1. S.-R. Kim, Y. Saito, M. Itoda, K. Maekawa, M. Kawamoto, N. Kamatani, S. Ozawa and J. Sawada: Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population. Drug Metab. Pharmacokinet., in press, 2009.

2. H. Ueno, N. Kaniwa, T. Okusaka, M. Ikeda, C. Morizane, S. Kondo, E. Sugiyama, S.-R. Kim, R. Hasegawa, Y. Saito, T. Yoshida, N. Saijo and J. Sawada: Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients. Br. J. Cancer, 100, 870-873, 2009.

3. M. Matsunaga, H. Yamazaki, K. Kiyotani, S. Iwano, J. Saruwatari, K. Nakagawa, A. Soyama, S. Ozawa, J. Sawada, E. Kashiyama, M. Kinoshita and T. Kamataki: Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese. Drug Metab. Dispos., 37, 699-701, 2009.

4. J. Matsubara, M. Ono, A. Negishi, H. Ueno, T. Okusaka, J. Furuse, K.Furuta, E. Sugiyama, Y. Saito, N. Kaniwa, J. Sawada, K. Honda, T. Sakuma, T. Chiba, N. Saijo, S. Hirohashi and T. Yamada: Identification of a predictive biomarker for hematological toxicities of gemcitabine. J. Clin. Oncol., in press, 2009.

5. Y. Sato, N.M. Laird, K. Nagashima, R. Kato, T. Hamano, A. Yafune, N. Kaniwa, Y. Saito, E. Sugiyama, S.-R. Kim, J. Furuse, H. Ishii, H. Ueno, T. Okusaka, N. Saijo, J. Sawada and T. Yoshida: A New Statistical Screening Approach for Finding Pharmacokinetics-related Genes in Genome-wide Studies. Pharmacogenomics J., 9, 137-146, 2009.

6. S. Horiuchi, S. Ishida, T. Hongo, Y. Ishikawa, A. Miyajima, J. Sawada, Y. Ohno, K. Nakazawa and S. Ozawa: Global gene expression changes including drug metabolism and disposition induced by three-dimensional culture of HepG2 cells - involvement of microtubules. Biochem. Biophys. Res. Commun., 378, 558-562, 2009.

7. K. Maekawa, T. Yoshimura, Y. Saito, Y. Fujimura, F. Aohara, C. Emoto, K. Iwasaki, N. Hanioka, S. Narimatsu, T. Niwa, and J. Sawada: Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine. Xenobiotica, 39, 140-147, 2009.

8. Y. Saito, K. Sai, K. Maekawa, N. Kaniwa, K,. Shirao, T. Hamaguchi, N. Yamamoto, H. Kunitoh, Y. Ohe, Y. Yamada, T. Tamura, T. Yoshida, H. Minami, A. Ohtsu, Y. Matsumura, N. Saijo and J. Sawada: Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6 or *60 haplotype and its apparent influence on SN-38 glucuronidation in Japanese. Drug Metab. Dispos., 37, 272-276, 2009.

9. N. Tatewaki, K. Maekawa, N. Katori, K. Kurose, N. Kaniwa, N. Yamamoto, H. Kunitoh, Y. Ohe, H. Nokihara, I. Sekine, T. Tamaura, T. Yoshida, N. Saijo, Y. Saito and J. Sawada: Genetic variations and haplotype structures of the glutathione S-transferase genes, GSTT1 and GSTM1, in a Japanese patient population. Drug Metab. Pharmacokinet., 24, 118-126, 2009.

10. N. Kaniwa, Y. Saito, M. Aihara, K. Matsunaga, M. Tohkin, K. Kurose, J. Sawada, H. Furuya, Y. Takahashi, M. Muramatsu, S. Kinoshita, M. Abe, H. Ikeda, M. Kashiwagi, Y. Song, M. Ueta, C. Sotozono, Z. Ikezawa and R. Hasegawa, for the JSAR research group: HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics, 9, 1617-1622, 2008.

11. T. Yin, K. Maekawa, K. Kamide, Y. Saito, H. Hanada, K. Miyashita, Y. Kokubo, Y. Akaiwa, R. Otsubo, K. Nagatsuka, T. Otsuki, T. Horio, S. Takiuchi, Y. Kawano, K. Minematsu, H. Naritomi, H. Tomoike, J. Sawada and T. Miyata: Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan. Hypertens. Res., 31, 1549-1557, 2008.

12. S.-R. Kim, Y. Saito, K. Maekawa, E. Sugiyama, N. Kaniwa, H. Ueno, T. Okusaka, M. Ikeda, C. Morizane, N. Yamamoto, T. Yoshida, N. Kamatani, J. Furuse, H. Ishii, N. Saijo, S. Ozawa and J. Sawada: Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). Drug Metab. Pharmacokinet., 23, 379-384, 2008.

13. K. Sai, Y. Saito, M. Itoda, H. Fukushima-Uesaka, S. Ozawa, K. Kurose, N. Kaniwa, M. Kawamoto, N. Kamatani, K. Shirao, N. Yamamoto, T. Hamaguchi, H. Kunitoh, Y. Ohe, Y. Yamada, T. Tamura, T. Yoshida, H. Minami, Y. Matsumura, A. Ohtsu, N. Saijo and J. Sawada: Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. Drug. Metab. Pharmacokinet., 23, 139-147, 2008.

14. K. Sai, Y. Saito, H. Sakamoto, K. Shirao, K. Kurose, M. Saeki, S. Ozawa, N. Kaniwa, S. Hirohashi, N. Saijo, J. Sawada, T. Yoshida: Importance of UDP-glucuronosyltransferase 1A1 *6 for irinotecan toxicities in Japanese cancer patients. Cancer Lett., 261, 165-171, 2008.

