出水 庸介

Yosuke DEMIZU, Ph. D.

 

Education
2001年     九州大学 薬学部 卒業
2003
年     九州大学大学院 薬学府 博士前期課程 修了
2006
年     九州大学大学院 薬学府 博士後期課程 修了

 

Research Experience
2004年     徳島文理大学 香川薬学部 助手
2006
年     長崎大学大学院 医歯薬学総合研究科 助教
2008
年     国立医薬品食品衛生研究所 有機化学部第二室 研究員

2011年     国立医薬品食品衛生研究所 有機化学部第二室 主任研究官

2011年     国立医薬品食品衛生研究所 有機化学部第二室 室長

2012年     ウィスコンシン大学マディソン校化学科 JSPS海外特別研究員

2013年     東京工業大学 生命理工学部 非常勤講師 (併任)

2013年     横浜市立大学 客員教授 (併任)

2016年     長崎大学大学院 医歯薬学総合研究科 非常勤講師(併任)

2017年     国立医薬品食品衛生研究所 有機化学部 部長(現職)

 

Award

1.   日本ペプチド学会奨励賞:「短鎖ペプチドのヘリカル構造制御と機能化」(2014

2.   JSPS Postdoctoral Fellowships for Research Abroad (2011)

3.   2010年有機合成化学協会研究企画賞(カネカ):「高度に空間制御されたペプチドフォルダマーを利用した不斉有機触媒の開発」(2010

4.   2006年有機合成化学協会研究企画賞(大正製薬):「電極酸化反応を用いた非天然型アミノ酸の合成と機能性ペプチドへの展開」(2006

5.   20回日本薬学会九州支部大会優秀発表賞:「α位に不斉を持たない光学活性アミノ酸によるヘリカル構造の制御は可能か?」(2003

 

Research Publication

2017

1.     Rational design and synthesis of post-functionalizable peptide foldamers as helical templates

T. Misawa,* Y. Kanda, Y. Demizu*

Bioconj. Chem., in press.

2.     Right-handed and left-handed helical structures with fourteen (R)-chiral centers

R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*

Chem. Eur. J., in press.

3.     Preorganized cyclic a,a-disubstituted a-amino acids bearing functionalized side chains that act as peptide-helix inducers

H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*

J. Org. Chem., 82, 10722-10726 (2017).

4.     Development of a peptide-based inducer of protein degradation targeting NOTCH1

N. Ohoka,# T. Misawa,# M. Kurihara, Y. Demizu,* M. Naito*

#These authors contributed equally to this work.

Bioorg. Med. Chem. Lett., 27, 4985-4988 (2017).

5.     Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide

T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*

Bioorg. Med. Chem. Lett., 27, 4478-4481 (2017).

6.     Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic a,a-disubstituted a-amino acid residues

T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*

Bioorg. Med. Chem. Lett., 27, 3950-3953 (2017).

7.     PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA

T. Sugiyama,* G. Hasegawa, C. Niikura, K. Kuwata, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka*

Bioorg. Med. Chem. Lett., 27, 3337-3341 (2017).

8.     Low pH-responsive change in side chain structure of an amino acid from cyclic acetal to acyclic diol leads to conformational change in a peptide from a helical to random structure

K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*

Org. Biomol. Chem., 15, 6302-6305 (2017).

9.     Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety

Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*

ChemistrySelect, 2, 8108-8114 (2017).

10.  Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells

K. Okitsu, T. Misawa,* T. Shoda, M. Kurihara, Y. Demizu*

Bioorg. Med. Chem. Lett., 27, 3417-3422 (2017).

11.  Development of a small hybrid molecule that mediates degradation of His tag-fused proteins

K. Okitsu,# T. Hattori,# T. Misawa, T. Shoda, M. Kurihara, M. Naito,* Y. Demizu*

J. Med. Chem., in press.

12.  Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic

T. Misawa,* K. Tanaka, Y. Demizu, M. Kurihara*

Bioorg. Med. Chem. Lett., 27, 2590-2593 (2017).

13.  Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator

T. Shoda,* M. Kato, T. Fujisato, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*

Med. Chem. (Bentham), 13, 206-213 (2017).

14.  Development of non-secosteroidal vitamin D receptor (VDR) ligands bearing a long alkyl chain

T. Misawa,* Y. Demizu, T. Yachide, N. Ohoka, H. Nojiri, A. Kittaka, M. Makishima, M. Naito, M. Kurihara*

Bitamin, 91, 113-120 (2017).

15.  Development of helix-stabilized cell-penetrating peptides containing cationic a,a-disubstituted amino acids as helical promoters

H. Yamashita, T. Misawa, M. Oba, M. Tanaka, M. Naito, M. Kurihara,* Y. Demizu*

Bioorg. Med. Chem., 25, 1846-1851 (2017).

16.  Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules

K. Okuhira, T. Shoda, R. Omura, N. Ohoka, T. Hattori, N. Shibata, Y. Demizu, R. Sugihara, A. Ichino, H. Kawahara, Y. Ito, M. Ishikawa, Y. Hashimoto, M. Kurihara, H. Saito, M. Naito*

Mol. Pharmacol., 91, 159-166 (2017).

17.  Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton

T. Misawa,* T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, M. Kurihara*

MedChemComm, 8, 239-246 (2017).

2016

18.  Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib-based dodecapeptides

Y. Demizu,* K. Okitsu, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*

ChemistrySelect, 1, 5805-5811 (2016).

19.  Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand

Y. Demizu,#,* N. Shibata,# T. Hattori, N. Ohoka, H. Motoi, T. Misawa, T. Shoda, M. Naito,* M. Kurihara*

# These authors contributed equally to this work.

Bioorg. Med. Chem. Lett., 26, 4865-4869 (2016).

20.  Helical structures of homo-chiral isotope-labeled a-aminoisobutyric acid peptides

A. Ueda, M. Oba, Y. Izumi, Y. Sueyoshi, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*

Tetrahedron, 39, 5864-5871 (2016).

21.  Development of a cell-penetrating peptide that exhibits responsive changes in its secondary structure in the cellular environment

H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara,* Y. Demizu*

Sci. Rep., 6, 33003, DOI:10.1038/srep33003 (2016).

22.  The side-chain hydroxy groups of a cyclic a,a-disubstituted a-amino acid promote oligopeptide helix packing in the crystalline state

Y. Demizu,* M. Doi, H. Yamashita, T. Misawa, M. Oba, M. Kurihara, H. Suemune, M. Tanaka

Biopolymers (Pept. Sci.), 106, 757-768 (2016).

23.  Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

N. Akiyama, N. Takizawa, M. Miyauchi, H. Yanai, R. Tateishi, M. Shinzawa, R. Yoshinaga, M. Kurihara, Y. Demizu, H. Yasuda, S. Yagi, G. Wu, M. Matsumoto, R. Sakamoto, N. Yoshida, J. M. Penninger, Y. Kobayashi, J. Inoue, T. Akiyama*

J. Exp. Med., 213, 1441-1458 (2016).

24.  Syntheses of chiral five-membered ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopepitdes

Y. Koba, Y. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*

Biopolymers (Pept. Sci.), 106, 555-562 (2016).

25.  Peptide nucleic acid with a lysine side chain at the b-position: synthesis and application for DNA cleavage

T. Sugiyama,* K. Kuwata, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Chem. Pharm. Bull., 64, 817-823 (2016).

26.  Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator

T. Shoda,* M. Kato, T. Fujisato, T. Misawa, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*

Bioorg. Med. Chem., 24, 2914-2919 (2016).

27.  a-Helical structures of oligopeptides with alternating L-Leu-Aib segment

Y. Demizu,* K. Okitsu, H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*

Eur. J. Org. Chem., 2815-2820 (2016).

28.  Plasmid DNA delivery using arginine-rich cell-penetrating peptides containing unnatural amino acids

T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu,* M. Oba*

Bioorg. Med. Chem., 24, 2681-2687 (2016).

29.  Development of peptide-based nuclear receptors degradation inducer

Y. Demizu,* N. Ohoka, T. Nagakubo, H. Yamashita, T. Misawa, K. Okuhira, M. Naito, M. Kurihara*

Bioorg. Med. Chem. Lett., 26, 2655-2658 (2016).

30.  1,4-Bis[(N-acetyl-L-phenylalanyl-glycyl-L-alanyl)aminomethyl]benzene

Y. Demizu,* K. Tsutsui, T. Misawa, M. Kurihara*

Molbank, doi:10.3390/M893 (2016).

31.  Handedness preferences of heterochiral helical peptides containing homochiral peptide segments

Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Oba, M. Tanaka, M. Kurihara*

Eur. J. Org. Chem., 840-846 (2016).

32.  A helix-stabilized cell-penetrating peptide as an intracellular-delivery tool

H. Yamashita, M. Oba, T. Misawa, M. Tanaka, T. Hattori, M. Naito, M. Kurihara,* Y. Demizu*

ChemBioChem, 17, 137-140 (2016).

<Selected as Cover Picture>

 

33.  Induction of proteasomal degradation of ERa and subsequent cell death in breast cancer cells

K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*

Methods Mol. Biol., 1366, 549-560 (2016).

2015

34.  Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

T. Misawa, M. Yorioka, Y. Demizu, T. Noguchi-Yachide, N. Ohoka, M. Kurashima-Kinoshita, H. Motoyoshi, H. Nojiri, A. Kittaka, M. Makishima, M. Naito, M. Kurihara*

Bioorg. Med. Chem. Lett., 25, 5362-5366 (2015).

35.  Topological study of the structures of heterochiral peptides with equal amounts of L-Leu and D-Leu

Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*

J. Org. Chem., 80, 8597-8603 (2015).

36.  A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products

N. Uchiyama,* Y. Shimokawa, R. Kikura-Hanajiri, Y. Demizu, Y. Goda, T. Hakamatsuka

Forensic Toxicol., 33, 244-259 (2015).

37.  Synthesis, evaluation, and molecular docking studies of novel carbocyclic oxetanocin A (COA-Cl) derivatives as potential tube formation agents

N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto

Chem. Pharm. Bull., 63, 701-709 (2015).

38.  Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives

N. Sakakibara,* G. Balboni, C. Congiu, V. Onnis, Y. Demizu, T. Misawa, M. Kurihara, Y. Kato, T. Maruyama, M. Toyama, M. Okamoto, M. Baba

Antiviral Chem. Chemother., 24, 62-71 (2015).

39.  Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides

M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka

Bioorg. Med. Chem., 23, 4911-4918 (2015).

40.  Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription

Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*

Bioorg. Med. Chem., 23, 4132-4138 (2015).

