 186-95 (2004).

626. Kim, S. R., Matsui, K., Yamada, M., Kohno, T., Kasai, H., Yokota, J. & Nohmi, T. Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase. Mutat Res 554, 365-74 (2004).

627. Kuroda M, Tanabe H, Yoshida K, Oikawa K, Saito A, Kiyuna T, Mizusawa H, Mukai K. Alteration of chromosome positioning during adipocyte differentiation. J Cell Sci 117, 5897-903 (2004).

628. Nohmi, T. & Masumura, K. Gpt delta transgenic mouse: a novel approach for molecular dissection of deletion mutations in vivo. Adv Biophys 38, 97-121 (2004).

629. Nohmi, T. & Masumura, K. I. Gpt delta transgenic mouse: A novel approach for molecular dissection of deletion mutations in vivo. Adv Biophys 38, 97-121 (2004).

630. Satoh T, Yamamoto K, Miura KF, Sofuni T Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells. . Cytogenet Genome Res 104, 289-294 (2004).

631. Shibata, A., Masutani, M., Kamada, N., Masumura, K., Nakagama, H., Kobayashi, S., Teraoka, H., Suzuki, H. & Nohmi, T. Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes. Environ Mol Mutagen 43, 204-7 (2004).

632. Suzuki H, Shirotori T, Hayashi M A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. . Cytogenet Genome Res 104, 299-303 (2004).

633. Wang, W., Seki, M., Otsuki, M., Tada, S., Takao, N., Yamamoto, K., Hayashi, M., Honma, M. & Enomoto, T. The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells. Biochim Biophys Acta 1688, 137-44 (2004).

634. Yamada, K., Suzuki,T., Kohara,A., Hayashi,M., Mizutani,T., Saeki,K. In Vivo Mutagenicity of benzo [f] quinoline,benzo [h] quinoline, and 1,7-phenanthroline using the lacZ transgenic mice. Mutation Research 559, 83-95 (2004).

635. Yatagai, F., Morimoto, S., Kato, T. & Honma, M. Further characterization of loss of heterozygosity enhanced by p53 abrogation in human lymphoblastoid TK6 cells: disappearance of endpoint hotspots. Mutat Res 560, 133-45 (2004).

636. Yatagai, F., Takayama, Y., Inoue, M., Honma, M. & Iwaki, M. Detection of adaptive response at chromosome level. Biol Sci Space 18, 112-3 (2004).

637. Zhan, L., Sakamoto, H., Sakuraba, M., Wu, D. S., Zhang, L. S., Suzuki, T., Hayashi, M. & Honma, M. Genotoxicity of microcystin-LR in human lymphoblastoid TK6 cells. Mutat Res 557, 1-6 (2004).

638. 能美 健彦、清水 雅富、ピーター グルーズ. DNA前駆体の酸化損傷と突然変異. Environ.Mutagen Res. 26, 159-165 (2004).

639. 上田 高嘉、高瀬 圭子、林 真. ゼブラフィッシュを用いた小核試験の検討. 宇都宮大学教育学部紀要 54(2004).

640. 林 真、長尾 美奈子、祖父尼 俊雄、森田 健、能美 健彦、本間 正充、宇野 芳文、葛西 宏、佐々木 有、太田 敏博、田中 憲穂、中嶋 圓、布柴 達夫. 「食品および食品添加物に関する遺伝毒性の検出・評価・解釈」に関する臨時委員会の活動中間報告. Environ.Mutagen Res. 26, 275-283 (2004).

641. 既存添加物43品目の遺伝毒性試験. (2005).

642. Asada S, Sasaki K, Tanaka N, Takeda K, Hayashi M, Umeda M. . Detection of initiating as well as promoting activity of chemicals by a novel cell transformation assay using v-Ha-ras-transfected BALB/c 3T3 cells (Bhas 42 cells). Mutat Res 588, 7-21 (2005).

643. Hashimoto, A. H., Amanuma, K., Hiyoshi, K., Takano, H., Masumura, K., Nohmi, T. & Aoki, Y. In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice. Environ Mol Mutagen 45, 365-73 (2005).

644. Hayashi M, Kamata E, Hirose A, Takahashi M, Morita T, Ema M. In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals. . Mutat Res 588, 129-135 (2005).

645. Honma, M. Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells. Environ Mol Mutagen 45, 162-76 (2005).

646. Kanki, K., Nishikawa, A., Masumura, K., Umemura, T., Imazawa, T., Kitamura, Y., Nohmi, T. & Hirose, M. In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate. Mol Carcinog 42, 9-17 (2005).

647. Kim, S. R., Kokubo, K., Matsui, K., Yamada, N., Kanke, Y., Fukuoka, M., Yamada, M. & Nohmi, T. Light-dependent mutagenesis by benzo[a]pyrene is mediated via oxidative DNA damage. Environ Mol Mutagen 46, 141-9 (2005).

648. Kokubo, K., Yamada, M., Kanke, Y. & Nohmi, T. Roles of replicative and specialized DNA polymerases in frameshift mutagenesis: mutability of Salmonella typhimurium strains lacking one or all of SOS-inducible DNA polymerases to 26 chemicals. DNA Repair (Amst) 4, 1160-71 (2005).

649. Miyazaki, M., Yamazaki, H., Takeuchi, H., Saoo, K., Yokohira, M., Masumura, K., Nohmi, T., Funae, Y., Imaida, K. & Kamataki, T. Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Carcinogenesis 26, 1947-55 (2005).

650. Nakajima M, Shimada S, Nagai M, Mizuhashi F, Sugiyama C, Masuda S, Hayashi M, Kinae N 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone [MX] shows initiating and promoting activities in a two-stage BALB/c 3T3 cell transformation assay. . Mutagenesis 20, 375-9 (2005).

651. Nohmi, T., Kim, S. R. & Yamada, M. Modulation of oxidative mutagenesis and carcinogenesis by polymorphic forms of human DNA repair enzymes. Mutat Res 591, 60-73 (2005).

652. Nohmi, T. & Masumura, K. Molecular nature of intrachromosomal deletions and base substitutions induced by environmental mutagens. Environ Mol Mutagen 45, 150-61 (2005).