15. K. Sai, Y. Saito, H. Fukushima-Uesaka, K. Kurose, N. Kaniwa, N. Kamatani, K. Shirao, N. Yamamoto, T. Hamaguchi, H. Kunitoh, Y. Ohe, T. Tamura, Y. Yamada, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo and J. Sawada: Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients. Cancer Chemother. Pharmacol., 62, 529-537, 2008.

16. N. Hanioka, Y. Tsuneto, Y. Saito, K. maekawa, J. Sawada and S. Narimatsu: Influence of CYP2C19*18 and CYP2C9*19 alleles on omeprazole 5-methylhydroxylation: In vitro functional analysis of recombinant enzymes expressed in Saccharomyces cerevisiae. Basic Clin. Pharmacol. Toxicol., 102, 388-393, 2008.

17. K. Sai, H. Minami, Y. Saito and J. Sawada: Impact of UDP-glucuronosyltransferase 1A haplotypes on irinotecan treatment. In "Cancer Drug Discovery and Development: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response", ed. by F. Innocenti, Humana Press, pp.267-286, 2008.

18. M. Ukaji, Y. Saito, H. Fukushima-Uesaka, K. Maekawa, N. Katori, N. Kaniwa, T. Yoshida, H. Nokihara, I. Sekine, H. Kunitoh, Y. Ohe, N. Yamamoto, T. Tamura, N. Saijo and J. Sawada: Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population. Drug Metab. Pharmacokinet., 22, 462-467, 2007.

19. S.-R. Kim, Y. Saito, K. Sai, K. Kurose, K. Maekawa, N. Kaniwa, S. Ozawa, N. Kamatani, K. Shirao, N. Yamamoto, T. Hamaguchi, H. Kunitoh, Y. Ohe, Y. Yamada, T. Tamura, T. Yoshida, H. Minami, A. Ohtsu, N. Saijo and J. Sawada: Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects - SLCO1B1*17 is more prevalent than *15. Drug. Metab. Pharmakokinet., 22, 456-461, 2007.

20. N. Kaniwa, E. Sugiyama, S.-R. Kim, Y. Saito, J. Sawada, J. Furuse, H. Ishii, T. Yoshida, H. Ueno, T. Okusaka and N. Saijo: In reply to Mercier et al. "Genotype-based methods for anticipating gemcitabine-related severe toxicities may lead to false-negative results". J. Clin. Oncol., 25, 4855-4856, 2007.

21. K. Maekawa, M. Saeki, Y. Saito, S. Ozawa, K. Kurose, N. Kaniwa, M. Kawamoto, N. Kamatani, T. Hamaguchi, K. Shirao, M. Muto, A. Ohtsu, T. Yoshida, Y. Matsumura, N. Saijo and J. Sawada: Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences. J. Hum. Genet., 52, 804-819, 2007.

22. S.-R. Kim, K. Sai, T. Tanaka-Kagawa, H. Jinno, S. Ozawa, N. Kaniwa, Y. Saito, A. Akasawa, K. Matsumoto, H. Saito, N. Kamatani, K, Shirao, N. Yamamoto, T. Yoshida, H. Minami, A. Ohtsu, N. Saijo and J. Sawada: Haplotypes and a novel defective allele of CES2 found in a Japanese population. Drug Metab. Dispos., 35, 1865-1872, 2007.

23. U. Yokoyama, Y. Sato, T. Akaike, S. Ishida, J. Sawada, T. Nagao, H. Quan, M. Jin, M. Iwamoto, S. Yokota, Y. Ishikawa, S. Minamisawa: Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus. Physiol. Genomics, 31, 139-157, 2007.

24. Y. Kanno, M. Suzuki, Y. Miyazaki, M. Matsuzaki, T. Nakahama, K. Kurose, J. Sawada and Y. Inouye: Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor. Biochim. Biophys. Acta, 1773, 934-944, 2007.

25. H. Fukushima-Uesaka, Y. Saito, K. Maekawa, N. Kamatani, H. Kajio, N. Kuzuya, M. Noda, K. Yasuda and J. Sawada: Genetic variations and haplotype structures of a transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese. Drug Metab. Pharmacokinet., 22, 212-219, 2007.

26. Y. Saito, N. Katori, A. Soyama, Y. Nakajima, T. Yoshitani, S.-R. Kim, H. Fukushima-Uesaka, K. Kurose, N. Kaniwa, S. Ozawa, N. Kamatani, K. Komamura, S. Kamakura, M. Kitakaze, H. Tomoike, K. Sugai, N. Minami, H. Kimura, Y. Goto, H. Minami, T. Yoshida, H. Kunitoh, Y. Ohe, N. Yamamoto, T. Tamura, N. Saijo and J. Sawada: CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenet. Genomics, 17, 461-471, 2007.

27. N. Hanioka, Y. Tsuneto, Y. Saito, T. Sumada, K. Maekawa, K. Saito, J. Sawada and S. Narimatsu: Functional characterization of two novel CYP2C19 variants (CYP2C19*18 and CYP2C19*19) found in a Japanese populaltion. Xenobiotica, 37, 342-355, 2007.

28. H. Fukushima-Uesaka, Y. Saito, K. Maekawa, R. Hasegawa, K. Suzuki, T. Yanagawa, H. Kajio, N. Kuzuya, M. Noda, K. Yasuda, M. Tohkin and J. Sawada: Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. Drug Metab. Pharmacokinet., 22, 129-135, 2007.

29. H. Minami, K. Sai, M. Saeki, Y. Saito, S. Ozawa, K. Suzuki, N. Kaniwa, J. Sawada, T. Hamaguchi, N. Yamamoto, K. Shirao, Y. Yamada, H. Ohmatsu, K. Kubota, T. Yoshida, A. Ohtsu and N. Saijo: Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: Roles of UGT1A1*6 and *28. Pharmacogenet. Genomcs, 17, 497-504, 2007.