41.  Synthesis and resolution of substituted [5]carbohelicenes

K. Usui,* K. Yamamoto, T. Shimizu, M. Biao, M. Okazumi, Y. Demizu, M. Kurihara, H. Suemune*

J. Org. Chem., 80, 6502-6508 (2015).

42.  Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators

T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*

Bioorg. Med. Chem., 23, 3091-3096 (2015).

43.  A preorganized b-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

Y. Demizu,* M. Oba, K. Okitsu, H. Yamashita, T. Misawa, M. Tanaka, M. Kurihara, S. H. Gellman

Org. Biomol. Chem., 13, 5617-5620 (2015).

44.  Methyl 2-[(2-aminophenyl)ethynyl]benzoate and 2-[(2-acetamidophenyl)ethynyl]benzoic acid

Y. Demizu,* T. Misawa, N. Yamagata, M. Doi, M. Kurihara*

Molbank, M854, doi:10.3390/M854 (2015).

45.  Peptide foldamers composed of six-membered ring a,a-disubstituted a-amino acid with two changeable chiral acetal moieties

K. Tanda, R. Eto, K. Kato, M. Oba, A. Ueda, H. Suemune, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*

Tetrahedron, 71, 3909-3914 (2015).

46.  Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and a-helices

T. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Nagano, H. Suemune, M. Tanaka*

Tetrahedron, 71, 2409-2420 (2015).

47.  Synthesis of a bis-cationic a,a-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides

H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*

Tetrahedron, 71, 2241-2245 (2015).

48.  Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors

T. Misawa, Y. Demizu,* M. Kawamura, N. Yamagata, M. Kurihara*

Bioorg. Med. Chem., 23, 1055-1061 (2015).

49.  Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides

Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara*

Chem. Pharm. Bull., 63, 218-224 (2015).

50.  Design, synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives

N. Sakakibara,* M. Baba, M. Okamoto, M. Toyama, Y. Demizu, T. Misawa, M. Kurihara, K. Irie, Y. Kato, T. Maruyama

Antiviral Chem. Chemother., 24, 3-18 (2015).

2014

51.  Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription

T. Nagakubo, Y. Demizu*, Y. Kanda, T. Misawa, T. Shoda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*

Bioconjugate Chem., 25, 1921-1924 (2014).

52.  短鎖ペプチドのヘリカル構造制御と機能化

出水庸介*三澤隆史,栗原正明*

有機合成化学協会誌72, 1336-1347 (2014).

53.  Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues

M. Oba,* N. Kawabe, H. Takazaki, Y. Demizu, M. Doi, M. Kurihara, H. Suemune, M. Tanaka*

Tetrahedron, 70, 8900-8907 (2014).

54.  Helical peptide-foldamers having chiral five-membered ring amino acid with two azido functional groups

M. Oba, H. Takazaki, N. Kawabe, M. Doi, Y. Demizu, M. Kurihara, H. Kawakubo, M. Nagano, H. Suemune, M. Tanaka*

J. Org. Chem., 79, 9125-9140 (2014).

55.  NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

S. Yamada, Y. Kotake, Y. Demizu, M. Kurihara, Y. Sekino, Y. Kanda*

Sci. Rep., 4, 5952, DOI:10.1038/srep05952 (2014).

56.  Amphipathic short helix-stabilized peptides with cell-membrane penetration

H. Yamashita, Y. Demizu,* T. Shoda, Y. Sato, M. Oba, M. Tanaka, M. Kurihara*

Bioorg. Med. Chem., 22, 2403-2408 (2014).

57.  Design and synthesis of a tamoxifen derivative of selective estrogen receptor down-regulator

T. Shoda,* K. Okuhira, M. Kato, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*

Bioorg. Med. Chem. Lett., 24, 87-89 (2014).

58.  Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium

K. Zaima, D. Wakana, Y. Demizu, Y. Kumeta, H. Kamakura, T. Maruyama, M. Kurihara, Y. Goda*

J. Nat. Med., 68, 432-435 (2014).

2013

59.  Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense

Y. Demizu,* H. Yamashita, N. Yamazaki, Y. Sato, M. Doi, M. Tanaka, M. Kurihara*

J. Org. Chem., 78, 12106-12113 (2013).

60.  Helical oligomer with changeable chiral acetal moiety

M. Oba, N. Ishikawa, Y. Demizu, M. Kurihara, H. Suemune, M. Tanaka*

Eur. J. Org. Chem., 7679-7682 (2013).

61.  Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells

K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*

Cancer Science, 104, 1492-1498 (2013).

62.  Helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid

N. Yamazaki, Y. Demizu,* Y. Sato, M. Doi, M. Kurihara*

J. Org. Chem., 78, 9991-9994 (2013).

63.  Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions

Y. Demizu,* S. Nagoya, M. Shirakawa, M. Kawamura, N. Yamagata, Y. Sato, M. Doi, M. Kurihara*

Bioorg. Med. Chem. Lett., 23, 4292-4296 (2013).

64.  Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

N. Sakakibara,* T. Hamasaki, M. Baba, Y. Demizu, M. Kurihara, K. Irie, M. Iwai, R. Asada, Y. Kato, T. Maruyama

Bioorg. Med. Chem., 21, 5900-5906 (2013).

2012

65.  Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments

Y. Demizu*, S. Nagoya, M. Doi, Y. Sato, M. Tanaka, M. Kurihara*

J. Org. Chem., 77, 9361-9365 (2012).

66.  Helical structures of bicyclic a-amino acid homo-chiral oligomers with the chiral centers at the side-chain fused-ring junctions

K. Anan, Y. Demizu, M. Oba, M. Kurihara, M. Doi, H. Suemune, M. Tanaka*

Helv. Chim. Acta, 95, 1694-1713 (2012).         

67.  Conformations of helical Aib peptides containing a pair of L- and D-amino acids

Y. Demizu*, Y. Yabuki, M. Doi, Y. Sato, M. Tanaka, M. Kurihara*

J. Pept. Sci., 18, 466-475 (2012).

68.  Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy

Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito*, M. Kurihara*

Bioorg. Med. Chem. Lett., 22, 1793-1796 (2012).

69.  Monoallylation of 1,2-diols by Pd/Sn bimetallic catalysis

M. Kuriyama, T. Takeuchi, M. Ito, N. Yamasaki, R. Yamamura, Y. Demizu, O. Onomura*

Chem. Eur. J., 18, 2477-2480 (2012).

70.  One-handed helical-screw direction of homopeptide-foldamer exclusively induced by cyclic a-amino acid side-chain chiral centers

Y. Demizu, M. Doi, M. Kurihara, T. Maruyama, H. Suemune, M. Tanaka*

Chem. Eur. J., 18, 2430-2439 (2012).

71.  Solid-phase nucleophilic fluorination

Y. Demizu, K. Sano, N. Terayama, W. Hakamata, Y. Sato, H. Inoue, H. Okuda, M. Kurihara*

Synth. Commun., 42, 1724-1730 (2012).

2011

72.  b-PNA: Peptide nucleic acid (PNA) with a chiral center at the b-position of the PNA backbone

T. Sugiyama*, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Bioorg. Med. Chem. Lett., 21, 7317-7320 (2011).

73.  Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands

Y. Demizu, T. Takahashi, F. Kaneko, Y. Sato, H. Okuda, E. Ochiai, K. Horie, K. Takagi, S. Kakuda, M. Takimoto-Kamimura, M. Kurihara*

Bioorg. Med. Chem. Lett., 21, 6104-6107 (2011).

74.  Screw-sense control of helical oligopeptides containing equal amounts of L- and D-amino acids

Y. Demizu*, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara*

Chem. Eur. J., 17, 11107-11109 (2011).

75.  Identification of mutdenafil in a dietary supplement and its subsequent synthesis

Y. Demizu#, D. Wakana#, H. Kamakura, M. Kurihara, H. Okuda, Y. Goda*

# These authors contributed equally to this work.

Chem. Pharm. Bull., 59, 1314-1316 (2011).

76.  Enantioselective epoxidation of a,b-unsaturated ketones catalyzed by stapled helical peptides

Y. Demizu*, N. Yamagata, S. Nagoya, Y. Sato, M. Doi, M. Tanaka, K. Nagasawa, H. Okuda, M. Kurihara*

Tetrahedron, 67, 6155-6165 (2011).

77.  Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state

Y. Demizu*, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara*

J. Pept. Sci., 17, 420-426 (2011).

78.  Conformational studies on peptides containing a,a-disubstituted a-amino acids: chiral cyclic a,a-disubstituted a-amino acid as an a-helical inducer

Y. Demizu*, M. Doi, M. Kurihara, H. Okuda, M. Nagano, H. Suemune, M. Tanaka*

Org. Biomol. Chem., 9, 3303-3312 (2011).

79.  Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone

N. Yamagata, Y. Demizu*, Y. Sato, M. Doi, M. Tanaka, K. Nagasawa, H. Okuda, M. Kurihara*

Tetrahedron Lett., 52, 798-801 (2011).

80.  Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor

Y. Demizu*, A. Nakatsu, S. Honzawa, A. Yamashita, T. Sugiura, A. Kittaka, S. Kato, H. Okuda, M. Kurihara*

Lett. Org. Chem., 8, 43-47 (2011).

2010

81.  Three-dimensional structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state

Y. Demizu*, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara*

J. Org. Chem., 75, 5234-5239 (2010).

82.  Conformations of peptides containing a chiral cyclic a,a-disubstituted a-amino acid within the sequence of Aib residues

Y. Demizu*, M. Tanaka*, M. Doi, M. Kurihara, H. Okuda, H. Suemune

J. Pept. Sci., 16, 621-626 (2010).

83.  Solid-state conformation of diastereomeric -Pro-Pro-(Aib)4 sequences

M. Oba, Y. Demizu*, N. Yamagata, Y. Sato, M. Doi, M. Tanaka, H. Suemune, H. Okuda, M. Kurihara*

Tetrahedron, 66, 2293-2296 (2010).

84.  Controlling the helical screw sense of peptides with C-terminal L-valine

Y. Demizu*, N. Yamagata, Y. Sato, M. Doi, M. Tanaka, H. Okuda, M. Kurihara*

J. Pept. Sci., 16, 153-158 (2010).

85.  Facile synthesis of optically active oxindoles by copper-catalyzed asymmetric monotosylation of prochiral 1,3-diols

M. Kuriyama, S. Tanigawa, Y. Kubo, Y. Demizu, O. Onomura*

Tetrahedron: Asymmetry, 21, 1370-1373 (2010).

2009

86.  Non-enzymatic kinetic resolution of racemic alpha-hydroxyalkanephosphonates with chiral copper catalyst

Y. Demizu, A. Moriyama, O. Onomura

Tetrahedron Lett., 50, 5241-5244 (2009).