653. Satou, K., Yamada, M., Nohmi, T., Harashima, H. & Kamiya, H. Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli. Chem Res Toxicol 18, 1271-8 (2005).

654. Sawai, T., Nohmi, T., Ohnishi, Y., Takauchi, Y. & Kuro, M. Cardiac output measurement using the transesophageal Doppler method is less accurate than the thermodilution method when changing PaCO2. Anesth Analg 101, 1597-601 (2005).

655. Shibata, A., Kamada, N., Masumura, K., Nohmi, T., Kobayashi, S., Teraoka, H., Nakagama, H., Sugimura, T., Suzuki, H. & Masutani, M. Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. Oncogene 24, 1328-37 (2005).

656. Shinzawa, M., Nohmi, T., Tsuzuki, M., Ohnishi, Y. & Kuro, M. [Successful weaning from cardiopulmonary bypass with administration of landiolol hydrochloride in a patient with hypertrophic obstructive cardiomyopathy]. Masui 54, 785-7 (2005).

657. Shuzuki, H., Ikeda,N., Kobayashi,K., Terashima,Y., Shimada,Y., Suzuki,Y., Hagiwara,T., Hatakeyama,S., Nagaoka,K., Yoshida,J., Saito,Y., Tanaka,J., Hayashi,M. Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats A study by the collaborative Study Group for the Micronucleus Test (CSGMT)/ Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group(MMS). Mutation Research 583, 133-145 (2005).

658. Tanabe H, Kupper K, Ishida T, Neusser M, Mizusawa H Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys. . Cytogenet Genome Res 108, 255-261 (2005).

659. Totsuka, Y., Nishigaki, R., Enomoto, S., Takamura-Enya, T., Masumura, K., Nohmi, T., Kawahara, N., Sugimura, T. & Wakabayashi, K. Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates. Chem Res Toxicol 18, 1553-62 (2005).

660. 祖父尼 俊雄、能美 健彦、太田 敏博、林 真. 遺伝毒性:DNA直接作用物資にしき値は存在するのか!?. 環境変異原研究 27(2005).

661. 林 真. げっ歯類を用いる小核試験の基礎研究ならびにその行政面への応用. Environ.Mutagen Res. 27, 13-20 (2005).

662. 松浦(永崎)克子、坂本 浩子、祖父尼 俊雄、林 真、本間 正充. 無機および有機ヒ素化合物の in vitro 遺伝子突然変異誘発性と、その食物摂取からの遺伝毒性リスク. Environ.Mutagen Res. 27, 153-160 (2005).

663. Asami, Y., Murakami, M., Shimizu, M., Pisani, F. M., Hayata, I. & Nohmi, T. Visualization of the interaction between archaeal DNA polymerase and uracil-containing DNA by atomic force microscopy. Genes Cells 11, 3-11 (2006).

664. Asano N, Torous DK, Tometsko CR, Dertinger SD, Morita T, Hayashi M Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine. . Mutagenesis 21, 15-20 (2006).

665. Dertinger SD, Bishop ME, McNamee JP, Hayashi M, Suzuki T, Asano N, Nakajima M, Saito J, Moore M, Torous DK, Macgregor JT Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring. . Toxicol Sci 94, 83-91 (2006).

666. Hashimoto, A. H., Amanuma, K., Hiyoshi, K., Takano, H., Masumura, K., Nohmi, T. & Aoki, Y. In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene. Environ Mol Mutagen 47, 277-83 (2006).

667. Hayashi, M., Kamata,E., Hirose,A., Takahashi,M., Morita,T., Ema,M. Erratum to "In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals". Mutation Research 603, 196 (2006).

668. Ikeda M, Masumura K, Matsui K, Kohno H, Sakuma K, Tanaka T, Nohmi T. Chemopreventive effects of nobiletin against genotoxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lung of gpt delta transgenic mice. . Genes & Environ, 28, 84-91 (2006).

669. Jiang, L., Zhong, Y., Akatsuka, S., Liu, Y. T., Dutta, K. K., Lee, W. H., Onuki, J., Masumura, K., Nohmi, T. & Toyokuni, S. Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment. Cancer Sci 97, 1159-67 (2006).

670. Kirkland D, Aardema M, Müller L, Hayashi M. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: II. Further analysis of mammalian cell results, relative predictivity and tumour profiles. . Mutat Res 608, 29-42 (2006).

671. Koyama, N., Sakamoto, H., Sakuraba, M., Koizumi, T., Takashima, Y., Hayashi, M., Matsufuji, H., Yamagata, K., Masuda, S., Kinae, N. & Honma, M. Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells. Mutat Res 603, 151-8 (2006).

672. MacGregor JT, Bishop ME, McNamee JP, Hayashi M, Asano N, Wakata A, Nakajima M, Saito J, Aidoo A, Moore MM, Dertinger SD. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat. Toxicol Sci 94, 92-107 (2006).

673. Matsui, K., Yamada, M., Imai, M., Yamamoto, K. & Nohmi, T. Specificity of replicative and SOS-inducible DNA polymerases in frameshift mutagenesis: mutability of Salmonella typhimurium strains overexpressing SOS-inducible DNA polymerases to 30 chemical mutagens. DNA Repair (Amst) 5, 465-78 (2006).

674. Mazaki, M., Kataoka, K., Kinouchi, T., Vinitketkumnuen, U., Yamada, M., Nohmi, T., Kuwahara, T., Akimoto, S. & Ohnishi, Y. Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity. J Med Invest 53, 123-33 (2006).

675. Moore, M. M., Honma, M., Clements, J., Bolcsfoldi, G., Burlinson, B., Cifone, M., Clarke, J., Delongchamp, R., Durward, R., Fellows, M., Gollapudi, B., Hou, S., Jenkinson, P., Lloyd, M., Majeska, J., Myhr, B., O'Donovan, M., Omori, T., Riach, C., San, R., Stankowski, L. F., Jr., Thakur, A. K., Van Goethem, F., Wakuri, S. & Yoshimura, I. Mouse lymphoma thymidine kinase gene mutation assay: follow-up meeting of the International Workshop on Genotoxicity Testing--Aberdeen, Scotland, 2003--Assay acceptance criteria, positive controls, and data evaluation. Environ Mol Mutagen 47, 1-5 (2006).