30. M. Saeki, Y. Saito, K. Sai, K. Maekawa, N. Kaniwa, J. Sawada, M. Kawamoto, A. Saito and N. Kamatani: A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers. Clin. Chem., 53, 356-358, 2007.

31. H. Fukushima-Uesaka, Y. Saito, M. Tohkin, K. Maekawa, R. Hasegawa, M. Kawamoto, N. KaSmatani, K. Suzuki, T. Yanagawa, H. Kajio, N. Kuzuya, K. Yasuda and J. Sawada: Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Drug Metab. Pharmacokinet., 22, 48-60, 2007.

32. Y. Saito, K. Maekawa, S. Ozawa and J. Sawada: Genetic polymorphisms and haplotypes of major drug metabolizing enzymes in East Asians and their comparison with other ethnic populations. Curr. Pharmacogenomics, 5, 49-78, 2007.

33. E. Sugiyama, N. Kaniwa, S.-R. Kim, R. Kikura-Hanajiri, R. Hasegawa, K. Maekawa, Y. Saito, S. Ozawa, J. Sawada, N. Kamatani, J. Furuse, H. Ishii, T. Yoshida, H. Ueno, T. Okusaka and N. Saijo: Pharmacokinetics of gemcitabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism. J. Clin. Oncol., 25, 32-47, 2007.

34. S. Ishida, H. Tanabe, Y. Shinozaki, S. Koyano, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno and K.Inoue: How DNA microarray technology contributes to the retinoid evaluations. In “Vitamin A: New research”, ed. by I..T. Loessing, Nova Science Publishers, pp. 71-92, 2007.

35. H. Ueno, K. Kiyosawa, N. Kaniwa: Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy? Br. J. Cancer, 97, 145-151, 2007.

36. S.-R. Kim, S. Ozawa, Y. Saito, K. Kurose, N. Kaniwa, N. Kamatani, T. Hamaguchi, K. Shirao, M. Muto, A. Ohtsu, T. Yoshida, Y. Matsumura, N. Saijo and J. Sawada: Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS). Drug Metab. Pharmacokinet., 21, 509-516, 2006.

37. A. Soyama, Y. Saito, Y. Ohno, K. Komamura, S. Kamakura, M. Kitakaze, H. Tomoike, S. Ozawa and J. Sawada: Diverse structures of chimeric CYP-REP7/6-containing CYP2D6 and a novel defective CYP2D6 haplotype harboring single-type *36 and CYP-REP7/6 in Japanese. Drug Metab. Pharmacokinet., 21, 395-405, 2006.

38. Y. Nakajima, T. Yoshitani, H. Fukushima-Uesaka, Y. Saito, N. Kaniwa, K. Kurose, S. Ozawa, N. Aoyagi, N. Kamatani, N. Yamamoto, H. Kunitoh, Y. Ohe, T. Tamura, T. Yoshida, H. Minami, N. Saijo, N. Katori and J. Sawada: Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer. Clin. Pharmacol. Ther., 80, 179-191, 2006.

39. H. Fukushima-Uesaka, Y. Saito, K. Maekawa, M. Saeki, N. Kamatani, H. Kajio, N. Kuzuya, K. Yasuda and J. Sawada: Novel genetic variations and haplotypes of hepatocyte nuclear factor 4a (HNF4A) found in Japanese type II diabetic patients. Drug Metab. Pharmacokinet., 21, 337-346, 2006.

40. K. Maekawa, H. Fukushima-Uesaka, M. Tohkin, R. Hasegawa, H. Kajio, N. Kuzuya, K. Yasuda, M. Kawamoto, N. Kamatani, K. Suzuki, T. Yanagawa, Y. Saito and J. Sawada: Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese. Pharmacogenet. Genomics, 16, 497-514, 2006.

41. N. Hanioka, Y. Okumura, Y. Saito, H. Hichiya, A. Soyama, K. Saito, K. Ueno, J. Sawada and S. Narimatsu: Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae. Biochem. Pharmacol., 71, 1386-1395, 2006.

42. S. Kim, Y. Saito, K. Maekawa, E. Sugiyama, N. Kaniwa, H. Ueno, T. Okusaka, C. Morizane, N. Yamamoto, M. Ikeda, T. Yoshida, H. Minami, J. Furuse, H. Ishii, N. Saijo, N. Kamatani, S. Ozawa and J. Sawada: Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1). Drug Metab. Pharmacokinet., 21, 248-256, 2006.

43. T. Hongo, M. Kajikawa, S. Ishida, S. Ozawa, Y. Ohno, J. Sawada, Y. Ishikawa and H. Honda: Gene expression property of high density three-dimensional tissue of HepG2 formed in radial-flow bioreactor. J. Biosci. Bioeng., 101, 243-250, 2006.

44. K. Mutoh, J. Mitsuhashi, Y. Kimura, S. Tsukahara, E. Ishikawa, K. Sai, S. Ozawa, J. Sawada, K. Ueda, K. Katayama, Y. Sugimoto: A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein. Mol. Cancer Ther., 5, 877-884, 2006.

45. A. Soyama, Y. Saito, T. Kubo, A Miyajima, Y. Ohno, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, H. Tomoike, S. Ozawa and J. Sawada: Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population. Drug Metab. Pharmacokinet., 21, 208-216, 2006.

46. K. Maekawa, M. Itoda, K. Sai, Y. Saito, N. Kaniwa, K. Shirao, T. Hamaguchi, H. Kunitoh, N. Yamamoto, T. Tamura, H. Minami, K. Kubota, A. Ohtsu, T. Yoshida, N. Saijo, N. Kamatani, S. Ozawa and J. Sawada: Genetic variations and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population. Drug Metab. Pharmacokinet., 21, 109-121, 2006.