<Highlighted by Synfacts 1126 (2009)>

87.  Helical-screw directions of diastereoisomeric cyclic a-amino acid oligomers

M. Nagano, M. Tanaka, M. Doi, Y. Demizu, M. Kurihara, H. Suemune

Org. Lett., 11, 1135-1137 (2009).

88.  Direct electrochemical a-cyanation of N-protected cyclic amines

S. S. Libendi, Y. Demizu, O. Onomura

Org. Biomol. Chem., 7, 351-356 (2009).

89.  Ring contraction of a,b-unsaturated cyclic amines with cis-dihydroxylation at the a,b-position

S. S. Libendi, Y. Demizu, Y. Matsumura, O. Onomura

Heterocycles, 77, 311-321 (2009).

2008

90.  Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls

Y. Demizu, H. Shiigi, H. Mori, K. Matsumoto, O. Onomura

Tetrahedron: Asymmetry, 19, 2659-2665 (2008).

91.  Efficient kinetic resolution of racemic-aminoaldehydes by oxidation with NIS

D. Minato, Y. Nagasue, Y. Demizu, O. Onomura

Angew. Chem. Int. Ed., 47, 9458-9461 (2008).

92.  Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid

O. Onomura, A. Moriyama, K. Fukae, Y. Yamamoto, T. Maki, Y. Matsumura, Y. Demizu

Tetrahedron Lett., 49, 6728-6731 (2008).

93.  Regioselective protection of sugars catalyzed by dimethyltin dichloride

Y. Demizu, Y. Kubo, H. Miyoshi, T. Maki, Y. Matsumura, N. Moriyama, O. Onomura

Org. Lett., 10, 5075-5077 (2008).

94.  Regioselective introduction of electrophiles into piperidine derivatives at the 4-position

O. Onomura, N. Fujimura, T. Oda, Y. Matsumura, Y. Demizu

Heterocycles, 76, 177-182 (2008).

95.  Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols

H. Shiigi, H. Mori, T. Tanaka, Y. Demizu, O. Onomura

Tetrahedron Lett., 49, 5247-5251 (2008).

96.  Diastereoselective arylation of L-proline derivatives at the 5-position

O. Onomura, P. G. Kirira, T. Tanaka, S. Tsukada, Y. Matsumura, Y. Demizu

Tetrahedron, 64, 7498-7503 (2008)

97.  Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols and aminoaldehydes in the presence of chiral copper catalyst

D. Minato, H. Arimoto, Y. Nagasue, Y. Demizu, O. Onomura

Tetrahedron, 64, 6675-6683 (2008).

98.  High regioselective in electrochemical a-methoxylation of N-protected cyclic amines

S. S. Libendi, Y. Demizu, Y. Matsumura, O. Onomura

Tetrahedron, 64, 3935-3942 (2008).

99.  Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst

Y. Demizu, Y. Kubo, Y. Matsumura, O. Onomura

Synlett, 433-437 (2008).

100.           Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls

Y. Demizu, H. Shiigi, T. Oda, Y. Matsumura, O. Onomura

Tetrahedron Lett., 49, 48-52 (2008).

2007

101.           Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst

O. Onomura, M. Mitsuda, T. T. M. Nguyen, Y. Demizu

Tetrahedron Lett., 48, 9080-9084 (2007).

102.           Asymmetric oxidation of 1,2-diols using N-bromosuccinimide in the presence of chiral copper catalyst

O. Onomura, H. Arimoto, Y. Matsumura, Y. Demizu

Tetrahedron Lett., 48, 8668-8672 (2007).

<Highlighted by Synfacts 276 (2008)>

103.           Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols

Y. Demizu, K. Matsumoto, O. Onomura, Y. Matsumura

Tetrahedron Lett., 48, 7605-7609 (2007).

104.           Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: Synthetic application to chiral seven-membered ring a,a-disubstituted a-amino acid

M. Tanaka, Y. Demizu, M. Nagano, M. Hama, Y. Yoshida, M. Kurihara, H. Suemune

J. Org. Chem., 72, 7750-7756 (2007).

<Hot off the press in Nat. Prod. Rep., 24, 1207-1210 (2008)>

105.           Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV

T. Maruyama, Y. Demizu, S. Kozai, M. Witvrouw, C. Pannecouque, P. J. Balzarini, R. Snoecks, G. Andrei, E. De Clercq

Nucleosides, Nucleotides & Nucleic Acids, 26, 1553-1558 (2007).

106.           Controlling 310-helix and a-helix of short peptides in the solid state

Y. Demizu, M. Tanaka, M. Nagano, M. Kurihara, M. Doi, T. Maruyama, H. Suemune

Chem. Pharm. Bull., 55, 840-842 (2007).

107.           1,2-ジオール分子認識に基づく選択的分子変換反応

松村功啓,尾野村治,出水庸介

有機合成化学協会誌,第65巻,46-552007).

2006

108.           Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with a chiral Cu(II) complex

K. Matsumoto, M. Mitsuda, N. Ushijima, Y. Demizu, O. Onomura, Y. Matsumura

Tetrahedron Lett., 47, 8453-8456 (2006).

<Selected as Cover Picture>

109.           Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex

M. Mitsuda, T. Tanaka, T. Tanaka, Y. Demizu, O. Onomura, Y. Matsumura

Tetrahedron Lett., 47, 8073-8077 (2006).

110.           Electrochemical oxidation of L-prolinol derivative protected with 1-alkoxy-2,2,2-trifluoroethyl group

O. Onomura, Y. Ishida, T. Maki, D. Minato, Y. Demizu, Y. Matsumura

Electrochemistry, 74, 645-648 (2006).

111.           Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication

T. Torii, T. Onishi, K. Izawa, T. Maruyama, Y. Demizu, J. Neyts, E. De Clercq

Nucleosides, Nucleotides & Nucleic Acids, 25, 655-665 (2006).

112.           Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives

T. Maruyama, S. Kozai, Y. Demizu, M. Witvrouw, C. Pannecouque, J. Balzarini, R. Snoecks, G. Andrei, E. De Clercq

Chem. Pharm. Bull., 54, 325-333 (2006).

2005

113.           Reaction of O6-methyl-guanosine with nitrite in the presence of carboxylic acid: synthesis of the purin-2-yl carboxylate

T. Maruyama, N. Moriwaka, Y. Demizu, M. Ohtsuka

Tetrahedron Lett., 46, 8225-8228 (2005).

114.           Side-chain chiral centers of amino acid and helical-screw handedness of its peptides

M. Tanaka, K. Anan, Y. Demizu, M. Kurihara, M. Doi, H. Suemune

J. Am. Chem. Soc., 127, 11570-11571 (2005).

2004

115.           Chiral centers in the side chains of a-amino acids control the helical screw sense of peptides

M. Tanaka, Y. Demizu, M. Doi, M. Kurihara, H. Suemune

Angew. Chem. Int. Ed., 43, 5360-5363 (2004).

<Selected as VIP & Cover Picture>

116.           Asymmetric ring cleavage reaction with a combination of optically active cycloalkane-1,2-diol and Lewis acid: application to formal synthesis of (-)-alloyohimbane and approach to construction of adjacent chiral quaternary centers

M. Tanaka, E. Toyofuku, Y. Demizu, O. Yoshida, K. Nakazawa, K. Sakai, H. Suemune

Tetrahedron, 60, 2271-2281 (2004).

2003

117.           An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse a-ethylated a,a-disubstituted a-amino acids

M. Tanaka, S. Nishimura, M. Oba, Y. Demizu, M. Kurihara, H. Suemune

Chem. Eur. J., 9, 3082-3090 (2003).

 

Proceedings

118.           Development of helix-stabilized amphipathic cell-penetrating peptide using helical promoter

T. Misawa,* Y. Demizu, H. Yamashita, T. Kato, M. Oba, M. Tanaka, M. Kurihara

Peptide Science 2016, in press.

119.           Development of helical peptides as inhibitors of estrogen receptor-mediated transcription

Y. Demizu,* T. Misawa, Y. Kanda, N. Ohoka, Y. Sekino, M. Naito, M. Kurihara

Peptide Science 2015, 283-284 (2016).

120.           Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors

T. Misawa,* Y. Demizu, M. Kurihara

Peptide Science 2015, 209-210 (2016).

121.           Development of helix-stabilized cationic peptides with cell-membrane penetrating ability

H. Yamashita, Y. Demizu,* T. Misawa, T. Hattori, M. Oba, M. Tanaka, M. Naito, M. Kurihara*

Peptide Science 2015, 29-30 (2016).

122.           Conformational analysis of peptides composed of chiral cyclic amino acids

Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka

Peptide Science 2015,145-146 (2016).

123.           Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA

T. Sugiyama,* K. Kuwata, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2015, 307-308 (2016).

124.           Development of stabilized short helical peptides and their functionalization

Y. Demizu*

Peptide Science 2014, 7-10 (2015).

125.           Sequence-specific cleavage of DNA by b-peptide nucleic acid bearing a pendant metal complex

T. Sugiyama,* K. Kuwata, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2014, 87-88 (2015).

126.           Development of stabilized short helical peptides with cell-membrane penetrating ability

H. Yamashita, Y. Demizu,* T. Misawa, M. Oba, M. Tanaka, M. Kurihara*

Peptide Science 2014, 149-150 (2015).

127.           Development of cell-permeable peptide for transcriptional inhibitor of estrogen receptor

T. Nagakubo, Y. Demizu,* T. Misawa, Y. Sato, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*

Peptide Science 2014, 155-156 (2015).

128.           Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety

R. Eto, M. Oba, A. Ueda, N. Ishikawa, M. Kurihara, Y. Demizu, H. Suemune, M. Doi, M. Tanaka

Peptide Science 2014, 217-218 (2015).

129.           Helical screw-sense control of LD-peptides containing equal amounts of L- and D-amino acids

Y. Demizu,* H. Yamashita, Y. Sato, M. Doi, M. Oba, M. Tanaka, M. Kurihara*

Peptide Science 2013, 2013, 271-272 (2014).

130.           Development of helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid

N. Yamazaki, Y. Demizu,* Y. Sato, M. Doi, M. Kurihara*

Peptide Science 2013, 273-274 (2014).

131.           Sequence-specific cleavage of DNA by b-peptide nucleic acid bearing a pendant metal complex

T. Sugiyama,* K. Kuwata, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2013, 369-370 (2014).

132.           Synthesis of chiral five-membered ring amino acids with an azido group, and their peptides

A. Imanishi, M. Oba, Y. Demizu, M. Kurihara, M. Doi, H. Takazaki, H. Suemune, M. Tanaka*

Peptide Science 2012, 131-132 (2013).

133.           Synthesis of b-chiral peptide nucleic acids bearing lysine side chains

T. Sugiyama,* Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2012, 385-386 (2013).

134.           Design of stapled helical peptides for catalytic enantioselective epoxidation of a,b-unsaturated ketones

Y. Demizu,* S. Nagoya, Y. Sato, M. Tanaka, M. Doi, H. Okuda, M. Kurihara

Peptide Science 2011, 149-150 (2012).