676. Nishikawa, A., Sai, K., Okazaki, K., Son, H. Y., Kanki, K., Nakajima, M., Kinae, N., Nohmi, T., Trosko, J. E., Inoue, T. & Hirose, M. MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells. Environ Mol Mutagen 47, 48-55 (2006).

677. Nohmi, T. Environmental stress and lesion-bypass DNA polymerases. Annu Rev Microbiol 60, 231-53 (2006).

678. Nohmi, Takehiko. Genes and Environment: Voice of JEMS. Genes and Environment 28, 1 (2006).

679. Oka, H., Ikeda, K., Yoshimura, H., Ohuchida, A. & Honma, M. Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines. Mutat Res 606, 52-60 (2006).

680. Sato, Y., Takahashi, S., Kinouchi, Y., Shiraki, M., Endo, K., Matsumura, Y., Kakuta, Y., Tosa, M., Motida, A., Abe, H., Imai, G., Yokoyama, H., Nomura, E., Negoro, K., Takagi, S., Aihara, H., Masumura, K., Nohmi, T. & Shimosegawa, T. IL-10 deficiency leads to somatic mutations in a model of IBD. Carcinogenesis 27, 1068-73 (2006).

681. Sugawara A, Goto K, Sotomaru Y, Sofuni T, Ito T. Current status of chromosomal abnormalities in mouse embryonic stem cell lines used in Japan. . Comp Med 56(1), 31-34 (2006).

682. Takeiri, A., Mishima, M., Tanaka, K., Shioda, A., Harada, A., Watanabe, K., Masumura, K. & Nohmi, T. A newly established GDL1 cell line from gpt delta mice well reflects the in vivo mutation spectra induced by mitomycin C. Mutat Res 609, 102-15 (2006).

683. Takeshi Morita, Makoto Hayashi, Kaoru Morikawa. Globally Harmonized System on Hazard Classification and Labeling of Chemicals and Other Existing Classification Systems for Germ Cell Mutagens. Genes and Environment 28, 141–152 (2006).

684. Torous D, Asano N, Tometsko C, Sugunan S, Dertinger S, Morita T, Hayashi M Performance of flow cytometric analysis for the micronucleus assay – a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood. Mutagenesis 21, 11-13 (2006).

685. Umebayashi Y, Honma M, Abe T, Ryuto H, Suzuki H, Shimazu T, Ishioka N, Iwaki M, Yatagai F. Mutation induction after low-dose carbon-ion beam irradiation of frozen human cultured cells. Biological Sci in Space 19, 237-241 (2006).

686. Umemura, T., Kanki, K., Kuroiwa, Y., Ishii, Y., Okano, K., Nohmi, T., Nishikawa, A. & Hirose, M. In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate. Cancer Sci 97, 829-35 (2006).

687. Yamada, M., Nunoshiba, T., Shimizu, M., Gruz, P., Kamiya, H., Harashima, H. & Nohmi, T. Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli. J Bacteriol 188, 4992-5 (2006).

688. Yamada M, MatsuiK, NohmiT Development of a bacterial hyper-sensitive tester strain for specific detection of the genotoxicity of polycyclic aromatic hydrocarbons. . Genes & Environ 28, 23-30 (2006).

689. Zhan, L, Honma, M, Wang, L, Hayashi, M., Wu, D, Zhang, L, Rajaguru, P, Suzuki, T. Microcystin-LR is not Mutagenic in vivo in the λ/lacZ Transgenic Mouse (Muta™Mouse). Genes & Environ, 28, 68-73. (2006).

690. Aoki, Y., Hashimoto, A. H., Amanuma, K., Matsumoto, M., Hiyoshi, K., Takano, H., Masumura, K., Itoh, K., Nohmi, T. & Yamamoto, M. Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. Cancer Res 67, 5643-8 (2007).

691. Barone, F., McCulloch, S. D., Macpherson, P., Maga, G., Yamada, M., Nohmi, T., Minoprio, A., Mazzei, F., Kunkel, T. A., Karran, P. & Bignami, M. Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. DNA Repair (Amst) 6, 355-66 (2007).

692. Burlinson, B., Tice, R. R., Speit, G., Agurell, E., Brendler-Schwaab, S. Y., Collins, A. R., Escobar, P., Honma, M., Kumaravel, T. S., Nakajima, M., Sasaki, Y. F., Thybaud, V., Uno, Y., Vasquez, M., Hartmann, A. & In Vivo Comet Assay Workgroup, part of the Fourth International Workgroup on Genotoxicity Testing. Fourth International Workgroup on Genotoxicity testing: results of the in vivo Comet assay workgroup. Mutat Res 627, 31-5 (2007).

693. De Felice, M., Medagli, B., Esposito, L., De Falco, M., Pucci, B., Rossi, M., Gruz, P., Nohmi, T. & Pisani, F. M. Biochemical evidence of a physical interaction between Sulfolobus solfataricus B-family and Y-family DNA polymerases. Extremophiles 11, 277-82 (2007).

694. Hashimoto, A. H., Amanuma, K., Hiyoshi, K., Sugawara, Y., Goto, S., Yanagisawa, R., Takano, H., Masumura, K., Nohmi, T. & Aoki, Y. Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust. Environ Mol Mutagen 48, 682-93 (2007).

695. Hayashi, M. Guidance on genetoxicity testing of pharmaceuticals ( in japanese ). Pharm.Regul.Sci. 38, 359-365 (2007).

696. Hayashi, M. & Honma, M. [Evaluation of in vivo genotoxicity of chemicals--development and application of rodent micronucleus assay]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku, 17-34 (2007).

697. Hayashi M, MacGregor JT, Gatehouse DG, Blakey DH, Dertinger SD, Abramsson-Zetterberg L, Krishna G, Morita T, Russo A, Asano N, Suzuki H, Ohyama W, Gibson D In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test. Mutat Res 627, 10-30 (2007).

698. Honma, M., Sakuraba, M., Koizumi, T., Takashima, Y., Sakamoto, H. & Hayashi, M. Non-homologous end-joining for repairing I-SceI-induced DNA double strand breaks in human cells. DNA Repair (Amst) 6, 781-8 (2007).