47. K. Sai, M. Itoda, Y. Saito, K. Kurose, N. Katori, N. Kaniwa, K. Komamura, T. Kotake, H. Morishita, H. Tomoike, S. Kamakura, M. Kitakaze, T. Tamura, N. Yamamoto, H. Kunitoh, Y. Yamada, Y. Ohe, Y. Shimada, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, N. Kamatani, S. Ozawa and J. Sawada: Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences. Ann. Hum. Genet., 70, 605-622, 2006.

48. M. Saeki, Y. Saito, H. Jinno, K. Sai, S. Ozawa, K. Kurose, N. Kaniwa, K. Komamura, T. Kotake, H. Morishita, S. Kamakura, M. Kitakaze, H. Tomoike, K. Shirao, T. Tamura, N. Yamamoto, H. Kunitoh, T. Hamaguchi, T. Yoshida, K. Kubota, A. Ohtsu, M. Muto, H. Minami, N. Saijo, N. Kamatani and J. Sawada: Haplotype structures of the UGT1A gene complex in a Japanese population. Pharmacogenomics J., 6, 63-75, 2006.

49. K. Kurose, S. Ikeda, S. Koyano, M. Tohkin, R. Hasegawa, J. Sawada: Identification of regulatory sites in the human PXR (NR1I2) promoter region. Mol. Cell. Biochem., 281, 35-43, 2006.

50. Y. Saito, N. Hanioka, K. Maekawa, T. Isobe, Y. Tsuneto, R. Nakamura, A. Soyama, S. Ozawa, T. Tanaka-Kagawa, H. Jinno, S. Narimatsu and J. Sawada: Functional analysis of three CYP1A2 variants found in a Japanese population. Drug Metab. Dispos., 33, 1905-1910, 2005.

51. T. Kubo, S.-R. Kim, K. Sai, Y. Saito,　T. Nakajima, H. Saito, K. Shirao, N. Yamamoto, H. Minami, A. 7htsu, T. Yoshida, N. Saijo, Y. Ohno, S. Ozawa and J. Sawada: Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (hCE-2). Drug Metab. Dispos., 33, 1482-1487, 2005.

52. H. Fukushima-Uesaka, Y. Saito, K. Maekawa, S. Ozawa, R. Hasegawa, H. Kajio, N. Kuzuya, K. Yasuda, M. Kawamoto, N. Kamatani, K. Suzuki, T. Yanagawa , M. Tohkin and J. Sawada: Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab. Pharmacokinet., 20, 300-307, 2005.

53. S. Ikeda, K. Kurose, H. Jinno, K. Sai, S. Ozawa, R. Hasegawa, K. Komamura, T. Kotake, H. Morishita, S. Kamakura, M. Kitakaze, H. Tomoike, T. Tamura, N. Yamamoto, H. Kunitoh, Y. Yamada, Y. Ohe, Y. Shimada, K. Shirao, K. Kubota, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, Y. Saito and J. Sawada: Functional analysis of four naturally occurring variants of human constitutive androstane receptor (CAR). Mol. Genet. Metab., 86, 314-319, 2005.

54. S. Koyano, Y. Saito, S. Ozawa, A. Miyajima and J. Sawada: Functional characterization of a human glucocorticoid receptor variant K140N. Int. J. Pharmacol., 1, 316-323, 2005.

55. S. Koyano, Y. Saito, H. Fukushima-Uesaka, S. Ishida, S. Ozawa, N. Kamatani, H. Minami, A.Ohtsu, T. Hamaguchi, K. Shirao, T.Yoshida, N. Saijo, H. Jinno and J. Sawada: Functional analysis of six human arylhydrocarbon receptor variants in a Japanese population. Drug Metab. Dispos., 33, 1254-1260, 2005.

56. M. Saeki, Y. Saito, H. Jinno, K. Sai, A. Hachisuka, N. Kaniwa, S. Ozawa, M. Kawamoto, N. Kamatani, K. Shirao, H. Minami, A Ohtsu, T. Yoshida, N. Saijo, K. Komamura, T. Kotake, H. Morishita, S. Kamakura, M. Kitakaze, H. Tomoike and J. Sawada: Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab. Pharmacokinet., 20, 144-151, 2005.

57. H. Hichiya, T. Tanaka-Kagawa, A. Soyama, H. Jinno, S. Koyano, N. Katori, E. Matsushima, S. Uchiyama, H. Tokunaga, H. Kimura, N. Minami, M. Katoh, K. Sugai, Y. Goto, T. Tamura, N. Yamamoto, Y. Ohe, H. Kinitoh, H. Nokihara, T. Yoshida, H. Minami, N. Saijo, M. Ando, S. Ozawa, Y. Saito and J. Sawada: Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R and K383N, found in a Japanese population. Drug Metab. Dispos., 33, 630-636, 2005.

58. K. Yonemori, H. Ueno, T. Okusaka, N. Yamamoto, M. Ikeda, N. Saijo, T. Yoshida, H. Ishii, J. Furuse, E. Sugiyama, S.-R. Kim, R. Kikura-Hanajiri, R. Hasegawa, Y. Saito, S. Ozawa, N. Kaniwa, J. Sawada: Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin. Cancer Res., 11, 2620-2624, 2005.

59. T. Hongo, M. Kajikawa, S. Ishida, S. Ozawa, Y. Ohno, J. Sawada, A. Umezawa, Y. Ishikawa, T. Kobayashi and H. Honda: Three-dimensional high density culture of HepG2 cells in a 5-ml radial-flow bioreactor for construction of artificial liver. J. Biosci. Bioeng., 99, 237-244, 2005.