135.           Design of stable helical peptides

M. Kurihara,* Y. Demizu, S. Nagoya, Y. Sato, M. Doi, M. Tanaka

Peptide Science 2011, 213-214 (2012).

136.           Design and synthesis of conformational freedom restricted endomorphine-2 analogues

T. Hanada, T. Kato, E. Ikeda, Y. Demizu, M. Kurihara, M. Doi, Y. Tsuda, M. Fukudome, M. Oba, M. Tanaka*

Peptide Science 2011, 103-104 (2012).

137.           Synthesis and conformational analysis of peptides composed of five-membered ring amino acids

Y. Hirata, M. Oba, M. Fukudome, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*

Peptide Science 2011, 101-102 (2012).

138.           Synthesis of beta-chiral peptide nucleic acids and their DNA binding properties

T. Sugiyama,* Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2011, 353-354 (2012).

139.           Design of non-secosteroidal VDR ligands and binding mode to VDR-LBD

Y. Demizu,* Y. Sato, K. Horie, K. Takagi, S. Kakuda, M. Takimoto-Kamimura, H. Okuda, M. Kurihara

Proceeding of 4ECCLS, 17-20 (2011).

140.           Conformational studies of diastereomeric _Leu-Aib- peptides

Y. Demizu,* M. Doi, Y. Sato, M. Tanaka, H. Okuda, H. Kurihara*

Peptide Science 2010, 140 (2011).

141.           Computational study on conformation of oligopeptides containing a,a-disubstituted a-amino acids

M. Kurihara, Y. Demizu, Y. Sato, N. Yamagata, H. Okuda, M. Nagano, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2010, 135 (2011).

142.           Design of short a-helical peptides for transcriptional inhibitor of nuclear receptor

N. Yamagata, Y. Demizu, Y. Sato, K. Nagasawa, M. Doi, M. Tanaka, H. Okuda, M. Kurihara

Peptide Science 2010, 137 (2011).

143.           Synthesis of 4-substituted chiral PNA monomers

T. Sugiyama, Y. Imamura, Y. Demizu, M. Kurihara, M. Takano, A. Kittaka

Peptide Science 2010, 284 (2011).

144.           Helical secondary structures of oligopeptides composed of chiral five-membered ring amino acids

M. Tanaka, M. Nagano, Y. Demizu, M. Doi, M. Kurihara, H. Suemune

Peptide: Building Bridges, 124-125 (2011).

145.           Design of a stabilized short helical peptide and its application

M. Kurihara, Y. Demizu, N. Yamagata, Y. Sato, Y. Takeuchi, M. Doi, M. Tanaka, H. Okuda

Peptide: Building Bridges, 124-125 (2011).

146.           Computational study on helical structure of chiral a,a-disubstituted oligopeptides

M. Kurihara, Y. Sato, N. Yamagata, Y. Demizu, H. Okuda, M. Nagano, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2009, 385-386 (2010).

147.           Controlling the helical screw sense of peptides by N-terminal proline

N. Yamagata, Y. Demizu, Y. Sato, M. Oba, M. Tanaka, M. Doi, K. Nagasawa, H. Suemune, H. Okuda, M. Kurihara

Peptide Science 2009, 383-384 (2010).

148.           Conformational analysis of water-soluble oligopeptides composed of chiral cyclic a,a-disubstituted a-amino acids

Y. Demizu,* M. Tanaka, H. Suemune, M. Doi, Y. Sato, H. Okuda, M. Kurihara*

Peptide Science 2009, 381-382 (2010).

149.           Computational study on helical structure of a,a-disubstituted oligopeptides containing chiral a-amino acids

M. Kurihara, Y. Sato, N. Yamagata, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2008, 149-150 (2009).

150.           Computational study on secondary structure of oligopeptides containing a,a-disubstituted a-amino acids

M. Kurihara, Y. Sato, F. Kaneko, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2007, 137-138 (2008).

151.           Computational study on conformation of oligopeptides containing chiral cyclic a,a-disubstituted a-amino acids

M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, M. Nagano, N. Kawabe, M. Doi, M. Tanaka, H. Suemune

Peptides 2006, 546-547 (2007).

152.           Side-chain chiral centers of amino acids and helical-screw handedness of their peptides

M. Tanaka, M. Nagano, Y. Demizu, K. Anan, M. Kurihara, M. Doi, H. Suemune

Peptides 2006, 268-269 (2007).

153.           Secondary structure of heteropeptides using chiral cyclic a,a-disubstituted amino acids

M. Nagano, M. Tanaka, Y. Demizu, M. Kurihara, M. Doi, H. Suemune

Peptides 2006, 476-477 (2007).

154.           Synthesis of various chiral cyclic a,a-disubstituted amino acids and conformational analysis of their peptides

N. Kawabe, Y. Demizu, M. Tanaka, M. Kurihara, H. Suemune

Peptide Science 2005, 346-347 (2006).

155.           Chiral cyclic a,a-disubstituted a-amino acids bearing two chiral centers and conformation of their peptides

M. Nagano, Y Demizu, M. Tanaka, M. Kurihara, M. Doi, H. Suemune

Peptide Science 2005, 345-346 (2006).

156.           Computational study on conformation of oligopeptides containing chiral cyclic a,a-disubstituted a-amino acids

M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, M. Nagano, N. Kawabe, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2005, 371-372 (2006).

157.           Synthesis of optically active cyclic a,a-disubstituted amino acids by enzymatic kinetic resolution and conformational analysis of their peptides

M. Hama, M. Tanaka, Y. Yoshida, Y. Demizu, M. Kurihara, H. Suemune

Peptide Science 2006, 39 (2006).

158.           Controlling helical secondary structures by cyclic a,a-disubstituted amino acids having side-chain chiral centers

M. Tanaka, M. Nagano, M. Hama, N. Kawabe, Y. Demizu, M. Kurihara, M. Doi, H. Suemune

Peptide Science 2006, 135 (2006).

159.           Synthesis of purin-2-yl carboxylate from O6-methylguanosine

T. Maruyama, N. Moriwaka, Y. Demizu, M. Ohtsuka

Nucleic Acids Symposium Series, 49 109-110 (2005).

160.           Computational study on conformation of oligopeptides controlled by side chain chiralities of a-amino acids

M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, K. Anan, Y. Takano, M. Oba, M. Doi, M. Tanaka, H. Suemune

Peptide Science 2004, 297-298 (2005).

161.           Relationship between a-amino acid chiral center and helical secondary structure of its oligopeptides

M. Tanaka, Y. Demizu, K. Anan, N. Kawabe, Y. Takano, M. Oba, T. Maruyama, M. Doi, M. Kurihara, and H. Suemune

Peptide Science 2004, 45-46 (2005).

162.           Prediction of helical screw sense of oligopeptides containing chiral alpha,alpha-disubstituted alpha-amino acids: Computational study

M. Kurihara, H. Okuda, M. Oba, Y. Demizu, M. Tanaka, H. Suemune

Peptides 2004, 206-207 (2005).

163.           Design and synthesis of chiral cyclic alpha, alpha-disubstituted alpha-amino acids and its peptides

Y. Demizu, M. Tanaka, K. Anan, Y. Yoshida, M. Doi, M. Kurihara, T. Maruyama, H. Suemune

Peptides 2004, 1027-1028 (2005).

164.           Controlling the helical screw sense of oligopeptide by alpha-amino acid side-chain chirality

M. Tanaka, Y. Demizu, M. Doi, M. Kurihara H. Suemune

Peptides 2004, 277-278 (2005).

165.           Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1

T. Maruyama, S. Kozai, Y. Demizu, M. Witvrouw, C. Pannecouque, J. Balzarini, R. Snoeck, G. Andrei, E. De Clercq

Nucleic Acids Symposium Series, 48, 3-4 (2004).

166.           Prediction of helical screw sense of oligopeptides containing chiral amino acids: computational study

M. Kurihara, Y. Sato, S. Nomoto, H. Okuda, M. Oba, Y. Demizu, M. Tanaka, H. Suemune

Peptide Science 2003, 411-412 (2004).

167.           Controlling the helical screw sense of oligopeptides by chiral cyclic a,a-disubstituted a-amino acid

M. Tanaka, Y. Demizu, M. Doi, M. Kurihara, H. Suemune

Peptide Science 2003, 109-110 (2004).

168.           Conformational study of heteropeptide prepared from chiral alpha-ethylated alpha, alpha-disubstituted alpha-amino acids

M. Tanaka, S. Nishimura, M. Oba, Y. Demizu, M. Kurihara, and H. Suemune

Peptides 2002, 902-903(2003).

169.           Synthesis of chiral cyclic a,a-disubstituted a-amino acid and its peptides

Y. Demizu, M. Tanaka, M. Kurihara, H. Suemune

Peptide Science 2002, 321-322 (2003).

170.           Prediction of the helical screw sense of oligopeptides containing chiral alpha, alpha-disubstituted amino acids

M. Kurihara, Y. Sato, M. Tanaka, M. Oba, Y. Demizu, H. Suemune, H. Okuda

Peptide Science 2002, 323-324 (2003).

 

Patent

1.  出水庸介,栗原正明,三澤隆史細胞膜透過性を有するペプチド,構築物,及び,カーゴ分子を細胞内に輸送する方法,特願2016018416(PCT/JP2017/003520)

2.  内藤幹彦,奥平桂一郎,出水庸介,栗原正明アポトーシス阻害タンパク質リガンド−エストロゲン受容体リガンドハイブリッド化合物並びにそれを利用したエストロゲン受容体分解誘導剤及び乳癌,子宮頚癌又は卵巣癌の予防及び治療剤,特開2013056837

3.  尾野村治,出水庸介,森山敦,岩崎史哲光学活性α−アシルオキシリン酸誘導体の製造方法,特開2010111632

4.  尾野村治,出水庸介岩崎史哲グルコシドエステル誘導体およびその製造方法,特開2009221161

5.  尾野村治,出水庸介,岩崎史哲:ピラノシドエステル化合物およびその製造方法,特開2009215175

6.  尾野村治,出水庸介,岩崎史哲:キシロシドエステル誘導体およびその製造方法,特開2009227610

7.  尾野村治,出水庸介,久保裕紀,岩崎史哲:ラムノシドエステル誘導体およびその製造方法,特開2010030916

8.  尾野村治,出水庸介,岩崎史哲:脂肪族ジカルボン酸化合物の製造方法,特開2009184950

9.  尾野村治,出水庸介,山本博将:光学活性アミノ酸エステル誘導体,および光学活性アミノアセタール誘導体の製造方法,特開2009227594

10.松村功啓,尾野村治,出水庸介光学活性ビスオキサゾリン−銅錯体を不斉触媒とするN保護アミノアルコール化合物の不斉エステル化反応,特開200837865

11.尾野村治,出水庸介,岩崎史哲:光学活性α−スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法,特開2009091327

12.松村功啓,尾野村治,出水庸介光学活性モノスルホネート化合物の製造方法,特開2008290981

13.松村功啓,尾野村治,出水庸介α,α−ジ置換環状含窒素化合物の製造方法,特開2008056164

14.Matsumura, Y.; Demizu, Y.; Onomura, O.Nitrogen-containing redox catalyst, PCT Int. Appl. WO 2008117871 (PCT/JP2008/056164).

