Detailed Information

SNP ID FP0000230 Gene Symbol UGT1A1 Chromosome 2q37 Original ID MPJ6_U1A033 Site UGT1A1 Enhancer Reference Sequence AF297093.1 Position 1 171698 Position 4 1A1 -3345 Obserbed C/- 5'-Flanking GTTATCTCACCAGAACAAACTTCTGAGTTTATATAACCTCTAGTTACATAACCTGAAACC 3'-Flanking GGACTTGGCACTTGGTAAGCACGCAATGAACAGTCATAGTAAGCTGGCCAAGGGTAGAGT Effect Frequency 7/392 Method Sequencing 1st Forward Primer UGT1A1CAR-Ex5ZF GGTGGTGGGAGTGAGTTTAGT 1st Reverse Primer UGT1A1CAR-Ex5ZR AGAGGGAAATAGTGGACAGAA 2nd Forward Primer UGTCAR1stF2 AAGAACATTCTAACGGTTCATAA 2nd Reverse Primer UGTCAR1stR2 TGAATCATTGCATCGGCTGCCCA SQ Forward Primer UGTCAR1stF2 AAGAACATTCTAACGGTTCATAA SQ Reverse Primer CAR-Rseq2 TGCCCACCTGAATAAACCCCACC Reference 1 Sai et al., 2004, Clin. Pharmacol. Ther., 75, 501-515. Reference 2 Saeki et al., 2006, Pharmacogenomics J., 6, 63-75. Haplotype 1A1*1b Comment 1 Position 4: cDNA-based numbering. Numbered from the initiation codon ATG. Comment 2 Frequency and haplotype: Reference 2. CAR-binding site. -3329 from the transcriptional start site. Release Date 2004/7/15 Update Date 2005/10/6

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SQ=Sequencing; TP=Typing; IVS=Intervening Sequence; CYPalleles, http://www.imm.ki.se/CYPalleles/ .