60. A. Yawata, S.-R. Kim, A. Miyajima, T. Kubo, S. Ishida, Y. Saito, Y. Nakajima, N. Katori, Y. Matsumoto, M. Fukuoka, Y. Ohno, S. Ozawa and J. Sawada: Polymorphic tandem repeat sequences of thymidylate synthase gene correlates with cellular based sensitivity to fluoropyrimidine anti-tumor agents. Cancer Chemother. Pharmacol., 56, 465-472, 2005.

61. T. Kanayasu-Toyoda, T. Fujino, T. Oshizawa, T. Suzuki, T. Nishimaki-Mogami, Y. Sato, J. Sawada, K. Inoue, K. Shudo and T. Yamaguchi: HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 using surface plasmon resonance. J. Steroid Biochem. Mol. Biol., 94, 303-309, 2005.

62. A. Soyama, Y. Saito, N. Hanioka, K. Maekawa, K. Komamura, S. Kamakura, M. Kitakaze, H. Tomoike, K. Ueno, Y. Goto, H. Kimura, M. Katoh, K. Sugai, O. Saitoh, M. Kawai, T. Ohnuma, T. Ohtsuki, C. Suzuki, N. Minami, N. Kamatani, S. Ozawa and J. Sawada: Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. Drug Metab. Pharmacokinet., 20, 24-33, 2005. (Erratum)

63. K. Kurose, S. Koyano, S. Ikeda, M. Tohkin, R. Hasegawa, J. Sawada: 5' diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site. Mol. Cell. Biochem., 273, 79-85, 2005.

64. S. Koyano, Y. Saito, K. Sai, K. Kurose, S. Ozawa, T. Nakajima, K. Matsumoto, H. Saito, K. Shirao, T. Yoshida, H. Minami, A. Ohtsu, N. Saijo and J. Sawada: Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population. Drug Metab. Pharmacokinet., 20, 79-84, 2005.

65. R. Nakamura, H. Okunuki, S. Ishida, Y. Saito, R. Teshima and J. Sawada: Gene expression profiling of dexamethasone-treated RBL-2H3 cells: induction of anti-inflammatory molecules. Immunol. Lett., 98, 272-279, 2005.

66. M. Saeki, Y. Saito, H. Jinno, K. Sai, N. Kaniwa, S. Ozawa, K. Komamura, T. Kotake, H. Morishita, S. Kamakura, M. Kitakaze, H. Tomoike, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, N. Kamatani and J. Sawada: Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab. Pharmacokinet., 20, 85-90, 2005.

67. Y. Nakajima, Y. Saito, K. Shiseki, H. Fukushima-Uesaka, R. Hasegawa, S. Ozawa, K. Sugai, M. Katoh, O. Saitoh, T. Ohnuma, M. Kawai, T. Ohtsuki, C. Suzuki, N. Minami, H. Kimura, Y. Goto, N. Kamatani, N. Kaniwa and J. Sawada: Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients. Eur. J. Clin. Pharmacol., 61, 25-34, 2005.

68. N. Kaniwa, K. Kurose, H. Jinnno, T. Tanaka-Kagawa, Y. Saito, M. Saeki, J. Sawada, M. Tohkin and R. Hasegawa: Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel SNP 686C>T (P229L) foun in an African-American. Drug Metab. Dispos., 33, 458-465, 2005.

69. K. Maekawa, Y. Saito, S. Ozawa, S. Adachi-Akahane, M. Kawamoto, K. Komamura, W. Shimizu, K. Ueno, S. Kamakura, N. Kamatani, M. Kitakaze and J. Sawada: Genetic polymorphisms and haplotypes of the human cardiac sodium channel alpha subunit gene (SCN5A) in Japanese and their association with arrhythmia. Ann. Hum. Genet., 69, 413-428, 2005.

70. Y. Shinozaki, S. Koizumi, S.Ishida, J. Sawada, Y. Ohno and K. Inoue: Cytoprotection against oxidative-stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors. Glia, 49, 288-300, 2005.

71. H. Jinno, N. Hanioka, T. Tanaka-Kagawa, Y. Saito, S. Ozawa and J. Sawada: Functional analysis of UDP-glucuronosyltransferase variants. In "Pharmacogenomics. Methods and Applications. (Methods in Molecular Biology, Vol. 311)", ed. by F. Innocenti, Human Press, pp.1-30, 2005.

72. C. Kondo, H. Suzuki, M. Itoda, S. Ozawa, J. Sawada, D. Kobayashi, I. Ieiri, K. Mine, K. Ohtsubo and Y. Sugiyama: Functional analysis of SNPs variants of BCRP/ABCG2. Pharm Res. 21, 1895-1903, 2004.

73. S. Ishida, Y. Shigemoto-Mogami, Y. Shinozaki, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno, K. Inoue: Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem. Pharmacol., 68, 2177-2186, 2004. (Supplementary Tables 1 and 2)

74. H. Fukushima-Uesaka, K. Sai, K. Maekawa, S. Koyano, N. Kaniwa, S. Ozawa, M. Kawamoto, N. Kamatani, K. Komamura, S. Kamakura, M. Kitakaze, H. Tomoike, K. Ueno, H. Minami, A. Ohtsu, K. Shirao, T. Yoshida, N. Saijo, Y. Saito and J. Sawada: Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population. Drug Metab. Pharmakokinet., 19, 320-326, 2004.

75. A. Soyama, T. Kubo, A. Miyajima, Y. Saito, K. Shiseki, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, H. Tomoike, S. Ozawa and J. Sawada: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab. Pharmacokinet., 19, 313-319, 2004.