 

記事・解説

1.   出水庸介ペプチド二次構造制御に基づく創薬研究,薬事日報, 11673, 3 (2016).

2.   出水庸介,栗原正明,ディスタンス・ジオメトリー法(十字路),有機合成化学協会誌, 72, 1405 (2014).

3.   出水庸介短鎖ペプチドのヘリカル構造制御と機能化,ペプチドニュースレター, 94, 3-7 (2014).

4.   出水庸介DNAを不斉触媒として利用した不斉Diels-Alder反応,ファルマシア, 42(3), 262-263 (2006).

 

招待講演

1.   出水庸介,タンパク質の寿命を制御できる分子の開発,生体分子コバレント修飾の革新的解析拠点形成シンポジウム,東京(2018.

2.   出水庸介,二次構造制御を基盤としたペプチド創薬研究,早稲田大学講演会,東京(2017.

3.   出水庸介,核内受容体を標的とした転写活性化阻害および分解誘導ペプチドの開発,第48回若手ペプチド夏の勉強会,東京(2016.

4.   出水庸介,短鎖ペプチドのヘリカル構造制御と機能化,第51回ペプチド討論会,徳島(2014.

5.   出水庸介,分子認識に基づくキラル銅触媒を用いたアルコール類の不斉トシル化,第1回若手交流合宿セミナー,福岡(2007.

 

国際学会

1.   Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y., Development of helical cell penetrating peptides using non-proteinogenic amino acids, Lindau Nobel Laureate Meetings 2017, Germany (2017.6).

2.   Demizu, Y., Yamashita, H., Misawa, T., Oba, M., Tanaka, M., Kurihara, M., Development of helix-stabilized cell-penetrating peptides as an intracellular delivery tool, 34th European Peptide Symposium & 8th International Peptide Symposium, Germany (2016.9).

3.   Tanaka, M., Koba, Y., Ueda, A., Doi, M., Demizu, Y., Kurihara, M., Oba, M., Helical secondary structures of peptides having chiral five-membered ring amino acids with an acetal moiety, 34th European Peptide Symposium & 8th International Peptide Symposium, Germany (2016.9).

4.   Naito, M., Hattori, T., Ohoka, N., Shibata, N., Shoda, T., Demizu, Y., Kurihara, M., Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy, The 10th AACR-JCA Joint Conference, Hawaii (2016.2).

5.   Misawa, T., Demizu, Y., Kurihara, M., Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors, PACIFICHEM 2015, Hawaii (2015.12).

6.   Shoda, T., Kato, M., Okuhira, K., Demizu, Y., Inoue, H., Naito, M., Kurihara, M., Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators, PACIFICHEM 2015, Hawaii (2015.12).

7.   Demizu, Y., Misawa, T., Kurihara, M., Development of stabilized helical peptides and their functionalization, 13th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto (2015.11).

8.   Demizu, Y., Misawa, T., Kanda, Y., Sekino, Y., Kurihara, M., Development of cell-penetrating fragment conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription, The 11th Australian Peptide Conference 2015, Australia (2015.10).

9.   Oba, M., Furukawa, K., Kato, T., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M., Cell-penetrating ability and plasmid DNA delivary using fluorescein-labeled arginine-rich peptides, The 11th Australian Peptide Conference 2015, Australia (2015.10).

10. Misawa, T., Demizu, Y., Kurihara, M., Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors43回構造活性相関シンポジウム10回薬物の分子設計と開発に関する日中シンポジウム20159).

11. Demizu, Y., Misawa, T., Yamashita, H., Doi, M., Sato, Y., Tanaka, M., Kurihara, M., Conformations of LD-peptides containing equal amounts of L-amino acids, D-amino acids, and achiral a,a-disubstitued amino acids, 33rd European Peptide Symposium, Sophia (2014.9).

12. Kurihara, M., Kawamura, M., Misawa, T., Sato, Y., Demizu, Y., Stapled short helical peptides for vitamin D receptor-coactivator interaction inhibitor, 33rd European Peptide Symposium, Sophia (2014.9).

13. Tanaka, M., Takazaki, H., Kawabe, N., Doi, M., Demizu, Y., Kurihara, M., Suemune, H., Oba, M., Helical secondary structures of peptides having chiral cyclic amino acid with two azido functional groups, 33rd European Peptide Symposium, Sophia (2014.9).

14. Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M., Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells, Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery, Big Sky (2014.1).

15. Demizu, Y., Yamashita, H., Sato, Y., Doi, M., Oba, M., Tanaka, M., Kurihara, M., Helical screw-sense control of LD-peptides containing equal amounts of L- and D-amino acids, 4th Asia-Pacific International Peptide Symposium (APIPS2013), Osaka (2013.11).

16. Yamazaki, N., Demizu, Y., Sato, Y., Doi, M., Kurihara, M., Development of helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid, 4th Asia-Pacific International Peptide Symposium (APIPS2013), Osaka (2013.11).

17. Sugiyama, T., Kuwata, K., Imamura, Y., Demizu, Y., Kurihara, M., Takano, M., Kittaka, A. Sequence-specific cleavage of DNA by b-peptide nucleic acid bearing a pendant metal complex, 4th Asia-Pacific International Peptide Symposium (APIPS2013), Osaka (2013.11).

18. Demizu, Y., Kawamura, M., Sato, Y., Doi, M., Tanaka, M., Kurihara, M., Development of short helical peptides capable for inhibiting vitamin D receptor-coactivator interactions, The 2nd Official Conference of the International Chemical Biology Society (ICBS2013), Kyoto (2013.10).

19. Yamada, S., Kotake, Y., Demizu, Y., Kurihara, M., Sekino, Y., Kanda, Y., Mitochondrial isocitrate dehydrogenase is the target of tributyltin, The 4th International Symposium on Dynamics of Mitochondria, Okinawa (2013.10).

20. Oba, M., Kato, I., Demizu, Y., Kurihara, M., Doi, M., Takano, Y., Suemune, H., Tanaka, M., Synthesis of cyclic _,_-disubstituted amino acids bearing a pendent chiral center and conformational analysis of heteropeptides containing their amino acids, The 10th Australian Peptide Conference 2013, Malaysia (2013.9).

21. Demizu, Y., Kawamura, M., Sato, Y., Doi, M., Tanaka, M., Kurihara, M., Development of stabilized helical peptides for vitamin D receptor-coactivator interaction inhibitor, The 10th Australian Peptide Conference 2013, Malaysia (2013.9).

22. Demizu, Y., Nagoya, S., Sato, Y., Doi, M., Tanaka, M., Kurihara, M., Development of stabilized helical peptides for VDR-coactivator interaction inhibitor, The 23rd French-Japanese Symposium on Medicinal and Fine Chemistry, Nagasaki (2013.5).

23. Oba, M., Kato, I., Demizu, Y., Kurihara, M., Doi, M., Takano, Y., Suemune, H., Tanaka, M., Synthesis of cyclic a-amino acids bearing a pendent chiral center and conformational studies on peptides containing their amino acids in Aib sequence, The 23rd French-Japanese Symposium on Medicinal and Fine Chemistry, Nagasaki (2013.5).

24. Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M., Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapid cell death in breast cancer cells, The 9th AACR-JCA Joint Conference, Hawaii (2013.2).

25. Nagoya, S., Demizu, Y., Sato, Y., Nagumo, S., Doi, M., Tanaka, M., Kurihara, M., Design and synthesis of stabilized helical peptide for transcriptional inhibitor of vitamin D receptor, The 11th International Symposium on Advanced Technology (ISAT-Special), Tokyo (2012.10).

26. Naito, M., Okuhira, K., Demizu, Y., Itoh, Y., Ishikawa, M., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Hashimoto, Y., Development of hybrid small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner, Genetics and Chemistry Sharing a Language of Discovery, Boston (2012.5).

27. Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M., Development of SNIPER(ER) that induces estrogen receptor degradation, 6th International Conference SUMO, Ubiquitin, UBL Protein: Implications for Human Diseases, Houston (2012.2).

28. Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M., Degradation of estrogen receptor induced by a small hybrid molecule SNIPER(ER), 16th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy, Tokyo (2012.1).

29. Demizu, Y., Motoi, H., Okuhira, K., Fukuhara, K., Okuda, H., Naito, M., Kurihara, M., Design and synthesis of ER degradation inducer for protein knockdown strategy, 8th AFMC International Medicinal Chemistry Symposium, Tokyo (2011.12).

30. Kurihara, M., Demizu, Y., Kurashima, M., Sato, Y., Horie, K., Takagi, K., Kakuda, S., Takimoto-Kamimura, M., Okuda, H., Design of non-secosteroidal VDR ligands and hydrogen-bond network in VDR-LBD, 8th AFMC International Medicinal Chemistry Symposium, Tokyo (2011.11).

31. Nagoya, S., Demizu, Y., Sato, Y., Doi, M., Tanaka, M., Okuda, H., Kurihara, M. Design of stabilized a-helical peptides for transcriptional inhibitor of nuclear receptor, 8th AFMC International Medicinal Chemistry Symposium, Tokyo (2011.11).

32. Sugiyama, T., Imamura, Y., Demizu, Y., Kurihara, M., Takano, M., Kittaka, A. Synthesis and DNA binding properties of β-chiral peptide nucleic Acid, 8th AFMC International Medicinal Chemistry Symposium, Tokyo (2011.11).

33. Oba, M., Hirata, T., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., Tanaka, M. Synthesis of cyclic amino acids with two chiral centers and secondary structures of their peptides, 8th AFMC International Medicinal Chemistry Symposium, Tokyo (2011.11).

34. Demizu, Y., Sato, Y., Horie, K., Takagi, K., Kakuda, S., Takimoto-Kamimura, M., Okuda, H., Kurihara, M., Design of non-secosteroidal VDR ligands and binding mode to VDR-LBD, 4th European Conference on Chemisitry for Life Sciences, Budapest (2011.8).

35. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M., Controlling helical peptides containing equal numbers of L- and D-amino acids, 22nd American Peptide Symposium, SanDiego (2011.6).