699. Ikeda, M., Masumura, K., Sakamoto, Y., Wang, B., Nenoi, M., Sakuma, K., Hayata, I. & Nohmi, T. Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice. Mutat Res 626, 15-25 (2007).

700. Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. . Mutat Res 628, 31-55 (2007).

701. Kirkland DJ, Hayashi M, Jacobson-Kram D, Kasper P, MacGregor JT, Müller L, Uno Y. The International Workshops on Genotoxicity Testing (IWGT): history and achievements. Mutat Res 627, 1-4 (2007).

702. Kirkland DJ, Hayashi M, Jacobson-Kram D, Kasper P, MacGregor JT, Müller L, Uno Y. Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September, 2005. . Mutat Res 627, 5-9 (2007).

703. Ku, W. W., Bigger, A., Brambilla, G., Glatt, H., Gocke, E., Guzzie, P. J., Hakura, A., Honma, M., Martus, H. J., Obach, R. S., Roberts, S. & Strategy Expert Group, Iwgt. Strategy for genotoxicity testing--metabolic considerations. Mutat Res 627, 59-77 (2007).

704. Kuroiwa, Y., Umemura, T., Nishikawa, A., Kanki, K., Ishii, Y., Kodama, Y., Masumura, K., Nohmi, T. & Hirose, M. Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice. Arch Toxicol 81, 63-9 (2007).

705. Luan, Y., Suzuki, T., Palanisamy, R., Takashima, Y., Sakamoto, H., Sakuraba, M., Koizumi, T., Saito, M., Matsufuji, H., Yamagata, K., Yamaguchi, T., Hayashi, M. & Honma, M. Potassium bromate treatment predominantly causes large deletions, but not GC>TA transversion in human cells. Mutat Res 619, 113-23 (2007).

706. Moore, M. M., Honma, M., Clements, J., Bolcsfoldi, G., Burlinson, B., Cifone, M., Clarke, J., Clay, P., Doppalapudi, R., Fellows, M., Gollapudi, B., Hou, S., Jenkinson, P., Muster, W., Pant, K., Kidd, D. A., Lorge, E., Lloyd, M., Myhr, B., O'Donovan, M., Riach, C., Stankowski, L. F., Jr., Thakur, A. K., Van Goethem, F. & Mouse Lymphoma Assay Workgroup, Iwgt. Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment. Mutat Res 627, 36-40 (2007).

707. Neuwirth, E. A., Honma, M. & Grosovsky, A. J. Interchromosomal crossover in human cells is associated with long gene conversion tracts. Mol Cell Biol 27, 5261-74 (2007).

708. Nohmi, Takehiko. Novel DNA Polymerases and Novel Genotoxicity Assays. Genes and Environment 29, 75-88 (2007).

709. Shimizu, M., Gruz, P., Kamiya, H., Masutani, C., Xu, Y., Usui, Y., Sugiyama, H., Harashima, H., Hanaoka, F. & Nohmi, T. Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta. Biochemistry 46, 5515-22 (2007).

710. Takeiri A, Mishima M, Tanaka K, Shioda A, Harada A, Masumura K, Nohmi T. . Mutation spectra in cisplatin- and transplatin-treated GDL1 cells clarified the different mode of action of these compounds in mammalian cells. Genes Environ 29, 89-99. (2007).

711. Thybaud V, Aardema M, Clements J, Dearfield K, Galloway S, Hayashi M. Jacobson-Kram D, Kirkland D, MacGregor JT, Marzin D, Ohyama W, Schuler M, Suzuki H, Zeiger E; Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing. Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing. . Mutat Res 627, 41-58 (2007).

712. Tweats, D. J., Blakey, D., Heflich, R. H., Jacobs, A., Jacobsen, S. D., Morita, T., Nohmi, T., O'Donovan, M. R., Sasaki, Y. F., Sofuni, T., Tice, R. & Group, Iwgt Working. Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards. Mutat Res 627, 78-91 (2007).

713. Tweats, D. J., Blakey, D., Heflich, R. H., Jacobs, A., Jacobsen, S. D., Morita, T., Nohmi, T., O'Donovan, M. R., Sasaki, Y. F., Sofuni, T., Tice, R. & Group, Iwgt Working. Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test. Mutat Res 627, 92-105 (2007).

714. Umebayashi, Y., Honma, M., Suzuki, M., Suzuki, H., Shimazu, T., Ishioka, N., Iwaki, M. & Yatagai, F. Mutation induction in cultured human cells after low-dose and low-dose-rate gamma-ray irradiation: detection by LOH analysis. J Radiat Res 48, 7-11 (2007).

715. Umemura, T., Kuroiwa, Y., Tasaki, M., Okamura, T., Ishii, Y., Kodama, Y., Nohmi, T., Mitsumori, K., Nishikawa, A. & Hirose, M. Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice. Mutat Res 633, 46-54 (2007).

716. Wang, J., Chen, T., Honma, M., Chen, L. & Moore, M. M. 3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells. Environ Mol Mutagen 48, 248-57 (2007).

717. Wang J, Chen T, Honma M, Chen L, Moore MM. 3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells. . Environ Mol Mutagen 48, 248-57 (2007).

718. Xu, A., Smilenov, L. B., He, P., Masumura, K., Nohmi, T., Yu, Z. & Hei, T. K. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect 115, 87-92 (2007).

719. Yatagai, F, Umebayashi, Y., Suzuki, M., Abe, T., Suzuki, H., Shimazu, T., Ishioka, N., Iwaki, M, and Honma, M. . Influence of low-dose and low-dose-rate ionizing radiation on mutation induction in human cells. Advances in Space Res, 40, 470-473. (2007).

720. Anderson, H. J., Vonarx, E. J., Pastushok, L., Nakagawa, M., Katafuchi, A., Gruz, P., Di Rubbo, A., Grice, D. M., Osmond, M. J., Sakamoto, A. N., Nohmi, T., Xiao, W. & Kunz, B. A. Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2. Plant J 55, 895-908 (2008).

721. Fukuhara K, Nakanishi I, Matsuoka A, Matsumura T, Honda S, Hayashi M, Ozawa T, Miyata N, Saito S, Ikota N, Okuda H Effect of methyl substitution on the antioxidative property and genotoxicity of resveratrol. . Chem Res Toxicol 21, 282-287 (2008).

722. Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F. & Nohmi, T. Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta. DNA Repair (Amst) 7, 497-506 (2008).

723. Kobayashi K, Pillai KS, Sakuratani Y, Abe T, Kamata E, Hayashi M. Evaluation of statistical tools used in short-term repeated dose administration toxicity studies with rodents. J Toxicol Sci 33, 97-104 (2008).

724. Kuroiwa, Y., Yamada, M., Matsui, K., Okamura, T., Ishii, Y., Masumura, K., Tasaki, M., Umemura, T., Mitsumori, K., Nohmi, T., Hirose, M. & Nishikawa, A. Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium. Toxicol Sci 104, 274-82 (2008).

725. Matsuoka A, Kodama Y, Fukuhara K, Honda S, Hayashi M, Sai K, Hasebe M, Fujiwara Y. A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice. . Food Chem Toxicol 46, 1125-1130 (2008).

726. Nishikawa, A., Umemura,T., Ishii,Y., Tasaki,M., Okamura,T., Inoue,T., Masumura,K., Nohmi,T. In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens. Genese and Environment 30, 120-124 (2008).

727. Nohmi, Takehiko. Possible Mechanisms of Practical Thresholds for Genotoxicity. Genes and Environment 30, 108-113 (2008).

728. Nohmi T, Toyoda-Hokaiwado N, Yamada M, Masumura K, Honma M and Fukushima S. . International symposium on genotoxic and carcinogenic thresholds. Genes and Environ., 30, 101-107 (2008).

729. Uchida, K., Furukohri, A., Shinozaki, Y., Mori, T., Ogawara, D., Kanaya, S., Nohmi, T., Maki, H. & Akiyama, M. Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal. Mol Microbiol 70, 608-22 (2008).

730. Yamauchi, K., Kakinuma, S., Sudo, S., Kito, S., Ohta, Y., Nohmi, T., Masumura, K., Nishimura, M. & Shimada, Y. Differential effects of low- and high-dose X-rays on N-ethyl-N-nitrosourea-induced mutagenesis in thymocytes of B6C3F1 gpt-delta mice. Mutat Res 640, 27-37 (2008).

731. Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M. & Honma, M. Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. J Mol Biol 377, 1015-23 (2008).

732. Yatagai, F., Suzuki, M., Ishioka, N., Ohmori, H. & Honma, M. Repair of I-SceI induced DSB at a specific site of chromosome in human cells: influence of low-dose, low-dose-rate gamma-rays. Radiat Environ Biophys 47, 439-44 (2008).

733. Yatagai, F., Umebayashi, Y., Honma, M., Sugasawa, K., Takayama, Y. & Hanaoka, F. Mutagenic radioadaptation in a human lymphoblastoid cell line. Mutat Res 638, 48-55 (2008).

734. Eastmond, D. A., Hartwig, A., Anderson, D., Anwar, W. A., Cimino, M. C., Dobrev, I., Douglas, G. R., Nohmi, T., Phillips, D. H. & Vickers, C. Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. Mutagenesis 24, 341-9 (2009).

735. Fukuda, H., Takamura-Enya, T., Masuda, Y., Nohmi, T., Seki, C., Kamiya, K., Sugimura, T., Masutani, C., Hanaoka, F. & Nakagama, H. Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus. J Biol Chem 284, 25585-92 (2009).

736. Galhardo, R. S., Do, R., Yamada, M., Friedberg, E. C., Hastings, P. J., Nohmi, T. & Rosenberg, S. M. DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli. Genetics 182, 55-68 (2009).

737. Hajime Sui, Kumiko Kawakami, Noriko Sakurai,Takumi Hara,Takehiko Nohmi. Improvement and Evaluation of High Throughput Fluctuation Ames Test Using 384-well Plate with Salmonella typhimurium TA100 and TA98. Genes and Environment 31, 47-55 (2009).

738. Hashimoto AH, Amanuma K, Masumura K, Nohmi T, Aoki Y. . In vivo mutagenesis caused by diesel exhaust in the testis of gpt delta transgenic mice. Genes Environ 31, 1-8 (2009).

739. K., Masumura. Spontaneous and induced gpt and Spi- mutant frequencies in gpt delta transgenic rodents. Genes Environ 31, 105-118 (2009).

740. Masami Yamada, Keiko Matsui, Atsushi Katafuchi, Makiko Takamune, Takehiko Nohmi. Development of Tester Strains Deficient in Nth/Nei DNA Glycosylases to Selectively Detect the Mutagenicity of Oxidized DNA Pyrimidines. Genes and Environment 31, 69-79 (2009).

741. Miyazaki, S., Shinzawa, M., Yoshitani, K., Nohmi, T. & Ohnishi, Y. [Giant cerebral aneurysm with fontan circulation]. Masui 58, 753-6 (2009).

742. Morita, T., Hayashi, M., Nakajima, M., Tanaka, N., Tweats, D. J., Morikawa, K. & Sofuni, T. Practical issues on the application of the GHS classification criteria for germ cell mutagens. Regul Toxicol Pharmacol 55, 52-68 (2009).

743. Nakahira, J., Ohnishi, Y., Nohmi, T., Sawai, T. & Kuro, M. Usefulness of transesophageal echocardiography for identifying the precise location of a left ventricular rupture in a patient with collapsed cardiac chamber. J Anesth 23, 108-10 (2009).

744. Niimi, N., Sassa, A., Katafuchi, A., Gruz, P., Fujimoto, H., Bonala, R. R., Johnson, F., Ohta, T. & Nohmi, T. The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa. Biochemistry 48, 4239-46 (2009).

745. Salem, A. M., Nakano, T., Takuwa, M., Matoba, N., Tsuboi, T., Terato, H., Yamamoto, K., Yamada, M., Nohmi, T. & Ide, H. Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli. J Bacteriol 191, 5657-68 (2009).

746. Shibata, A., Maeda, D., Ogino, H., Tsutsumi, M., Nohmi, T., Nakagama, H., Sugimura, T., Teraoka, H. & Masutani, M. Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. Mutat Res 664, 20-7 (2009).