76. M. Saeki, Y. Saito, H. Jinno, T. Tanaka-Kagawa, A. Ohno, S. Ozawa, K. Ueno, S. Kamakura, N. Kamatani, K. Komamura, M. Kitakaze and J. Sawada: Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population. Drug Metab. Dispos., 32, 1048. 2004.

77. M. Itoda, Y. Saito, K. Maekawa, H. Hichiya, K. Komamura, K. Ueno, M. Shibakawa, S. Kamakura, M. Kitakaze, H. Tomoike, S. Ozawa and J. Sawada: Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). Drug Metab. Pharmacokinet., 19, 308-312, 2004.

78. H. Fukushima-Uesaka, K. Maekawa, S. Ozawa, K. Komamura, K. Ueno, M. Shibakawa, S. Kamakura, M. Kitakaze, H. Tomoike, Y. Saito and J. Sawada: Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2). Drug Metab. Pharmacokinet., 19, 239-244, 2004.

79. K. Sai, M. Saeki, Y. Saito, S. Ozawa, N. Katori, H. Jinno, R. Hasegawa, N. Kaniwa, J. Sawada, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, Y. Kitamura, N. Kamatani, H. Minami, A. Ohtsu, K. Shirao, T. Yoshida and N. Saijo: UGT1A1 Haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin. Pharmacol. Ther., 501-515, 2704.

80. M. Hirouchi, H. Suzuki, M. Itoda, S. Ozawa, J. Sawada, I. Ieiri, K. Ohtsubo, Y. Sugiyama: Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. Pharm. Res., 21, 742-748, 2004.

81. S. Ozawa, A. Soyama, M. Saeki, H. Fukushima-Uesaka, M. Itoda, S. Koyano, K. Sai, Y. Ohno, Y. Saito and J. Sawada: Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab. Pharmacokinet., 19, 83-95, 2004.

82. K. Toda, S. Ishida, K. Nakata, R. Matsuda, S. Ozawa, J. Sawada, Y. Ohno, K. Inoue, K. Shudo and Y. Hayashi: Improvement in reliability of probabilistic test of significant differences in GeneChip experiments. Anal. Sci., 20, 731-733, 2004.

83. H. Jinno, T. Tanaka-Kagawa, N. Hanioka, S. Ishida, M. Saeki, A. Soyama, M. Itoda, T. Nishimura, Y. Saito, S. Ozawa, M. Ando and J. Sawada: Identification of novel alternative splice variants of human constitutive androstane receptor (hCAR) and characterization of their expression in the liver. Mol. Pharmacol., 65, 496-502, 2004.

84. H. Fukushima-Uesaka, Y. Saito, H. Watanabe, K. Shiseki, M. Saeki, T. Nakamura, K. Kurose, K. Sai, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, S. Hanai, T. Nakajima, K. Matsumoto, H. Saito, Y. Goto, H. Kimura, M. Katoh, K. Sugai, N. Minami, K. Shirao, T. Tamura, N. Yamamoto, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, Y. Kitamura, N. Kamatani, S. Ozawa and J. Sawada: Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population. Hum. Mutat., 23, 100, Mutat. Brief #681, 2004.

85. A. Ohno, Y. Saito, N. Hanioka, H. Jinnno, M. Saeki, M. Ando, S. Ozawa, and J. Sawada: Involvement of human hepatic UGT1A1, UGT2B4 and UGT2B7 in the glucuronidation of carvedilol . Drug Metab. Dispos., 32, 235-239, 2004.

86. N. Murayama, A. Soyama, Y. Saito, Y. Nakajima, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, H. Kimura, Y. Goto, O. Saitoh, M. Katoh, T. Ohnuma, M. Kawai, K. Sugai, T. Ohtsuki, C. Suzuki, N. Minami, S. Ozawa and J. Sawada: Six novel non-synonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes. J. Pharmacol. Exp. Ther., 308, 300-306, 2004. (Erratum)

87. S. Koyano, K. Kurose, Y. Saito, S. Ozawa, R. Hasegawa, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, T. Nakajima, K. Matsumoto, A. Akasawa, H. Saito, and J. Sawada: Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. Drug Metab. Dispos., 32, 149-154, 2004.

88. Y. Saito, M. Saeki, K. Maekawa, A. Hachisuka, R. Teshima, S. Ozawa, and J. Sawada: CYP2D6-mediated mexiletine-protein adduct formation. J. Health Sci. (Tokyo), 50, 82-85, 2004.

89. K. Toda, S. Ishida, K. Nakata, R. Matsuda, Y. Shigemoto-Mogami, K. Fujishita, S. Ozawa, J. Sawada, K. Inoue, K. Shudo and Y. Hayashi: Test of significant differences with a priori probability in microarray experiments. Anal. Sci., 19, 1529-1535, 2003.

90. S. Ikeda, K. Kurose, S. Ozawa, K. Sai, R. Hasegawa, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, H. Tomoike, T. Nakajima, K. Matsumoto, H. Saito, Y. Goto, H. Kimura, M. Katoh, K. Sugai, N. Minami, K. Shirao, T. Tamura, N. Yamamoto, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, Y. Saito and J. Sawada: Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. Drug Metab. Pharmacokinet., 18, 413-418, 2003.

91. S.-R. Kim, T. Nakamura, Y. Saito, K. Sai, T. Nakajima, H. Saito, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, S. Ozawa, and J. Sawada: Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). Drug Metab. Pharmacokinet., 18, 327-332, 2003.

92. K. Sai, N. Kaniwa, M. Itoda, Y. Saito, R. Hasegawa, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, Y. Kitamura, N. Kamatani, S. Ozawa and J. Sawada: Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. Pharmacogenetics, 13, 741-757, 2003.