36. Kurihara, M., Demizu, Y., Yamagata, N., Sato, Y., Takeuchi, Y., Doi, M., Tanaka, M., Okuda, H., Design of a stabilized short helical peptide and its application, 22nd American Peptide Symposium, SanDiego (2011.6).

37. Tanaka, M., Nagano, M., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., Helical secondary structures of oligopeptides composed of chiral five-membered ring amino acids, 22nd American Peptide Symposium, SanDiego (2011.6).

38. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M., Conformational studies of diastereomeric -Leu-Aib- peptides, 5th International Peptide Symposium, Kyoto (2010.12).

39. Yamagata, N., Demizu, Y., Doi, M., Sato, Y., Nagasawa, K., Tanaka, M., Okuda, H., Kurihara, M., Design of short a-helical peptides for transcriptional inhibitor of nuclear receptor, 5th International Peptide Symposium, Kyoto (2010.12).

40. Kurihara, M., Demizu, Y., Sato, Y., Yamagata, N., Okuda, H., Nagano, M., Doi, M., Tanaka, M., Suemune, H., Computational study on conformation of oligopeptides containing a,a-disubstituted Amino acids, 5th International Peptide Symposium, Kyoto (2010.12).

41. Sugiyama, T., Imamura, Y., Demizu, Y., Kurihara, M., Takano, M., Kittaka, A., Synthesis of 4-substituted chiral PNA monomers, 5th International Peptide Symposium, Kyoto (2010.12).

42. Demizu, Y., Sato, Y., Tanaka, M., Doi, M., Suemune, H., Okuda, H., Kurihara, M., Controlling the helical screw sense of Aib-based peptides with chiral a-amino acids, PACIFICHEM 2010, Hawaii (2010.12).

43. Kurihara, M., Demizu, Y., Sato, Y., Yamagata, N., Okuda, H., Nagano, M., Doi, M., Tanaka, M., Suemune, H., Computational study on helical structure of alpha,alpha-disubstituted oligopeptides containing chiral alpha-amino acids, 31st European Peptide Symposium, Copenhagen (2010.9).

44. Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M., Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences, 31st European Peptide Symposium, Copenhagen (2010.9).

45. Demizu, Y., Sato, Y., Ochiai, E., Horie, K., Kakua, S., Takimoto-Kamimura, M., Okuda, H., Kurihara, M., Development of non-secosteroidal VDR ligands, The 21st French-Japanese Symposium on Medicinal and Fine Chemistry, Kyoto (2010.5).

46. Libendi, S. S., Demizu, Y., Kuriyama, M., Onomura, O., Selective anodic cyanation of protected amines at α-position, 2nd Asian Symposium on Pharmaceutical Sciences, Nagasaki (2009).

47. Tanaka, M., Nagano, M., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., Controlling a-helical secondary structure of oligopeptides and its use as a chiral catalyst, 30th European Peptide Symposium, Helsinki (2008).

48. Kurihara, M., Sato, Y., Yamagata, N., Sano, K., Okuda, H., Nagano, M., Demizu, Y., Doi, M., Tanaka, M., Suemune, H., Computational study on secondary structure of oligopeptides containing chiral a,a-disubstituted a-amino acids, 30th European Peptide Symposium, Helsinki (2008).

49. Kubo, Y., Demizu, Y., Onomura, O. Regioselective protection of sugars catalyzed by organotin, The 1st International Symposium on Process Chemistry, Kyoto (2008).

50. Demizu, Y., Shiigi, H., Mori, H., Matsumoto, K., Matsumura, Y., Onomura, O., Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them, 213th ECS Meeting, Phoenix (2008).

51. Minato, D., Arimoto, H., Nagasue, Y., Demizu, Y., Matsumura, Y., Onomura, O., Asymmetric electrochemical oxidation of 1,2-diols and 1,2-amino aldehydes catalyzed by chiral copper catalyst, 213th ECS Meeting, Phoenix (2008).

52. Demizu, Y., Oda, T., Onomura, O., Matsumura, Y., Electrochemical oxidation of alcohols catalyzed by new organic mediators, 211th ECS Meeting, Chicago (2007).

53. Matsumura, Y., Demizu, Y., Libendi, S.S., Onomura, O., Chemical and electrochemical devices for high regioselectivity in electrochemical a-methoxylation of N-protected cyclic amines, 211th ECS Meeting, Chicago (2007).

54. Matsumura, Y., Arimoto, H., Nagasue, Y., Demizu, Y., Onomura, O., Asymmetric electrochemical oxidation of 1,2-diols and the related compounds, The 2nd International Symposium on Organic Electron Transfer Chemistry, Yokohama (2007).

55. Matsumoto, K., Demizu, Y., Onomura, O., Matsumura, Y., Chiral copper(II) catalyzed asymmetric mono-tosylation of meso-diols, Second International Conference on Advanced Organic Synthesis Directed toward the Ultimate Efficiency and Practicability (International Conference on Asymmetric Organocatalysis), Shiga (2007).

56. Arimoto, H., Demizu, Y., Onomura, O., Matsumura, Y., Chiral copper(II) catalyzed enantioselective oxidation of 1,2-diols, 14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Nara (2007).

57. Nagano, M., Tanaka, M., Demizu, Y., Kurihara, M., Doi, M., Suemune, H., Controlling 310-helix and a-helix of short L-leucine-peptides by a,a-disubstituted amino acid, 4th International Peptide Symposium, Australia (2007).

58. Tanaka, M., Nagano, M., Tanda, K., Takazaki, H., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., Molecular design for chiral a,a-disubstituted amino acids and conformational study of their peptides, 4th International Peptide Symposium, Australia (2007).

59. Nagano, M., Demizu, Y., Tanaka, M., Doi, M., Kurihara, M., Suemune, H., Conformational analysis of oligopeptides composed of chiral cyclic a,a-disubstituted a-amino acids bearing two chiral centers, The Post Symposium for ICOB-5 & ISCNP-25 International Conference, Fukuoka (2006).

60. Matsumoto, K., Onomura, O., Demizu, Y., Matsumura. Y., Asymmetric desymmetrization of meso-1,2-diols, The Post Symposium for ICOB-5 & ISCNP-25 International Conference, Fukuoka (2006).

61. Mitsuda, M., Tanaka, T., Demizu, Y., Onomura, O., Matsumura, Y., Asymmetric benzoylation of 1,2-amino alcohols, 10th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto (2006).

62. Tanaka, M., Nagano, M., Demizu, Y., Anan, K., Kurihara, M., Doi, M., Suemune, H., Side-chain chiral centers of amino acids and helical-screw handedness of their peptides, 29th European Peptide Symposium, Gdansk (2006).

63. Nagano, M., Tanaka, M., Demizu, Y., Kurihara, M., Doi, M., Suemune, H., Controlling the helical secondary structure of heteropeptides using chiral cyclic a,a-disubstituted amino acids, 29th European Peptide Symposium, Gdansk (2006).

64. Kurihara, M., Hakamata, W., Sato, Y., Okuda, H., Demizu, Y., Nagano, M., Anan, K., Doi, M., Tanaka, M., Suemune, H., Computational study on helical structures of oligopeptides containing chiral cyclic a-amino acids, 29th European Peptide Symposium, Gdansk (2006).

65. Kurihara, M., Sato, Y., Hakamata, W., Okuda, H., Nagano, M., Hama, M., Demizu, Y., Doi, M., Tanaka, M., Suemune, H., Computational study on helical structures of oligopeptides containing chiral cyclic a,a-disubstituted a-amino acids, The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting (43JPS/PEM4), Yokohama (2006).

66. Tanaka, M., Nagano, M., Hama, M., Kawabe, N., Anan, K., Demizu, Y., Kurihara, M., Doi, M., Suemune, H., Controlling helical secondary structures by cyclic a,a-disubstituted amino acids having side-chain chiral centers, The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting (43JPS/PEM4), Yokohama (2006).

67. Hama, M., Tanaka, M., Yoshida, Y., Demizu, Y., Kurihara, M., Suemune, H., Synthesis of optically active cyclic a,a-disubstituted amino acids by enzymatic kinetic resolution and conformational analysis of their peptides, The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting (43JPS/PEM4), Yokohama (2006).

68. Maruyama, T., Moriwaka, N., Demizu, Y., Ohtsuka, M., Synthesis of purin-2-yl carboxylate from O6-methylguanosine, 4th International Symposium on Nucleic Acids Chemistry, Fukuoka (2005).

69. Nagano, M., Demizu, Y., Tanaka, M., Kurihara, M., Doi, M., Suemune, H., Helical secondary structure of oligopeptides composed of cyclic a,a-disubstituted a-amino acid having two chiral centers at the a- and g-positions, The 17th Japan-Korea Joint Seminar for Young Organic Chemists, Nagasaki (2005).

70. Kawabe, N., Demizu, Y., Tanaka, M., Suemune, H., Design and synthesis of peptides containing various chiral cyclic a,a-disubstituted a-amino acids, The 17th Japan-Korea Joint Seminar for Young Organic Chemists, Nagasaki (2005).

71. Kurihara, M., Okuda, H., Oba, M., Demizu, Y., Tanaka, M., Suemune, H., Prediction of helical screw sense of oligopeptides containing chiral a,a-disubstituted a-amino acids, Computational study, 4th International and 28th European Peptide Symposium, Prague (2004).

72. Demizu, Y., Tanaka, M., Anan, K., Yoshida, Y., Doi, M., Kurihara, M., Maruyama, T., Suemune, H., Design and synthesis of chiral cyclic a,a-disubstituted a-amino acids and its peptides, 4th International and 28th European Peptide Symposium, Prague (2004).

73. Tanaka, M., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., Controlling the helical screw sense of oligopeptides by a-amino acid side-chain chirality, 4th International and 28th European Peptide Symposium, Prague (2004).

74. Kurihara, M., Sato, Y., Hakamata, W., Okuda, H., Demizu, Y., Anan, K., Takano, Y., Oba, M., Doi, M., Tanaka, M., Suemune, H., Computational study on conformation of oligopeptides controlled by side chain chiralities of alpha-amino acids, 1st Asian-Pacific International Peptide Symposium-41st Japanese Peptide Symposium, Fukuoka (2004).

75. Tanaka, M., Demizu, Y., Anan, K., Kawabe, N., Takano, Y., Oba, M., Maruyama, T., Doi, M., Kurihara, M., Suemune, H., Relationship between alpha-amino acid chiral center and helical secondary structure of its oligopeptides, 1st Asian-Pacific International Peptide Symposium-41st Japanese Peptide Symposium, Fukuoka (2004).

76. Tanaka, M., Demizu, Y., Doi, M., Kurihara, M., Suemune, H., 310-Helical structure of peptides composed of chiral cyclic a,a-disubstituted a-amino acid, 9th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto (2003).