747. T., Masumura K and Nohmi. Spontaneous mutagenesis in rodents: spontaneous gene mutations identified by neutral reporter genes in gpt delta transgenic mice and rats. Journal of Health Science 55, 40-49 (2009).

748. Takashima, Y., Sakuraba, M., Koizumi, T., Sakamoto, H., Hayashi, M. & Honma, M. Dependence of DNA double strand break repair pathways on cell cycle phase in human lymphoblastoid cells. Environ Mol Mutagen 50, 815-22 (2009).

749. Totsuka, Y., Higuchi, T., Imai, T., Nishikawa, A., Nohmi, T., Kato, T., Masuda, S., Kinae, N., Hiyoshi, K., Ogo, S., Kawanishi, M., Yagi, T., Ichinose, T., Fukumori, N., Watanabe, M., Sugimura, T. & Wakabayashi, K. Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems. Part Fibre Toxicol 6, 23 (2009).

750. Umemura, T., Tasaki, M., Kijima, A., Okamura, T., Inoue, T., Ishii, Y., Suzuki, Y., Masui, N., Nohmi, T. & Nishikawa, A. Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate. Toxicology 257, 46-52 (2009).

751. Valenti, A., Perugino, G., Nohmi, T., Rossi, M. & Ciaramella, M. Inhibition of translesion DNA polymerase by archaeal reverse gyrase. Nucleic Acids Res 37, 4287-95 (2009).

752. Wang, J., Sawyer, J. R., Chen, L., Chen, T., Honma, M., Mei, N. & Moore, M. M. The mouse lymphoma assay detects recombination, deletion, and aneuploidy. Toxicol Sci 109, 96-105 (2009).

753. Whitehead, K., Pan, M., Masumura, K., Bonneau, R. & Baliga, N. S. Diurnally entrained anticipatory behavior in archaea. PLoS One 4, e5485 (2009).

754. Xu, A., Chai, Y., Nohmi, T. & Hei, T. K. Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part Fibre Toxicol 6, 3 (2009).

755. Yatagai, F., Sugasawa, K., Enomoto, S. & Honma, M. An approach to estimate radioadaptation from DSB repair efficiency. J Radiat Res 50, 407-13 (2009).

756. Aoi Kimura, Naohiko Torigoe, Atsuro Miyata, Masamitsu Honma. Validation of a Simple In Vitro Comet Assay Method Using CHL Cells. Genes and Environment 32, 61-65 (2010).

757. Facciotti, M. T., Pang, W. L., Lo, F. Y., Whitehead, K., Koide, T., Masumura, K., Pan, M., Kaur, A., Larsen, D. J., Reiss, D. J., Hoang, L., Kalisiak, E., Northen, T., Trauger, S. A., Siuzdak, G. & Baliga, N. S. Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysis. BMC Syst Biol 4, 64 (2010).

758. Honma, M. [Structural activity relationship approaches for assessing genotoxicity]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku, 39-43 (2010).

759. Hori, M., Yonekura, S., Nohmi, T., Gruz, P., Sugiyama, H., Yonei, S. & Zhang-Akiyama, Q. M. Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine. J Nucleic Acids 2010, 807579 (2010).

760. Katafuchi, A. & Nohmi, T. DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: their efficiency and template base preference. Mutat Res 703, 24-31 (2010).

761. Katafuchi, A., Sassa, A., Niimi, N., Gruz, P., Fujimoto, H., Masutani, C., Hanaoka, F., Ohta, T. & Nohmi, T. Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides. Nucleic Acids Res 38, 859-67 (2010).

762. Nohmi, T. & Bignami, M. Nucleotide pool damage and its biological consequences. Mutat Res 703, 1 (2010).

763. Okamura, T., Ishii, Y., Suzuki, Y., Inoue, T., Tasaki, M., Kodama, Y., Nohmi, T., Mitsumori, K., Umemura, T. & Nishikawa, A. Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice. J Toxicol Sci 35, 731-41 (2010).

764. Okamura, T., Ishii, Y., Suzuki, Y., Inoue, T., Tasaki, M., Kodama, Y., Nohmi, T., Mitsumori, K., Umemura, T. & Nishikawa, A. Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). J Toxicol Sci 35, 709-20 (2010).

765. Okudaira, N., Uehara, Y., Fujikawa, K., Kagawa, N., Ootsuyama, A., Norimura, T., Saeki, K., Nohmi, T., Masumura, K., Matsumoto, T., Oghiso, Y., Tanaka, K., Ichinohe, K., Nakamura, S., Tanaka, S. & Ono, T. Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice. Radiat Res 173, 138-47 (2010).

766. Sheh, A., Lee, C. W., Masumura, K., Rickman, B. H., Nohmi, T., Wogan, G. N., Fox, J. G. & Schauer, D. B. Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection. Proc Natl Acad Sci U S A 107, 15217-22 (2010).

767. Shimizu, Petr Gruz and Masatomi. Origins of Age-Related DNA Damage and Dietary Strategies for Its Reduction. Rejuvenation Research 13, 285-287 (2010).

768. Takeuchi, M., Nohmi, T., Ichikawa, M. & Ohnishi, Y. [Anesthetic management of a child with moyamoya disease combined with von Gierke's disease]. Masui 59, 260-3 (2010).

769. Tasaki, M., Umemura, T., Suzuki, Y., Hibi, D., Inoue, T., Okamura, T., Ishii, Y., Maruyama, S., Nohmi, T. & Nishikawa, A. Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency. Cancer Sci 101, 2525-30 (2010).

770. Toyoda-Hokaiwado, N., Inoue, T., Masumura, K., Hayashi, H., Kawamura, Y., Kurata, Y., Takamune, M., Yamada, M., Sanada, H., Umemura, T., Nishikawa, A. & Nohmi, T. Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers. Toxicol Sci 114, 71-8 (2010).

771. Wong, J. H., Brown, J. A., Suo, Z., Blum, P., Nohmi, T. & Ling, H. Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. EMBO J 29, 2059-69 (2010).

772. Yasui, M., Koyama, N., Koizumi, T., Senda-Murata, K., Takashima, Y., Hayashi, M., Sugimoto, K. & Honma, M. Live cell imaging of micronucleus formation and development. Mutat Res 692, 12-8 (2010).