93. S. Koyano, Y. Saito, M. Nagano, K. Maekawa, Y. Kikuchi, N. Murayama, T. Fujino, S. Ozawa, T. Nakajima, K. Matsumoto, H. Saito and J. Sawada: Functional analysis of three genetic polymorphisms in the glucocorticoid receptor gene. J. Pharmacol. Exp. Ther., 307, 110-116, 2003.

94. M. Itoda, Y. Saito, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, H. Suzuki, Y. Sugiyama, S. Ozawa and J. Sawada: Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotecan. Drug Metab. Pharmacokinet., 18, 212-217, 2003.

95. M. Saeki, Y. Saito, H. Jinno, M. Tohkin, K. Kurose, N. Kaniwa, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, S. Ozawa and J. Sawada: Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing. Clin. Chem., 49, 1182-1185, 2003.

96. H. Jinno, M. Saeki, Y. Saito, T. Tanaka-Kagawa, N. Hanioka, K. Sai, N. Kaniwa, M. Ando, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, S. Ozawa and J. Sawada: Functional characterization of human UDP-glucuronosyltransferase (UGT) 1A9 variant, D256N, found in Japanese cancer patients. J. Pharmacol. Exp. Ther., 306, 688-693, 2003.

97. K. Shiseki, M. Itoda, Y. Saito, Y. Nakajima, K. Maekawa, H, Kimura, Y. Goto, O. Saitoh, M. Katoh, T. Ohnuma, M. Kawai, K. Sugai, T. Ohtsuki, C. Suzuki, N. Minami, S. Ozawa and J. Sawada: Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase. Drug Metab. Pharmacokinet., 18, 150-153, 2003.

98. M. Saeki, Y. Saito, H. Jinno, K. Sai, K. Komamura, K. Ueno, S. Kamakura, M. Kitakaze, K.Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, S. Ozawa and J. Sawada: Three novel single nucleotide polymorphisms in UGT1A9. Drug Metab. Pharmacokinet., 18, 146-149, 2003.

99. M. Saeki, Y. Saito, T. Nakamura, N. Murayama, S.-R. Kim, S. Ozawa, K. Komamura, K. Ueno, S. Kamakura, T. Nakajima, H. Saito, Y. Kitamura, N. Kamatani and J. Sawada: Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population. Hum. Mutat., 21, 653, 2003 (Mutation in Brief #618),

100. H. Jinno, M. Saeki, T. Tanaka-Kagawa, N. Hanioka, Y. Saito, S. Ozawa, M. Ando, K. Shirao, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo and J. Sawada: Functional characterization of wild-type and variant (T202I and M591I) human UDP-glucuronosyltransferase (UGT) 1A10. Drug Metab. Dispos., 31, 528-532, 2003.

101 H. Jinno, T. Tanaka-Kagawa, A. Ohno, Y. Makino, E. Matsushima, N. Hanioka and M. Ando: Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab. Dispos. 31, 398-403, 2003.

102. S. Ishida, Y. Shigemoto-Mogami, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno and K. Inoue: Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol. Cancer Ther., 2, 49-58, 2003.

103. N. Hanioka, T. Tanaka-Kagawa, Y. Miyata, E. Matsushima, Y. Makino, A. Ohno, R. Yoda, H. Jinno and M. Ando: Functional characterization of three human cytochrome P450 2E1 variants with amino acid substitutions. Xenobiotica, 33, 575-586, 2003.

104. K. Maekawa, M. Itoda, N. Hanioka, Y. Saito, N. Murayama, O. Nakajima, A. Soyama, S. Ishida, S. Ozawa, M. Ando, and J. Sawada: Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects.  Xenobiotica, 33, 277-287, 2003.

105. H. Jinno, T. Tanaka-Kagawa, N. Hanioka, M. Saeki, S. Ishida, T. Nishimura, M. Ando, Y. Saito, S. Ozawa, and J. Sawada: Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q and Y486D.  Drug Metab. Dispos., 31, 108-113, 2003.

106. M. Nagano, T. Nakamura, S. Ozawa, Y. Saito, and J. Sawada: Allele-specific long range PCR/sequencing (ALP/S) method for allelic assignment of multiple single nucleotide polymorphisms.  J. Biochem. Biophys. Methods, 55, 1-9,2003

107. M. Itoda, Y. Saito, K. Komamura, K. Ueno, S. Kamakura, S. Ozawa and J. Sawada: Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone. Drug Metab. Pharmacokinet., 17, 566-571, 2002.

108. S. Koyano, K. Kurose, S. Ozawa, M. Saeki, Y. Nakajima, R. Hasegawa, K. Komamura, K. Ueno, S. Kamakura, T. Nakajima, H. Saito, H. Kimura, Y. Goto, O. Saitoh, M. Katoh, T. Ohnuma, M. Kawai, K. Sugai, T. Ohtsuki, C. Suzuki, N. Minami, Y. Saito and J. Sawada: Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations. Drug Metab. Pharmacokinet., 17, 561-565, 2002.

109. M. Saeki, S. Ozawa, Y. Saito, H. Jinno, T. Hamaguchi, H. Nokihara, Y. Shimada, H. Kunitoh, N. Yamamoto, Y. Ohe, Y. Yamada, K. Shirao, M. Muto, K. Mera, K. Goto, H. Ohmatsu, K. Kubota, S. Niho, R. Kakinuma, H. Minami, A. Ohtsu, T. Yoshida, N. Saijo, and J. Sawada: Three novel single nucleotide polymorphisms in UGT1A10.  Drug Metab. Pharmacokinet., 488-490, 2002.

110. R. Nakamura, S. Ishida, S. Ozawa, Y. Saito, H. Okunuki, R. Teshima and J. Sawada: Gene expression profiling of Ca2+-ATPase inhibitor DTBHQ and antigen-stimulated RBL-2H3 cells. Inflamm. Res., 51, 611-618, 2002.