77. Tanaka, M., Nishimura, S., Oba, M., Demizu, Y., Kurihara, M., Suemune, H., Conformational study of heteropeptide prepared from chiral a-ethylated a,a-disubstituted a-amino acids, 27th European Peptide Symposium, Italy (2002).

78. Demizu, Y., Tanaka, M., Kurihara, M., Suemune, H., Synthesis of chiral cyclic a,a-disubstituted a-amino Acid and its peptides, The 13th Japan-Korea Joint Seminar for Young Organic Chemists, Yamaguchi (2001).

国内学会

平成29

79. 大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦,芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発,2017年度生命科学系学会合同年次大会(ConBio2017),神戸(201712).

80. 池田光生,古場百合恵,上田篤志,大庭誠,出水庸介,栗原正明,田中正一,側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成34回日本薬学会九州支部大会,熊本(201711).

81. 小林寛幸三澤隆史大庭誠田中正一内藤幹彦松野研司出水庸介Development of cationic cell-penetrating peptides focused on their secondary structures54回ペプチド討論会,大阪(201711).

82. 三澤隆史出水庸介Development of post functionalizable oligopeptides as helical templates54回ペプチド討論会,大阪(201711).

83. 古川かほり大庭誠,遠山琴美George Ouma Opiyo出水庸介栗原正明土井光暢田中正一Peptide foldamers changing their conformations in response to low pH trigger54回ペプチド討論会,大阪(201711).

84. 古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,土井光暢,田中正一,Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides54回ペプチド討論会,大阪(201711).

85. 杉山亨小原美咲桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine54回ペプチド討論会,大阪(201711).

86. 出水庸介三澤隆史,栗原正明二次構造制御に基づくペプチド創薬研究43回反応と合成の進歩シンポジウム,富山(201711).

87. 小林寛幸,三澤隆史,松野研司,出水庸介Post-modification可能なa,a-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析43回反応と合成の進歩シンポジウム,富山(201711).

88. 江藤諒,大庭誠,上田篤志,土井光暢出水庸介,栗原正明,宇久翼田中正一,側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造43回反応と合成の進歩シンポジウム,富山(201711).

89. 小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介,二次構造に着目したカチオン性膜透過ペプチドの創製研究34回メディシナルケミストリーシンポジウム,名古屋(201710).

90. 大庭誠,古川かほり,遠山琴美George Ouma Opiyo出水庸介栗原正明,土井光暢,田中正一,pHに応答して二次構造を変化させるペプチドフォルダマーの開発34回メディシナルケミストリーシンポジウム,名古屋(201710).

91. 古場百合恵上田篤志大庭誠出水庸介土井光暢田中正一小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究34回メディシナルケミストリーシンポジウム,名古屋(201710).

92. 杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,正電荷を帯びたグアニン誘導体をもつPNAの合成34回メディシナルケミストリーシンポジウム,名古屋(201710).

93. 小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発47回複素環化学討論会,高知(201710).

94. 大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦,芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発,76回日本癌学会学術総会,横浜(20179).

95. 小林寛幸,三澤隆史,内藤幹彦,出水庸介カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発61回日本薬学会関東支部大会,東京20179).

96. 三澤隆史,出水庸介,多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発61回日本薬学会関東支部大会,東京20179).

97. 小林寛幸,三澤隆史松野研司,出水庸介,カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発,第49回若手ペプチド夏の勉強会,長崎(20178.

98. 栗原正明,三澤隆史,出水庸介,ジフェニルメタンを基本骨格とするリガンドの創製,東京,第3Neo Vitamin D Workshop20178).

99. 出水庸介,田中理恵,袴塚高志,栗原正明,花尻瑠理,コンピュータシミュレーションによる違法薬物の活性予測に関する研究,日本法中毒学会第36回年会,東京(20177).

100.     三澤隆史,小林寛幸,大庭誠,田中正一,栗原正明出水庸介二次構造制御を基盤とした膜透過性ペプチドの開発33回日本DDS学会学術集会,京都(20177).

101.     古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,栗原正明,田中正一,キラルな三員環状ジ置換アミノ酸とそのペプチドの合成54回化学関連支部合同九州大会,北九州(20177).

102.     三澤隆史,出水庸介栗原正明,ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製,日本ビタミン学会69回大会,横浜(20176).

103.     沖津航陽,服部隆行,三澤隆史,栗原正明内藤幹彦,出水庸介Hisタグ融合タンパク質分解誘導分子の設計と合成ケミカルバイオロジー第12回年会,札幌(20176).

104.     三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,栗原正明出水庸介親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発,第15回次世代を担う有機化学シンポジウム20165).

105.     _島一史出水庸介,三澤隆史,菊池裕,栗原正明,抗菌活性を有するヘリカルプチドの設計と合成日本薬学会第137回年会,仙台(20173).

106.     三澤隆史,大岡伸通,山下博子,加藤巧馬,大庭誠,田中正一,内藤幹彦,出水庸介栗原正明親水性分子の細胞内導入を志向した膜透過性ペプチドの開発日本薬学会第137回年会,仙台(20173).

107.     沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明ユビキチンープロテアソーム系を介したHisグタンパク質分解誘導分子の開発日本薬学会第137回年会,仙台(20173).

108.     小林寛幸,出水庸介三澤隆史,山下博子,大庭誠,田中正一,松野研司栗原正明,プロリンの二次構造特異性を生かした細胞膜透過性ペプチドの開発, 日本薬学会第137回年会,仙台(20173).

109.     正田卓司,藤里卓磨,三澤隆史,出水庸介井上英史,内藤幹彦,栗原正明,選択的エストロゲン受容体分解薬(SERD)の分子設計日本薬学会第137回年会,仙台(20173).

110.     大岡伸通,鈴木孝昌,橋井則貴,出水庸介,栗原正明,石川明子,内藤幹彦,分子標的薬オフターゲット効果の新しい評価法開発, 日本薬学会第137回年会,仙台(20173).

111.     古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,栗原正明,田中正一,3員環状ジ置換アミノ酸とその含有ペプチドの合成日本薬学会第137回年会,仙台(20173).

112.     杉山亨,長谷川元気,新倉千絵,桑田啓子,今村保忠出水庸介栗原正明橘高敦史標準的Fmoc法固相合成のための2-チオウラシルPNAモノマー,日本薬学会第137回年会,仙台(20173).

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113.     出水庸介三澤隆史,山下博子,大庭誠,田中正一,内藤幹彦,栗原正明,二次構造制御を基軸とした膜透過ペプチドの創製研究, 33回メディシナルケミストリーシンポジウム,つくば(201611).

114.     杉山亨,長谷川元気,新倉千絵,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史Fmoc法による擬似相補的PNAの合成, 33回メディシナルケミストリーシンポジウム,つくば(201611).

115.     三澤隆史,大岡伸通,山下博子,服部隆行,加藤巧馬,大庭誠,田中正一,内藤幹彦,出水庸介栗原正明核酸医薬を志向した高膜透過性ペプチドの開発日本バイオマテリアル学会シンポジウム2016,福岡(201611).

116.     出水庸介沖津航陽,服部隆行,三澤隆史,内藤幹彦,栗原正明Hisタグ融合タンパク質分解誘導分子の開発42回反応と合成の進歩シンポジウム,静岡(201611).

117.     正田卓司,藤里卓磨,三澤隆史,出水庸介井上英史,内藤幹彦,栗原正明,長鎖アルキル基を有する新規エストロゲン受容体分解誘導剤の合成と評価42回反応と合成の進歩シンポジウム,静岡(201611).

118.     三澤隆史出水庸介山下博子加藤巧馬大庭誠田中正一栗原正明Development of helix-stabilized amphipathic cell-penetrating peptide using helical promoter53回ペプチド討論会,京都(201610).

119.     沖津航陽服部隆行出水庸介三澤隆史正田卓司内藤幹彦栗原正明Design and synthesis of degradation of inducers targeted on His-tag fused proteins53回ペプチド討論会,京都(201610).

120.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史New Fmoc 2-thiouracil monomer for the synthesis of pseudo-complementary PNA53回ペプチド討論会,京都(201610).

121.     上田篤志,大庭誠,和泉有紀,末吉康人,土井光暢,出水庸介栗原正明,田中正一,Enantioselective synthesis of isotope-labeled a-aminoisobutyric acids and the secondary structures of their homo-chiral homopeptides53回ペプチド討論会,京都(201610).

122.     出水庸介小林寛幸,山下博子三澤隆史大庭誠田中正一松野研司栗原正明側鎖にグアニジノ基を有するプロリン誘導体の合成と細胞膜透過性ペプチドへの応用,46回複素環化学討論会,金沢(20169).

123.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史,機能性分子を目指した修飾デアザグアニンのペプチド核酸への導入46回複素環化学討論会,金沢(20169).

124.     三澤隆史,山下博子,加藤巧馬,大岡伸通,服部隆行,大庭誠,田中正一,内藤幹彦,出水庸介栗原正明ヘリカルテンプレート導入によるオリゴアルギニンの二次構造制御と膜透過能への効果60回日本薬学会関東支部大会,東京20169).

125.     沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明Hisタグ融合タンパク質分解誘導分子の開発,第60回日本薬学会関東支部大会,東京(20169.

126.     正田卓司,藤里卓磨,三澤隆史,出水庸介井上英史,内藤幹彦,栗原正明,長鎖アルキル基を利用した新規エストロゲン受容体分解誘導剤の創製10回バイオ関連化学シンポジウム,金沢(20169).

127.     三澤隆史,山下博子,出水庸介服部隆行,加藤巧馬,大庭誠,田中正一,内藤幹彦,栗原正明二次構造に着目した高膜透過性ペプチドの開発10回バイオ関連化学シンポジウム,金沢(20169).

128.     沖津航陽,出水庸介,三澤隆史,栗原正明Hisタグ融合タンパク質分解誘導分子の開発48回若手ペプチド夏の勉強会,東京(20168.

129.     小林寛幸,出水庸介三澤隆史栗原正明二次構造制御を基軸とした膜透過ペプチドの開発,第48回若手ペプチド夏の勉強会,東京(20168.

130.     三澤隆史,山下博子,出水庸介服部隆行,原屋佑樹,加藤巧馬,大庭誠,加藤くみ子,田中正一,合田幸広,内藤幹彦,栗原正明二次構造制御に基づく高膜透過性ペプチドの開発32回日本DDS学会学術集会20166).

131.     三澤隆史,出水庸介,谷内出友美,大岡伸通,野尻久雄,橘高敦史,槇島誠,内藤幹彦,栗原正明,ビタミンD受容体(VDR)の活性を制御するノンセコステロイド型VDRリガンドの創製,日本ビタミン学会68回大会20166).