773. Hakulinen, P., Yamamoto, A., Koyama, N., Kumita, W., Yasui, M. & Honma, M. Induction of TK mutations in human lymphoblastoid TK6 cells by the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). Mutat Res 725, 43-9 (2011).

774. Hibi, D., Suzuki, Y., Ishii, Y., Jin, M., Watanabe, M., Sugita-Konishi, Y., Yanai, T., Nohmi, T., Nishikawa, A. & Umemura, T. Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A. Toxicol Sci 122, 406-14 (2011).

775. Honma, M. Cytotoxicity measurement in in vitro chromosome aberration test and micronucleus test. Mutat Res 724, 86-7 (2011).

776. Honma, M. & Hayashi, M. Comparison of in vitro micronucleus and gene mutation assay results for p53-competent versus p53-deficient human lymphoblastoid cells. Environ Mol Mutagen 52, 373-84 (2011).

777. Horibata, K., Saijo, M., Bay, M. N., Lan, L., Kuraoka, I., Brooks, P. J., Honma, M., Nohmi, T., Yasui, A. & Tanaka, K. Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex. Genes Cells 16, 101-14 (2011).

778. Horibata K, Ukai A, Koyama N, Takagi A, Kanno J, Kimoto T, Miura D, Hirose A, Honma M Fullerene (C60) is negative in the in vivo Pig-A gene mutation assay. Genes and Environ 33, 27-31 (2011).

779. Jin, M., Kijima, A., Suzuki, Y., Hibi, D., Inoue, T., Ishii, Y., Nohmi, T., Nishikawa, A., Ogawa, K. & Umemura, T. Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats. Toxicology 290, 312-21 (2011).

780. Kimoto, T., Chikura, S., Suzuki, K., Kobayashi, Xm, Itano, Y., Horibata, K., Honma, M., Dobrovolsky, V. N., Heflich, R. H., Miura, D. & Kasahara, Y. Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ Mol Mutagen 52, 774-83 (2011).

781. Koyama, N., Yasui, M., Kimura, A., Takami, S., Suzuki, T., Masumura, K., Nohmi, T., Masuda, S., Kinae, N., Matsuda, T., Imai, T. & Honma, M. Acrylamide genotoxicity in young versus adult gpt delta male rats. Mutagenesis 26, 545-9 (2011).

782. Koyama, N., Yasui, M., Oda, Y., Suzuki, S., Satoh, T., Suzuki, T., Matsuda, T., Masuda, S., Kinae, N. & Honma, M. Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems. Environ Mol Mutagen 52, 11-9 (2011).

783. Lynch, A. M., Sasaki, J. C., Elespuru, R., Jacobson-Kram, D., Thybaud, V., De Boeck, M., Aardema, M. J., Aubrecht, J., Benz, R. D., Dertinger, S. D., Douglas, G. R., White, P. A., Escobar, P. A., Fornace, A., Jr., Honma, M., Naven, R. T., Rusling, J. F., Schiestl, R. H., Walmsley, R. M., Yamamura, E., van Benthem, J. & Kim, J. H. New and emerging technologies for genetic toxicity testing. Environ Mol Mutagen 52, 205-23 (2011).

784. Masumura, K., Sakamoto, Y., Ikeda, M., Asami, Y., Tsukamoto, T., Ikehata, H., Kuroiwa, Y., Umemura, T., Nishikawa, A., Tatematsu, M., Ono, T. & Nohmi, T. Antigenotoxic effects of p53 on spontaneous and ultraviolet light B--induced deletions in the epidermis of gpt delta transgenic mice. Environ Mol Mutagen 52, 244-52 (2011).

785. Moore, M. M., Honma, M., Clements, J., Awogi, T., Douglas, G. R., van Goethem, F., Gollapudi, B., Kimura, A., Muster, W., O'Donovan, M., Schoeny, R. & Wakuri, S. Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup. Mutat Res 723, 84-6 (2011).

786. Rothfuss, A., Honma, M., Czich, A., Aardema, M. J., Burlinson, B., Galloway, S., Hamada, S., Kirkland, D., Heflich, R. H., Howe, J., Nakajima, M., O'Donovan, M., Plappert-Helbig, U., Priestley, C., Recio, L., Schuler, M., Uno, Y. & Martus, H. J. Improvement of in vivo genotoxicity assessment: combination of acute tests and integration into standard toxicity testing. Mutat Res 723, 108-20 (2011).

787. Sassa, A., Niimi, N., Fujimoto, H., Katafuchi, A., Gruz, P., Yasui, M., Gupta, R. C., Johnson, F., Ohta, T. & Nohmi, T. Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa. Mutat Res 718, 10-7 (2011).

788. Sassa, A., Ohta, T., Nohmi, T., Honma, M. & Yasui, M. Mutational specificities of brominated DNA adducts catalyzed by human DNA polymerases. J Mol Biol 406, 679-86 (2011).

789. Takahashi, M., Inoue, K., Koyama, N., Yoshida, M., Irie, K., Morikawa, T., Shibutani, M., Honma, M. & Nishikawa, A. Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicity. Arch Toxicol 85, 1109-20 (2011).

790. Takehiko Nohmi, Malyn Chulasiri. Special Issue for the 2nd Asian Conference on Environmental Mutagens (2nd ACEM): Harmonization of Genes and Environment. Genes and Environment 33, 111 (2011).

791. Thybaud, V., Macgregor, J. T., Muller, L., Crebelli, R., Dearfield, K., Douglas, G., Farmer, P. B., Gocke, E., Hayashi, M., Lovell, D. P., Lutz, W. K., Marzin, D., Moore, M., Nohmi, T., Phillips, D. H. & Van Benthem, J. Strategies in case of positive in vivo results in genotoxicity testing. Mutat Res 723, 121-8 (2011).

792. Toyoda-Hokaiwado, N., Yasui, Y., Muramatsu, M., Masumura, K., Takamune, M., Yamada, M., Ohta, T., Tanaka, T. & Nohmi, T. Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats. Carcinogenesis 32, 1512-7 (2011).