111. A. Soyama, Y. Saito, S. Kamakura, K. Ueno, K. Komamura, S. Ozawa, J. Sawada: Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6*2 and/or CYP2D6*10 alleles.  Drug Metab. Pharmocokinet., 475-478, 2002.

112. A. Soyama, Y. Saito, K. Komamura, K. Ueno, S. Kamakura, S. Ozawa, J. Sawada: Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift.  Drug Metab. Pharmacokinet., 17, 374-377, 2002.

113. S. Ozawa, M. Hamada, N. Murayama, Y. Nakajima, N. Kaniwa, Y. Matsumoto, M. Fukuoka, J. Sawada, and Y. Ohno: Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human livers.  Cancer Chemother. Pharmacol., 50, 454-458, 2002.

114. S. Ishida, H. Jinno, T. Tanaka-Kagawa, M. Ando, Y. Ohno, S. Ozawa, J. Sawada: Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.  Biochem. Biophys. Res. Commun., 296, 172-177 2002.

115 A. Soyama, N. Hanioka, Y. Saito, N. Murayama, M. Ando, S. Ozawa and J. Sawada: Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A.  Pharmacol. Toxicol., 91, 174-178, 2002.

116. S. Ishida, A. Soyama, Y. Saito, N. Murayama, M. Saeki, K. Sai, S. Ozawa and J. Sawada: Determination of CYP2D6 gene alleles by the CYP450 probe array using the Affymetrix GeneChip system: Comparison with sequencing results.  Drug Metab. Pharmacokinet., 17, 157-160, 2002.

117. N. Murayama, T. Nakamura, M. Saeki, A. Soyama, Y. Saito, K. Sai, S. Ishida, O. Nakajima, M. Itoda, Y. Ohno, S. Ozawa and J. Sawada: CYP3A4 gene polymorphisms influence testosterone 6b-hydroxylation.  Drug Metab. Pharmacokinet., 17, 150-156, 2002.

118. N. Hanioka, Y. Saito, A. Soyama, M. Ando, S. Ozawa and J. Sawada: High-performance liquid chromatographic assay for amiodarone N-deethylation activity in human liver microsomes using solid-phase extraction.  J. Chromatogr. B.,  774, 105-113, 2002.

119. M. Nagano,T. Nakamura, S. Niimi, T. Fujino, T. Nishimura, N. Murayama, S. Ishida, S. Ozawa, Y. Saito and J. Sawada: Substitution of arginine for cysteine 643 of the glucocorticoid receptor reduces its steroid-binding affinity and transcriptional activity. Cancer Lett., 181, 109-114, 2002.

120. M. Itoda, Y. Saito, A. Soyama, M. Saeki, N. Murayama, S. Ishida, K. Sai, M. Nagano, H. Suzuki, Y. Sugiyama, S. Ozawa and J. Sawada: Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5’-untranslated region and exon 28.   Drug Metab. Dispos., 30, 363-364, 2002.

121. K. Sai, N. Kaniwa, S. Ozawa and J. Sawada: An analytical method for irinotecan （CPT-11） and its metabolites using a high-performance liquid chromatography: parallel detection with fluorescence and mass spectrometry.  Biomed. Chromatogr., 16, 209-218, 2002.

122. M. Saeki, Y. Saito, M. Nagano, R. Teshima, S. Ozawa and J. Sawada: The mRNA expression of multiple cytochrome P450 isozymes in four types of cultured skin cells. Int. Arch. Allergy Immunol., 127, 333-336, 2002

123. N. Hanioka, S. Ozawa, T. Tanaka-Kagawa, H. Jinno, T. Nishimura, M. Ando and J. Sawada: Interaction of irinotecan （CPT-11） and its active metabolite （SN-38） with human cytochrome P450 enzymes. Drug Metab. Dispos., 30, 391-396, 2002.

124. N. Murayama, K. Sai, Y. Nakajima, N. Kaniwa, S. Ozawa and J. Sawada: Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.  Jpn. J. Cancer Res., 92, 524-528, 2001.

125. K. Sai, N. Kaniwa, S. Ozawa, and J. Sawada: A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P450 3A4. Drug Metab. Dispos. 29, 1505-1513, 2001.

126. N. Hanioka, H. Jinno, T. Nishimura, M. Ando, S. Ozawa and J. Sawada: High-performance liquid chromatographic assay for glucuronidation activity of 7-ethyl-10-hydroxycamptothecin （SN-38）, the active metabolite of irinotecan （CPT-11）, in human liver microsomes.  Biomed. Chromatogr., 15, 328-333, 2001.

127. N. Hanioka, S. Ozawa, H. Jinno, T. Nishimura, M. Ando, Y. Saito and J. Sawada: Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin.  Xenobiotica, 31, 687-699, 2001.

128. T. Nakamura, Y. Saito, N. Murayama, M. Saeki, A. Soyama. K. Sai, S. Ozawa and J. Sawada: Apparent low frequency in sequence variability in the proximal promoter region of cytochrome P450 （CYP） 3A5 gene in established cell lines from Japanese individuals.  Biol. Pharm. Bull., 24, 954-957, 2001.

129 A. Soyama, Y. Saito, N. Hanioka, N. Murayama, O. Nakajima, N. Katori, S. Ishida, K. Sai, S. Ozawa and J. Sawada: Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in the reduced in vitro paclitaxel metabolism. Biol. Pharm. Bull., 24, 1427-1430, 2001.

130. N. Hanioka, H. Jinno, T. Tanaka-Kagawa, T. Nishimura and Ando, M:  Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection.  J. Pharm. Biomed. Anal., 25, 65-75, 2001.

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