132.     出水庸介山下博子加藤巧馬大岡伸通三澤隆史服部隆行田中正一内藤幹彦大庭誠栗原正明,ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの創製,ケミカルバイオロジー第11回年会(20166).

133.     出水庸介山下博子三澤隆史大庭誠田中正一栗原正明,ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの開発,第14回次世代を担う有機化学シンポジウム20165).

134.     出水庸介大岡伸通,三澤隆史,内藤幹彦,栗原正明,エストロゲン受容体分解誘導ペプチドの創製日本薬学会第136回年会(20163).

135.     三澤隆史,山下博子,加藤巧馬,服部隆行,大庭誠,田中正一,内藤幹彦,出水庸介,栗原正明,ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果,日本薬学会第136回年会(20163).

136.     山下博子出水庸介加藤巧馬大岡伸通三澤隆史服部隆行田中正一内藤幹彦大庭誠栗原正明環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発日本薬学会第136回年会(20163).

137.     沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明,Hisタグタンパク質分解誘導分子の開発日本薬学会第136回年会(20163).

138.     小澤佑斗出水庸介,三澤隆史,菊池裕,栗原正明,二次構造制御に基づく抗菌ペプチドフォルダマーの開発日本薬学会第136回年会(20163).

139.     正田卓司,加藤雅士,藤里卓磨,三澤隆史,出水庸介井上英史,内藤幹彦,栗原正明,エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発日本薬学会第136回年会(20163).

140.     古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一,エチレンアセタールを有するキラル5員環アミノ酸を含有するペプチドのヘリカル二次構造日本薬学会第136回年会(20163).

141.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史,デアザグアニン誘導体を持つPNAの合成,日本薬学会第136回年会(20163).

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142.     野尻久雄,村田拓哉,橘高敦史,出水庸介三澤隆史,栗原正明ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導36回日本臨床薬理学会学術総会201512).

143.     出水庸介山下博子,三澤隆史,大庭誠,田中正一,栗原正明グアニジノ基を有する環状アミノ酸の合成と細胞膜透過性ペプチドへの応用45回複素環化学討論会201511).

144.     榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用45回複素環化学討論会201511).

145.     出水庸介三澤隆史,諫田泰成,大岡伸通,関野祐子,内藤幹彦,栗原正明,エストロゲン受容体を標的とした転写活性化阻害および分解誘導ペプチドの創製33回メディシナルケミストリーシンポジウム201511).

146.     三澤隆史,依岡桃子,出水庸介,谷内出友美,大岡伸通,木下恵愛,野尻久雄,橘高敦史,槇島誠,内藤幹彦,栗原正明,ノンセコステロイド型ビタミンD受容体リガンドの創製―官能基変換による活性制御―33回メディシナルケミストリーシンポジウム201511).

147.     依岡桃子,三澤隆史,出水庸介大岡伸通,諫田泰成,槇島誠,南雲紳史,関野祐子内藤幹彦,栗原正明,エストロゲン受容体転写阻害剤および分解誘導剤の創製33回メディシナルケミストリーシンポジウム201511).

148.     正田卓司,加藤雅士,藤里卓磨,三澤隆史,出水庸介井上英史,内藤幹彦,栗原正明,ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発33回メディシナルケミストリーシンポジウム201511).

149.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史,修飾デアザグアニン含有PNAオリゴマーの合成,33回メディシナルケミストリーシンポジウム201511).

150.     榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子血管新生促進作用を有する新規2-クロル炭素環オキセタノシンACOA-Cl)誘導体の創製33回メディシナルケミストリーシンポジウム201511).

151.     出水庸介三澤隆史,諫田泰成大岡伸通,関野祐子内藤幹彦栗原正明,Development of helical peptide as inhibitors of estrogen receptor-mediated transcription52回ペプチド討論会201511).

152.     三澤隆史,出水庸介栗原正明,Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors52回ペプチド討論会201511).

153.     山下博子出水庸介三澤隆史服部隆行大庭誠田中正一内藤幹彦栗原正明Development of helix-stabilized cationic peptides with cell-membrane penetrating ability52回ペプチド討論会201511).(優秀発表賞

154.     沖津航陽服部隆行出水庸介三澤隆史正田卓司内藤幹彦栗原正明Development of His-tag fused protein degradation inducer based on protein knockdown strategy52回ペプチド討論会201511).

155.     古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一,Conformational analysis of peptides composed of chiral cyclic amino acids52回ペプチド討論会201511).

156.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA,第52回ペプチド討論会201511).

157.     榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子血管新生促進剤を指向した2-クロル炭素環オキセタノシンACOA-Cl)の新規誘導体の創製研究,第54回薬学会中国四国支部学術大会201510).

158.     三澤隆史,依岡桃子,出水庸介大岡伸通,木下恵愛,槇島誠,内藤幹彦,栗原正明,長鎖アルキルを有するノンセコステロイド型VDRリガンドの創製41回反応と合成の進歩シンポジウム201510).

159.     山下博子,出水庸介三澤隆史,服部隆行,大庭誠,田中正一,内藤幹彦,栗原正明細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用41回反応と合成の進歩シンポジウム201510).(優秀発表賞

160.     出水庸介,三澤隆史,内山奈穂子花尻瑠理,袴塚高志,栗原正明コンピュータシミュレーションによる合成カンナビノイドのCB1受容体への結合様式解析,第59回日本薬学会関東支部大会20159).

161.     田中克哉,三澤隆史,出水庸介諫田泰成,槇島誠,関野祐子,内藤幹彦,栗原正明_フェニルメタンを基本骨格とするエストロケ_ン受容体アンタコ_ニストの創製,59回日本薬学会関東支部大会20159).

162.     依岡桃子,三澤隆史,出水庸介大岡伸通,槇島誠,南雲紳史,内藤幹彦,栗原正明_フェニルメタンを基本骨格としたエストロケ_ン受容体転写阻害剤および分解誘導剤の開発,59回日本薬学会関東支部大会20159).

163.     三澤隆史,依岡桃子,出水庸介大岡伸通,木下恵愛,槇島誠,内藤幹彦,栗原正明,長鎖アルキル基を有するビタミンD受容体リガンドの創製,第59回日本薬学会関東支部大会20159).

164.     三澤隆史,出水庸介槇島誠栗原正明,ノンセコステロイド型VDRリガンドの創製,第1Neo Vitamin D Workshop20158).

165.     平田尚也,山田茂,出水庸介,栗原正明,関野祐子,諫田泰成エストロゲンによるNOを介した乳癌幹細胞の増殖132回日本薬理学会関東部会20157).

166.     山下博子,出水庸介三澤隆史,大庭誠,田中正一,服部隆行,内藤幹彦,栗原正明DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発31回日本DDS学会学術集会20157).

167.     大庭誠,古川かほり,加藤巧馬,山下博子,出水庸介栗原正明,田中正一,アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究31回日本DDS学会学術集会20157).

168.     出水庸介三澤隆史,長久保貴哉諫田泰成奥平桂一郎関野祐子,内藤幹彦,栗原正明,エストロゲン受容体転写活性化阻害能を有するヘリカルペプチドの開発ケミカルバイオロジー第10回年会(20156).

169.     三澤隆史,出水庸介栗原正明,ヘリカルペプチドを用いたビタミンD受容体(VDR-コアクチベータ相互作用阻害剤の創製ケミカルバイオロジー第10回年会(20156).

170.     沖津航陽,出水庸介,三澤隆史,正田卓司,服部隆行,内藤幹彦,栗原正明,Hisタグタンパク質応答性蛍光プローブの開発,ケミカルバイオロジー第10回年会(20156).

171.     榊原紀和Gianfranco BalboniCenzo CongiuValentina Onnis出水庸介三澤隆史栗原正明,加藤善久,丸山徳見外山政明岡本実佳馬場昌範新規トリアジン誘導体の合成とそれらのHIV-1活性評価ケミカルバイオロジー第10回年会(20156).

172.     Hirata, N.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y., Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP signaling pathway, 13回幹細胞シンポジウム2015.5.

173.     出水庸介,長久保貴哉三澤隆史,諫田泰成奥平桂一郎関野祐子,内藤幹彦,栗原正明,エストロゲン受容体転写活性化阻害ペプチドの創製日本薬学会第135回年会(20153).

174.     三澤隆史,出水庸介,船田正彦,栗原正明,カンナビノイド受容体調整薬の設計と合成,日本薬学会第135回年会(20153).

175.     山下博子, 出水庸介, 三澤隆史, 服部隆行, 大庭誠, 田中正一, 内藤幹彦, 栗原正明,二次構造制御に基づくカチオン性膜透過ペプチドの開発日本薬学会第135回年会(20153).

176.     沖津航陽,出水庸介,三澤隆史,正田卓司,服部隆行,内藤幹彦,栗原正明,細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発,日本薬学会第135回年会(20153).

177.     田中克哉,依岡桃子,三澤隆史,諫田泰成関野祐子,出水庸介栗原正明,非対称シ_フェニルメタンを基本骨格とするエストロケ_ン受容体アンタコ_ニストの設計と合成,日本薬学会第135回年会(20153).

178.     岡崎優祐出水庸介,細谷翼栗原正明,須原義智,糖アミノ酸を用いた新規糖質類縁体の合成と抗ウィルス薬への応用日本薬学会第135回年会(20153).

179.     杖本望出水庸介百合野翔太郎,中村陽菜土井麻緒,栗原正明,須原義智,三重螺旋構造の安定化を指向したβ-ペプチド導入型コラーゲン模倣物の創製日本薬学会第135回年会(20153).

180.     古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一,アセタールを有するキラル環状ジ置換アミノ酸によるヘリカル二次構造の制御日本薬学会第135回年会(20153).

181.     江藤諒,大庭誠,上田篤志,栗原正明,出水庸介末宗洋,田中正一,D-トレイトール由来のアセタールを有する六員環状ジ置換アミノ酸よりなるペプチドのコンフォメーション解析,日本薬学会第135回年会(20153).

182.     清水貴士,山本耕介,メイビョウ,出水庸介,栗原正明,末宗洋,臼井一晃,リパーゼ触媒を用いた[5]ヘリセン類の速度論的光学分割,日本薬学会第135回年会(20153).

183.     榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,三澤隆史,栗原正明,入江晃司,加藤善久,丸山徳見,3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価日本薬学会第135回年会(20153).

184.     杉山亨,桑田啓子,今村保忠出水庸介栗原正明高野真史橘高敦史,デアザグアニン誘導体を持つPNAモノマーの合成,日本薬学会第135回年会(20153).

平成26

185.     三澤隆史,長久保貴哉出水庸介,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明,ヘリカルペプチドを用いたエストロゲン受容体転写阻害剤の創製32回メディシナルケミストリーシンポジウム201411).

186.     杖本望出水庸介