793. Toyoda-Hokaiwado N, Yasui Y, Takamune M, Yamada M, Muramatsu M, Masumura K, Ohta T, Tanaka T, Nohmi T. Modulatory effects of capsaicin on N-diethylnitrosamine (DEN)-induced mutagenesis in Salmonella typhimurium YG7108 and DEN-induced hepatocarcinogenesis in gpt delta transgenic rats. Genes and Environment, 33, 160-166 (2011).

794. Yamamoto, A., Sakamoto, Y., Masumura, K., Honma, M. & Nohmi, T. Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N'-nitro-N-nitrosoguanidine against gamma-induced genotoxicity in human cells. Mutat Res 713, 56-63 (2011).

795. Yatagai, F., Honma, M., Takahashi, A., Omori, K., Suzuki, H., Shimazu, T., Seki, M., Hashizume, T., Ukai, A., Sugasawa, K., Abe, T., Dohmae, N., Enomoto, S., Ohnishi, T., Gordon, A. & Ishioka, N. Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation. Radiat Environ Biophys 50, 125-34 (2011).

796. Bailey, A. D., Gray, L. T., Pavelitz, T., Newman, J. C., Horibata, K., Tanaka, K. & Weiner, A. M. The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst) 11, 488-501 (2012).

797. H. Sui, R. Ohta, T. Shiragiku, A. Akahori, K. Suzuki, M.Nakajima, H. Hayashi, K. Masumura and T. Nohmi. Evaluation of in vivo mutagenicity by 2,4-diaminotoluene and 2,6-diaminotoluene in liver of F344 gpt delta transgenic rat dosed for 28 days: a collaborative study of the gpt delta transgenic rat mutation assay. Genes and Environ 34, 25-33. (2012).

798. Jin, M., Kijima, A., Suzuki, Y., Hibi, D., Ishii, Y., Nohmi, T., Nishikawa, A., Ogawa, K. & Umemura, T. In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice. J Toxicol Sci 37, 711-21 (2012).

799. Luan, Y., Xing, G., Qi, X., Wu, M., Li, C., Yao, J., Gong, L., Nohmi, T., Gu, J., Zhou, W., Zheng, S. & Ren, J. The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis. Arch Toxicol 86, 1753-61 (2012).

800. Mekenyan, O. G., Petkov, P. I., Kotov, S. V., Stoeva, S., Kamenska, V. B., Dimitrov, S. D., Honma, M., Hayashi, M., Benigni, R., Donner, E. M. & Patlewicz, G. Investigating the relationship between in vitro-in vivo genotoxicity: derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism. Chem Res Toxicol 25, 277-96 (2012).

801. Nohmi, Takehiko, Honma, Masamitsu, Yamada, Masami, Masumura, Kenichi, Yasui, Manabu, Horibata, Katsuyoshi & Fukushima, Shoji. 2nd International Symposium on Genotoxic and Carcinogenic Thresholds. Genes and Environment 34, 141-145 (2012).

802. Nohmi, Takehiko, Yamada, Masami & Masumura, Kenichi. in vivo Approaches to Identify Mutations and in vitro Research to Reveal Underlying Mechanisms of Genotoxic Thresholds. Genes and Environment 34, 146-152 (2012).

803. Ono A, Takahashi M, Hirose A, Kamata E, Kawamura T, Yamazaki T, Sato K, Yamada M, Fukumoto T, Okamura H, Mirokuji Y, Honma M. . Validation of the (Q)SAR combination approach for mutagenicity prediction of flavor chemicals. . Food Chem Toxicol. 50, 1538-46. (2012).

804. Saito, Y., Ono, T., Takeda, N., Nohmi, T., Seki, M., Enomoto, T., Noda, T. & Uehara, Y. Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline. Tohoku J Exp Med 226, 75-83 (2012).

805. Suzuki, Y., Umemura, T., Hibi, D., Inoue, T., Jin, M., Ishii, Y., Sakai, H., Nohmi, T., Yanai, T., Nishikawa, A. & Ogawa, K. Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats. Arch Toxicol 86, 1593-601 (2012).

806. Suzuki, Y., Umemura, T., Ishii, Y., Hibi, D., Inoue, T., Jin, M., Sakai, H., Kodama, Y., Nohmi, T., Yanai, T., Nishikawa, A. & Ogawa, K. Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice. Mutat Res 749, 23-8 (2012).

807. T Kamigaito, T Noguchi, K Narumi, R Takashima, S Hamada, H Sanada, M Hasuko, H Hayashi, K Masumura, T Nohmi. Evaluation of the in vivo mutagenicity of nickel subsulfide in the lung of F344 gpt delta transgenic rats exposed by intratracheal instillation: a collaborative study for the gpt delta transgenic rat mutation assay. Genes and Environ 34, 34-44 (2012).

808. Tasaki, M., Kuroiwa, Y., Inoue, T., Hibi, D., Matsushita, K., Ishii, Y., Maruyama, S., Nohmi, T., Nishikawa, A. & Umemura, T. Oxidative DNA damage and in vivo mutagenicity caused by reactive oxygen species generated in the livers of p53-proficient or -deficient gpt delta mice treated with non-genotoxic hepatocarcinogens. J Appl Toxicol (2012).

809. Xing, G., Qi, X., Chen, M., Wu, Y., Yao, J., Gong, L., Nohmi, T., Luan, Y. & Ren, J. Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res 743, 52-8 (2012).

810. Y. Kawamura, H. Hayashi, O. Tajima, S. Yamada, T. Takayanagi, H. Hori, W. Fujii, K. Masumura and T. Nohmi. Evaluation of the genotoxicity of aristolochic acid in the kidney and liver of F344 gpt delta transgenic rat using a 28-day repeated-dose protocol: a collaborative study of the gpt delta transgenic rat mutation assay. Genes and Environ 34, 18-24 (2012).

811. Yamada, M., Shimizu, M., Katafuchi, A., Gruz, P., Fujii, S., Usui, Y., Fuchs, R. P. & Nohmi, T. Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains. Mol Microbiol 86, 1364-75 (2012).

812. Zhang, X., Horibata, K., Saijo, M., Ishigami, C., Ukai, A., Kanno, S., Tahara, H., Neilan, E. G., Honma, M., Nohmi, T., Yasui, A. & Tanaka, K. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet 44, 593-7 (2012).




2012年以降の研究業績に戻る

ページトップへ